PE20020974A1 - Quinolincarboxamidas sustituidas como agentes antivirales - Google Patents

Quinolincarboxamidas sustituidas como agentes antivirales

Info

Publication number
PE20020974A1
PE20020974A1 PE2002000167A PE2002000167A PE20020974A1 PE 20020974 A1 PE20020974 A1 PE 20020974A1 PE 2002000167 A PE2002000167 A PE 2002000167A PE 2002000167 A PE2002000167 A PE 2002000167A PE 20020974 A1 PE20020974 A1 PE 20020974A1
Authority
PE
Peru
Prior art keywords
methyl
type
dihydro
oxo
chlorobenzyl
Prior art date
Application number
PE2002000167A
Other languages
English (en)
Inventor
Valerie A Vaillancourt
Joseph W Strohbach
Audris Huang
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20020974A1 publication Critical patent/PE20020974A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DISUSTITUIDOS DE 4-OXO-1,4-DIHIDRO-3-QUINOLINCARBOXAMIDA DE FORMULA I, DONDE X ES Cl, Br, CN, NO2, F; Y ES MORFOLINILMETILO, TETRAHIDRO-2H-PIRANILMETILO, HIDROXIPROPINILO, HIDROXIPROPILO; Z ES HETEROCICLO1, ALQUILO C1-C7 OPCIONALMENTE SUSTITUIDO CON NR1R2, OR3; R1 Y R2 SON H, ALQUILO C1-C7; R3 ES H, ALQUILO C1-C7, HETEROCICLO1 ES UN HETEROCICLO DE 5-6 MIEMBROS OPCIONALMENTE FUSIONADO CON UN ANILLO BENCENO OPCIONALMENTE SUSTITUIDO CON OR3, CN, FENILO, CO2R3, CF3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-(4-CLOROBENCIL)-8-(3-HIDROXI-1-PROPINIL)-1-METIL-4-OXO-6-(TETRAHIDRO-2H-PIRAN-4-ILMETIL)-1,4-DIHIDRO-3-QUINOLINCARBOXAMIDA; N-(4-CLOROBENCIL)-8-(4-HIDROXI-1-BUTINIL)-1-METIL-4-OXO-6-TETRAHIDRO-2H-PIRAN-4-ILMETIL)-1,4-DIHIDRO-3-QUINOLINCARBOXAMIDA; N-(4-CLOROBENCIL)-8-(4-HIDROXI-1-BUTINIL)-1-METIL-6-(4-MORFONILMETIL)-4-OXO-1,4-DIHIDRO-3-QUINOLINCARBOXAMIDA, ENTRE OTROS; UTILIZANDO DE 0,1mg/Kg A 300mg/Kg. LOS COMPUESTOS SON AGENTES ANTIVIRALES Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE HERPES SIMPLE TIPO 1, TIPO 2, VIRUS VARICELLA ZOSTER, CITOMEGALOVIRUS, VIRUS EPSTEIN BARR, VIRUS DEL HERPES HUMANO TIPO 6, TIPO 7, TIPO 8
PE2002000167A 2001-03-01 2002-02-28 Quinolincarboxamidas sustituidas como agentes antivirales PE20020974A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27260701P 2001-03-01 2001-03-01

Publications (1)

Publication Number Publication Date
PE20020974A1 true PE20020974A1 (es) 2002-10-27

Family

ID=23040509

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000167A PE20020974A1 (es) 2001-03-01 2002-02-28 Quinolincarboxamidas sustituidas como agentes antivirales

Country Status (6)

Country Link
US (2) US6544990B2 (es)
EP (1) EP1363887A1 (es)
JP (1) JP2004520424A (es)
CA (1) CA2433467A1 (es)
PE (1) PE20020974A1 (es)
WO (1) WO2002070487A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2433467A1 (en) * 2001-03-01 2002-09-12 Joseph W. Strohbach Substituted quinolinecarboxamides as antiviral agents
WO2004019933A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019932A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2005009971A1 (ja) 2003-07-24 2005-02-03 Astellas Pharma Inc. キノロン誘導体又はその塩
CN100532362C (zh) * 2004-04-13 2009-08-26 中国科学院化学研究所 酯类反应性溶剂制备碘化n-甲基喹啉类化合物的方法
KR20150070348A (ko) 2012-10-16 2015-06-24 얀센 파마슈티카 엔.브이. RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제
MX2015004784A (es) 2012-10-16 2015-08-14 Janssen Pharmaceutica Nv Moduladores de quinolinilo unidos a fenilo de receptor nuclear de acido retinoico-gamma-t.
PT2909192T (pt) 2012-10-16 2017-08-04 Janssen Pharmaceutica Nv Moduladores de ror-gama-t quinolinilo ligados por metileno
JP6237779B2 (ja) * 2012-11-03 2017-11-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング サイトメガロウイルスの阻害薬
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
CN105848483A (zh) 2013-10-15 2016-08-10 詹森药业有限公司 RORγt 的喹啉基调节剂
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
WO2015057629A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv ALKYL LINKED QUINOLINYL MODULATORS OF RORyt
WO2020053654A1 (en) 2018-09-12 2020-03-19 Novartis Ag Antiviral pyridopyrazinedione compounds
AU2020353055B2 (en) 2019-09-26 2024-03-07 Gilead Sciences, Inc. Antiviral pyrazolopyridinone compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT841929E (pt) 1995-08-02 2003-09-30 Darwin Discovery Ltd Quinolonas e sua utilizacao terapeutica
ES2248923T3 (es) 1997-12-22 2006-03-16 PHARMACIA & UPJOHN COMPANY LLC 4-hydroxiquinolin-3-carboxamidas y hidrazidas como agentes antivirales.
US6248736B1 (en) * 1999-01-08 2001-06-19 Pharmacia & Upjohn Company 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
US6248739B1 (en) * 1999-01-08 2001-06-19 Pharmacia & Upjohn Company Quinolinecarboxamides as antiviral agents
US6682892B2 (en) * 2000-07-13 2004-01-27 Pharmacia & Upjohn Company Method for treating herpes viruses
CA2433467A1 (en) * 2001-03-01 2002-09-12 Joseph W. Strohbach Substituted quinolinecarboxamides as antiviral agents

Also Published As

Publication number Publication date
JP2004520424A (ja) 2004-07-08
CA2433467A1 (en) 2002-09-12
US6727248B2 (en) 2004-04-27
WO2002070487A1 (en) 2002-09-12
US6544990B2 (en) 2003-04-08
US20030149035A1 (en) 2003-08-07
US20020165253A1 (en) 2002-11-07
EP1363887A1 (en) 2003-11-26

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