CO5251442A1 - Uso de compuestos de 4-amino-1-fenilbutano-2-ol sustituidos en forma de sus racematos, enantiomeros diastereomeros o bases o sales correspondientes con acidos fisiologicamente tolerables como reguladores para el sistema nociceptina/ orfanina fq ligan - Google Patents
Uso de compuestos de 4-amino-1-fenilbutano-2-ol sustituidos en forma de sus racematos, enantiomeros diastereomeros o bases o sales correspondientes con acidos fisiologicamente tolerables como reguladores para el sistema nociceptina/ orfanina fq liganInfo
- Publication number
- CO5251442A1 CO5251442A1 CO00097383A CO00097383A CO5251442A1 CO 5251442 A1 CO5251442 A1 CO 5251442A1 CO 00097383 A CO00097383 A CO 00097383A CO 00097383 A CO00097383 A CO 00097383A CO 5251442 A1 CO5251442 A1 CO 5251442A1
- Authority
- CO
- Colombia
- Prior art keywords
- radical
- alkyl
- substituted
- racemates
- amino
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
Uso de al menos un compuesto de 4-amino-1-fenilbutano-2-ol sustituido de la fórmula general I <EMI FILE="00097383_1" ID="1" IMF=JPEG >en la cual A representa un radical arilo o heteroarilo, R1 y R2 pueden ser iguales o distintos entre sí y representan un radical C1-6 -alquilo, preferiblemente C1-3-alquilo, o R1 y R2 en conjunto forman un ciclo (CH2)2-6 que también puede estar sustituido con fenilo, R3 y R4 pueden ser iguales o distintos entre sí y representan un radical C1-6-alquilo, preferiblemente C1-3-alquilo, un radical arilo o un radical arilo ligado a través de un radical C1-3-alquileno o los radicales R3 y R4 en conjunto forman un grupo (CH2)3-6 o CH2CH2OCH2CH2, R5, R6, R7 pueden ser iguales o distintos entre sí y representan H, F, Cl, Br, 1, CF3, OR8, SO2CH3, SO2CF3, fenilo, CN, NO2 o un radical alquilo C1-6, R8 representa H, un radical C1-6-alquilo, preferiblemente C1-3-alquilo, o un radical arilo o heteroarilo ligado a través de un radical C1-3-alquileno, en forma de sus racematos, enantiómeros, diastereómeros o bases o sales correspondientes con ácidos fisiológicamente tolerables como regulador regulador ORL1 (receptor similar a opioide) para el sistema nociceptina/orfanina FQ ligando de receptor ORL1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19963175A DE19963175A1 (de) | 1999-12-27 | 1999-12-27 | Verwendung von substituierten 4-Amino-1-phenylbutan-2-ol-Verbindungen als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5251442A1 true CO5251442A1 (es) | 2003-02-28 |
Family
ID=7934620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00097383A CO5251442A1 (es) | 1999-12-27 | 2000-12-22 | Uso de compuestos de 4-amino-1-fenilbutano-2-ol sustituidos en forma de sus racematos, enantiomeros diastereomeros o bases o sales correspondientes con acidos fisiologicamente tolerables como reguladores para el sistema nociceptina/ orfanina fq ligan |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7012099B2 (es) |
| EP (1) | EP1253917B1 (es) |
| JP (1) | JP2003518491A (es) |
| AR (1) | AR032294A1 (es) |
| AT (1) | ATE289195T1 (es) |
| AU (1) | AU776229B2 (es) |
| CA (1) | CA2396516A1 (es) |
| CO (1) | CO5251442A1 (es) |
| DE (2) | DE19963175A1 (es) |
| ES (1) | ES2236018T3 (es) |
| HU (1) | HUP0203900A3 (es) |
| MX (1) | MXPA02006398A (es) |
| NZ (1) | NZ519933A (es) |
| PE (1) | PE20010996A1 (es) |
| PT (1) | PT1253917E (es) |
| UY (1) | UY26508A1 (es) |
| WO (1) | WO2001047506A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20030320A1 (es) * | 2001-07-17 | 2003-04-03 | Gruenenthal Chemie | Derivados sustituidos de 4-aminociclohexanol |
| DE10135636A1 (de) | 2001-07-17 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 4-Aminocyclohexanole |
| DE10161818A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Substituierte 1,5-Diaminopentan-3-ol-Verbindungen |
| DE10161809A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Arzneimittel enthaltend N,N'-disubstituierte Piperazin-Verbindungen |
| DE102004023507A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE913279A1 (en) | 1990-09-26 | 1992-04-08 | Astra Ab | (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties |
| FR2776016B1 (fr) | 1998-03-12 | 2000-06-30 | Lucas Conwell Frederic | Perfectionnement d'un moteur a combustion interne a injection |
| AU754716B2 (en) * | 1998-03-26 | 2002-11-21 | Japan Tobacco Inc. | Amide derivatives and nociceptin antagonists |
| DE19915601A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
-
1999
- 1999-12-27 DE DE19963175A patent/DE19963175A1/de not_active Ceased
-
2000
- 2000-12-20 WO PCT/EP2000/012975 patent/WO2001047506A2/de active Search and Examination
- 2000-12-20 CA CA002396516A patent/CA2396516A1/en not_active Abandoned
- 2000-12-20 US US10/149,434 patent/US7012099B2/en not_active Expired - Fee Related
- 2000-12-20 HU HU0203900A patent/HUP0203900A3/hu unknown
- 2000-12-20 NZ NZ519933A patent/NZ519933A/en unknown
- 2000-12-20 MX MXPA02006398A patent/MXPA02006398A/es not_active Application Discontinuation
- 2000-12-20 ES ES00985205T patent/ES2236018T3/es not_active Expired - Lifetime
- 2000-12-20 DE DE50009567T patent/DE50009567D1/de not_active Expired - Fee Related
- 2000-12-20 JP JP2001548101A patent/JP2003518491A/ja not_active Withdrawn
- 2000-12-20 EP EP00985205A patent/EP1253917B1/de not_active Expired - Lifetime
- 2000-12-20 AT AT00985205T patent/ATE289195T1/de not_active IP Right Cessation
- 2000-12-20 PT PT00985205T patent/PT1253917E/pt unknown
- 2000-12-20 AU AU21688/01A patent/AU776229B2/en not_active Ceased
- 2000-12-21 AR ARP000106838A patent/AR032294A1/es unknown
- 2000-12-22 CO CO00097383A patent/CO5251442A1/es not_active Application Discontinuation
- 2000-12-26 PE PE2000001400A patent/PE20010996A1/es not_active Application Discontinuation
- 2000-12-27 UY UY26508A patent/UY26508A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2236018T3 (es) | 2005-07-16 |
| DE50009567D1 (de) | 2005-03-24 |
| MXPA02006398A (es) | 2003-04-10 |
| WO2001047506A3 (de) | 2002-01-24 |
| CA2396516A1 (en) | 2001-07-05 |
| HUP0203900A3 (en) | 2005-06-28 |
| US20030008859A1 (en) | 2003-01-09 |
| HUP0203900A2 (hu) | 2003-07-28 |
| US7012099B2 (en) | 2006-03-14 |
| WO2001047506A2 (de) | 2001-07-05 |
| DE19963175A1 (de) | 2001-07-12 |
| PT1253917E (pt) | 2005-05-31 |
| ATE289195T1 (de) | 2005-03-15 |
| AU2168801A (en) | 2001-07-09 |
| PE20010996A1 (es) | 2001-10-06 |
| NZ519933A (en) | 2003-08-29 |
| AU776229B2 (en) | 2004-09-02 |
| EP1253917B1 (de) | 2005-02-16 |
| EP1253917A2 (de) | 2002-11-06 |
| UY26508A1 (es) | 2001-01-31 |
| AR032294A1 (es) | 2003-11-05 |
| JP2003518491A (ja) | 2003-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |