PE20000354A1 - Nuevos compuestos y usos anestesicos locales - Google Patents
Nuevos compuestos y usos anestesicos localesInfo
- Publication number
- PE20000354A1 PE20000354A1 PE1999000262A PE00026299A PE20000354A1 PE 20000354 A1 PE20000354 A1 PE 20000354A1 PE 1999000262 A PE1999000262 A PE 1999000262A PE 00026299 A PE00026299 A PE 00026299A PE 20000354 A1 PE20000354 A1 PE 20000354A1
- Authority
- PE
- Peru
- Prior art keywords
- alkylene
- linking
- link
- cr1r2
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE MULTIPLE ENLACE (L)p(X)q, DONDE L ES UN LIGANDO; X ES UN ENLACE; p ES 2-10; q ES 1-20; CADA LIGANDO COMPRENDE UN DOMINIO LIGANDO CAPAZ DE LIGARSE A UN CANAL DE SODIO; CADA LIGANDO INHIBE LA GENERACION Y CONDUCCION DE POTENCIALES DE ACCION; CADA LIGANDO COMPRENDE UN GRUPO Ar-W; Ar ES ARILO, HETEROCICLO, HETEROARILO; W ES -[CR1R2]rCO-, COO[CR1R2]r-, -OCO[CR1R2]r, ENTRE OTROS; r ES 0-10; R1 Y R2 SON H, ALQUILO, NRaRb, ENTRE OTROS; Ra Y Rb SON ALQUILO; CADA ENLACE X ES 1)-NR3-Z-NR4-; Z ES ALQUILENO, (ALQUILENO-O)w-ALQUILENO, ALQUENILENO, ENTRE OTROS; w ES 1-10; R3 Y R4 SON H, ALQUILO, ARALQUILO, LIGANDO, X-LIGANDO O R3 Y R4 FORMAN JUNTO CON Z UN HETEROCICLO CON UN N Y OPCIONALMENTE CON 1-4 O, S, SO2, SO, NR`'; R'' ES UN LIGANDO, H, ALQUILO; 2)-Ya-Z'-Yb-; Z' ES UN HETEROCICLO, ARILO, HETEROARILO, UN ANILLO CON 2 N, -NR-; R ES ALQUILO; Ya Y Yb SON UN ENLACE, ALQUILENO, (ALQUILENO-O)w-, ALQUILENO, -CO-(CH2)n-NR-; n ES 1-10. Ar-W ES DE PREFERENCIA 2,6-DIMETILFENIL-NH-CO-CH2-, -O-TOLIL-NH-CO-CH(CH2CH3), 4-[-CO-O-(CH2)2-N(CH2CH3)2]-FENILO, 4-AMINOFENIL-CO-, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO (L)p(X)q PUEDE SER UTIL COMO ANESTESICO LOCAL
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8053198P | 1998-04-03 | 1998-04-03 | |
US12207599P | 1999-03-01 | 1999-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20000354A1 true PE20000354A1 (es) | 2000-05-20 |
Family
ID=26763633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999000262A PE20000354A1 (es) | 1998-04-03 | 1999-03-31 | Nuevos compuestos y usos anestesicos locales |
Country Status (16)
Country | Link |
---|---|
US (3) | US6337423B1 (es) |
EP (1) | EP1066245A4 (es) |
JP (1) | JP2002510669A (es) |
KR (1) | KR20010034737A (es) |
CN (1) | CN1295558A (es) |
AR (1) | AR014809A1 (es) |
AU (1) | AU3464999A (es) |
BR (1) | BR9909377A (es) |
CA (1) | CA2315946A1 (es) |
CO (1) | CO5040088A1 (es) |
HU (1) | HUP0102831A2 (es) |
IL (1) | IL137411A0 (es) |
NO (1) | NO20004961D0 (es) |
PE (1) | PE20000354A1 (es) |
PL (1) | PL342991A1 (es) |
WO (1) | WO1999051565A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20000354A1 (es) * | 1998-04-03 | 2000-05-20 | Advanced Medicine Inc | Nuevos compuestos y usos anestesicos locales |
US6462034B1 (en) | 1998-04-03 | 2002-10-08 | Theravance, Inc. | Local anesthetic compounds and uses |
WO2001025235A1 (en) * | 1999-10-01 | 2001-04-12 | Advanced Medicine, Inc. | Macrocyclic quinazolinones and their use as local anesthetics |
AU7847800A (en) * | 1999-10-15 | 2001-04-30 | Mayo Foundation For Medical Education And Research | Topical anesthetics useful for treating cancer, autoimmune diseases and ischemia |
US20030124174A1 (en) * | 2001-10-25 | 2003-07-03 | Endo Pharmaceuticals, Inc | Method for treating non-neuropathic pain |
DE10161644A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | N,N'-disubstituierte Piperazin-Verbindungen |
US20050112183A1 (en) * | 2003-11-25 | 2005-05-26 | Galer Bradley S. | Compositions and methods for treating neuropathic sensory loss |
US7666914B2 (en) * | 2004-06-03 | 2010-02-23 | Richlin David M | Topical preparation and method for transdermal delivery and localization of therapeutic agents |
CA2628312A1 (en) * | 2005-11-02 | 2007-05-18 | Icagen, Inc. | Inhibitors of ion channels |
TW200804288A (en) | 2005-12-12 | 2008-01-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
WO2009054916A2 (en) * | 2007-10-19 | 2009-04-30 | Nektar Therapeutics Al, Corporation | Oligomer conjugates of lidocaine and its derivatives |
WO2014170648A1 (en) | 2013-04-19 | 2014-10-23 | Astrazeneca Ab | A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos) |
JP2017504656A (ja) * | 2013-12-05 | 2017-02-09 | エレックス バイオテック エルエルシー | 心不整脈の治療用化合物 |
CN105418489A (zh) * | 2016-01-22 | 2016-03-23 | 江苏宝众宝达药业有限公司 | 一种布比卡因的合成方法 |
CN110092731B (zh) * | 2018-01-31 | 2022-03-04 | 四川大学华西医院 | 长链胺取代的二甲基苯铵类化合物、制备、自组装结构及用途 |
JP7436370B2 (ja) * | 2018-02-11 | 2024-02-21 | ウェストチャイナホスピタル、スーチョワンユニバーシティ | 第四級アンモニウム塩系化合物およびその調製方法と使用 |
CN108514589A (zh) * | 2018-06-28 | 2018-09-11 | 河南科技大学第附属医院 | 一种用于局部麻醉的中药麻醉剂 |
US20220135526A1 (en) * | 2019-02-01 | 2022-05-05 | West China Hospital, Sichuan University | Quaternary ammonium salt compound, preparation method therefor and use thereof |
CN112574098B (zh) * | 2019-09-30 | 2022-06-07 | 四川大学华西医院 | 一种酰胺化合物及其制备方法和用途 |
TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
TW202245800A (zh) | 2020-02-18 | 2022-12-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
CN118598916A (zh) | 2020-02-18 | 2024-09-06 | 吉利德科学公司 | 抗病毒化合物 |
WO2022037590A1 (zh) * | 2020-08-17 | 2022-02-24 | 四川大学华西医院 | 一种用于麻醉的季铵盐类化合物及其制备方法和用途 |
CN111909039A (zh) * | 2020-09-07 | 2020-11-10 | 江苏湘园化工有限公司 | 一种高位阻效应的脂肪族二元仲胺的制备方法 |
US11697666B2 (en) | 2021-04-16 | 2023-07-11 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
CA3228162A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB692332A (en) | 1950-07-18 | 1953-06-03 | Geigy Ag J R | Improvements relating to quaternary ammonium compounds, and their uses |
DE1054462B (de) * | 1955-10-27 | 1959-04-09 | Espe Fabrik Pharm Praeparate G | Verfahren zur Herstellung von lokalanaesthetisch wirksamen Polyaminoacetaniliden |
DE1056619B (de) * | 1956-11-29 | 1959-05-06 | Bayer Ag | Verfahren zur Herstellung von 4-Nitro-diarylaminen |
DE1204226B (de) | 1963-12-10 | 1965-11-04 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von bisquaternaeren Zinnkomplexsalzen |
NL137318C (es) | 1964-06-09 | |||
GB1124837A (en) | 1966-06-03 | 1968-08-21 | Wyeth John & Brother Ltd | Substituted anilides |
US3898070A (en) | 1971-07-29 | 1975-08-05 | Ciba Geigy Corp | Chelates for the control of metal-deficiency-phenomena in biological systems |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
JPS52139060A (en) * | 1976-05-13 | 1977-11-19 | Nippon Soda Co Ltd | Imidazorium halides their preparation and fungicides for agriculture and horticulture |
GB1574019A (en) * | 1977-01-14 | 1980-09-03 | Joullie International Sa | Therapeutically useful 3,4,5-trimethoxybenzene derivatives |
US4169106A (en) | 1977-09-30 | 1979-09-25 | Cooper Laboratories, Inc. | Antiarrhythmic N,N'-bis(phenylcarbamoylalkyl)amidines |
US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
US4597903A (en) | 1984-08-21 | 1986-07-01 | University Of Maryland | Process for the direct preparation of N,N-disubstituted derivatives for 4,13-diaza-18-crown-6 |
GB8514209D0 (en) | 1985-06-05 | 1985-07-10 | Unilever Plc | Catalyst additives |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
US5719197A (en) | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5134232A (en) | 1988-11-14 | 1992-07-28 | The Regents Of The University Of California | Fluorescent indicator dyes for alkali metal cations |
JP2722250B2 (ja) | 1989-05-30 | 1998-03-04 | 興和株式会社 | 新規なジアミン化合物及びこれを含有する脳機能障害改善剤 |
US4948906A (en) | 1990-02-16 | 1990-08-14 | Ethyl Corporation | Trimethylaluminum process |
CA2036781A1 (en) | 1990-02-22 | 1991-08-23 | Fujio Antoku | Triamine derivatives and their acid-addition salts |
US5405975A (en) | 1993-03-29 | 1995-04-11 | Molecular Probes, Inc. | Fluorescent ion-selective diaryldiaza crown ether conjugates |
JPH06506455A (ja) | 1991-02-08 | 1994-07-21 | ケンブリッジ・ニューロサイエンス・インコーポレイテッド | 神経伝達物質放出調節剤としてのグアニジン置換体及びその誘導体ならびに神経伝達物質放出遮断物質を同定するための新規な方法 |
US5352705A (en) | 1992-06-26 | 1994-10-04 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
DK0603403T4 (da) * | 1992-07-03 | 2002-12-16 | Welfide Corp | Nyt chelaterende middel, kompleksforbindelse mellem dette middel og et metalatom og diagnostisk middel indeholdende denne forbindelse |
ES2125285T3 (es) | 1992-07-31 | 1999-03-01 | Bristol Myers Squibb Co | Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles. |
WO1997030019A1 (en) | 1996-02-13 | 1997-08-21 | Shaman Pharmaceuticals, Inc. | Aniline derivatives having antihyperglycemic activity |
US5731438A (en) * | 1996-08-01 | 1998-03-24 | Isis Pharmaceuticals, Inc. | N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles |
PE20000354A1 (es) * | 1998-04-03 | 2000-05-20 | Advanced Medicine Inc | Nuevos compuestos y usos anestesicos locales |
-
1999
- 1999-03-31 PE PE1999000262A patent/PE20000354A1/es not_active Application Discontinuation
- 1999-03-31 AR ARP990101483A patent/AR014809A1/es unknown
- 1999-03-31 CO CO99019383A patent/CO5040088A1/es unknown
- 1999-04-02 JP JP2000542287A patent/JP2002510669A/ja not_active Withdrawn
- 1999-04-02 US US09/285,054 patent/US6337423B1/en not_active Expired - Lifetime
- 1999-04-02 PL PL99342991A patent/PL342991A1/xx unknown
- 1999-04-02 IL IL13741199A patent/IL137411A0/xx unknown
- 1999-04-02 HU HU0102831A patent/HUP0102831A2/hu unknown
- 1999-04-02 AU AU34649/99A patent/AU3464999A/en not_active Abandoned
- 1999-04-02 EP EP99916299A patent/EP1066245A4/en not_active Withdrawn
- 1999-04-02 CA CA002315946A patent/CA2315946A1/en not_active Abandoned
- 1999-04-02 WO PCT/US1999/007263 patent/WO1999051565A1/en not_active Application Discontinuation
- 1999-04-02 BR BR9909377-4A patent/BR9909377A/pt not_active Application Discontinuation
- 1999-04-02 KR KR1020007011022A patent/KR20010034737A/ko not_active Application Discontinuation
- 1999-04-02 US US09/647,802 patent/US6576791B1/en not_active Expired - Lifetime
- 1999-04-02 CN CN99804507A patent/CN1295558A/zh active Pending
-
2000
- 2000-10-02 NO NO20004961A patent/NO20004961D0/no not_active Application Discontinuation
- 2000-10-17 US US09/690,019 patent/US6495681B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU3464999A (en) | 1999-10-25 |
US6495681B1 (en) | 2002-12-17 |
EP1066245A1 (en) | 2001-01-10 |
BR9909377A (pt) | 2000-12-05 |
KR20010034737A (ko) | 2001-04-25 |
CO5040088A1 (es) | 2001-05-29 |
EP1066245A4 (en) | 2001-01-24 |
PL342991A1 (en) | 2001-07-16 |
WO1999051565A1 (en) | 1999-10-14 |
US6576791B1 (en) | 2003-06-10 |
NO20004961L (no) | 2000-10-02 |
US6337423B1 (en) | 2002-01-08 |
WO1999051565A9 (en) | 1999-12-02 |
AR014809A1 (es) | 2001-03-28 |
JP2002510669A (ja) | 2002-04-09 |
CN1295558A (zh) | 2001-05-16 |
NO20004961D0 (no) | 2000-10-02 |
CA2315946A1 (en) | 1999-10-14 |
HUP0102831A2 (hu) | 2001-12-28 |
IL137411A0 (en) | 2001-07-24 |
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Legal Events
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FC | Refusal |