PE20020382A1 - Derivados de acido heteroarilalcanoico como antagonistas de la integrina - Google Patents
Derivados de acido heteroarilalcanoico como antagonistas de la integrinaInfo
- Publication number
- PE20020382A1 PE20020382A1 PE2001000576A PE2001000576A PE20020382A1 PE 20020382 A1 PE20020382 A1 PE 20020382A1 PE 2001000576 A PE2001000576 A PE 2001000576A PE 2001000576 A PE2001000576 A PE 2001000576A PE 20020382 A1 PE20020382 A1 PE 20020382A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- alkyl
- derivatives
- ilamine
- oxadiazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE ACIDO HETEROARILALCANOICO DE FORMULA I DONDE A ES UN ANILLO MONOCICLICO DE 4-8 MIEMBROS O UN ANILLO BICICLICO DE 7-12 MIEMBROS QUE CONTIENE 1 A 4 HETEROATOMOS SELECCIONADOS DE O, N, S OPCIONALMENTE SATURADO O INSATURADO CON ALQUILO, HALOALQUILO, ARILO HETEROARILO, CON LA CONDICION DE QUE CUANDO Y4 EN LA FORMULA I ES H, EL ANILLO A PUEDE NO SER UN OXAZOL CON UNA CADENA LATERAL QUE CONTIENEN X-Y CONECTADA EL CARBONO 2; A1 ES UN HETEROCICLO MONOCICLICO DE 5-9 MIEMBROS, POLICICLICO DE 7-14 MIEMBROS DE FORMULA a QUE CONTIENE POR LO MENOS UN ATOMO DE N DONDE RK ES OH, ALQUILO, ALCOXI, ENTRE OTROS; R2 ES H, ALQUILO, ARILO, OH, ALCOXI, ENTRE OTROS; R2 JUNTO A R7 FORMA UN HETEROCICLO QUE CONTIENE DINITROGENO DE 4-12 MIEMBROS CON ALQUILO, TIOALQUILO, ALQUILAMINO, OH, CETO, ENTRE OTROS; Y2 ES ALQUILO, CICLOALQUILO, BICICLOALQUILO, ENTRE OTROS; Z1 ES CH2, O, NH, CO, ENTRE OTROS; Z2 ES UN ENLAZANTE DE 2-5 CARBONOS; X ES S, SO2, CO, ENTRE OTROS; Y ES CO, SO2, ENTRE OTROS; Y3 E Y4 SON H, ALQUILO, HALOALQUILO, ENTRE OTROS; Y5 ES C; Rb ES OH. SON COMPUESTOS PREFERIDOS ACIDO 3-METIL-4-(3-{3-[(PIRIDIN-2-ILAMINO)METIL]FENIL-1,2,4-OXADIAZOL-5-IL-BUTANOICO, ACIDO 3-METIL-4-(3-{4-[(PIRIDIN-2-ILAMINO)METIL]FENIL-1,2,4-OXADIAZOL-5-IL-BUTANOICO, ACIDO [1-({3-[4-(PIRIDIN-2-ILAMINO)BUTIL]-1,2,4-OXADIAZOL-5-IL}METIL)CICLOPENTIL]-ACETICO, ENTRE OTROS. LOS DERIVADOS DE ACIDO HETEROARILALCANOICO SON ANTAGONISTAS DE LA INTEGRINA E INHIBEN LA ANGIOGENES, METASTASIS TUMORAL
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21178200P | 2000-06-15 | 2000-06-15 | |
US21178100P | 2000-06-15 | 2000-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020382A1 true PE20020382A1 (es) | 2002-05-10 |
Family
ID=26906455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000576A PE20020382A1 (es) | 2000-06-15 | 2001-06-15 | Derivados de acido heteroarilalcanoico como antagonistas de la integrina |
Country Status (7)
Country | Link |
---|---|
US (2) | US6933304B2 (es) |
EP (1) | EP1289983A2 (es) |
JP (1) | JP2004511434A (es) |
AR (1) | AR031109A1 (es) |
AU (1) | AU2001269876A1 (es) |
PE (1) | PE20020382A1 (es) |
WO (1) | WO2001096334A2 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6933304B2 (en) * | 2000-06-15 | 2005-08-23 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
ATE468325T1 (de) | 2001-03-19 | 2010-06-15 | Dainippon Sumitomo Pharma Co | Arylsubstituierte alicyclische verbindung und diese enthaltende medizinische zusammensetzung |
US20040224986A1 (en) | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
CA2507958A1 (en) * | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Pyrazole compounds as integrin receptor antagonists derivatives |
JP2006518333A (ja) * | 2002-12-20 | 2006-08-10 | ファルマシア・コーポレーション | インテグリン受容体アンタゴニストとしてのヘテロアリールアルカン酸 |
US7115596B2 (en) | 2002-12-20 | 2006-10-03 | Pharmacia Corporation | Thiazole compounds as integrin receptor antagonists derivatives |
US7351711B2 (en) | 2003-07-31 | 2008-04-01 | Janssen Pharmaceutical, N.V. | Tricyclic indanyls as integrin inhibitors |
US20080306116A1 (en) * | 2007-06-08 | 2008-12-11 | Christ Andreas D | Aryloxazole, aryloxadiazole and benzimidazole derivatives |
TW201010700A (en) * | 2008-08-25 | 2010-03-16 | Piramal Lifesciences Ltd | Diacylglycerol acyltransferase inhibitors |
DE112010001898T5 (de) | 2009-04-27 | 2012-08-02 | Dow Agrosciences Llc | Insektizide Pyridinverbindungen |
CA2784710A1 (en) * | 2009-12-15 | 2011-06-23 | Shionogi & Co., Ltd. | Oxadiazole derivative having endothelial lipase inhibitory activity |
AU2011224287B2 (en) | 2010-03-12 | 2015-03-26 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
US8716226B2 (en) | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
AU2013292580B2 (en) | 2012-07-18 | 2017-07-20 | Saint Louis University | Beta amino acid derivatives as integrin antagonists |
GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
NZ716462A (en) | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
GB201417094D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417018D0 (en) * | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417002D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
CN107530313A (zh) | 2015-04-24 | 2018-01-02 | 奥默罗斯公司 | Pde10抑制剂以及相关组合物和方法 |
US9920045B2 (en) | 2015-11-04 | 2018-03-20 | Omeros Corporation | Solid state forms of a PDE10 inhibitor |
CA3008023A1 (en) | 2015-12-30 | 2017-07-06 | Saint Louis University | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
GB201604680D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
CN110167933B (zh) * | 2016-11-08 | 2022-06-21 | 百时美施贵宝公司 | 作为αV整联蛋白抑制剂的唑酰胺和胺 |
AU2017393297A1 (en) * | 2016-12-29 | 2019-06-13 | Indalo Therapeutics, Inc. | Integrin antagonists |
CN116283977A (zh) | 2017-02-28 | 2023-06-23 | 莫菲克医疗股份有限公司 | αvβ6整合蛋白的抑制剂 |
MA47692A (fr) | 2017-02-28 | 2020-01-08 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
JP7182568B2 (ja) | 2017-05-22 | 2022-12-02 | トパドゥール ファーマ アーゲー | 新規二重作用モード可溶性グアニル酸シクラーゼ活性化因子およびホスホジエステラーゼ阻害剤ならびにその使用 |
JOP20200212A1 (ar) * | 2018-03-07 | 2020-09-01 | Pliant Therapeutics Inc | مركبات حمض أميني وطرق استخدامها |
US20200071322A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibiting (alpha-v)(beta-6) integrin |
CN109369530B (zh) * | 2018-11-15 | 2022-03-04 | 河北三川化工有限公司 | 一种2,4-二氧-3-氮杂-螺[5,5]十一烷-1,5-二腈的制备方法 |
WO2021091823A1 (en) * | 2019-11-06 | 2021-05-14 | Albert Einstein College Of Medicine | Small molecule prostagladin transport inhibitors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9023289D0 (en) | 1990-10-25 | 1990-12-05 | Ici Plc | Herbicides |
CA2144762A1 (en) * | 1992-10-14 | 1994-04-28 | George D. Hartman | Fibrinogen receptor antagonists |
US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
JP2000510098A (ja) | 1996-03-29 | 2000-08-08 | ジー.ディー.サール アンド カンパニー | 桂皮酸誘導体 |
EP0889877B1 (en) * | 1996-03-29 | 2001-08-29 | G.D. Searle & Co. | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS |
DE19620041A1 (de) * | 1996-05-17 | 1998-01-29 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
CA2309204A1 (en) | 1997-11-26 | 1999-06-03 | Dupont Pharmaceuticals Company | 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as .alpha.v.beta.3 antagonists |
CA2315370A1 (en) * | 1997-12-17 | 1999-06-24 | Merck & Co., Inc. | Integrin receptor antagonists |
EP1044001B1 (en) | 1997-12-17 | 2005-07-06 | Merck & Co., Inc. | Integrin receptor antagonists |
CA2339666A1 (en) | 1998-08-07 | 2000-02-17 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
DE60035779T2 (de) | 1999-06-02 | 2008-04-30 | Merck & Co., Inc. | Alpha v integrin-rezeptor antagonisten |
CA2386030A1 (en) | 1999-10-04 | 2001-04-12 | Merck & Co., Inc. | Integrin receptor antagonists |
US6933304B2 (en) * | 2000-06-15 | 2005-08-23 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
-
2001
- 2001-06-15 US US09/881,913 patent/US6933304B2/en not_active Expired - Fee Related
- 2001-06-15 WO PCT/US2001/019375 patent/WO2001096334A2/en active Application Filing
- 2001-06-15 EP EP01948424A patent/EP1289983A2/en not_active Withdrawn
- 2001-06-15 US US10/311,385 patent/US7119098B2/en not_active Expired - Fee Related
- 2001-06-15 PE PE2001000576A patent/PE20020382A1/es not_active Application Discontinuation
- 2001-06-15 JP JP2002510476A patent/JP2004511434A/ja not_active Withdrawn
- 2001-06-15 AU AU2001269876A patent/AU2001269876A1/en not_active Abandoned
- 2001-06-19 AR ARP010102896A patent/AR031109A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20020133023A1 (en) | 2002-09-19 |
AR031109A1 (es) | 2003-09-10 |
AU2001269876A1 (en) | 2001-12-24 |
US7119098B2 (en) | 2006-10-10 |
JP2004511434A (ja) | 2004-04-15 |
US20040092497A1 (en) | 2004-05-13 |
EP1289983A2 (en) | 2003-03-12 |
US6933304B2 (en) | 2005-08-23 |
WO2001096334A2 (en) | 2001-12-20 |
WO2001096334A3 (en) | 2002-09-12 |
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