PA8557901A1 - Derivados de benzotiazol piridona sustituido - Google Patents

Derivados de benzotiazol piridona sustituido

Info

Publication number
PA8557901A1
PA8557901A1 PA20028557901A PA8557901A PA8557901A1 PA 8557901 A1 PA8557901 A1 PA 8557901A1 PA 20028557901 A PA20028557901 A PA 20028557901A PA 8557901 A PA8557901 A PA 8557901A PA 8557901 A1 PA8557901 A1 PA 8557901A1
Authority
PA
Panama
Prior art keywords
disease
lower rent
compounds
aquesia
antiepileptic
Prior art date
Application number
PA20028557901A
Other languages
English (en)
Inventor
Alexander Flohr
Roland Jakob-Roetne
Roger David Norcross
Claus Riemer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8557901A1 publication Critical patent/PA8557901A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL I EN DONDE R ES FENILO, PIRIDIN-2-ILO, -C(O) -O-ALQUILO INFERIOR, C(O) -ALQUILO INFERIOR, -C(O) -MORFOLINILO, -C(O) -NR'2, -(CH2)n-NR'2 O -(CH2)n-O-ALQUILO INFERIOR, Y R' PUEDE SER HIDROGENO O ALQUILO INFERIOR; Y A LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS DESCRITOS EN ESTA SOLICITUD TIENEN UNA BUENA AFINIDAD AL RECEPTOR A2A Y POR LO TANTO PUEDEN EMPLEARSE EN EL CONTROL O PREVENCION DE ENFERMEDADES BASADAS EN LA MODULACION DEL SISTEMA DE LA ADENOSINA, TALES COMO LA ENFERMEDAD DE ALZHEIMER, ENFERMEDAD DE PARKINSON, ENFERMEDAD DE HUNTINGTON, NEUROPROTECCION, ESQUIZOFRENIA, ANSIEDAD, DOLOR, DEFICITS RESPIRATORIOS, DEPRESION, ADICION A LAS DROGAS, TALES COMO LA ANFETAMINA, COCAINA, OPIODIES, ETANOL, NICOTINA, CANNABINOIDES, O CONTRA EL ASMA, RESPUESTAS ALERGICAS, HIPOXIA, ISQUEMIA, ATAQUES, Y ABUSO DE SUBSTANCIAS. ADEMAS LOS COMPUESTOS DE LA PRESENTE INVENCION PUEDEN SER DE UTILIDAD COMO SEDANTES, RELAJANTES MUSCULARES, ANTIPSICOTICOS, ANTIEPILEPTICOS, ANTIEPILEPTICOS, ANTICONVULASIVOS Y AGENTES CARDIOPROTECTORES PARA TRANSTORNOS TALES COMO LA ENFERMEDAD DE LA ARTERIA CORONARIA Y FALLO CARDIACO.
PA20028557901A 2001-11-19 2002-11-14 Derivados de benzotiazol piridona sustituido PA8557901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01127313 2001-11-19

Publications (1)

Publication Number Publication Date
PA8557901A1 true PA8557901A1 (es) 2003-06-30

Family

ID=8179264

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20028557901A PA8557901A1 (es) 2001-11-19 2002-11-14 Derivados de benzotiazol piridona sustituido

Country Status (21)

Country Link
US (1) US6599901B1 (es)
EP (1) EP1448196B1 (es)
JP (1) JP4216192B2 (es)
KR (1) KR100577109B1 (es)
CN (1) CN100346792C (es)
AR (1) AR037528A1 (es)
AT (1) ATE306265T1 (es)
AU (1) AU2002366194B8 (es)
BR (1) BR0214221A (es)
CA (1) CA2467551A1 (es)
DE (1) DE60206652T2 (es)
ES (1) ES2249639T3 (es)
GT (1) GT200200233A (es)
MX (1) MXPA04004683A (es)
PA (1) PA8557901A1 (es)
PE (1) PE20030715A1 (es)
PL (1) PL369470A1 (es)
RU (1) RU2295523C2 (es)
TW (1) TW200407137A (es)
UY (1) UY27543A1 (es)
WO (1) WO2003043634A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE521512C2 (sv) 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
US6727247B2 (en) * 2001-12-10 2004-04-27 Hoffman-La Roche Inc. Substituted benzothiazole amide derivatives
EP3473251B1 (en) 2002-12-20 2023-12-13 NicoNovum AB A nicotine-cellulose combination
CA2539314A1 (en) * 2003-09-19 2005-03-31 F. Hoffmann-La Roche Ag Thiazolopyridine derivatives as adenosine receptor ligands
JP4842829B2 (ja) 2003-10-31 2011-12-21 武田薬品工業株式会社 含窒素縮合複素環化合物
BRPI0513511A (pt) * 2004-07-22 2008-05-06 Hoffmann La Roche derivados de benzotiazol
RU2381227C2 (ru) 2004-07-22 2010-02-10 Ф. Хоффманн-Ля Рош Аг Замещенные бензотиазолы
ES2273599B1 (es) * 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
WO2007104573A2 (en) 2006-03-16 2007-09-20 Niconovum Ab Improved snuff composition
EP2073797A2 (en) * 2006-10-11 2009-07-01 Alpharma, Inc. Pharmaceutical compositions
RS52661B (en) * 2007-04-04 2013-06-28 Merck Sharp & Dohme Corp. THERAPEUTIC MEANS
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
RU2731179C2 (ru) 2015-12-22 2020-08-31 Зодженикс Интернэшнл Лимитед Фенфлураминовые композиции и способы их получения
EP3393470B1 (en) 2015-12-22 2021-01-20 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
JP2019526544A (ja) 2016-08-24 2019-09-19 ゾゲニクス インターナショナル リミテッド ５−ｈｔ２ｂアゴニストの形成を阻害するための製剤およびその使用方法
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
US11571397B2 (en) 2018-05-11 2023-02-07 Zogenix International Limited Compositions and methods for treating seizure-induced sudden death
WO2019241005A1 (en) 2018-06-14 2019-12-19 Zogenix International Limited Compositions and methods for treating respiratory depression with fenfluramine
DE102019110904B4 (de) 2019-04-26 2022-01-20 Helmholtz-Zentrum Dresden - Rossendorf E. V. N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3374550D1 (en) 1982-12-21 1987-12-23 Johnsen Jorgensen Plastics Ltd Dispensing container
IL153278A0 (en) * 2000-06-21 2003-07-06 Hoffmann La Roche Benzothiazole derivatives

Also Published As

Publication number Publication date
AR037528A1 (es) 2004-11-17
RU2004118423A (ru) 2006-01-10
PL369470A1 (en) 2005-04-18
CN1589146A (zh) 2005-03-02
US6599901B1 (en) 2003-07-29
GT200200233A (es) 2003-06-17
BR0214221A (pt) 2004-09-21
DE60206652D1 (de) 2006-02-23
TW200407137A (en) 2004-05-16
UY27543A1 (es) 2003-05-30
ES2249639T3 (es) 2006-04-01
EP1448196B1 (en) 2005-10-12
RU2295523C2 (ru) 2007-03-20
JP2005515980A (ja) 2005-06-02
AU2002366194B2 (en) 2006-10-26
KR20050044537A (ko) 2005-05-12
AU2002366194B8 (en) 2006-11-16
MXPA04004683A (es) 2004-08-12
WO2003043634A1 (en) 2003-05-30
DE60206652T2 (de) 2006-06-22
JP4216192B2 (ja) 2009-01-28
CA2467551A1 (en) 2003-05-30
EP1448196A1 (en) 2004-08-25
PE20030715A1 (es) 2003-08-29
CN100346792C (zh) 2007-11-07
ATE306265T1 (de) 2005-10-15
KR100577109B1 (ko) 2006-05-10
AU2002366194A1 (en) 2003-06-10

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