ITMI932154A1 - Oligopeptidi immunomodulatori derivati di frammenti della proteina c- reattiva - Google Patents

Oligopeptidi immunomodulatori derivati di frammenti della proteina c- reattiva

Info

Publication number
ITMI932154A1
ITMI932154A1 IT93MI002154A ITMI932154A ITMI932154A1 IT MI932154 A1 ITMI932154 A1 IT MI932154A1 IT 93MI002154 A IT93MI002154 A IT 93MI002154A IT MI932154 A ITMI932154 A IT MI932154A IT MI932154 A1 ITMI932154 A1 IT MI932154A1
Authority
IT
Italy
Prior art keywords
absent
leu
optionally
immunomodulating
fragments
Prior art date
Application number
IT93MI002154A
Other languages
English (en)
Inventor
Patrizia Caretto
Flavio Leoni
Fabrizio Marcucci
Gianni Gromo
Paolo Mascagni
Massimo Pinori
Silvana Cappelletti
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of ITMI932154A0 publication Critical patent/ITMI932154A0/it
Priority to ITMI932154A priority Critical patent/IT1271486B/it
Priority to US08/624,405 priority patent/US6057295A/en
Priority to ES94916966T priority patent/ES2185652T3/es
Priority to DE69431603T priority patent/DE69431603T2/de
Priority to AU68441/94A priority patent/AU684511B2/en
Priority to CA002173939A priority patent/CA2173939C/en
Priority to DK94916966T priority patent/DK0723552T3/da
Priority to EP94916966A priority patent/EP0723552B1/en
Priority to PT94916966T priority patent/PT723552E/pt
Priority to JP50541495A priority patent/JP3221881B2/ja
Priority to CN94193726A priority patent/CN1041524C/zh
Priority to KR1019960701879A priority patent/KR100363408B1/ko
Priority to HU9600934A priority patent/HUT75538A/hu
Priority to PCT/EP1994/001574 priority patent/WO1995010531A1/en
Priority to AT94916966T priority patent/ATE226591T1/de
Priority to IL10976194A priority patent/IL109761A0/xx
Priority to ZA943610A priority patent/ZA943610B/xx
Publication of ITMI932154A1 publication Critical patent/ITMI932154A1/it
Priority to FI961584A priority patent/FI961584A/fi
Priority to NO961423A priority patent/NO961423L/no
Application granted granted Critical
Publication of IT1271486B publication Critical patent/IT1271486B/it
Priority to US09/439,164 priority patent/US6342481B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4737—C-reactive protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Oligopeptidi di formula (I) (FORMULA I) oppure è assente;A2, è Leu, Ile, Val, Lys, Orn, facoltativamente N-sostituiti da alchile, benzile o acile, oppure è Pro oppure è assente; A3 è Pro, Leu, Ile, o Val; A4 è Arg, Leu, o Gln, facoltativamente ammidati al C-terminale, oppure un residuo agmatinico, oppure è assente; a patto che solo uno di A1, A2, e A4 può essere assente; e i gruppi funzionali delle catene laterali dei suddetti residui amminoacidi e del residuo agmatinico possono essere facoltativamente sostituiti con uno o più gruppi scelti fra alchile, benzile,o acile; e i loro possibili diastereoisomeri o enantiomeri e sali con acidi o basi farmaceuticamente accettabili, sono utili come agenti immunoregolatori e nella terapiacardiovascolare ed antinfiammatoria, in particolare nello shock setico.
ITMI932154A 1993-10-12 1993-10-12 Oligopeptidi immunomodulatori derivati di frammenti della proteina c- reattiva IT1271486B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ITMI932154A IT1271486B (it) 1993-10-12 1993-10-12 Oligopeptidi immunomodulatori derivati di frammenti della proteina c- reattiva
CN94193726A CN1041524C (zh) 1993-10-12 1994-05-16 由ｃ－活性蛋白质片段衍生的寡肽及其药物组合物
HU9600934A HUT75538A (en) 1993-10-12 1994-05-16 Oligopeptides derived from c-reactive protein fragments
DE69431603T DE69431603T2 (de) 1993-10-12 1994-05-16 Oligopeptide hergeleitet von fragmenten des c-reaktiven proteins
AU68441/94A AU684511B2 (en) 1993-10-12 1994-05-16 Oligopeptides derived from C-reactive protein fragments
CA002173939A CA2173939C (en) 1993-10-12 1994-05-16 Oligopeptides derived from c-reactive protein fragments
DK94916966T DK0723552T3 (da) 1993-10-12 1994-05-16 Oligopeptider afledt af fragmenter af C-reaktivt protein
EP94916966A EP0723552B1 (en) 1993-10-12 1994-05-16 Oligopeptides derived from c-reactive protein fragments
PT94916966T PT723552E (pt) 1993-10-12 1994-05-16 Oligopeptidos derivados de fragmentos de proteina reactiva c
JP50541495A JP3221881B2 (ja) 1993-10-12 1994-05-16 Ｃ反応性タンパク質断片から誘導されたオリゴペプチド
US08/624,405 US6057295A (en) 1993-10-12 1994-05-16 Oligopeptides derived from C-reactive protein fragments
KR1019960701879A KR100363408B1 (ko) 1993-10-12 1994-05-16 C-반응성단백질단편으로부터유도된올리고펩티드
ES94916966T ES2185652T3 (es) 1993-10-12 1994-05-16 Oligopeptidos derivados de fragmentos de proteinas c-reactiva.
PCT/EP1994/001574 WO1995010531A1 (en) 1993-10-12 1994-05-16 Oligopeptides derived from c-reactive protein fragments
AT94916966T ATE226591T1 (de) 1993-10-12 1994-05-16 Oligopeptide hergeleitet von fragmenten des c- reaktiven proteins
IL10976194A IL109761A0 (en) 1993-10-12 1994-05-24 Oligopeptides derived from c-reactive protein fragments
ZA943610A ZA943610B (en) 1993-10-12 1994-05-24 Oligopeptides derived from c-reactive protein fragments
FI961584A FI961584A (fi) 1993-10-12 1996-04-11 C-reaktiivisista proteiinifragmenteista johdetut oligopeptidit
NO961423A NO961423L (no) 1993-10-12 1996-04-11 Oligopeptider avledet fra C-reaktive proteinfragmenter
US09/439,164 US6342481B1 (en) 1993-10-12 1999-11-12 Oligopeptides derived from C-reactive protein fragments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI932154A IT1271486B (it) 1993-10-12 1993-10-12 Oligopeptidi immunomodulatori derivati di frammenti della proteina c- reattiva

Publications (3)

Publication Number Publication Date
ITMI932154A0 ITMI932154A0 (it) 1993-10-12
ITMI932154A1 true ITMI932154A1 (it) 1995-04-12
IT1271486B IT1271486B (it) 1997-05-28

Family

ID=11367010

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI932154A IT1271486B (it) 1993-10-12 1993-10-12 Oligopeptidi immunomodulatori derivati di frammenti della proteina c- reattiva

Country Status (19)

Country Link
US (1) US6057295A (it)
EP (1) EP0723552B1 (it)
JP (1) JP3221881B2 (it)
KR (1) KR100363408B1 (it)
CN (1) CN1041524C (it)
AT (1) ATE226591T1 (it)
AU (1) AU684511B2 (it)
CA (1) CA2173939C (it)
DE (1) DE69431603T2 (it)
DK (1) DK0723552T3 (it)
ES (1) ES2185652T3 (it)
FI (1) FI961584A (it)
HU (1) HUT75538A (it)
IL (1) IL109761A0 (it)
IT (1) IT1271486B (it)
NO (1) NO961423L (it)
PT (1) PT723552E (it)
WO (1) WO1995010531A1 (it)
ZA (1) ZA943610B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342481B1 (en) * 1993-10-12 2002-01-29 Italfarmaco S.P.A. Oligopeptides derived from C-reactive protein fragments
EP1408031A1 (en) * 2002-10-09 2004-04-14 3 D Gene Pharma Pyrolidine derivatives useful in treatment of hepatitis C virus infection
WO2010033240A2 (en) 2008-09-19 2010-03-25 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
EP2526119B1 (en) 2010-01-19 2018-05-30 President and Fellows of Harvard College Engineered opsonin for pathogen detection and treatment
AU2012284097B2 (en) 2011-07-18 2017-08-03 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
US10551379B2 (en) 2013-03-15 2020-02-04 President And Fellows Of Harvard College Methods and compositions for improving detection and/or capture of a target entity
EP3848044A1 (en) 2013-05-21 2021-07-14 President and Fellows of Harvard College Engineered heme-binding compositions and uses thereof
US10513546B2 (en) 2013-12-18 2019-12-24 President And Fellows Of Harvard College CRP capture/detection of gram positive bacteria
US10435457B2 (en) 2015-08-06 2019-10-08 President And Fellows Of Harvard College Microbe-binding molecules and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2945239A1 (de) * 1979-11-09 1981-05-21 Troponwerke GmbH & Co KG, 5000 Köln Oligopeptide, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US4353823A (en) * 1981-09-01 1982-10-12 Chipens Gunar I Synthetic analog of tuftisin
GB8525615D0 (en) * 1985-10-17 1985-11-20 Hoffmann La Roche Polypeptides
EP0253190B1 (en) * 1986-07-16 1992-12-30 ENIRICERCHE S.p.A. Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
IT1254883B (it) * 1992-04-16 1995-10-11 Italfarmaco Spa Tetrapeptidi parzialmente modificati e retroinvertiti, analoghi di frammenti della proteina c-reattiva.

Also Published As

Publication number Publication date
CN1133048A (zh) 1996-10-09
DE69431603D1 (de) 2002-11-28
FI961584A0 (fi) 1996-04-11
IT1271486B (it) 1997-05-28
ES2185652T3 (es) 2003-05-01
EP0723552B1 (en) 2002-10-23
DE69431603T2 (de) 2003-03-13
JP3221881B2 (ja) 2001-10-22
ZA943610B (en) 1995-01-25
JPH09503200A (ja) 1997-03-31
KR100363408B1 (ko) 2003-02-11
NO961423D0 (no) 1996-04-11
ATE226591T1 (de) 2002-11-15
PT723552E (pt) 2003-02-28
FI961584A (fi) 1996-04-11
IL109761A0 (en) 1994-08-26
CA2173939A1 (en) 1995-04-20
ITMI932154A0 (it) 1993-10-12
NO961423L (no) 1996-06-10
HUT75538A (en) 1997-05-28
CN1041524C (zh) 1999-01-06
CA2173939C (en) 2002-08-27
AU6844194A (en) 1995-05-04
AU684511B2 (en) 1997-12-18
HU9600934D0 (en) 1996-08-28
EP0723552A1 (en) 1996-07-31
DK0723552T3 (da) 2003-02-24
US6057295A (en) 2000-05-02
WO1995010531A1 (en) 1995-04-20

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971017