PE20020189A1 - Oxazinquinolonas utiles en el tratamiento de infecciones virales - Google Patents

Oxazinquinolonas utiles en el tratamiento de infecciones virales

Info

Publication number
PE20020189A1
PE20020189A1 PE2001000677A PE2001000677A PE20020189A1 PE 20020189 A1 PE20020189 A1 PE 20020189A1 PE 2001000677 A PE2001000677 A PE 2001000677A PE 2001000677 A PE2001000677 A PE 2001000677A PE 20020189 A1 PE20020189 A1 PE 20020189A1
Authority
PE
Peru
Prior art keywords
alkyl
het
aryl
oxazinquinolones
useful
Prior art date
Application number
PE2001000677A
Other languages
English (en)
Inventor
Steven R Turner
Atli Thorarensen
Suvit Thaisrivongs
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20020189A1 publication Critical patent/PE20020189A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A DERIVADOS DE OXAZINQUINOLONAS Y TIOAZINQUINOLONAS CON UN ANILLO EN LA POSICION 4(N-4) CON LA POSICION 11(C-11) DE FORMULA I DONDE X ES O, S; Y ES Cl, F, Br, CN, NO2; R1, R2, R3, R4 SON H, N3, CN, F, TRIFLUOROMETILO, ARILO, ENTRE OTROS; R5 ES ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO CON N3, HALO, CN, R6, R7; R6 ES ARILO, HET, SOiR8, OR8, ENTRE OTROS; R7 ES PO(OR10)2, CO(CH2)CON(CH3)(CH2)kSO3(-)M(+), AMINOACIDO, ENTRE OTROS; R8 Y R9 SON H, CICLOALQUILO C3-C8, ARILO, HET, ENTRE OTROS; R10 ES H, ALQUILO C1-C8; R11 Y R12 SON H, HALO, NO2CN, ENTRE OTROS; ARILO ES FENILO FUSIONADO CON CARBOCICLO O HETEROCICLO; HET ES HETEROCICLO DE 4-7 MIEMBROS CON O, S, NW; W ES H, ALQUILO C1-C4, COO-ALQUILO C1-C4, ENTRE OTROS; i ES 0-2; j, k Y n SON 1-6; AL MENOS UNO DE R1, R2, R3, R4 ES DISTINTO DE H; CUANDO R1, R2, R3, R4 SON ALQUILO C1-C8, AL MENOS UNO DE LOS ALQUILO ESTA SUSTITUIDO CON R6, OR7; SON COMPUESTOS PREFERIDOS N-(4-CLOROBENCIL)-9-(MORFOLIN-4-ILMETIL)-7-OXO-2-(S)-PIRIDIN-2-IL-2,3-DIHIDRO-7H-[1,4]OXAZINO[2,3,4-ij]QUINOLIN-6-CARBOXAMIDA, N-(4-CLOROBENCIL)-2-(1-METIL-1H-IMIDAZOL-2-IL)-9-(MORFOLIN-4-ILMETIL)-7-OXO-2,3-DIHIDRO-7H-[1,4]OXAZINO[2,3,4-ij]QUINOLIN-6-CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS SON INHIBIDORES DE DNA POLIMERASA VIRAL Y PUEDEN SER UTILES PARA PREVENIR INFECCIONES POR HERPESVIRUS, VARICELA ZOSTER, CITOMEGALOVIRUS, VIRUS DE EPSTEIN BARR
PE2001000677A 2000-07-12 2001-07-09 Oxazinquinolonas utiles en el tratamiento de infecciones virales PE20020189A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21755500P 2000-07-12 2000-07-12
US26221101P 2001-01-17 2001-01-17
US26825501P 2001-02-13 2001-02-13

Publications (1)

Publication Number Publication Date
PE20020189A1 true PE20020189A1 (es) 2002-03-02

Family

ID=27396428

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000677A PE20020189A1 (es) 2000-07-12 2001-07-09 Oxazinquinolonas utiles en el tratamiento de infecciones virales

Country Status (11)

Country Link
EP (1) EP1299395B1 (es)
JP (1) JP2004502777A (es)
AR (1) AR030304A1 (es)
AT (1) ATE276262T1 (es)
AU (1) AU2001269704A1 (es)
DE (1) DE60105614T2 (es)
ES (1) ES2227232T3 (es)
PE (1) PE20020189A1 (es)
PT (1) PT1299395E (es)
TR (1) TR200402534T4 (es)
WO (1) WO2002004462A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821969B2 (en) * 2001-02-13 2004-11-23 Pharmacia & Upjohn Company Thioxazinoquinolones as antiviral agents
BRPI0409105A (pt) * 2003-04-07 2006-04-25 Cylene Pharmaceuticals Inc análogos de quinobenzoxazina substituìdos
CN101443314B (zh) 2006-03-13 2014-04-09 杏林制药株式会社 作为gsk-3抑制剂的氨基喹诺酮类
AU2008299903B2 (en) 2007-09-11 2013-08-29 Kyorin Pharmaceutical Co., Ltd Cyanoaminoquinolones and tetrazoloaminoquinolones as GSK-3 inhibitors
KR101597841B1 (ko) 2007-09-12 2016-02-26 교린 세이야꾸 가부시키 가이샤 Ｇｓｋ-３ 억제제로서의 스피로시클릭 아미노퀴놀론
MX2011009414A (es) 2009-03-11 2011-10-19 Kyorin Seiyaku Kk 7-cicloalquiloaminoquinolonas como inhibidores de gsk-3.
WO2014062658A1 (en) 2012-10-16 2014-04-24 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of ror-gamma-t
EP2909189B8 (en) 2012-10-16 2017-04-19 Janssen Pharmaceutica NV Heteroaryl linked quinolinyl modulators of ror-gamma-t
CN105073729A (zh) 2012-10-16 2015-11-18 詹森药业有限公司 RORγt的苯基连接的喹啉基调节剂
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9346782B2 (en) 2013-10-15 2016-05-24 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
WO2015057626A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv QUINOLINYL MODULATORS OF RORyT
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
WO2020053654A1 (en) 2018-09-12 2020-03-19 Novartis Ag Antiviral pyridopyrazinedione compounds
CA3155287A1 (en) 2019-09-26 2021-04-01 Novartis Ag Antiviral pyrazolopyridinone compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959363A (en) * 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
US5792774A (en) * 1996-02-21 1998-08-11 Chiroscience Limited Quinolones and their therapeutic use
AU2657499A (en) * 1998-02-04 1999-08-23 Board Of Regents, The University Of Texas System Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents
US6248739B1 (en) * 1999-01-08 2001-06-19 Pharmacia & Upjohn Company Quinolinecarboxamides as antiviral agents
TW500724B (en) * 1999-10-05 2002-09-01 Pharmacia & Amp Upjohn Company Oxazinoquinolones useful for the treatment of viral infections

Also Published As

Publication number Publication date
WO2002004462A1 (en) 2002-01-17
ATE276262T1 (de) 2004-10-15
EP1299395A1 (en) 2003-04-09
PT1299395E (pt) 2005-01-31
TR200402534T4 (tr) 2004-12-21
JP2004502777A (ja) 2004-01-29
AR030304A1 (es) 2003-08-20
AU2001269704A1 (en) 2002-01-21
ES2227232T3 (es) 2005-04-01
EP1299395B1 (en) 2004-09-15
DE60105614T2 (de) 2005-10-06
DE60105614D1 (de) 2004-10-21

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