PE20020505A1 - Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedades - Google Patents

Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedades

Info

Publication number
PE20020505A1
PE20020505A1 PE2001000834A PE2001000834A PE20020505A1 PE 20020505 A1 PE20020505 A1 PE 20020505A1 PE 2001000834 A PE2001000834 A PE 2001000834A PE 2001000834 A PE2001000834 A PE 2001000834A PE 20020505 A1 PE20020505 A1 PE 20020505A1
Authority
PE
Peru
Prior art keywords
cycloalkyl
rent
carboxamide
oct
alkyl
Prior art date
Application number
PE2001000834A
Other languages
English (en)
Spanish (es)
Inventor
Jason K Myers
Bruce N Rogers
Groppi
David W Piotrowski
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20020505A1 publication Critical patent/PE20020505A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PE2001000834A 2000-08-21 2001-08-21 Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedades PE20020505A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22665200P 2000-08-21 2000-08-21
US28483201P 2001-04-19 2001-04-19

Publications (1)

Publication Number Publication Date
PE20020505A1 true PE20020505A1 (es) 2002-06-12

Family

ID=26920741

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000834A PE20020505A1 (es) 2000-08-21 2001-08-21 Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedades

Country Status (5)

Country Link
EP (1) EP1311505A2 (fr)
JP (1) JP2004506734A (fr)
AU (1) AU2001282910A1 (fr)
PE (1) PE20020505A1 (fr)
WO (1) WO2002016355A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214686B2 (en) 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
SE0000540D0 (sv) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
NZ533259A (en) 2001-12-14 2007-10-26 Targacept Inc Methods and compositions for treatment of central nervous system disorders
DE10211416A1 (de) * 2002-03-15 2003-09-25 Bayer Ag Essig- und Propionsäureamide
DE10211415A1 (de) * 2002-03-15 2003-09-25 Bayer Ag Bicyclische N-Biarylamide
DE10234424A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Benzothiophen-, Benzofuran- und Indolharnstoffe
WO2004052889A1 (fr) * 2002-12-06 2004-06-24 Pharmacia & Upjohn Company Llc Composes utilises comme ligands radioactifs pour diagnostiquer une maladie
PL378026A1 (pl) * 2003-01-22 2006-02-20 Pharmacia & Upjohn Company Llc Leczenie chorób z zastosowaniem pełnych agonistów receptora Ó-7 nACh
JP2007533641A (ja) 2003-10-15 2007-11-22 ターガセプト，インコーポレイテッド 疼痛緩和および中枢神経系障害治療のためのアザビシクロ化合物
SE0303075D0 (sv) * 2003-11-19 2003-11-19 Astrazeneca Ab 4-substituted imidazoles
SE0303076D0 (sv) * 2003-11-19 2003-11-19 Astrazeneca Ab 5-substituted imidazoles
US20070270458A1 (en) * 2003-12-22 2007-11-22 Glen Ernst Nicotinic Acetylcholine Receptor Ligands
MXPA06007024A (es) * 2003-12-22 2006-08-31 Astrazeneca Ab Ligandos del receptor nicotinico de acetilcolina.
EP1751150A2 (fr) 2004-05-19 2007-02-14 Neurosearch A/S Nouveaux derives aryle azabicycliques
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
BRPI0614874A2 (pt) 2005-08-22 2011-04-19 Targacept Inc diazatricicloalcanos substituìdos com heteroarila, métodos para sua preparação e uso dos mesmos
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
AU2008293542B9 (en) 2007-08-27 2014-08-07 Dart Neuroscience (Cayman) Ltd. Therapeutic isoxazole compounds
MX2010003375A (es) 2007-10-01 2010-05-17 Comentis Inc Derivados de 1h-indol-3-carboxilato de quinuclidin-4-ilmetilo como ligandos del receptor de acetilcolina alfa 7 nicotinico para el tratamiento de enfermedad de alzheimer.
WO2009098282A1 (fr) * 2008-02-06 2009-08-13 Novasaid Ab Dérivés de thiophène 2,5-disubstitués de faible poids moléculaire et leur utilisation en thérapie
PT2254598E (pt) 2008-02-13 2013-10-16 Targacept Inc Combinação de agonistas nicotínicos alfa 7 e antipsicóticos
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
MA34957B1 (fr) * 2011-02-23 2014-03-01 Lupin Ltd Derives heteroaryle a titre modulateurs des nachr alpha 7
ES2606043T3 (es) * 2011-07-05 2017-03-17 Lupin Limited Derivados de biarilo como moduladores de nAChR
JPWO2013161871A1 (ja) * 2012-04-25 2015-12-24 興和株式会社 Ｔｌｒ阻害作用を有するチオフェン誘導体
JPWO2014069554A1 (ja) * 2012-10-31 2016-09-08 東レ株式会社 キヌクリジンアミド誘導体及びその医薬用途
TW201617342A (zh) 2014-07-11 2016-05-16 阿法馬根公司 調節α７活性之啶類

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863919A (en) * 1988-02-01 1989-09-05 A. H. Robins Company, Incorporated Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes
IT1228288B (it) * 1989-01-09 1991-06-07 Zambon Spa Composti ad attivita' antiserotoninica
JPH04247081A (ja) * 1991-02-01 1992-09-03 Takeda Chem Ind Ltd ５員複素環酸アミド類
SE9600683D0 (sv) * 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
JP2002500652A (ja) * 1997-05-30 2002-01-08 ニューロサーアチ・アクティーゼルスカブ スピロ−キヌクリジン誘導体、その製造方法及びその使用方法
SE9904176D0 (sv) * 1999-11-18 1999-11-18 Astra Ab New use
SE0000540D0 (sv) * 2000-02-18 2000-02-18 Astrazeneca Ab New compounds

Also Published As

Publication number Publication date
AU2001282910A1 (en) 2002-03-04
WO2002016355A2 (fr) 2002-02-28
EP1311505A2 (fr) 2003-05-21
WO2002016355A3 (fr) 2002-07-18
JP2004506734A (ja) 2004-03-04

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