PE20020299A1 - BENZOPIRAN[3,4-f]QUINOLINAS COMO LIGANDOS SELECTIVOS DE RECEPTORES DE GLUCOCORTICOIDES - Google Patents

BENZOPIRAN[3,4-f]QUINOLINAS COMO LIGANDOS SELECTIVOS DE RECEPTORES DE GLUCOCORTICOIDES

Info

Publication number
PE20020299A1
PE20020299A1 PE2001000663A PE2001000663A PE20020299A1 PE 20020299 A1 PE20020299 A1 PE 20020299A1 PE 2001000663 A PE2001000663 A PE 2001000663A PE 2001000663 A PE2001000663 A PE 2001000663A PE 20020299 A1 PE20020299 A1 PE 20020299A1
Authority
PE
Peru
Prior art keywords
alkyl
benzopyran
quinolines
glucocorticoid receptors
cycloalkyl
Prior art date
Application number
PE2001000663A
Other languages
English (en)
Inventor
Todd K Jones
Michael J Goghlan
James P Edwards
John K Pratt
Alan X Wang
Steven W Elmore
Michael E Kort
Jimmie L Moore
Philip R Kym
Original Assignee
Abbott Lab
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab, Ligand Pharm Inc filed Critical Abbott Lab
Publication of PE20020299A1 publication Critical patent/PE20020299A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A BENZOPIRAN[3,4-f]QUINOLINAS DE FORMULA I; DONDE R1 ES L1-RA; L1 ES ENLACE, O, S, NR7, NR8CXNR9, X'CX, ENTRE OTROS t ES 0-2; X Y X' SON O, S; R7 ES H, ARILO, CICLOALQUILO, ENTRE OTROS; R8 Y R9 SON H, ARILO, CICLOALQUILO, ENTRE OTROS; RA ES OH, OG, CO2R20CN, ENTRE OTROS; G ES UN GRUPO PROTECTOR DE OH; R20 ES H, ALQUILO; R2, R3, R4 SON H, R1; R1 Y R2 SON X*-Y*-Z*; X* ES O, CH2, Y* ES CO, (C(R12)(R13))v; R12 Y R13 SON H, ALQUILO; v ES 1-3; Z* ES CH2, CH2SOt, CH2O; L2 ES ENLACE, ALQUILENO, ESPIROALQUILO, ENTRE OTROS; R5 ES HALO, H, C=NR7OR10CN; R6 ES H, ALQUILO; L2-R5 Y R6 JUNTOS SON O, CH2, R16 Y R16' SON H, ALQUILO O JUNTOS SON =CH2; Y ES C, N, N+(=O(-)); R17 ES H, ALQUILO; R18 Y R18' SON H, ALQUILO O JUNTOS ON HETEROALQUILO, CICLOALQUILO. SON COMPUESTOS PREFERIDOS 10-ETENIL-2,5-DIHIDRO-2,2,4-TRIMETIL-5-(2-PROPENIL)-1H-[1]-BENZOPIRAN[3,4-f]QUINOLINA; 10-ETENIL-2,5-DIHIDRO-10-METOXI-2,2,4-TRIMETIL-5-(2-PROPENIL)-1H-[1]-BENZOPIRAN[3,4-fQUINOLINA, ENTRE OTROS. LOS COMPUESTOS SON SELECTIVOS DE RECEPTORES DE GLUCOCORTICOIDES Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, INMUNES, AUTOINMUNES
PE2001000663A 2000-07-05 2001-07-04 BENZOPIRAN[3,4-f]QUINOLINAS COMO LIGANDOS SELECTIVOS DE RECEPTORES DE GLUCOCORTICOIDES PE20020299A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/610,638 US6506766B1 (en) 1998-02-13 2000-07-05 Glucocortiocoid-selective antinflammatory agents

Publications (1)

Publication Number Publication Date
PE20020299A1 true PE20020299A1 (es) 2002-04-17

Family

ID=24445838

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000663A PE20020299A1 (es) 2000-07-05 2001-07-04 BENZOPIRAN[3,4-f]QUINOLINAS COMO LIGANDOS SELECTIVOS DE RECEPTORES DE GLUCOCORTICOIDES

Country Status (12)

Country Link
US (2) US6506766B1 (es)
EP (1) EP1299392A2 (es)
JP (1) JP2004502693A (es)
CN (1) CN1451009A (es)
AU (1) AU2001270194A1 (es)
BR (1) BR0112160A (es)
CA (1) CA2415037A1 (es)
HK (1) HK1056165A1 (es)
MX (1) MXPA03000183A (es)
PE (1) PE20020299A1 (es)
UY (1) UY26817A1 (es)
WO (1) WO2002002565A2 (es)

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Also Published As

Publication number Publication date
US6951942B2 (en) 2005-10-04
US20030073703A1 (en) 2003-04-17
AU2001270194A1 (en) 2002-01-14
JP2004502693A (ja) 2004-01-29
CA2415037A1 (en) 2002-01-10
WO2002002565A3 (en) 2002-05-30
HK1056165A1 (zh) 2004-02-06
US6506766B1 (en) 2003-01-14
BR0112160A (pt) 2003-10-07
UY26817A1 (es) 2002-01-31
WO2002002565A2 (en) 2002-01-10
MXPA03000183A (es) 2004-01-29
CN1451009A (zh) 2003-10-22
EP1299392A2 (en) 2003-04-09

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