AR029458A1 - Compuestos activos en el receptor de glucocorticoide - Google Patents

Compuestos activos en el receptor de glucocorticoide

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Publication number
AR029458A1
AR029458A1 ARP000106507A ARP000106507A AR029458A1 AR 029458 A1 AR029458 A1 AR 029458A1 AR P000106507 A ARP000106507 A AR P000106507A AR P000106507 A ARP000106507 A AR P000106507A AR 029458 A1 AR029458 A1 AR 029458A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
perfluoro
group selected
hydrogen
Prior art date
Application number
ARP000106507A
Other languages
English (en)
Original Assignee
Karobio Ab
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karobio Ab, Abbott Lab filed Critical Karobio Ab
Publication of AR029458A1 publication Critical patent/AR029458A1/es

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    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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Abstract

Se refiere a compuestos nuevos que son antagonistas selectivos del receptor de glucocorticoide del hígado, a métodos para la preparacion de dichos compuestos, y a métodos para utilizar dichos compuestos en el tratamiento y en la regulacion del metabolismo, en especial, en la disminucion de los niveles de glucosa en la sangre. Los compuestos mencionados son compuestos de acuerdo con la formula (1): R1 se selecciona de COOH, C(O)NHOH, C(O)COOH, SO3H, P(O)(OH)(OR8); P(O)(OH)[N(R9)(R10)] y heteroarilo, donde cualquier residuo de heteroarilo puede ser sustituido en forma opcional en una o más posiciones en forma independiente de cada una por un grupo seleccionado de alquilo C1-6, perfluoro alquilo de C1-6, halogeno, ciano, nitro, R8O, R8S, R8S(O), R8S(O)2, y (R9) (R10)N; R2 y R3 se seleccionan en forma independiente entre sí de hidrogeno, halogeno, y alquilo C1-6, hidroxi, alcoxi C1-6, alquiltio C1-6, halo alquilo C1-6, perfluoro alquilo C1-6, halo alquiloxi C1-6, perfluoro alquiloxi C1-6, y halo alquiltio C1-6, con la condicion de que uno de R2 o R3 no sea hidrogeno; R4, R5, R6 y R7 se seleccionan en forma independiente de los otros de (i) alquilo C1-12 y perfluoro alquilo C1-6, donde cualquier residuo puede ser sustituido en forma opcional en una o más posiciones independientes entre sí por un grupo seleccionado de A; (ii) cicloalquilo C3-8, alquenilo C2-6, alquinilo C2-6, donde cualquier residuo puede ser sustituido en forma opcional en una o más posiciones en forma independiente entre sí por un grupo seleccionado de B; R4 y R5 se seleccionan, en forma independiente entre sí, de (iii) heterocicloalquilo C3-8, opcionalmente sustituido por un grupo seleccionado de B; (iv) arilo y heteroarilo, donde cualquier residuo puede ser sustituido en forma opcional en una o más posiciones en forma independiente entre sí por un grupo seleccionado de C; R4 se selecciona en forma opcional de halogeno, R8O, R8S, R8S(O), R8S(O)2, y (R9)(R10)N, R8C(Z)N(R11), (R9)(R10)NC(Z)N(R11), R8S(O)2N(R11), y (R9)(R10)NS(O)2N(R11); R6 y R7 se seleccionan en forma opcional, y en forma independientemente entre sí, de hidrogeno, halogeno, R8O, R8S, R8S(O), R8S(O)2, y (R9)(R10)N, R8C(Z)O, R8OC(Z)O, R8C(Z)N(R11), R8OC(Z)N(R11), R8S(O)nO, (R9)(R10)NC(Z)O, (R9)(R10)NS(O)2O, R8S(O)2N(R11), (R9)(R10)NS(O)2; y (R9)(R10)NS(O)2N(R11), con la condicion de que R8 no sea hidrogeno en R8OC(Z)O, R8S(O)nO, y R8S(O)2N(R11), y que solo uno de los R6 y R7 sea hidrogeno, y que si R6 es HO, R7 es hidrogeno, y que si R7 es OH, R6 es hidrogeno, R8, R9, R10 y R11 se seleccionan en forma independiente entre sí, de (v) hidrogeno; (vi) alquilo C1-12, perfluoro alquilo C1-6, donde cualquiera de sus residuos pueden ser sustituidos en forma opcional en una o más posiciones en forma independiente entre sí, por un grupo seleccionado de A; (vii) cicloalquilo C3-8, alquenilo C2-6, alquinilo C2-6, donde cualquier residuo puede ser sustituido en forma opcional en una o más posiciones en forma independiente entre sí por un grupo seleccionado de B; (viii) arilo y heteroarilo, donde cualquier residuo puede ser sustituido en forma opcional en una o más posiciones en forma independiente entre sí por un grupo seleccionado de C; o donde cualquier par de R8, R9, R10 y R11 junto con el átomo o los átomos a los cuales se encuentran unidos forman un anillo que tiene 3 a 7 elementos, y donde el anillo contiene, en forma opcional C1-3 heteroátomos o de 1 a 3 uniones dobles, y que, en forma opcional, está sustituido por un grupo seleccionado de B; A se selecciona de halogeno, perfluoro alquilo C1-6, cicloalquilo C3-8, alquenilo C2-6, alquinilo C2-6, arilo, heterocicloalquilo C3-8, heteroarilo, ciano, nitro, azido, Z, R8O, R8C(Z), R8C(Z)O, R8OC(Z), R8S, R8S(O), R8S(O)2, R8S(O)2O, R8OS(O)2, (R9)(R10)N, (R9)(R10)NC(Z), (R9)(R10)NC(Z)O, R8C(Z)N(R11), R8OC(Z)N(R11), (R9)(R10)NC(Z) N(R11), (R9)(R10)NS(O)2, R8S(O)2N(R11), (R9)(R10)NS(O)2N(R11), y R8SC(Z)N(R11), donde cualquier residuo de perfluoro alquilo C1-6, cicloalquilo C3-8, alquenilo C2-6, alquinilo C2-6, heterocicloalquilo C3-8 está sustituido en forma opcional en una o más posiciones en forma independiente entre sí por un grupo seleccionado de B, y además donde cualquier residuo de arilo o heteroarilo está sustituido en forma opcional en una o más posiciones en forma independiente entre sí por un grupo seleccionado de C; B se define como A o un alquilo C1-6 sustituido en forma opcional en una o más posiciones en forma independiente entre sí por un grupo seleccionado de D, con la condicion de que si B está adherido en forma directa a una union doble o a una union triple, o a un carbono adherido en forma directa a un heteroátomo, B no es HO, HS, R9HN, (R9)(R10)NC(Z) NH, (R9)(R10)NS(O)2NH, o R8S(O)2NH, y con la condicion adicional de que si B está adherido en forma directa a una doble union o a una triple union, B no sea Z, C se define como A, o un grupo alquilo C1-6 sustituido en forma opcional en una o más posiciones en forma independiente entre sí por un grupo seleccionado de D, con la condicion de que C no sea Z; D se selecciona de halogeno, ciano, nitro, azido, Z, R8O, R8C(Z), R8C(Z)O, R8OC(Z), R8S, R8S(O), R8S(O)2, R8S(O)2O, R8OS(O)2, (R9)(R10)N, (R9)(R10)NC(Z), (R9)(R10)NC(Z)N(R11), (R9)(R10)NS(O)2, R8S(O)2N(R11), (R9)(R10)NS(O)2N(R11); y se selecciona de hidrogeno, halogeno, hidroxi, alcoxi C1-6, halo alcoxi C1-6, perfluoro alcoxi C1-6, aciloxi C1-6, alquiltio C1-6, halo alquiltio C1-6, perfluoro alquiltio C1-6, alquilsulfoniloxi C1-6, azido y (R9)(R10)N; Z es un sustituyente conectado a una doble union, y se selecciona de O=, S=, R8N=, (R9)(R10)NN=, R8ON=, (R9)(R10)NS(O)2N=, NCN=, O2NCH= y (R9)(R10)C=; n es 0, 1, 2 o 3 o sus sales estereoisomeros o prodrogas aceptables para uso farmacéutico.
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US7250408B2 (en) 2002-12-16 2007-07-31 Bayer Schering Pharma Ag Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility
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