ITMI932153A1 - Peptidi retroinvertiti ad attivita' immunomodulatrice - Google Patents
Peptidi retroinvertiti ad attivita' immunomodulatriceInfo
- Publication number
- ITMI932153A1 ITMI932153A1 IT93MI002153A ITMI932153A ITMI932153A1 IT MI932153 A1 ITMI932153 A1 IT MI932153A1 IT 93MI002153 A IT93MI002153 A IT 93MI002153A IT MI932153 A ITMI932153 A IT MI932153A IT MI932153 A1 ITMI932153 A1 IT MI932153A1
- Authority
- IT
- Italy
- Prior art keywords
- peptides
- immunomodulatory activity
- formula
- terminal
- retroinverted
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000011861 anti-inflammatory therapy Methods 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Abstract
[1, 2]-retro-inverso-peptidi di formula (I) (FORMULA I) facoltativamente ammidato al C-terminale; A4 è Arg, Leu e Gln, facoltativamente ammidato al C-terminale, oppure è assente; essendo tali residui nella D o L sull'atomo di carbonio recente la catena laterale, oppure in forma di uno dei possibili diastereoisomeri o enantiomeri; e i loro sali con acidi o basi farmaceuticamente accettabili, sono utili come agenti immunoregolatori e nella terapia cardiovascolare ed antinfiammatoria, in particolare nello shock settico.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI932153A IT1271485B (it) | 1993-10-12 | 1993-10-12 | Peptidi retroinvertiti ad attivita' immunomodulatrice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI932153A IT1271485B (it) | 1993-10-12 | 1993-10-12 | Peptidi retroinvertiti ad attivita' immunomodulatrice |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI932153A0 ITMI932153A0 (it) | 1993-10-12 |
| ITMI932153A1 true ITMI932153A1 (it) | 1995-04-12 |
| IT1271485B IT1271485B (it) | 1997-05-28 |
Family
ID=11367009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI932153A IT1271485B (it) | 1993-10-12 | 1993-10-12 | Peptidi retroinvertiti ad attivita' immunomodulatrice |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1271485B (it) |
-
1993
- 1993-10-12 IT ITMI932153A patent/IT1271485B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IT1271485B (it) | 1997-05-28 |
| ITMI932153A0 (it) | 1993-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960926 |