PE20000945A1 - Compuesto de maleimida disustituida y su uso farmaceutico - Google Patents

Compuesto de maleimida disustituida y su uso farmaceutico

Info

Publication number
PE20000945A1
PE20000945A1 PE1999000774A PE00077499A PE20000945A1 PE 20000945 A1 PE20000945 A1 PE 20000945A1 PE 1999000774 A PE1999000774 A PE 1999000774A PE 00077499 A PE00077499 A PE 00077499A PE 20000945 A1 PE20000945 A1 PE 20000945A1
Authority
PE
Peru
Prior art keywords
alkyl
alcoxy
disustituted
maleimide compound
diona
Prior art date
Application number
PE1999000774A
Other languages
English (en)
Inventor
Takashi Inaba
Masahiro Tanaka
Kenji Sakoda
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of PE20000945A1 publication Critical patent/PE20000945A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE MALEIMIDA DISUSTITUIDA DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C6; R2 ES ARILO C6-C18, CICLOALQUILO C3-C8, HETEROCICLO DE 5-12 MIEMBROS CON 1-4 O, S, N; R3, R5, R6, R7 Y R8 SON H, OH, HALOGENO, AMINO, ALQUILO C1-C6, ALCOXI C1-C6; R4 ES W; O R4 Y R3 JUNTOS FORMAN *-(CH2)p-C(W)(W`)-(CH2)q-, *-(CH2)p-C(W')(W)-CH=CH-, O R4 Y R5 SON *-(CH2)p-C(W')(W)-(CH2)r-O-; W ES -(CH2)l-(Y)m-(CH2)n-Z; Y ES CR9R9', NR10, O, S, CONH, ENTRE OTROS; R9 Y R9' SON H, OH, ALQUILO C1-C6, ALCOXI C1-C6, ALQUILTIO C1-C6, ALQUILAMINO C1-C6, DIALQUILAMINO C1-C6, HETEROCICLO DE 5-12 MIEMBROS, ENTRE OTROS; Z ES H, OH, HALOGENO, ALCOXI C1-C6, ALCOXICARBONIL C1-C6, NR11R12, AMIDINA, ENTRE OTROS; R10, R11 Y R12 SON H, ALQUILO C1-C6; l ES 0-4; m ES 0-1; n ES 0-4; W' ES H, W, -(CH2)l-(Y)m-(CH2)n-Z; p, q r SON 0-4; * ES EL ENLACE AL NITROGENO DEL INDOL. SON COMPUESTOS PREFERIDOS 3-(1H-INDO-3-LIL)-4-[(3-METOXIFENIL)AMINO]-1H-PIRROL-2,5-DIONA, 3-(1H-INDO-3-LIL)-4-(FENILAMINO)-1H-PIRROL-2,5-DIONA, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR SELECTIVO DE ß ISOZIMA DE CINASA PROTEICA C POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE COMPLICACIONES DIABETICAS COMO RETINOPATIA, NEFROPATIA, CARDIOMIOPATIA, NEUROPATIA
PE1999000774A 1998-07-30 1999-08-02 Compuesto de maleimida disustituida y su uso farmaceutico PE20000945A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21507098 1998-07-30

Publications (1)

Publication Number Publication Date
PE20000945A1 true PE20000945A1 (es) 2000-09-25

Family

ID=16666269

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000774A PE20000945A1 (es) 1998-07-30 1999-08-02 Compuesto de maleimida disustituida y su uso farmaceutico

Country Status (12)

Country Link
EP (1) EP1120414A1 (es)
KR (1) KR20010085305A (es)
CN (1) CN1320123A (es)
AU (1) AU4929999A (es)
BR (1) BR9912612A (es)
CA (1) CA2338866A1 (es)
HU (1) HUP0103381A3 (es)
ID (1) ID27510A (es)
IL (1) IL141080A0 (es)
NO (1) NO20010487L (es)
PE (1) PE20000945A1 (es)
WO (1) WO2000006564A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1119548B1 (en) * 1998-10-08 2004-12-08 SmithKline Beecham plc 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrole-2,5-dione as glycogen synthase kinase-3 inhibitor (gsk-3)
US6719520B2 (en) 1998-10-08 2004-04-13 Smithkline Beecham Corporation Method and compounds
EP1224932A4 (en) * 1999-08-20 2002-10-16 Sagami Chem Res DRUGS INHIBITING CELL DEATH
GB0008264D0 (en) * 2000-04-04 2000-05-24 Smithkline Beecham Plc Novel method and compounds
CA2431166A1 (en) 2000-12-08 2002-06-13 Ortho-Mcneil Pharmaceutical, Inc. Indazolyl-substituted pyrroline compounds as kinase inhibitors
BR0212676A (pt) 2001-09-21 2006-05-23 Upjohn Co compostos terapêuticos ligantes de 5-ht, composições farmacêuticas compreendendo tais compostos e seus usos
TW200918046A (en) 2002-04-03 2009-05-01 Novartis Ag Indolylmaleimide derivatives
ES2312785T3 (es) 2002-06-05 2009-03-01 Janssen Pharmaceutica Nv Pirrolinas sustituidas utiles como inhibidores de quinasa.
AU2003238874A1 (en) 2002-06-05 2003-12-22 Janssen Pharmaceutica N.V. Bisindolyl-maleimid derivatives as kinase inhibitors
DE602004016174D1 (de) 2003-06-13 2008-10-09 Janssen Pharmaceutica Nv Substituierte indazolyl(indolyl)maleimid-derivate als kinase inhibitoren
GB0316232D0 (en) 2003-07-11 2003-08-13 Astrazeneca Ab Therapeutic agents
CN101094852A (zh) 2004-11-01 2007-12-26 惠氏公司 作为cns活性剂的取代的吲嗪以及衍生物
PL1846406T3 (pl) 2005-02-09 2011-04-29 Arqule Inc Pochodne imidowe kwasu maleinowego, kompozycje farmaceutyczne i sposoby leczenia nowotworów
BRPI0813355A2 (pt) 2007-06-22 2014-12-30 Arqule Inc Compostos de quinazolinona e métodos de uso dos mesmos
JP5490688B2 (ja) 2007-06-22 2014-05-14 アークル インコーポレイテッド 癌の治療のためのインドリルピロリジン
CN101801961B (zh) * 2007-06-22 2014-09-24 艾科尔公司 吡咯烷酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺衍生物、组合物以及治疗癌症的方法
CN101671329B (zh) * 2009-06-17 2012-11-07 东华大学 3-氨基醇取代的吲哚马来酰亚胺化合物、其制备和应用
CN102344443A (zh) * 2011-07-15 2012-02-08 南开大学 点击化学合成开环马来酰亚胺类化合物及其在治疗疾病中的应用
WO2013029043A1 (en) * 2011-08-25 2013-02-28 Reaction Biology Corp. Selective kinase inhibitors
CN112574163B (zh) * 2021-01-29 2023-04-07 山西省肿瘤研究所 巴西苏木素类天然产物(+)-Brazilin的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4005970A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides

Also Published As

Publication number Publication date
BR9912612A (pt) 2001-11-20
HUP0103381A2 (hu) 2002-02-28
HUP0103381A3 (en) 2002-07-29
WO2000006564A1 (fr) 2000-02-10
ID27510A (id) 2001-04-12
CA2338866A1 (en) 2000-02-10
EP1120414A1 (en) 2001-08-01
KR20010085305A (ko) 2001-09-07
NO20010487D0 (no) 2001-01-29
NO20010487L (no) 2001-03-28
AU4929999A (en) 2000-02-21
CN1320123A (zh) 2001-10-31
IL141080A0 (en) 2002-02-10

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