PE20000354A1 - Nuevos compuestos y usos anestesicos locales - Google Patents

Nuevos compuestos y usos anestesicos locales

Info

Publication number
PE20000354A1
PE20000354A1 PE1999000262A PE00026299A PE20000354A1 PE 20000354 A1 PE20000354 A1 PE 20000354A1 PE 1999000262 A PE1999000262 A PE 1999000262A PE 00026299 A PE00026299 A PE 00026299A PE 20000354 A1 PE20000354 A1 PE 20000354A1
Authority
PE
Peru
Prior art keywords
alkylene
linking
link
cr1r2
alkyl
Prior art date
Application number
PE1999000262A
Other languages
English (en)
Inventor
Yu-Hua Ji
Sabine M Axt
Witold Hruzewicz
Thomas E Jenkins
J Kevin Judice
John R Jacobsen
Timothy J Church
Original Assignee
Advanced Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc filed Critical Advanced Medicine Inc
Publication of PE20000354A1 publication Critical patent/PE20000354A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE MULTIPLE ENLACE (L)p(X)q, DONDE L ES UN LIGANDO; X ES UN ENLACE; p ES 2-10; q ES 1-20; CADA LIGANDO COMPRENDE UN DOMINIO LIGANDO CAPAZ DE LIGARSE A UN CANAL DE SODIO; CADA LIGANDO INHIBE LA GENERACION Y CONDUCCION DE POTENCIALES DE ACCION; CADA LIGANDO COMPRENDE UN GRUPO Ar-W; Ar ES ARILO, HETEROCICLO, HETEROARILO; W ES -[CR1R2]rCO-, COO[CR1R2]r-, -OCO[CR1R2]r, ENTRE OTROS; r ES 0-10; R1 Y R2 SON H, ALQUILO, NRaRb, ENTRE OTROS; Ra Y Rb SON ALQUILO; CADA ENLACE X ES 1)-NR3-Z-NR4-; Z ES ALQUILENO, (ALQUILENO-O)w-ALQUILENO, ALQUENILENO, ENTRE OTROS; w ES 1-10; R3 Y R4 SON H, ALQUILO, ARALQUILO, LIGANDO, X-LIGANDO O R3 Y R4 FORMAN JUNTO CON Z UN HETEROCICLO CON UN N Y OPCIONALMENTE CON 1-4 O, S, SO2, SO, NR`'; R'' ES UN LIGANDO, H, ALQUILO; 2)-Ya-Z'-Yb-; Z' ES UN HETEROCICLO, ARILO, HETEROARILO, UN ANILLO CON 2 N, -NR-; R ES ALQUILO; Ya Y Yb SON UN ENLACE, ALQUILENO, (ALQUILENO-O)w-, ALQUILENO, -CO-(CH2)n-NR-; n ES 1-10. Ar-W ES DE PREFERENCIA 2,6-DIMETILFENIL-NH-CO-CH2-, -O-TOLIL-NH-CO-CH(CH2CH3), 4-[-CO-O-(CH2)2-N(CH2CH3)2]-FENILO, 4-AMINOFENIL-CO-, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO (L)p(X)q PUEDE SER UTIL COMO ANESTESICO LOCAL
PE1999000262A 1998-04-03 1999-03-31 Nuevos compuestos y usos anestesicos locales PE20000354A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8053198P 1998-04-03 1998-04-03
US12207599P 1999-03-01 1999-03-01

Publications (1)

Publication Number Publication Date
PE20000354A1 true PE20000354A1 (es) 2000-05-20

Family

ID=26763633

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000262A PE20000354A1 (es) 1998-04-03 1999-03-31 Nuevos compuestos y usos anestesicos locales

Country Status (16)

Country Link
US (3) US6337423B1 (es)
EP (1) EP1066245A4 (es)
JP (1) JP2002510669A (es)
KR (1) KR20010034737A (es)
CN (1) CN1295558A (es)
AR (1) AR014809A1 (es)
AU (1) AU3464999A (es)
BR (1) BR9909377A (es)
CA (1) CA2315946A1 (es)
CO (1) CO5040088A1 (es)
HU (1) HUP0102831A2 (es)
IL (1) IL137411A0 (es)
NO (1) NO20004961D0 (es)
PE (1) PE20000354A1 (es)
PL (1) PL342991A1 (es)
WO (1) WO1999051565A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20000354A1 (es) * 1998-04-03 2000-05-20 Advanced Medicine Inc Nuevos compuestos y usos anestesicos locales
US6462034B1 (en) 1998-04-03 2002-10-08 Theravance, Inc. Local anesthetic compounds and uses
WO2001025235A1 (en) * 1999-10-01 2001-04-12 Advanced Medicine, Inc. Macrocyclic quinazolinones and their use as local anesthetics
AU7847800A (en) * 1999-10-15 2001-04-30 Mayo Foundation For Medical Education And Research Topical anesthetics useful for treating cancer, autoimmune diseases and ischemia
US20030124174A1 (en) * 2001-10-25 2003-07-03 Endo Pharmaceuticals, Inc Method for treating non-neuropathic pain
DE10161644A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh N,N'-disubstituierte Piperazin-Verbindungen
US20050112183A1 (en) * 2003-11-25 2005-05-26 Galer Bradley S. Compositions and methods for treating neuropathic sensory loss
US7666914B2 (en) * 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
CA2628312A1 (en) * 2005-11-02 2007-05-18 Icagen, Inc. Inhibitors of ion channels
TW200804288A (en) 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
WO2009054916A2 (en) * 2007-10-19 2009-04-30 Nektar Therapeutics Al, Corporation Oligomer conjugates of lidocaine and its derivatives
WO2014170648A1 (en) 2013-04-19 2014-10-23 Astrazeneca Ab A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
JP2017504656A (ja) * 2013-12-05 2017-02-09 エレックス バイオテック エルエルシー 心不整脈の治療用化合物
CN105418489A (zh) * 2016-01-22 2016-03-23 江苏宝众宝达药业有限公司 一种布比卡因的合成方法
CN110092731B (zh) * 2018-01-31 2022-03-04 四川大学华西医院 长链胺取代的二甲基苯铵类化合物、制备、自组装结构及用途
JP7436370B2 (ja) * 2018-02-11 2024-02-21 ウェストチャイナホスピタル、スーチョワンユニバーシティ 第四級アンモニウム塩系化合物およびその調製方法と使用
CN108514589A (zh) * 2018-06-28 2018-09-11 河南科技大学第附属医院 一种用于局部麻醉的中药麻醉剂
US20220135526A1 (en) * 2019-02-01 2022-05-05 West China Hospital, Sichuan University Quaternary ammonium salt compound, preparation method therefor and use thereof
CN112574098B (zh) * 2019-09-30 2022-06-07 四川大学华西医院 一种酰胺化合物及其制备方法和用途
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
TW202245800A (zh) 2020-02-18 2022-12-01 美商基利科學股份有限公司 抗病毒化合物
CN118598916A (zh) 2020-02-18 2024-09-06 吉利德科学公司 抗病毒化合物
WO2022037590A1 (zh) * 2020-08-17 2022-02-24 四川大学华西医院 一种用于麻醉的季铵盐类化合物及其制备方法和用途
CN111909039A (zh) * 2020-09-07 2020-11-10 江苏湘园化工有限公司 一种高位阻效应的脂肪族二元仲胺的制备方法
US11697666B2 (en) 2021-04-16 2023-07-11 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
CA3228162A1 (en) 2021-08-18 2023-02-23 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB692332A (en) 1950-07-18 1953-06-03 Geigy Ag J R Improvements relating to quaternary ammonium compounds, and their uses
DE1054462B (de) * 1955-10-27 1959-04-09 Espe Fabrik Pharm Praeparate G Verfahren zur Herstellung von lokalanaesthetisch wirksamen Polyaminoacetaniliden
DE1056619B (de) * 1956-11-29 1959-05-06 Bayer Ag Verfahren zur Herstellung von 4-Nitro-diarylaminen
DE1204226B (de) 1963-12-10 1965-11-04 Boehringer Sohn Ingelheim Verfahren zur Herstellung von bisquaternaeren Zinnkomplexsalzen
NL137318C (es) 1964-06-09
GB1124837A (en) 1966-06-03 1968-08-21 Wyeth John & Brother Ltd Substituted anilides
US3898070A (en) 1971-07-29 1975-08-05 Ciba Geigy Corp Chelates for the control of metal-deficiency-phenomena in biological systems
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
JPS52139060A (en) * 1976-05-13 1977-11-19 Nippon Soda Co Ltd Imidazorium halides their preparation and fungicides for agriculture and horticulture
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
US4169106A (en) 1977-09-30 1979-09-25 Cooper Laboratories, Inc. Antiarrhythmic N,N'-bis(phenylcarbamoylalkyl)amidines
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4597903A (en) 1984-08-21 1986-07-01 University Of Maryland Process for the direct preparation of N,N-disubstituted derivatives for 4,13-diaza-18-crown-6
GB8514209D0 (en) 1985-06-05 1985-07-10 Unilever Plc Catalyst additives
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5719197A (en) 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5134232A (en) 1988-11-14 1992-07-28 The Regents Of The University Of California Fluorescent indicator dyes for alkali metal cations
JP2722250B2 (ja) 1989-05-30 1998-03-04 興和株式会社 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
US4948906A (en) 1990-02-16 1990-08-14 Ethyl Corporation Trimethylaluminum process
CA2036781A1 (en) 1990-02-22 1991-08-23 Fujio Antoku Triamine derivatives and their acid-addition salts
US5405975A (en) 1993-03-29 1995-04-11 Molecular Probes, Inc. Fluorescent ion-selective diaryldiaza crown ether conjugates
JPH06506455A (ja) 1991-02-08 1994-07-21 ケンブリッジ・ニューロサイエンス・インコーポレイテッド 神経伝達物質放出調節剤としてのグアニジン置換体及びその誘導体ならびに神経伝達物質放出遮断物質を同定するための新規な方法
US5352705A (en) 1992-06-26 1994-10-04 Merck & Co., Inc. Inhibitors of farnesyl protein transferase
DK0603403T4 (da) * 1992-07-03 2002-12-16 Welfide Corp Nyt chelaterende middel, kompleksforbindelse mellem dette middel og et metalatom og diagnostisk middel indeholdende denne forbindelse
ES2125285T3 (es) 1992-07-31 1999-03-01 Bristol Myers Squibb Co Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles.
WO1997030019A1 (en) 1996-02-13 1997-08-21 Shaman Pharmaceuticals, Inc. Aniline derivatives having antihyperglycemic activity
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles
PE20000354A1 (es) * 1998-04-03 2000-05-20 Advanced Medicine Inc Nuevos compuestos y usos anestesicos locales

Also Published As

Publication number Publication date
AU3464999A (en) 1999-10-25
US6495681B1 (en) 2002-12-17
EP1066245A1 (en) 2001-01-10
BR9909377A (pt) 2000-12-05
KR20010034737A (ko) 2001-04-25
CO5040088A1 (es) 2001-05-29
EP1066245A4 (en) 2001-01-24
PL342991A1 (en) 2001-07-16
WO1999051565A1 (en) 1999-10-14
US6576791B1 (en) 2003-06-10
NO20004961L (no) 2000-10-02
US6337423B1 (en) 2002-01-08
WO1999051565A9 (en) 1999-12-02
AR014809A1 (es) 2001-03-28
JP2002510669A (ja) 2002-04-09
CN1295558A (zh) 2001-05-16
NO20004961D0 (no) 2000-10-02
CA2315946A1 (en) 1999-10-14
HUP0102831A2 (hu) 2001-12-28
IL137411A0 (en) 2001-07-24

Similar Documents

Publication Publication Date Title
PE20000354A1 (es) Nuevos compuestos y usos anestesicos locales
SE7702609L (sv) Aminoalkylheterocykler
PE20020753A1 (es) Heteroaromaticos fusionados como activadores de la glucoquinasa
PE20001467A1 (es) Derivados de 4-fenilpiridina como antagonistas del receptor de neuroquinina
DK322783D0 (da) Amidderivater
TR200103335T2 (tr) Proteaz inhibitörleri olarak amin türevleri
DK441080A (da) Fremgangsmaade til fremstilling af morpholinderivater
PE20040772A1 (es) Composicion y actividad antiviral de derivados de piperazina azaindoloxoaceticos
DK283487D0 (da) Thiazolyl-2-yl-imidazo(1,2-a)pyrimidiner, deres fremstilling og brug
ES515904A0 (es) "procedimiento para preparar nuevas triazoloquinazolonas".
DE602004017622D1 (de) Matrixmetalloproteinaseinhibitoren
DK184388D0 (da) 3h-1,2,3-triazolooe4,5-daapyrimidiner
BR8203704A (pt) Compostos utilizaveis em especial como herbicidas processos para preparacao de tais compostos composicao herbicidas e processo para destruicao seletiva das ervas daninhas das culturas
AR029308A1 (es) Compuestos de sulfonamidas, composiciones farmaceuticas formuladas con dichos compuestos y uso de los compuestos mencionados para la preparacion de dichas composiciones para potenciar la funcion glutamato receptora
SE7606424L (sv) Substituerade bensamider
PT906295E (pt) Dibenzo-oxazepina e derivados de dioxepina e a respectiva utilizacao como agentes anti-tumores
SE8506125L (sv) 8alfa-acylaminoergoliner, deras framstellning och farmaceutiska kopositioner innehallande dessa
NO914577L (no) Fremgangsmaate for fremstilling av heterocyklisk substituerte piperazinoalkylbenzoksazin- og -tiazinforbindelser
PE107499A1 (es) Derivados de 2-(arilfenil) amino-imidazolina
ATE29877T1 (de) Mittel zur senkung der herzfrequenz.
SE7907540L (sv) Diuretiska medel
TR200300359T4 (tr) İkameli yeni (dihidro)benzoksazin ve (dihidro)benzotiyazin türevleri bunların hazırlanma yöntemleri ve bunları içeren farmasötik bileşimler
GB1549172A (en) Benzobicyclononene derivatives
GB1307590A (en) 4-1-substituted-3-pyrrolidinyl-2h-1,4-benzoxazin-3- 4h-ones

Legal Events

Date Code Title Description
FC Refusal