ES2195382T3 - Compuestos indolcarboxilicos y su uso como compuestos farmaceuticos. - Google Patents
Compuestos indolcarboxilicos y su uso como compuestos farmaceuticos.Info
- Publication number
- ES2195382T3 ES2195382T3 ES98942786T ES98942786T ES2195382T3 ES 2195382 T3 ES2195382 T3 ES 2195382T3 ES 98942786 T ES98942786 T ES 98942786T ES 98942786 T ES98942786 T ES 98942786T ES 2195382 T3 ES2195382 T3 ES 2195382T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- alkyl
- indolcarboxyl
- pharmaceutical
- chr3r4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A LA UTILIZACION COMO PRINCIPIO ACTIVO, EN UN MEDIO FISIOLOGICAMENTE ACEPTABLE, EN UNA COMPOSICION, DE UNA CANTIDAD EFICAZ DE AL MENOS UN COMPUESTO DE LA FAMILIA DE LOS INDOLCARBOXILICOS, DESTINANDOSE ESTE COMPUESTOS O ESTAS COMPOSICIONES A TRATAR LOS TRASTORNOS LIGADOS A LA SOBREACTIVIDAD DE LA 5 AL - REDUCTASA. ESTOS COMPUESTOS O LAS COMPOSICIONES QUE LOS CONTIENEN SE DESTINAN MAS EN PARTICULAR A TRATAR LOS TRASTORNOS ANDROGENODEPENDIENTES COMO POR EJEMPLO LA SEBORREA Y/O EL ACNE Y/O EL HIRSUTISMO Y/O LA ALOPECIA ANDROGENICA. LA INVENCION SE REFIERE TAMBIEN A NUEVOS COMPUESTOS DE LA FAMILIA DE LOS INDO - CARBOXILICOS ASI COMO A LAS COMPOSICIONES QUE LOS CONTIENEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9711076A FR2768146B1 (fr) | 1997-09-05 | 1997-09-05 | Nouveaux composes de la famille des indole-carboxyliques et leur utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2195382T3 true ES2195382T3 (es) | 2003-12-01 |
Family
ID=9510808
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES03000188T Expired - Lifetime ES2268169T3 (es) | 1997-09-05 | 1998-08-26 | Compuestos indol-carboxilicos y su utilizacion como compuestos farmaceuticos. |
ES98942786T Expired - Lifetime ES2195382T3 (es) | 1997-09-05 | 1998-08-26 | Compuestos indolcarboxilicos y su uso como compuestos farmaceuticos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES03000188T Expired - Lifetime ES2268169T3 (es) | 1997-09-05 | 1998-08-26 | Compuestos indol-carboxilicos y su utilizacion como compuestos farmaceuticos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US6448285B1 (es) |
EP (2) | EP1302460B1 (es) |
JP (2) | JP4090515B2 (es) |
AT (2) | ATE334962T1 (es) |
AU (1) | AU9079198A (es) |
CA (2) | CA2271085C (es) |
DE (2) | DE69812073T2 (es) |
ES (2) | ES2268169T3 (es) |
FR (1) | FR2768146B1 (es) |
WO (1) | WO1999012905A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6495538B2 (en) * | 1999-06-23 | 2002-12-17 | Zinc Therapeutics, Canada Inc. | Zinc ionophores as therapeutic agents |
FR2796279B1 (fr) * | 1999-07-16 | 2001-09-21 | Oreal | Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour le traitement de la seborrhee |
FR2796274B1 (fr) * | 1999-07-16 | 2001-09-21 | Oreal | Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
AU2002357003A1 (en) * | 2001-12-28 | 2003-07-24 | Guilford Pharmaceuticals Inc. | Indoles as naaladase inhibitors |
AU2003214462A1 (en) | 2002-04-03 | 2003-10-13 | Astrazeneca Ab | Indole derivatives having anti-angiogenetic activity |
US7041636B1 (en) | 2004-01-22 | 2006-05-09 | Benton Melody M | Composition for counteracting hair loss |
UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
US20080063673A1 (en) * | 2006-09-13 | 2008-03-13 | Akridge Robert E | Method and kit for treatment/prevention of hair loss |
US20080160509A1 (en) * | 2006-09-13 | 2008-07-03 | Pacific Bioscience Laboratories, Inc. | Assays for predicting and assessing predisposition to male pattern baldness |
WO2008042571A2 (en) * | 2006-09-29 | 2008-04-10 | Smithkline Beecham Corporation | Substituted indole compounds |
KR20090106539A (ko) | 2006-12-22 | 2009-10-09 | 쉐링 코포레이션 | Hcv 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체 |
EP2081922B1 (en) | 2006-12-22 | 2012-02-01 | Schering Corporation | 5,6-Ring annulated indole derivatives and use thereof |
AU2007339382B2 (en) | 2006-12-22 | 2013-05-02 | Merck Sharp & Dohme Llc | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
KR20090001013A (ko) * | 2007-06-29 | 2009-01-08 | 주식회사 웰스킨 | 인돌-3-알킬카복실산을 함유하는 여드름 치료제 및 피지분비 억제제, 및 이를 포함하는 광역학적 치료용 키트 |
MX2010002317A (es) | 2007-08-29 | 2010-03-22 | Schering Corp | Derivados de indol sustituidos y metodos para su utilizacion. |
AU2008295476B2 (en) | 2007-08-29 | 2013-08-01 | Merck Sharp & Dohme Corp. | 2, 3-Substituted Indole Derivatives for treating viral infections |
EP2195317B1 (en) | 2007-08-29 | 2012-01-18 | Schering Corporation | 2,3-substituted azaindole derivatives for treating viral infections |
CN102099351A (zh) | 2007-11-16 | 2011-06-15 | 先灵公司 | 3-杂环取代的吲哚衍生物及其使用方法 |
WO2009064852A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
JP5580814B2 (ja) | 2008-06-13 | 2014-08-27 | メルク・シャープ・アンド・ドーム・コーポレーション | 3環式インドール誘導体およびその使用方法 |
WO2010143803A2 (en) * | 2009-06-08 | 2010-12-16 | Industry Foundation Of Chonnam National University | New nicotinamide derivatives with anti-androgen effects, processes of preparing, and antiandrogens comprising the same |
FR2953722B1 (fr) | 2009-12-16 | 2012-03-09 | Expanscience Lab | Composition comprenant au moins un sucre en c7 pour le traitement de l'alopecie, pour le traitement cosmetique des phaneres, et pour le soin des cheveux, cils ou ongles |
KR101213495B1 (ko) * | 2010-06-03 | 2013-01-14 | 삼성디스플레이 주식회사 | 유기 발광 소자 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB359876A (en) | 1930-05-20 | 1931-10-29 | British Thomson Houston Co Ltd | Improvements in and relating to polyphase thermionic generators |
BE794483A (fr) * | 1972-01-26 | 1973-07-24 | Boehringer Mannheim Gmbh | Derives de l'acide indol-carbonique a effet hypoglycemiant et procedes pour leur preparation |
LU86347A1 (fr) * | 1986-03-06 | 1987-11-11 | Oreal | Compositions pour la coloration de la peau a base de derives d'indole |
FR2686345A1 (fr) * | 1992-01-16 | 1993-07-23 | Oreal | Produit a base de particules minerales colorees comportant un pigment melanique, son procede de preparation et son utilisation en cosmetique. |
FR2689898B1 (fr) * | 1992-04-08 | 1994-06-10 | Oreal | Pigments comportant un support inorganique et le produit de reaction d'un derive indolique et d'un derive quinonique, leur procede de preparation et leur utilisation en cosmetique. |
JPH07507574A (ja) * | 1993-04-05 | 1995-08-24 | 藤沢薬品工業株式会社 | テストステロン5α−レダクターゼ阻害剤用インドール誘導体 |
DE4314317A1 (de) | 1993-04-30 | 1994-11-03 | Henkel Kgaa | Isatinhaltige Mittel zum Färben von keratinhaltigen Fasern |
WO1997035572A1 (en) * | 1996-03-28 | 1997-10-02 | Smithkline Beecham Corporation | Carboxylic acid indole inhibitors of chemokines |
GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
-
1997
- 1997-09-05 FR FR9711076A patent/FR2768146B1/fr not_active Expired - Fee Related
-
1998
- 1998-08-26 ES ES03000188T patent/ES2268169T3/es not_active Expired - Lifetime
- 1998-08-26 DE DE69812073T patent/DE69812073T2/de not_active Expired - Fee Related
- 1998-08-26 CA CA002271085A patent/CA2271085C/fr not_active Expired - Fee Related
- 1998-08-26 EP EP03000188A patent/EP1302460B1/fr not_active Expired - Lifetime
- 1998-08-26 ES ES98942786T patent/ES2195382T3/es not_active Expired - Lifetime
- 1998-08-26 JP JP51515199A patent/JP4090515B2/ja not_active Expired - Fee Related
- 1998-08-26 AT AT03000188T patent/ATE334962T1/de not_active IP Right Cessation
- 1998-08-26 AT AT98942786T patent/ATE234283T1/de not_active IP Right Cessation
- 1998-08-26 EP EP98942786A patent/EP0964852B1/fr not_active Expired - Lifetime
- 1998-08-26 DE DE69835460T patent/DE69835460T2/de not_active Expired - Fee Related
- 1998-08-26 WO PCT/FR1998/001853 patent/WO1999012905A1/fr active IP Right Grant
- 1998-08-26 CA CA002569685A patent/CA2569685A1/fr not_active Abandoned
- 1998-08-26 US US09/297,636 patent/US6448285B1/en not_active Expired - Fee Related
- 1998-08-26 AU AU90791/98A patent/AU9079198A/en not_active Abandoned
-
2002
- 2002-06-24 US US10/176,674 patent/US6596753B2/en not_active Expired - Fee Related
-
2003
- 2003-07-09 JP JP2003272606A patent/JP2004035566A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2268169T3 (es) | 2007-03-16 |
EP0964852A1 (fr) | 1999-12-22 |
WO1999012905A1 (fr) | 1999-03-18 |
ATE334962T1 (de) | 2006-08-15 |
US20030050325A1 (en) | 2003-03-13 |
DE69812073T2 (de) | 2003-09-25 |
CA2569685A1 (fr) | 1999-03-18 |
CA2271085C (fr) | 2007-04-17 |
JP4090515B2 (ja) | 2008-05-28 |
US6596753B2 (en) | 2003-07-22 |
CA2271085A1 (fr) | 1999-03-18 |
EP0964852B1 (fr) | 2003-03-12 |
US6448285B1 (en) | 2002-09-10 |
EP1302460A1 (fr) | 2003-04-16 |
AU9079198A (en) | 1999-03-29 |
FR2768146B1 (fr) | 2000-05-05 |
DE69835460T2 (de) | 2007-07-26 |
JP2004035566A (ja) | 2004-02-05 |
EP1302460B1 (fr) | 2006-08-02 |
ATE234283T1 (de) | 2003-03-15 |
DE69812073D1 (de) | 2003-04-17 |
JP2000508352A (ja) | 2000-07-04 |
DE69835460D1 (de) | 2006-09-14 |
FR2768146A1 (fr) | 1999-03-12 |
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