PE20001395A1 - Composicion de administracion oral con liberacion controlada de un analgesico opioide - Google Patents
Composicion de administracion oral con liberacion controlada de un analgesico opioideInfo
- Publication number
- PE20001395A1 PE20001395A1 PE2000000012A PE0000122000A PE20001395A1 PE 20001395 A1 PE20001395 A1 PE 20001395A1 PE 2000000012 A PE2000000012 A PE 2000000012A PE 0000122000 A PE0000122000 A PE 0000122000A PE 20001395 A1 PE20001395 A1 PE 20001395A1
- Authority
- PE
- Peru
- Prior art keywords
- crystals
- cellulose
- analgesic
- controlled release
- coating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION ORAL DE LIBERACION CONTROLADA DE UN ANALGESICO OPIOIDE TAL COMO OXICODON, MORFINA, LEVORFANOL, METADONA, DIHIDROCODEINA, CODEINA, DIHIDROMORFINA, PETIDINA, PIRITRAMIDA, FENTANIL, TILIDINA, BUPRENORFINA, DE 10 mg A 1000 mg DE TRAMADOL, CARACTERIZADA PORQUE SE PRESENTA EN FORMA DE CRISTALES CON UNA GRANULOMETRIA DE 10 µm HASTA 3 mm, SIENDO MONOCRISTALES O CON ESTRUCTURA POLICRISTALINA PUDIENDO LOS CRISTALES ESTAR COMPRIMIDOS EN FORMA DE TABLETAS CON AUXILIARES Y ADITIVOS CONVENCIONALES QUE TIENEN AL MENOS UN REVESTIMIENTO RETARDANTE QUE COMPRENDE AL MENOS HASTA UN 30% EN PESO DE UN POLIMERO NO RETARDANTE COMO RESINAS ACRILICAS, DERIVADOS DE CELULOSA, (ETILCELULOSA, ACIDO ACRILICO, ACIDO POLIMETACRILICO, HASTA UN 30% EN PESO DE HIDROXIPROPILCELULOSA, HIDROXIMETILCELULOSA, HIDROXIPROPILMETILCELULOSA, POLIVIDONA Y OTRO REVESTIMIENTO CONSTITUIDO POR UN MATERIAL DISTINTO DEL REVESTIMIENTO RETARDANTE APLICADO EN FORMA DE CAPA SEPARADORA NO RETARDANTE DIRECTAMENTTE SOBRE LA SUPERFICIE DE LOS CRISTALES, RESISTENTE AL JUGO GASTRICO; ADEMAS EL REVESTIMIENTO CONTIENE UN ANALGESICO DISTINTO DEL ANALGESICO DE LOS CRISTALES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19901687A DE19901687B4 (de) | 1999-01-18 | 1999-01-18 | Opioide Analgetika mit kontrollierter Wirkstofffreisetzung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001395A1 true PE20001395A1 (es) | 2000-12-23 |
Family
ID=7894566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000012A PE20001395A1 (es) | 1999-01-18 | 2000-01-06 | Composicion de administracion oral con liberacion controlada de un analgesico opioide |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6685964B1 (es) |
| EP (1) | EP1020185B1 (es) |
| JP (1) | JP2000212072A (es) |
| KR (1) | KR20000071247A (es) |
| CN (1) | CN1244327C (es) |
| AR (1) | AR022254A1 (es) |
| AT (1) | ATE257012T1 (es) |
| AU (1) | AU771064B2 (es) |
| CA (1) | CA2295471A1 (es) |
| CO (1) | CO5251462A1 (es) |
| DE (2) | DE19901687B4 (es) |
| DK (1) | DK1020185T3 (es) |
| ES (1) | ES2213971T3 (es) |
| HK (1) | HK1029749A1 (es) |
| HU (1) | HUP0000138A3 (es) |
| IL (1) | IL134076A (es) |
| NZ (1) | NZ502261A (es) |
| PE (1) | PE20001395A1 (es) |
| PL (1) | PL337867A1 (es) |
| PT (1) | PT1020185E (es) |
| RU (1) | RU2239417C2 (es) |
| SI (1) | SI1020185T1 (es) |
| SK (1) | SK285129B6 (es) |
| ZA (1) | ZA200000173B (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| ES2374717T3 (es) | 1999-10-29 | 2012-02-21 | Euro-Celtique S.A. | Formulaciones de hidrocodona de liberación controlada. |
| ES2228789T3 (es) * | 2000-09-22 | 2005-04-16 | Smb Technology | Composicion oral de tramadol en forma de granulados para tomar una vez por dia. |
| JP2004512354A (ja) | 2000-10-30 | 2004-04-22 | ユーロ−セルティーク，エス．エイ． | ヒドロコドン放出制御製剤 |
| AU2002303718B2 (en) * | 2001-05-11 | 2008-02-28 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US20040024005A1 (en) * | 2002-01-23 | 2004-02-05 | The Regents Of The University Of California | Methods and compositions for reducing the development of drug tolerance and/or physical dependence |
| US8128957B1 (en) | 2002-02-21 | 2012-03-06 | Valeant International (Barbados) Srl | Modified release compositions of at least one form of tramadol |
| US20050182056A9 (en) * | 2002-02-21 | 2005-08-18 | Seth Pawan | Modified release formulations of at least one form of tramadol |
| US20040156844A1 (en) * | 2002-05-22 | 2004-08-12 | Curtis Wright | Tamper resistant oral dosage form |
| WO2004026308A1 (fr) * | 2002-09-21 | 2004-04-01 | Shuyi Zhang | Compose d'acetamidophenol et de tramadol a liberation prolongee |
| TWI319713B (en) | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
| US8487002B2 (en) | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
| DE602004031096D1 (de) | 2003-03-26 | 2011-03-03 | Egalet As | Morphin-system mit kontrollierter freisetzung |
| CN100336501C (zh) * | 2003-08-06 | 2007-09-12 | 健乔信元医药生技股份有限公司 | 醋炎痛缓释性圆粒组成物及制备方法 |
| US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
| EP1754471A1 (de) * | 2005-08-18 | 2007-02-21 | ORAMON-Arzneimittel GmbH & Co. KG | Verwendung einer quellbaren Zwischenschicht zur Steuerung des Freisetzungsprofils einer festen Arzneimittelformulierung zur peroralen Anwendung und diese enthaltende Arzneimittelformulierung |
| JP5269595B2 (ja) | 2005-09-09 | 2013-08-21 | アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー | １日１回投与用トラゾドン組成物 |
| US8343546B2 (en) * | 2005-09-13 | 2013-01-01 | Coating Place, Inc. | Ion exchange resin treated to control swelling |
| US7842312B2 (en) | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
| US20070190141A1 (en) * | 2006-02-16 | 2007-08-16 | Aaron Dely | Extended release opiate composition |
| US9265732B2 (en) | 2006-03-06 | 2016-02-23 | Pozen Inc. | Dosage forms for administering combinations of drugs |
| MX2008011441A (es) * | 2006-03-06 | 2008-11-18 | Pozen Inc | Formas de dosificacion para administrar combinaciones de farmacos. |
| US20080069891A1 (en) * | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| GB0625646D0 (en) * | 2006-12-21 | 2007-01-31 | Jagotec Ag | Improvements in or relating to organic compounds |
| CA2687192C (en) | 2007-06-04 | 2015-11-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
| GB0714790D0 (en) * | 2007-07-30 | 2007-09-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| AU2009290712A1 (en) | 2008-09-09 | 2010-03-18 | Astrazeneca Ab | Method for delivering a pharmaceutical composition to patient in need thereof |
| US9005660B2 (en) | 2009-02-06 | 2015-04-14 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
| EP3045043B1 (en) * | 2009-02-26 | 2020-04-29 | Relmada Therapeutics, Inc. | Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use |
| WO2010149169A2 (en) | 2009-06-24 | 2010-12-29 | Egalet A/S | Controlled release formulations |
| WO2010151216A1 (en) | 2009-06-25 | 2010-12-29 | Astrazeneca Ab | Method for treating a patient at risk for developing an nsaid-associated ulcer |
| MX2012000057A (es) * | 2009-06-25 | 2012-06-01 | Pozen Inc | Metodo para tratar a un paciente con necesidad de terapia de aspirina. |
| WO2011143120A1 (en) | 2010-05-11 | 2011-11-17 | Cima Labs Inc. | Alcoholres i stant metoprolol - containing extended - release oral dosage forms |
| CA2860231A1 (en) | 2011-12-28 | 2013-07-04 | Pozen Inc. | Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
| PL2872121T3 (pl) | 2012-07-12 | 2019-02-28 | SpecGx LLC | Kompozycje farmaceutyczne o przedłużonym uwalnianiu, zniechęcające do nadużywania |
| US20150118300A1 (en) | 2013-10-31 | 2015-04-30 | Cima Labs Inc. | Immediate Release Abuse-Deterrent Granulated Dosage Forms |
| US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
| CN106176683B (zh) * | 2016-08-31 | 2019-04-16 | 贵州益康制药有限公司 | 一种盐酸曲马多缓释胶囊及其制备方法和用途 |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| US20220062200A1 (en) | 2019-05-07 | 2022-03-03 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
| EP3965733A4 (en) | 2019-05-07 | 2023-01-11 | Clexio Biosciences Ltd. | ABUSE DETERRENT DOSAGE FORMS CONTAINING ESKETAMINE |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3306250A1 (de) * | 1983-02-23 | 1984-08-23 | Basf Ag, 6700 Ludwigshafen | Sphaerische einkristalle fuer pharmazeutische zwecke |
| DE3586600T2 (de) * | 1984-02-10 | 1993-02-18 | Benzon Pharma As | Dosierungsform eine vielzahl mit einer diffusionshuelle ueberzogener einheiten enthaltend. |
| US5095151A (en) * | 1985-05-21 | 1992-03-10 | American Home Products Corporation | Preparation of propranolol hydrochloride macrocrystals |
| IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| EP1442745A1 (en) | 1993-10-07 | 2004-08-04 | Euro-Celtique | Orally administrable opioid formulations having extended duration of effect |
| ATE212224T1 (de) * | 1993-11-23 | 2002-02-15 | Euro Celtique Sa | Verfahren zur herstellung einer arzneizusammensetzung mit verzögerter wirkstoffabgabe |
| DE19630035A1 (de) * | 1996-07-25 | 1998-01-29 | Asta Medica Ag | Tramadol Multiple Unit Formulierungen |
| DE19901683B4 (de) * | 1999-01-18 | 2005-07-21 | Grünenthal GmbH | Analgetikum mit kontrollierter Wirkstofffreisetzung |
-
1999
- 1999-01-18 DE DE19901687A patent/DE19901687B4/de not_active Expired - Fee Related
- 1999-12-21 AT AT99125470T patent/ATE257012T1/de active
- 1999-12-21 EP EP99125470A patent/EP1020185B1/de not_active Expired - Lifetime
- 1999-12-21 DE DE59908195T patent/DE59908195D1/de not_active Expired - Lifetime
- 1999-12-21 ES ES99125470T patent/ES2213971T3/es not_active Expired - Lifetime
- 1999-12-21 DK DK99125470T patent/DK1020185T3/da active
- 1999-12-21 PT PT99125470T patent/PT1020185E/pt unknown
- 1999-12-21 SI SI9930501T patent/SI1020185T1/xx unknown
-
2000
- 2000-01-05 AU AU10113/00A patent/AU771064B2/en not_active Ceased
- 2000-01-06 PE PE2000000012A patent/PE20001395A1/es not_active Application Discontinuation
- 2000-01-11 AR ARP000100111A patent/AR022254A1/es unknown
- 2000-01-11 NZ NZ502261A patent/NZ502261A/en not_active IP Right Cessation
- 2000-01-14 CA CA002295471A patent/CA2295471A1/en not_active Abandoned
- 2000-01-14 JP JP2000006879A patent/JP2000212072A/ja not_active Withdrawn
- 2000-01-15 KR KR1020000001839A patent/KR20000071247A/ko not_active Application Discontinuation
- 2000-01-17 SK SK64-2000A patent/SK285129B6/sk not_active IP Right Cessation
- 2000-01-17 ZA ZA200000173A patent/ZA200000173B/xx unknown
- 2000-01-17 HU HU0000138A patent/HUP0000138A3/hu unknown
- 2000-01-17 CN CNB001045237A patent/CN1244327C/zh not_active Expired - Fee Related
- 2000-01-17 CO CO00002029A patent/CO5251462A1/es not_active Application Discontinuation
- 2000-01-17 RU RU2000101024/15A patent/RU2239417C2/ru not_active IP Right Cessation
- 2000-01-17 IL IL13407600A patent/IL134076A/xx not_active IP Right Cessation
- 2000-01-17 PL PL00337867A patent/PL337867A1/xx not_active Application Discontinuation
- 2000-01-18 US US09/484,016 patent/US6685964B1/en not_active Expired - Fee Related
-
2001
- 2001-01-05 HK HK01100109A patent/HK1029749A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ502261A (en) | 2001-11-30 |
| US6685964B1 (en) | 2004-02-03 |
| JP2000212072A (ja) | 2000-08-02 |
| DE19901687B4 (de) | 2006-06-01 |
| DK1020185T3 (da) | 2004-02-16 |
| IL134076A (en) | 2005-05-17 |
| AR022254A1 (es) | 2002-09-04 |
| SK285129B6 (sk) | 2006-07-07 |
| HU0000138D0 (en) | 2000-03-28 |
| AU771064B2 (en) | 2004-03-11 |
| ZA200000173B (en) | 2000-08-07 |
| IL134076A0 (en) | 2001-04-30 |
| CA2295471A1 (en) | 2000-07-18 |
| CN1270029A (zh) | 2000-10-18 |
| RU2239417C2 (ru) | 2004-11-10 |
| EP1020185B1 (de) | 2004-01-02 |
| KR20000071247A (ko) | 2000-11-25 |
| DE59908195D1 (de) | 2004-02-05 |
| ES2213971T3 (es) | 2004-09-01 |
| HUP0000138A2 (hu) | 2001-02-28 |
| CO5251462A1 (es) | 2003-02-28 |
| HUP0000138A3 (en) | 2001-03-28 |
| AU1011300A (en) | 2000-07-20 |
| CN1244327C (zh) | 2006-03-08 |
| SI1020185T1 (en) | 2004-04-30 |
| SK642000A3 (en) | 2000-08-14 |
| DE19901687A1 (de) | 2000-07-20 |
| HK1029749A1 (en) | 2001-04-12 |
| PL337867A1 (en) | 2000-07-31 |
| EP1020185A3 (de) | 2000-09-27 |
| PT1020185E (pt) | 2004-05-31 |
| EP1020185A2 (de) | 2000-07-19 |
| ATE257012T1 (de) | 2004-01-15 |
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