PA8561201A1 - Farmacos biotransformables en d-prolinas - Google Patents
Farmacos biotransformables en d-prolinasInfo
- Publication number
- PA8561201A1 PA8561201A1 PA20028561201A PA8561201A PA8561201A1 PA 8561201 A1 PA8561201 A1 PA 8561201A1 PA 20028561201 A PA20028561201 A PA 20028561201A PA 8561201 A PA8561201 A PA 8561201A PA 8561201 A1 PA8561201 A1 PA 8561201A1
- Authority
- PA
- Panama
- Prior art keywords
- molecular weight
- low molecular
- compounds
- rent
- och
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE LAS FORMULAS I O IA EN LAS QUE R1 Y R2 SON INDEPENDIENTES ENTRE SI Y SIGNIFICAN ALCOXI DE BAJO PESO MOLECULAR, ALQUENILOXI DE BAJO PESO MOLECULAR, BENCILOXI, HIDROXI, -OCH(CH3)OC(O)-ALQUILO DE BAJO PESO MOLECULAR U -OCH2C(O)N (R3)(R4), CON LA CONDICION DE QUE SOLAMENTE UNO DE R1 Y R2 PUEDE SER HIDROXI; R3 Y R4 SON INDEPENDIENTES ENTRE SI Y SIGNIFICAN HIDROGENO, ALQUILO DE BAJO PESO MOLECULAR, ALQUENILO DE BAJO PESO MOLECULAR O CICLOALQUILO; O BIEN R1 Y R2 JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN EL GRUPO DE ENLACE X, EN CUYO CASO X ES -O(CH2)NCH=CH(CH2)NO- U -O(CH2)NO-; N ES EL NUMERO 1, 2 O 3; Y m ES UN NUMERO DE 4 A 8, ASI COMO LAS SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS COMPUESTOS. LOS COMPUESTOS DE LA PRESENTE INVENCION PUEDEN DESTINARSE AL TRATAMIENTO DE ENFERMEDADES EN LAS QUE LA DEPLECION DEL COMPONENTE P DE AMILOIDE DE SUERO TIENE UN EFECTO BENEFICIOSO, EN ESPECIAL AL TRATAMIENTO O PREVENCION DE TODAS LAS FORMAS DE AMILOIDOSIS CENTRAL O SISTEMICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01129793 | 2001-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8561201A1 true PA8561201A1 (es) | 2004-03-26 |
Family
ID=8179542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20028561201A PA8561201A1 (es) | 2001-12-14 | 2002-12-11 | Farmacos biotransformables en d-prolinas |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6903129B2 (es) |
| EP (2) | EP1458680A1 (es) |
| JP (1) | JP4192100B2 (es) |
| KR (1) | KR100678785B1 (es) |
| CN (1) | CN100368397C (es) |
| AR (1) | AR038010A1 (es) |
| AU (1) | AU2002361982B2 (es) |
| BR (1) | BR0214932A (es) |
| CA (1) | CA2470037C (es) |
| GT (1) | GT200200275A (es) |
| HK (1) | HK1076100A1 (es) |
| HR (1) | HRP20040494A2 (es) |
| HU (1) | HUP0402600A3 (es) |
| IL (2) | IL162158A0 (es) |
| MX (1) | MXPA04005693A (es) |
| MY (1) | MY129431A (es) |
| NO (1) | NO20042979L (es) |
| NZ (1) | NZ533188A (es) |
| PA (1) | PA8561201A1 (es) |
| PE (1) | PE20030764A1 (es) |
| PL (1) | PL370803A1 (es) |
| RU (1) | RU2305679C2 (es) |
| TW (1) | TWI225400B (es) |
| UY (1) | UY27584A1 (es) |
| WO (1) | WO2003051836A1 (es) |
| ZA (1) | ZA200404546B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0313386D0 (en) * | 2003-06-10 | 2003-07-16 | Univ London | Treatment of disease |
| UA108227C2 (xx) | 2010-03-03 | 2015-04-10 | Антигензв'язуючий білок | |
| RU2530601C2 (ru) * | 2012-10-05 | 2014-10-10 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Ингибитор образования цинк-зависимых димеров бета-амилоида |
| GB201407506D0 (en) | 2014-04-29 | 2014-06-11 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| US9737505B2 (en) | 2014-04-29 | 2017-08-22 | Glaxosmithkline Intellectual Property Development Limited | Prodrug of 1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline |
| GB201518950D0 (en) * | 2015-10-27 | 2015-12-09 | Glaxosmithkline Ip Dev Ltd | Compound |
| WO2017072090A1 (en) * | 2015-10-27 | 2017-05-04 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
| GB202111866D0 (en) | 2021-08-18 | 2021-09-29 | Ucl Business Plc | Prodrugs for use in the treatment of tissue damage |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW385308B (en) | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
| ATE224366T1 (de) * | 1997-10-31 | 2002-10-15 | Hoffmann La Roche | D-prolinderivate |
-
2002
- 2002-12-02 US US10/307,699 patent/US6903129B2/en not_active Expired - Lifetime
- 2002-12-06 HU HU0402600A patent/HUP0402600A3/hu unknown
- 2002-12-06 EP EP02796578A patent/EP1458680A1/en not_active Withdrawn
- 2002-12-06 CN CNB028249348A patent/CN100368397C/zh not_active Expired - Fee Related
- 2002-12-06 NZ NZ533188A patent/NZ533188A/en not_active IP Right Cessation
- 2002-12-06 AU AU2002361982A patent/AU2002361982B2/en not_active Ceased
- 2002-12-06 IL IL16215802A patent/IL162158A0/xx unknown
- 2002-12-06 KR KR1020047009036A patent/KR100678785B1/ko not_active IP Right Cessation
- 2002-12-06 WO PCT/EP2002/013827 patent/WO2003051836A1/en not_active Application Discontinuation
- 2002-12-06 PL PL02370803A patent/PL370803A1/xx not_active Application Discontinuation
- 2002-12-06 RU RU2004121783/04A patent/RU2305679C2/ru not_active IP Right Cessation
- 2002-12-06 MX MXPA04005693A patent/MXPA04005693A/es active IP Right Grant
- 2002-12-06 EP EP06020711A patent/EP1743884A1/en not_active Withdrawn
- 2002-12-06 BR BR0214932-0A patent/BR0214932A/pt not_active Application Discontinuation
- 2002-12-06 JP JP2003552723A patent/JP4192100B2/ja not_active Expired - Fee Related
- 2002-12-06 CA CA2470037A patent/CA2470037C/en not_active Expired - Fee Related
- 2002-12-10 PE PE2002001184A patent/PE20030764A1/es not_active Application Discontinuation
- 2002-12-11 PA PA20028561201A patent/PA8561201A1/es unknown
- 2002-12-11 TW TW091135829A patent/TWI225400B/zh not_active IP Right Cessation
- 2002-12-12 AR ARP020104818A patent/AR038010A1/es unknown
- 2002-12-13 MY MYPI20024679A patent/MY129431A/en unknown
- 2002-12-13 GT GT200200275A patent/GT200200275A/es unknown
- 2002-12-13 UY UY27584A patent/UY27584A1/es not_active Application Discontinuation
-
2004
- 2004-05-24 IL IL162158A patent/IL162158A/en not_active IP Right Cessation
- 2004-06-01 HR HR20040494A patent/HRP20040494A2/hr not_active Application Discontinuation
- 2004-06-08 ZA ZA200404546A patent/ZA200404546B/en unknown
- 2004-07-13 NO NO20042979A patent/NO20042979L/no not_active Application Discontinuation
-
2005
- 2005-09-16 HK HK05108123A patent/HK1076100A1/xx not_active IP Right Cessation
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