PE20010996A1 - Uso de compuestos de 4-amino-1-fenilbutano-2-ol sustituidos como reguladores para el sistema nociceptina/orfanina fq ligando de receptor orl1 y para la preparacion de medicamentos - Google Patents
Uso de compuestos de 4-amino-1-fenilbutano-2-ol sustituidos como reguladores para el sistema nociceptina/orfanina fq ligando de receptor orl1 y para la preparacion de medicamentosInfo
- Publication number
- PE20010996A1 PE20010996A1 PE2000001400A PE0014002000A PE20010996A1 PE 20010996 A1 PE20010996 A1 PE 20010996A1 PE 2000001400 A PE2000001400 A PE 2000001400A PE 0014002000 A PE0014002000 A PE 0014002000A PE 20010996 A1 PE20010996 A1 PE 20010996A1
- Authority
- PE
- Peru
- Prior art keywords
- orphanine
- phenylbutane
- amino
- ligando
- nociceptin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
SE REFIERE AL USO DE 4-AMINO-1-FENILBUTANO-2-OL SUSTITUIDO DE FORMULA I, DONDE A ES ARILO, HETEROARILO; R1 Y R2 SON ALQUILO C1-C6, O JUNTOS FORMAN (CH2)(2-6); R3 Y R4 SON ALQUILO C1-C6, ARILO O JUNTOS FORMAN (CH2)(3-6), CH2CH2OCH2CH2; R5, R6, R7 SON H, F, Cl, Br, I, CF3, OR8, SO2CH3, SO2CF3, FENILO, CN, ENTRE OTROS; R8 ES H, ALQUILO C1-C6, ARILO, HETEROARILO. SON COMPUESTOS PREFERIDOS 1-(2-CLOROBENCIL)-2-(DIMETILAMINOFENILMETIL)CICLOHEXANOL, 1-(3-CLOROBENCIL)-2-(DIMETILAMINOFENILMETIL)CICLOHEXANOL, ENTRE OTROS. EL COMPUESTO ACTUA SOBRE EL SISTEMA NOCICEPTINA/ORFANINA FQ LIGANDO DE RECEPTOR ORL1 Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ANSIEDAD, DEPRESION, DIURESIS, HIPOTENSION, HIPERTENSION, DEMENCIA SENIL, ALZHEIMER, DISFUNCIONES CONGENITAS GENERALES, TINITUS, SORDERA, EPILEPSIA, OBESIDAD, CAQUEXIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19963175A DE19963175A1 (de) | 1999-12-27 | 1999-12-27 | Verwendung von substituierten 4-Amino-1-phenylbutan-2-ol-Verbindungen als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010996A1 true PE20010996A1 (es) | 2001-10-06 |
Family
ID=7934620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001400A PE20010996A1 (es) | 1999-12-27 | 2000-12-26 | Uso de compuestos de 4-amino-1-fenilbutano-2-ol sustituidos como reguladores para el sistema nociceptina/orfanina fq ligando de receptor orl1 y para la preparacion de medicamentos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7012099B2 (es) |
| EP (1) | EP1253917B1 (es) |
| JP (1) | JP2003518491A (es) |
| AR (1) | AR032294A1 (es) |
| AT (1) | ATE289195T1 (es) |
| AU (1) | AU776229B2 (es) |
| CA (1) | CA2396516A1 (es) |
| CO (1) | CO5251442A1 (es) |
| DE (2) | DE19963175A1 (es) |
| ES (1) | ES2236018T3 (es) |
| HU (1) | HUP0203900A3 (es) |
| MX (1) | MXPA02006398A (es) |
| NZ (1) | NZ519933A (es) |
| PE (1) | PE20010996A1 (es) |
| PT (1) | PT1253917E (es) |
| UY (1) | UY26508A1 (es) |
| WO (1) | WO2001047506A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20030320A1 (es) | 2001-07-17 | 2003-04-03 | Gruenenthal Chemie | Derivados sustituidos de 4-aminociclohexanol |
| DE10135636A1 (de) * | 2001-07-17 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 4-Aminocyclohexanole |
| DE10161809A1 (de) | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Arzneimittel enthaltend N,N'-disubstituierte Piperazin-Verbindungen |
| DE10161818A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Substituierte 1,5-Diaminopentan-3-ol-Verbindungen |
| DE102004023507A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE913279A1 (en) * | 1990-09-26 | 1992-04-08 | Astra Ab | (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties |
| FR2776016B1 (fr) | 1998-03-12 | 2000-06-30 | Lucas Conwell Frederic | Perfectionnement d'un moteur a combustion interne a injection |
| RU2202344C2 (ru) * | 1998-03-26 | 2003-04-20 | Джапан Тобакко Инк. | Антагонисты ноцицептина, производные амида, аналгетик, способ инициирования антагонистического действия к ноцицептину, способ лечения боли, фармацевтические композиции |
| DE19915601A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
-
1999
- 1999-12-27 DE DE19963175A patent/DE19963175A1/de not_active Ceased
-
2000
- 2000-12-20 DE DE50009567T patent/DE50009567D1/de not_active Expired - Fee Related
- 2000-12-20 WO PCT/EP2000/012975 patent/WO2001047506A2/de active Search and Examination
- 2000-12-20 MX MXPA02006398A patent/MXPA02006398A/es not_active Application Discontinuation
- 2000-12-20 ES ES00985205T patent/ES2236018T3/es not_active Expired - Lifetime
- 2000-12-20 HU HU0203900A patent/HUP0203900A3/hu unknown
- 2000-12-20 NZ NZ519933A patent/NZ519933A/en unknown
- 2000-12-20 US US10/149,434 patent/US7012099B2/en not_active Expired - Fee Related
- 2000-12-20 EP EP00985205A patent/EP1253917B1/de not_active Expired - Lifetime
- 2000-12-20 CA CA002396516A patent/CA2396516A1/en not_active Abandoned
- 2000-12-20 AT AT00985205T patent/ATE289195T1/de not_active IP Right Cessation
- 2000-12-20 AU AU21688/01A patent/AU776229B2/en not_active Ceased
- 2000-12-20 JP JP2001548101A patent/JP2003518491A/ja not_active Withdrawn
- 2000-12-20 PT PT00985205T patent/PT1253917E/pt unknown
- 2000-12-21 AR ARP000106838A patent/AR032294A1/es unknown
- 2000-12-22 CO CO00097383A patent/CO5251442A1/es not_active Application Discontinuation
- 2000-12-26 PE PE2000001400A patent/PE20010996A1/es not_active Application Discontinuation
- 2000-12-27 UY UY26508A patent/UY26508A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001047506A2 (de) | 2001-07-05 |
| JP2003518491A (ja) | 2003-06-10 |
| AU776229B2 (en) | 2004-09-02 |
| CA2396516A1 (en) | 2001-07-05 |
| UY26508A1 (es) | 2001-01-31 |
| DE19963175A1 (de) | 2001-07-12 |
| MXPA02006398A (es) | 2003-04-10 |
| HUP0203900A3 (en) | 2005-06-28 |
| DE50009567D1 (de) | 2005-03-24 |
| US20030008859A1 (en) | 2003-01-09 |
| NZ519933A (en) | 2003-08-29 |
| AU2168801A (en) | 2001-07-09 |
| HUP0203900A2 (hu) | 2003-07-28 |
| EP1253917A2 (de) | 2002-11-06 |
| ES2236018T3 (es) | 2005-07-16 |
| ATE289195T1 (de) | 2005-03-15 |
| AR032294A1 (es) | 2003-11-05 |
| PT1253917E (pt) | 2005-05-31 |
| CO5251442A1 (es) | 2003-02-28 |
| WO2001047506A3 (de) | 2002-01-24 |
| US7012099B2 (en) | 2006-03-14 |
| EP1253917B1 (de) | 2005-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |