PE16899A1 - Analogos peptidos lh-rh, su empleo y composiciones farmaceuticas en las que estan presentes - Google Patents
Analogos peptidos lh-rh, su empleo y composiciones farmaceuticas en las que estan presentesInfo
- Publication number
- PE16899A1 PE16899A1 PE1997001013A PE00101397A PE16899A1 PE 16899 A1 PE16899 A1 PE 16899A1 PE 1997001013 A PE1997001013 A PE 1997001013A PE 00101397 A PE00101397 A PE 00101397A PE 16899 A1 PE16899 A1 PE 16899A1
- Authority
- PE
- Peru
- Prior art keywords
- lis
- amino acid
- treatment
- combination
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIEREN A PEPTIDOS DE FORMULA V-W-X-SPL-Y-Pro-Z, EN DONDE: "V" ES A1A2, DONDE: A1 ES ACIDO PIROGLUTAMICO, ACETILSARCOSINA o D-AMINOACIDO AROMATICO; A2 ES UN ENLACE DIRECTO, His, DFen, DpFFen o DpClFen; "W" ES UN AMINOACIDO AROMATICO; "X" ES A3A4, DONDE: A3 ES Ala, Thr, Ser, DSer, Ser(OBzl) o N-METILSERINA; A4 ES Tir, Fen, CIS-3-(4-PIRAZINILCARBONILAMINOCICLOHEXIL)ALANINA, N-PICOLINOIL-Lis, N-NICOTIL-Lis, N-ISOPROPIL-Lis; SPL ES EL RADICAL DE FORMULA (i); "Y" ES A5A6, DONDE: A5 ES UN AMINOACIDO CON UNA CADENA LATERAL ALQUILO C1-C8 o CICLOALQUILO C3-C6; A6 ES Arg, HArg (OPCIONALMENTE SUSTITUIDOS POR ALQUILO C1-C4), Lis, HLis, Orn, p-AMINOFENILALANINA (OPCIONALMENTE SUSTITUIDOS POR ISOPROPIL, NICOTINOIL o PICOLINOIL), CITRULINA (Cit), HCit; "Z" ES GliNH2, DAlaNH2, AZAGliNH2 o NHR1, DONDE R1 ES ALQUILO C1-C4, CICLOALQUILO C3-C6 o HETEROCICLO. ESTOS PEPTIDOS ACTUAN COMO ANTAGONISTAS Y AGONISTAS DE LA HORMONA LUTEINIZANTE (LH-RH), SIENDO UTILES EN COMBINACION CON UN ESTEROIDE SEXUAL O UNA GONADOTROPINA EN EL TRATAMIENTO DE LA INFERTILIDAD, CONDICIONES HIPOGONADICAS, HIPERGONADICAS, O DE MANERA INVERSA COMO ANTICONCEPTIVO; EN COMBINACION CON UN INHIBIDOR DE ACCION ANDROGENICA, EN EL TRATAMIENTO DEL CANCER DE PROSTATA O DE LA HIPERTROFIA PROSTATICA BENIGNA O EN COMBINACION CON UN ANTIESTROGENO EN EL TRATAMIENTO DEL CANCER DE MAMA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96402441A EP0842946A1 (en) | 1996-11-14 | 1996-11-14 | Conformationally constrained LH-RH analogues, their uses and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE16899A1 true PE16899A1 (es) | 1999-02-19 |
Family
ID=8225315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997001013A PE16899A1 (es) | 1996-11-14 | 1997-11-12 | Analogos peptidos lh-rh, su empleo y composiciones farmaceuticas en las que estan presentes |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6153587A (es) |
| EP (2) | EP0842946A1 (es) |
| JP (1) | JP2001503444A (es) |
| KR (1) | KR20000068975A (es) |
| CN (1) | CN1237979A (es) |
| AP (1) | AP9901529A0 (es) |
| AT (1) | ATE196914T1 (es) |
| AU (1) | AU5481798A (es) |
| BR (1) | BR9713060A (es) |
| CA (1) | CA2270158A1 (es) |
| CO (1) | CO4930283A1 (es) |
| CZ (1) | CZ172899A3 (es) |
| DE (1) | DE69703308D1 (es) |
| EE (1) | EE9900174A (es) |
| HU (1) | HUP0000249A3 (es) |
| ID (1) | ID21990A (es) |
| IL (1) | IL129821A0 (es) |
| JO (1) | JO1999B1 (es) |
| MA (1) | MA26447A1 (es) |
| NO (1) | NO992298L (es) |
| NZ (1) | NZ335454A (es) |
| OA (1) | OA11045A (es) |
| PE (1) | PE16899A1 (es) |
| PL (1) | PL333358A1 (es) |
| TN (1) | TNSN97173A1 (es) |
| TR (1) | TR199901054T2 (es) |
| WO (1) | WO1998021229A1 (es) |
| ZA (1) | ZA9710254B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5677184A (en) * | 1994-04-19 | 1997-10-14 | Takeda Chemical Industries, Ltd. | CHO cells that express human LH-RH receptor |
| EP0842946A1 (en) * | 1996-11-14 | 1998-05-20 | Laboratoire Theramex S.A. | Conformationally constrained LH-RH analogues, their uses and pharmaceutical compositions containing them |
| EP0882736A1 (en) * | 1997-06-02 | 1998-12-09 | Laboratoire Theramex S.A. | LH-RH peptide analogues, their uses and pharmaceutical compositions containing them |
| EP0998940A1 (en) * | 1998-09-30 | 2000-05-10 | Laboratoire Theramex | Pharmaceutical compositions based on alpha-cyclodextrin for the oral administration of LH-RH analogues |
| WO2000064926A1 (fr) * | 1999-04-26 | 2000-11-02 | Ajinomoto Co., Inc. | Inhibiteur hormonal stimulant les melanocytes |
| US8821943B2 (en) * | 2006-09-12 | 2014-09-02 | Board Of Regents Of The University Of Nebraska | Methods and compositions for targeted delivery of therapeutic agents |
| JP2023546032A (ja) * | 2020-10-08 | 2023-11-01 | ディグニファイ セラピューティクス エルエルシー | 排尿および排便を誘発するための組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4377515A (en) * | 1979-10-01 | 1983-03-22 | Merck & Co., Inc. | Long lasting agonists and antagonists of LH-RH |
| US5110904A (en) * | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
| EP0842946A1 (en) * | 1996-11-14 | 1998-05-20 | Laboratoire Theramex S.A. | Conformationally constrained LH-RH analogues, their uses and pharmaceutical compositions containing them |
-
1996
- 1996-11-14 EP EP96402441A patent/EP0842946A1/en not_active Withdrawn
-
1997
- 1997-11-12 CZ CZ991728A patent/CZ172899A3/cs unknown
- 1997-11-12 CA CA002270158A patent/CA2270158A1/en not_active Abandoned
- 1997-11-12 JP JP52218798A patent/JP2001503444A/ja active Pending
- 1997-11-12 ID IDW990330A patent/ID21990A/id unknown
- 1997-11-12 HU HU0000249A patent/HUP0000249A3/hu unknown
- 1997-11-12 CN CN97199752A patent/CN1237979A/zh active Pending
- 1997-11-12 AP APAP/P/1999/001529A patent/AP9901529A0/en unknown
- 1997-11-12 DE DE69703308T patent/DE69703308D1/de not_active Expired - Lifetime
- 1997-11-12 AU AU54817/98A patent/AU5481798A/en not_active Abandoned
- 1997-11-12 TR TR1999/01054T patent/TR199901054T2/xx unknown
- 1997-11-12 PE PE1997001013A patent/PE16899A1/es not_active Application Discontinuation
- 1997-11-12 NZ NZ335454A patent/NZ335454A/xx unknown
- 1997-11-12 AT AT97951183T patent/ATE196914T1/de not_active IP Right Cessation
- 1997-11-12 IL IL12982197A patent/IL129821A0/xx unknown
- 1997-11-12 MA MA24865A patent/MA26447A1/fr unknown
- 1997-11-12 PL PL97333358A patent/PL333358A1/xx unknown
- 1997-11-12 TN TNTNSN97173A patent/TNSN97173A1/fr unknown
- 1997-11-12 BR BR9713060-5A patent/BR9713060A/pt not_active IP Right Cessation
- 1997-11-12 JO JO19971999A patent/JO1999B1/en active
- 1997-11-12 KR KR1019997004265A patent/KR20000068975A/ko not_active Application Discontinuation
- 1997-11-12 EP EP97951183A patent/EP0937101B1/en not_active Expired - Lifetime
- 1997-11-12 EE EEP199900174A patent/EE9900174A/xx unknown
- 1997-11-12 WO PCT/EP1997/006322 patent/WO1998021229A1/en not_active Application Discontinuation
- 1997-11-13 ZA ZA9710254A patent/ZA9710254B/xx unknown
- 1997-11-14 CO CO97067085A patent/CO4930283A1/es unknown
-
1999
- 1999-05-12 OA OA9900098A patent/OA11045A/en unknown
- 1999-05-12 NO NO992298A patent/NO992298L/no not_active Application Discontinuation
- 1999-05-24 US US09/317,125 patent/US6153587A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2270158A1 (en) | 1998-05-22 |
| US6153587A (en) | 2000-11-28 |
| EP0937101B1 (en) | 2000-10-11 |
| MA26447A1 (fr) | 2004-12-20 |
| EP0842946A1 (en) | 1998-05-20 |
| CO4930283A1 (es) | 2000-06-27 |
| CZ172899A3 (cs) | 1999-08-11 |
| ID21990A (id) | 1999-08-19 |
| JP2001503444A (ja) | 2001-03-13 |
| WO1998021229A1 (en) | 1998-05-22 |
| AP9901529A0 (en) | 1999-06-30 |
| ZA9710254B (en) | 1998-05-28 |
| TR199901054T2 (xx) | 1999-07-21 |
| CN1237979A (zh) | 1999-12-08 |
| IL129821A0 (en) | 2000-02-29 |
| DE69703308D1 (de) | 2000-11-16 |
| TNSN97173A1 (fr) | 2005-03-15 |
| EP0937101A1 (en) | 1999-08-25 |
| ATE196914T1 (de) | 2000-10-15 |
| NO992298L (no) | 1999-07-08 |
| KR20000068975A (ko) | 2000-11-25 |
| NO992298D0 (no) | 1999-05-12 |
| AU5481798A (en) | 1998-06-03 |
| BR9713060A (pt) | 2000-04-11 |
| EE9900174A (et) | 1999-12-15 |
| HUP0000249A3 (en) | 2000-11-28 |
| NZ335454A (en) | 2000-10-27 |
| OA11045A (en) | 2003-03-07 |
| PL333358A1 (en) | 1999-12-06 |
| HUP0000249A2 (en) | 2000-07-28 |
| JO1999B1 (en) | 1999-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |