PE20011097A1 - Compuestos fenoxi fenil activos en el receptor glucocorticoide - Google Patents

Compuestos fenoxi fenil activos en el receptor glucocorticoide

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Publication number
PE20011097A1
PE20011097A1 PE2000001319A PE0013192000A PE20011097A1 PE 20011097 A1 PE20011097 A1 PE 20011097A1 PE 2000001319 A PE2000001319 A PE 2000001319A PE 0013192000 A PE0013192000 A PE 0013192000A PE 20011097 A1 PE20011097 A1 PE 20011097A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
heteroaryl
isopropyl
glucocorticoid receptor
Prior art date
Application number
PE2000001319A
Other languages
English (en)
Inventor
Benjamin Pelcman
Mikael Gillner
Lars Hagberg
Marita Lindberg
Philip R Kym
Jinchang Wu
Eva Koch
Annika Gustavsson
Theresa Apelqvist
Original Assignee
Abbott Lab
Karobio Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab, Karobio Ab filed Critical Abbott Lab
Publication of PE20011097A1 publication Critical patent/PE20011097A1/es

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Abstract

SE REFIERE A COMPUESTOS 5-ISOPROPIL-FENOXI FENILACETICO DE FORMULA I DONDE R1 ES COOH, CONHOH, SO3H, P(O)(OH)(OR8), HETEROARILO; R2 Y R3 SON H, HALOGENO, ALQUILO C1-C6, ENTRE OTROS; R4, R5, R6 Y R7 SON ALQUILO C1-C12, PERFLUOROALQUILO C1-C6, ALQUILO C3-C8, ALQUENILO C2-C5, ENTRE OTROS; O R4 Y R5 SON HETEROCICLOALQUILO C3-C8, ARILO, HETEROARILO; O R4 ES HALOGENO, R80, R8S, R9S(O), ENTRE OTROS; R6 Y R7 SON H, HALOGENO, R8O, R9R10N, ENTRE OTROS; R8, R9, R10 SON H, ALQUILO C1-C12, CICLOALQUILO C3-C8, ARILO, HETEROARILO, ENTRE OTROS; Y ES H, HALOGENO, OH, ALCOXI C1-C6; ENTRE OTROS; n ES 0-3. SON COMPUESTOS PREFERIDOS ACIDO 3,5-DIBROMO-4-[2-(1-HIDROXIETIL)-5-ISOPROPIL-4-METOXIFENOXI]FENILACETICO, ACIDO 3,5-DIBROMO-4-[2(1-(3-INDOLIL)ETIL)-5-ISOPROPIL-4-METOXIFENOXI]FENILACETICO, ENTRE OTROS; EL COMPUESTO I MODULA RECEPTOR GLUCOCORTICOIDE SELECTIVO PARA HIGADO Y PUEDE SER UTIL PARA EL TRATAMIENTO DE DISFUNCION METABOLICA COMO DIABETES, ENFERMEDAD DE CUSHING, INFLAMACION, ENFERMEDADES AUTOINMUNES, RECHAZO DE TRASPLANTES, NEOPLASMA, LEUCEMIA
PE2000001319A 1999-12-07 2000-12-07 Compuestos fenoxi fenil activos en el receptor glucocorticoide PE20011097A1 (es)

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GB0029100D0 (en) * 2000-11-29 2001-01-10 Karobio Ab Compounds active at the glucocorticoid receptor
US6777442B2 (en) * 2001-03-12 2004-08-17 Bayer Aktiengesellschaft Diphenyl derivatives
MY142390A (en) * 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
EP2385032A1 (en) * 2002-11-08 2011-11-09 Takeda Pharmaceutical Company Limited GPR40 Receptor function regulator
US7250408B2 (en) 2002-12-16 2007-07-31 Bayer Schering Pharma Ag Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility
US7820837B2 (en) 2003-05-30 2010-10-26 Takeda Pharmaceutical Company Limited Condensed ring compound
CA2547212A1 (en) * 2003-11-25 2005-06-16 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
US20070270393A1 (en) * 2006-02-17 2007-11-22 Theresa Buckley Methods and compositions for modulation of sleep cycle
PL233938B1 (pl) * 2018-01-08 2019-12-31 CELON PHARMA Spólka Akcyjna Pochodne kwasu 3-fenylo-4-heksynowego jako agoniści GPR40

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GB9816935D0 (en) * 1998-08-05 1998-09-30 Karobio Ab Novel glucocortoid and thyroid receptor ligands for the treatment of metabolic disorders

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GB9928805D0 (en) 2000-02-02
JP2003519110A (ja) 2003-06-17
WO2001047859A1 (en) 2001-07-05
UY26473A1 (es) 2001-06-29
US20030166725A1 (en) 2003-09-04

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