PE20020193A1 - Pirroloquinolonas como agentes antivirales - Google Patents

Pirroloquinolonas como agentes antivirales

Info

Publication number
PE20020193A1
PE20020193A1 PE2001000659A PE2001000659A PE20020193A1 PE 20020193 A1 PE20020193 A1 PE 20020193A1 PE 2001000659 A PE2001000659 A PE 2001000659A PE 2001000659 A PE2001000659 A PE 2001000659A PE 20020193 A1 PE20020193 A1 PE 20020193A1
Authority
PE
Peru
Prior art keywords
cycloalkyl
aryl
alkyl
pyroloquinolones
halogen
Prior art date
Application number
PE2001000659A
Other languages
English (en)
Inventor
Valerie A Vaillancourt
Sandra Staley
Audris Huang
Richard A Nugent
Ke Chen
Sajiv K Nair
James A Nieman
Joseph W Strohbach
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20020193A1 publication Critical patent/PE20020193A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A PIRROLOQUINOLONAS DONDE R1 ES F, Cl, Br, CN, NO2: R2 Y R3 SON H, HALOGENO, OR11, COR7, COOR11, CICLOALQUILO C3-C8, ALQUILO C1-C7; R4 Y R5 SON H, HALOGENO, ARILO, SOmR7, COR7, ENTRE OTROS; R6 ES H, HALOGENO, CICLOALQUILO C3-C8, ALQUILO C1-C4; R7 ES ALQUILO C1-C7, CICLOALQUILO C3-C5, NR8R9, ARILO, HETEROCICLO; R8 Y R9 SON H, ARILO, CICLOALQUILO C3-C8; R11 ES H, CICLOALQUILO C3-C8, ALQUILO C1-C7, ARILO. SON COMPUESTOS PREFERIDOS N-(4-CLOROBENCIL)-2-(2-HIDROXIETIL)-6-OXO-8-(TETRAHIDRO-2H-PIRAN-4-ILMETIL)-6H-PIRROLO[3,2,1-ij]QUINOLEINA-5-CARBOXAMIDA; N-(4-CLOROBENCIL)-2-(HIDROXIMETIL)-8-(4-MORFOLINILMETIL)-6-OXO-6H-PIRROLO[3,2,1-ij]QUINOLEINA-5-CARBOXAMIDA. LOS COMPUESTOS SON INHIBIDORES DE ADN POLIMERASA UTILES COMO AGENTES ANTIVIRALES
PE2001000659A 2000-07-05 2001-07-03 Pirroloquinolonas como agentes antivirales PE20020193A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21598600P 2000-07-05 2000-07-05
US27701201P 2001-03-19 2001-03-19

Publications (1)

Publication Number Publication Date
PE20020193A1 true PE20020193A1 (es) 2002-03-02

Family

ID=26910543

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000659A PE20020193A1 (es) 2000-07-05 2001-07-03 Pirroloquinolonas como agentes antivirales

Country Status (14)

Country Link
US (2) US6525049B2 (es)
EP (1) EP1299386A1 (es)
JP (1) JP2004502689A (es)
KR (1) KR20030014320A (es)
CN (1) CN1437600A (es)
AR (1) AR031857A1 (es)
AU (1) AU2001271258A1 (es)
CA (1) CA2410658A1 (es)
MX (1) MXPA03000107A (es)
MY (1) MY117789A (es)
NZ (1) NZ523449A (es)
PE (1) PE20020193A1 (es)
TW (1) TW593316B (es)
WO (1) WO2002002558A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040102473A1 (en) * 2002-08-30 2004-05-27 Wathen Michael W. Method of preventing or treating atherosclerosis or restenosis
WO2005028478A1 (en) 2003-09-19 2005-03-31 Gilead Sciences, Inc. Aza-quinolinol phosphonate integrase inhibitor compounds
US20080076738A1 (en) * 2004-04-14 2008-03-27 Cai Zhenhong R Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds
DE102006005861A1 (de) * 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
KR101567096B1 (ko) * 2007-04-20 2015-11-06 글락소 그룹 리미티드 항균제로서의 트리시클릭 질소 함유 화합물
EP2909193B1 (en) 2012-10-16 2017-04-19 Janssen Pharmaceutica NV Phenyl linked quinolinyl modulators of ror-gamma-t
EP2909189B8 (en) 2012-10-16 2017-04-19 Janssen Pharmaceutica NV Heteroaryl linked quinolinyl modulators of ror-gamma-t
WO2014062658A1 (en) 2012-10-16 2014-04-24 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of ror-gamma-t
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
AU2014334616A1 (en) 2013-10-15 2016-04-28 Janssen Pharmaceutica Nv Quinolinyl modulators of RORyt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9346782B2 (en) 2013-10-15 2016-05-24 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
CA3155287A1 (en) 2019-09-26 2021-04-01 Novartis Ag Antiviral pyrazolopyridinone compounds
CN111349094B (zh) * 2020-04-23 2021-02-02 杭州师范大学 一种6H-咪唑[4,5,1-ij]并喹诺酮及其合成方法和应用
CN112349961B (zh) * 2020-11-12 2021-09-24 宁德新能源科技有限公司 电解液及包含其的电化学装置和电子设备

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917609A (en) 1973-06-27 1975-11-04 Minnesota Mining & Mfg Pyrroloquinoline carboxylic acids and derivatives
DE2914218C2 (de) 1978-04-12 1985-10-24 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo N-Acylderivate des Ampicillins und Amoxicillins, Verfahren zu deren Herstellung und pharmazeutische Zubereitungen, welche die Verbindungen enthalten
JPS55145612A (en) 1979-05-02 1980-11-13 Otsuka Pharmaceut Co Ltd Anti-bacterial agent
JPS55153792A (en) 1979-05-18 1980-11-29 Otsuka Pharmaceut Co Ltd Cephalosporanic acid derivative
IE52670B1 (en) 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
JPH0262875A (ja) 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB9108547D0 (en) 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
DK0775702T3 (da) 1994-08-12 2003-08-18 Toyama Chemical Co Ltd Hidtil ukendte quinolon- eller naphthylidoncarboxylsyrederivater eller salt deraf
CA2242598A1 (en) 1996-02-21 1997-08-28 John Gary Montana Quinolones and their therapeutic use
WO1997031000A1 (en) 1996-02-21 1997-08-28 Darwin Discovery Limited Quinolones and their therapeutic use
US5792774A (en) * 1996-02-21 1998-08-11 Chiroscience Limited Quinolones and their therapeutic use
CN1128790C (zh) 1997-12-22 2003-11-26 法玛西雅厄普约翰美国公司 用作抗病毒剂的4－羟基喹啉－3－甲酰胺和酰肼化合物
ITMI981670A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
US6248739B1 (en) 1999-01-08 2001-06-19 Pharmacia & Upjohn Company Quinolinecarboxamides as antiviral agents

Also Published As

Publication number Publication date
AU2001271258A1 (en) 2002-01-14
CA2410658A1 (en) 2002-01-10
US20030153561A1 (en) 2003-08-14
AR031857A1 (es) 2003-10-08
EP1299386A1 (en) 2003-04-09
KR20030014320A (ko) 2003-02-15
CN1437600A (zh) 2003-08-20
WO2002002558A1 (en) 2002-01-10
JP2004502689A (ja) 2004-01-29
US20020055636A1 (en) 2002-05-09
TW593316B (en) 2004-06-21
US6525049B2 (en) 2003-02-25
US6683181B2 (en) 2004-01-27
MY117789A (en) 2004-08-30
NZ523449A (en) 2004-09-24
MXPA03000107A (es) 2003-08-19

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