HUP0204106A2 - Kalcilitikus vegyületek és eljárás az alkalmazásukra - Google Patents

Kalcilitikus vegyületek és eljárás az alkalmazásukra

Info

Publication number
HUP0204106A2
HUP0204106A2 HU0204106A HUP0204106A HUP0204106A2 HU P0204106 A2 HUP0204106 A2 HU P0204106A2 HU 0204106 A HU0204106 A HU 0204106A HU P0204106 A HUP0204106 A HU P0204106A HU P0204106 A2 HUP0204106 A2 HU P0204106A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
condensed
hydrogen
cyano
Prior art date
Application number
HU0204106A
Other languages
English (en)
Inventor
Pradip Kumar Bhatnagar
William M. Bryan
Joelle L. Burgess
James Francis Callahan
Eric G. Del Mar
Amparo M. Lago
Original Assignee
Nps Pharmaceuticals, Inc.
Smithkline Beecham Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nps Pharmaceuticals, Inc., Smithkline Beecham Corp. filed Critical Nps Pharmaceuticals, Inc.
Publication of HUP0204106A2 publication Critical patent/HUP0204106A2/hu
Publication of HUP0204106A3 publication Critical patent/HUP0204106A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/616—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány (I) általános képletű vegyületekre - amelyek képletében Ajelentése adott esetben a következők közül kiválasztott bármelyatommal és/vagy csoporttal szubsztituált aril- vagy kondenzált aril-,kondenzált dihidro- vagy tetrahidroaril-, heteroaril-, kondenzáltheteroaril-, kondenzált dihidro- vagy tetrahidroarilcsoport:hidroxicsoport, halogénatom, 1-4 szénatomos alkilcsoport, 1-4szénatomos alkoxicsoport, 3-6 szénatomos cikloalkilcsoport, trifluor-metil-, trifluor-metoxi-, ciano- és nitrocsoport; X1 és X5 jelentéseegymástól függetlenül hidrogén-, halogénatom, ciano- vagynitrocsoport, azzal a megkötéssel, hogy X1 és X5 egyikének a jelentésehidrogénatom; X2, X3 és X4 jelentése hidrogén-, halogénatom, 1-4szénatomos alkoxicsoport vagy J-K általános képletű csoport; amelybenJ jelentése kovalens kötés, alkilén-, -O-alkilén vagyalkeniléncsoport; és K jelentése -CO2R5, -CONR4R'4 általános képletűcsoport, hidroxicsoport, -NR4R'4 általános képletű csoport éscianocsoport; R4 és R'4 jelentése egymástól függetlenül hidrogénatom,alkil-, aril- vagy heteroarilcsoport; R5 jelentése hidrogénatom,alkilcsoport vagy -alkil-(O-alkil)m-O-alkil általános képletű csoport;n értéke 0, 1, 2, 3 vagy 4; és m értéke 1, 2 vagy 3 - és a vegyületekkalciumreceptor-antagonistákként történő alkalmazására vonatkozik. Ó
HU0204106A 2000-01-24 2001-01-24 Calcilytic compounds and process for their use HUP0204106A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17768300P 2000-01-24 2000-01-24
PCT/US2001/002402 WO2001053254A1 (en) 2000-01-24 2001-01-24 Calcilytic compounds

Publications (2)

Publication Number Publication Date
HUP0204106A2 true HUP0204106A2 (hu) 2003-03-28
HUP0204106A3 HUP0204106A3 (en) 2003-05-28

Family

ID=22649559

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0204106A HUP0204106A3 (en) 2000-01-24 2001-01-24 Calcilytic compounds and process for their use

Country Status (31)

Country Link
EP (2) EP1254106B1 (hu)
JP (1) JP2003520265A (hu)
KR (1) KR20020073179A (hu)
CN (1) CN1396906A (hu)
AP (1) AP2002002547A0 (hu)
AR (1) AR030684A1 (hu)
AT (1) ATE423762T1 (hu)
AU (1) AU764746B2 (hu)
BG (1) BG106942A (hu)
BR (1) BR0107592A (hu)
CA (1) CA2397802A1 (hu)
CO (1) CO5251398A1 (hu)
DE (1) DE60137755D1 (hu)
DZ (1) DZ3284A1 (hu)
EA (1) EA200200798A1 (hu)
ES (1) ES2322641T3 (hu)
HK (1) HK1051356A1 (hu)
HU (1) HUP0204106A3 (hu)
IL (1) IL150398A0 (hu)
MA (1) MA25651A1 (hu)
MX (1) MXPA02007173A (hu)
MY (1) MY159417A (hu)
NO (1) NO20023508L (hu)
NZ (1) NZ519480A (hu)
OA (1) OA12163A (hu)
PE (1) PE20011062A1 (hu)
PL (1) PL356808A1 (hu)
SK (1) SK10742002A3 (hu)
UY (1) UY26556A1 (hu)
WO (1) WO2001053254A1 (hu)
ZA (1) ZA200205832B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916956B2 (en) 2000-08-11 2005-07-12 Japan Tobacco, Inc. Calcium receptor antagonist
EP1383511B1 (en) * 2000-10-25 2006-10-25 SmithKline Beecham Corporation Calcilytic compounds
AR042132A1 (es) * 2002-11-26 2005-06-08 Smithkline Beecham Corp Compuesto de 2- hidroxi -3-(2- aril - 1, 1 - dimetiletilamino) propoxifenilo, composicion farmaceutica que lo comprende y uso del mismo para prepararla
NZ541188A (en) 2003-04-23 2008-01-31 Japan Tobacco Inc calcium receptor antagonists
EP1713758A4 (en) * 2004-02-06 2008-02-13 Smithkline Beecham Corp CALCILYTIC COMPOUNDS
JP2007523076A (ja) * 2004-02-06 2007-08-16 スミスクライン・ビーチャム・コーポレイション カルシウム受容体アンタゴニスト化合物
DK2292592T3 (da) 2008-06-05 2012-10-08 Asahi Kasei Pharma Corp Sulfonamidforbindelse og anvendelse deraf
CA2748250A1 (en) 2008-12-24 2010-07-01 Daiichi Sankyo Company, Limited Indanyl compounds
CN107417594B (zh) * 2017-05-08 2020-03-27 凯莱英医药集团（天津）股份有限公司 一种酰胺醇解的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530613A1 (de) * 1974-11-01 1976-05-06 Haessle Ab Aminderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
FR2533210A1 (fr) * 1982-09-17 1984-03-23 Lyon I Universite Claude Edulcorants de synthese
DD298506A5 (de) * 1988-12-30 1992-02-27 Ernst-Moritz-Arndt-Universitaet Greifswald,De Verfahren zur herstellung halogensubstituierter 1-phenoxy-3-alkylamino-propan-2-ole
DE4040186A1 (de) * 1989-12-20 1991-06-27 Hoechst Ag Hypoglykaemisch aktive propandiolaminderivate mit insulin-aehnlicher wirkung und deren verwendung, neue propandiolaminderivate, diese substanzen enthaltende pharmazeutische zubereitungen und ihre verwendung zur behandlung von krankheiten
NZ332068A (en) * 1996-04-09 2001-03-30 Smithkline Beecham Alpha, alpha-disubstituted arylalkylamine derivatives as calcilytic compounds
UY24949A1 (es) * 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos
PE20000415A1 (es) * 1998-04-08 2000-05-21 Smithkline Beecham Corp Compuestos calciliticos
AR014975A1 (es) * 1998-04-08 2001-04-11 Nps Pharma Inc Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento
CO5180628A1 (es) * 1999-07-31 2002-07-30 Smithkline Beecham Corp Compuestos calcioliticos

Also Published As

Publication number Publication date
EP1254106B1 (en) 2009-02-25
MXPA02007173A (es) 2004-09-06
UY26556A1 (es) 2001-08-27
DE60137755D1 (de) 2009-04-09
OA12163A (en) 2006-05-08
CO5251398A1 (es) 2003-02-28
ES2322641T3 (es) 2009-06-24
EP2141146A1 (en) 2010-01-06
BR0107592A (pt) 2002-11-19
KR20020073179A (ko) 2002-09-19
WO2001053254A1 (en) 2001-07-26
NO20023508D0 (no) 2002-07-23
AU3796601A (en) 2001-07-31
EA200200798A1 (ru) 2002-12-26
AU764746B2 (en) 2003-08-28
PE20011062A1 (es) 2001-11-29
IL150398A0 (en) 2002-12-01
AR030684A1 (es) 2003-09-03
JP2003520265A (ja) 2003-07-02
EP1254106A1 (en) 2002-11-06
DZ3284A1 (fr) 2001-07-26
SK10742002A3 (sk) 2002-12-03
HK1051356A1 (zh) 2003-08-01
BG106942A (bg) 2003-01-31
PL356808A1 (en) 2004-07-12
AP2002002547A0 (en) 2002-06-30
ATE423762T1 (de) 2009-03-15
CN1396906A (zh) 2003-02-12
EP1254106A4 (en) 2005-09-14
NO20023508L (no) 2002-07-23
CA2397802A1 (en) 2001-07-26
MY159417A (en) 2017-01-13
MA25651A1 (fr) 2002-12-31
HUP0204106A3 (en) 2003-05-28
NZ519480A (en) 2004-05-28
ZA200205832B (en) 2003-03-05

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