UY26473A1 - Compuestos activos en el receptor de glucocorticoide - Google Patents

Compuestos activos en el receptor de glucocorticoide

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Publication number
UY26473A1
UY26473A1 UY26473A UY26473A UY26473A1 UY 26473 A1 UY26473 A1 UY 26473A1 UY 26473 A UY26473 A UY 26473A UY 26473 A UY26473 A UY 26473A UY 26473 A1 UY26473 A1 UY 26473A1
Authority
UY
Uruguay
Prior art keywords
compounds
active compounds
glucocorticoid receptor
methods
receptor
Prior art date
Application number
UY26473A
Other languages
English (en)
Inventor
Gillner Mikael
Apelqvist Theresa
Gustavsson Annika
Hagberg Lars
Koch Eva
Lindberg Marita
Original Assignee
Kari Bio Ab
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kari Bio Ab, Abbott Lab filed Critical Kari Bio Ab
Publication of UY26473A1 publication Critical patent/UY26473A1/es

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
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    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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Abstract

Esta invención se refiere a compuestos nuevos que son antagonistas selectivos del receptor de gluococorticoide del hígado, a métodos para la preparación de dichos compuestos, y a métodos para utilizar dichos compuestos en el tratamiento y en la regulación del metabolismo, en especial, en la disminución de los niveles de glucosa en la sangre. Los compuestos mencionados son compuestos de acuerdo con la fórmula I.
UY26473A 1999-12-07 2000-12-07 Compuestos activos en el receptor de glucocorticoide UY26473A1 (es)

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GBGB9928805.2A GB9928805D0 (en) 1999-12-07 1999-12-07 Compounds active at the Glucocorticoid and Thyroid Hormone Receptors

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UY26473A1 true UY26473A1 (es) 2001-06-29

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EP (1) EP1265839A1 (es)
JP (1) JP2003519110A (es)
AR (1) AR029458A1 (es)
AU (1) AU5787201A (es)
CA (1) CA2393583A1 (es)
GB (1) GB9928805D0 (es)
MX (1) MXPA02005158A (es)
PE (1) PE20011097A1 (es)
UY (1) UY26473A1 (es)
WO (1) WO2001047859A1 (es)

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GB0029100D0 (en) * 2000-11-29 2001-01-10 Karobio Ab Compounds active at the glucocorticoid receptor
US6777442B2 (en) * 2001-03-12 2004-08-17 Bayer Aktiengesellschaft Diphenyl derivatives
AR040083A1 (es) * 2002-05-22 2005-03-16 Smithkline Beecham Corp Compuesto bis-(monoetanolamina) del acido 3'-[(2z)-[1-(3,4-dimetilfenil) -1,5-dihidro-3-metil-5-oxo-4h-pirazol-4-iliden] hidrazino] -2'-hidroxi-[1,1'-bifenil]-3-carboxilico, procedimiento para prepararlo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion farmac
AU2003277576A1 (en) * 2002-11-08 2004-06-07 Takeda Pharmaceutical Company Limited Receptor function controlling agent
US7250408B2 (en) 2002-12-16 2007-07-31 Bayer Schering Pharma Ag Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility
EP1630152A4 (en) * 2003-05-30 2009-09-23 Takeda Pharmaceutical CONNECTION WITH CONDENSED RING
ES2299906T3 (es) * 2003-11-25 2008-06-01 Eli Lilly And Company Moduladores de receptores activados por proliferadores de peroxisomas.
US20070270393A1 (en) * 2006-02-17 2007-11-22 Theresa Buckley Methods and compositions for modulation of sleep cycle
PL233938B1 (pl) * 2018-01-08 2019-12-31 CELON PHARMA Spólka Akcyjna Pochodne kwasu 3-fenylo-4-heksynowego jako agoniści GPR40

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WO1998027986A1 (en) * 1996-12-24 1998-07-02 Zymogenetics, Inc. Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes
CA2334116A1 (en) * 1998-06-08 1999-12-16 Theresa Apelqvist Treatment of diabetes
GB9816935D0 (en) * 1998-08-05 1998-09-30 Karobio Ab Novel glucocortoid and thyroid receptor ligands for the treatment of metabolic disorders

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US20030166725A1 (en) 2003-09-04
EP1265839A1 (en) 2002-12-18
MXPA02005158A (es) 2002-12-09
AU5787201A (en) 2001-07-09
JP2003519110A (ja) 2003-06-17
CA2393583A1 (en) 2001-07-05
PE20011097A1 (es) 2001-10-27
GB9928805D0 (en) 2000-02-02
WO2001047859A1 (en) 2001-07-05
AR029458A1 (es) 2003-07-02

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