PE20011062A1 - Compuestos calciliticos - Google Patents

Compuestos calciliticos

Info

Publication number
PE20011062A1
PE20011062A1 PE2001000069A PE2001000069A PE20011062A1 PE 20011062 A1 PE20011062 A1 PE 20011062A1 PE 2001000069 A PE2001000069 A PE 2001000069A PE 2001000069 A PE2001000069 A PE 2001000069A PE 20011062 A1 PE20011062 A1 PE 20011062A1
Authority
PE
Peru
Prior art keywords
rent
compounds
halogen
alkyl
proproxy
Prior art date
Application number
PE2001000069A
Other languages
English (en)
Inventor
Pradip Kumar Bhatnagar
William M Bryan
Amparo M Lago
James Francis Callahan
Mar Eric G Del
Joelle L Burgess
Original Assignee
Smithkline Beecham Corp
Nps Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Nps Pharma Inc filed Critical Smithkline Beecham Corp
Publication of PE20011062A1 publication Critical patent/PE20011062A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/616—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA I DONDE A ES UN ARILO, HETEROARILO, HALOGENO, ALQUILO C1-C4, ALCOXI C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS; X1 Y X5 SON H, HALOGENO, CH Y NO2, SIEMPRE QUE X1 O X5 SEAN H; X2, X3 Y X4 SON H, HALOGENO, O-ALQUILO C1-C4, J-K; DONDE J ES UN ENLACE COVALENTE, ALQUILENO,O-ALQUILENO, ALQUENILENO Y K ES CO2R5, CONR4R'4, OH, NR4R4' Y CN; R4 Y R4' SON H, ALQUILO, ARILO, HETEROARILO; R5 ES H, ALQUILO, ALQUIL(O-ALQUIL)m -O-ALQUILO; n ES 0-4; m ES 0-3. SON COMPUESTOS PREFERIDOS ESTER ETILICO DE ACIDO 3-{4-CIANO-3-[(R)-2-HIDROXI-3-(2-INDAN-2-IL-1,1-DIMETIL-ETILAMINO)-PROPROXI]-FENIL}-PROPIONICO; ACIDO 3-{4-CIANO-3-[(R)-2-HIDROXI-3-(2-INDAN-2-IL-1,1-DIMETIL-ETILAMINO)-PROPROXI]-FENIL}-PROPIONICO, ENTRE OTROS. EL COMPUESTO I ES UN ANTAGONISTA DE LOS RECEPTORES DE CALCIO Y SE ADMINISTRA JUNTO A UN AGENTE ANTI-RESORBENTE TAL COMO ESTROGENOS,VITAMINA D3, CALCITONINA Y SON UTILES EN EL TRATAMIENTO DE OSTEOSARCOMA, ENFERMEDAD PERIODONTAL, FRACTURAS, OSTEOARTRITIS, OSTEOPOROSIS
PE2001000069A 2000-01-24 2001-01-23 Compuestos calciliticos PE20011062A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17768300P 2000-01-24 2000-01-24

Publications (1)

Publication Number Publication Date
PE20011062A1 true PE20011062A1 (es) 2001-11-29

Family

ID=22649559

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000069A PE20011062A1 (es) 2000-01-24 2001-01-23 Compuestos calciliticos

Country Status (31)

Country Link
EP (2) EP2141146A1 (es)
JP (1) JP2003520265A (es)
KR (1) KR20020073179A (es)
CN (1) CN1396906A (es)
AP (1) AP2002002547A0 (es)
AR (1) AR030684A1 (es)
AT (1) ATE423762T1 (es)
AU (1) AU764746B2 (es)
BG (1) BG106942A (es)
BR (1) BR0107592A (es)
CA (1) CA2397802A1 (es)
CO (1) CO5251398A1 (es)
DE (1) DE60137755D1 (es)
DZ (1) DZ3284A1 (es)
EA (1) EA200200798A1 (es)
ES (1) ES2322641T3 (es)
HK (1) HK1051356A1 (es)
HU (1) HUP0204106A3 (es)
IL (1) IL150398A0 (es)
MA (1) MA25651A1 (es)
MX (1) MXPA02007173A (es)
MY (1) MY159417A (es)
NO (1) NO20023508D0 (es)
NZ (1) NZ519480A (es)
OA (1) OA12163A (es)
PE (1) PE20011062A1 (es)
PL (1) PL356808A1 (es)
SK (1) SK10742002A3 (es)
UY (1) UY26556A1 (es)
WO (1) WO2001053254A1 (es)
ZA (1) ZA200205832B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001277752A1 (en) * 2000-08-11 2002-02-25 Japan Tobacco Inc. Calcium receptor antagonists
ATE343390T1 (de) * 2000-10-25 2006-11-15 Smithkline Beecham Corp Kalzilytische verbindungen
AR042132A1 (es) 2002-11-26 2005-06-08 Smithkline Beecham Corp Compuesto de 2- hidroxi -3-(2- aril - 1, 1 - dimetiletilamino) propoxifenilo, composicion farmaceutica que lo comprende y uso del mismo para prepararla
DK1619180T3 (da) 2003-04-23 2010-03-29 Japan Tobacco Inc CaSR-antagonist
WO2005077892A1 (en) * 2004-02-06 2005-08-25 Smithkline Beecham Corporation Calcilytic compounds
WO2005077886A1 (en) * 2004-02-06 2005-08-25 Smithkline Beecham Corporation Calcilytic compounds
PL2292592T3 (pl) 2008-06-05 2013-01-31 Asahi Kasei Pharma Corp Związki sulfonamidowe i ich zastosowanie
CN102307847A (zh) 2008-12-24 2012-01-04 第一三共株式会社 茚满基化合物
CN107417594B (zh) * 2017-05-08 2020-03-27 凯莱英医药集团（天津）股份有限公司 一种酰胺醇解的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530613A1 (de) * 1974-11-01 1976-05-06 Haessle Ab Aminderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
FR2533210A1 (fr) * 1982-09-17 1984-03-23 Lyon I Universite Claude Edulcorants de synthese
DD298506A5 (de) * 1988-12-30 1992-02-27 Ernst-Moritz-Arndt-Universitaet Greifswald,De Verfahren zur herstellung halogensubstituierter 1-phenoxy-3-alkylamino-propan-2-ole
DE4040186A1 (de) * 1989-12-20 1991-06-27 Hoechst Ag Hypoglykaemisch aktive propandiolaminderivate mit insulin-aehnlicher wirkung und deren verwendung, neue propandiolaminderivate, diese substanzen enthaltende pharmazeutische zubereitungen und ihre verwendung zur behandlung von krankheiten
EA002984B1 (ru) * 1996-04-09 2002-12-26 Эн Пи Эс Фармасьютикалз, Инк. Кальцилитические соединения, фармацевтические композиции и способ скрининга кальцилитических соединений
UY24949A1 (es) * 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos
AR014975A1 (es) * 1998-04-08 2001-04-11 Nps Pharma Inc Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento
AR018177A1 (es) * 1998-04-08 2001-10-31 Smithkline Beecham Corp Compuestos calciliticos, una composicion farmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento.
CO5180628A1 (es) * 1999-07-31 2002-07-30 Smithkline Beecham Corp Compuestos calcioliticos

Also Published As

Publication number Publication date
AU3796601A (en) 2001-07-31
EP1254106B1 (en) 2009-02-25
DZ3284A1 (fr) 2001-07-26
IL150398A0 (en) 2002-12-01
EA200200798A1 (ru) 2002-12-26
CN1396906A (zh) 2003-02-12
KR20020073179A (ko) 2002-09-19
EP1254106A1 (en) 2002-11-06
HUP0204106A3 (en) 2003-05-28
MA25651A1 (fr) 2002-12-31
EP1254106A4 (en) 2005-09-14
ZA200205832B (en) 2003-03-05
MY159417A (en) 2017-01-13
NZ519480A (en) 2004-05-28
NO20023508L (no) 2002-07-23
BR0107592A (pt) 2002-11-19
HUP0204106A2 (hu) 2003-03-28
AU764746B2 (en) 2003-08-28
JP2003520265A (ja) 2003-07-02
UY26556A1 (es) 2001-08-27
CO5251398A1 (es) 2003-02-28
OA12163A (en) 2006-05-08
PL356808A1 (en) 2004-07-12
WO2001053254A1 (en) 2001-07-26
EP2141146A1 (en) 2010-01-06
ES2322641T3 (es) 2009-06-24
HK1051356A1 (zh) 2003-08-01
AR030684A1 (es) 2003-09-03
CA2397802A1 (en) 2001-07-26
MXPA02007173A (es) 2004-09-06
AP2002002547A0 (en) 2002-06-30
DE60137755D1 (de) 2009-04-09
SK10742002A3 (sk) 2002-12-03
ATE423762T1 (de) 2009-03-15
BG106942A (bg) 2003-01-31
NO20023508D0 (no) 2002-07-23

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