PA8557901A1 - Derivados de benzotiazol piridona sustituido - Google Patents
Derivados de benzotiazol piridona sustituidoInfo
- Publication number
- PA8557901A1 PA8557901A1 PA20028557901A PA8557901A PA8557901A1 PA 8557901 A1 PA8557901 A1 PA 8557901A1 PA 20028557901 A PA20028557901 A PA 20028557901A PA 8557901 A PA8557901 A PA 8557901A PA 8557901 A1 PA8557901 A1 PA 8557901A1
- Authority
- PA
- Panama
- Prior art keywords
- disease
- lower rent
- compounds
- aquesia
- antiepileptic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL I EN DONDE R ES FENILO, PIRIDIN-2-ILO, -C(O) -O-ALQUILO INFERIOR, C(O) -ALQUILO INFERIOR, -C(O) -MORFOLINILO, -C(O) -NR'2, -(CH2)n-NR'2 O -(CH2)n-O-ALQUILO INFERIOR, Y R' PUEDE SER HIDROGENO O ALQUILO INFERIOR; Y A LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS DESCRITOS EN ESTA SOLICITUD TIENEN UNA BUENA AFINIDAD AL RECEPTOR A2A Y POR LO TANTO PUEDEN EMPLEARSE EN EL CONTROL O PREVENCION DE ENFERMEDADES BASADAS EN LA MODULACION DEL SISTEMA DE LA ADENOSINA, TALES COMO LA ENFERMEDAD DE ALZHEIMER, ENFERMEDAD DE PARKINSON, ENFERMEDAD DE HUNTINGTON, NEUROPROTECCION, ESQUIZOFRENIA, ANSIEDAD, DOLOR, DEFICITS RESPIRATORIOS, DEPRESION, ADICION A LAS DROGAS, TALES COMO LA ANFETAMINA, COCAINA, OPIODIES, ETANOL, NICOTINA, CANNABINOIDES, O CONTRA EL ASMA, RESPUESTAS ALERGICAS, HIPOXIA, ISQUEMIA, ATAQUES, Y ABUSO DE SUBSTANCIAS. ADEMAS LOS COMPUESTOS DE LA PRESENTE INVENCION PUEDEN SER DE UTILIDAD COMO SEDANTES, RELAJANTES MUSCULARES, ANTIPSICOTICOS, ANTIEPILEPTICOS, ANTIEPILEPTICOS, ANTICONVULASIVOS Y AGENTES CARDIOPROTECTORES PARA TRANSTORNOS TALES COMO LA ENFERMEDAD DE LA ARTERIA CORONARIA Y FALLO CARDIACO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01127313 | 2001-11-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8557901A1 true PA8557901A1 (es) | 2003-06-30 |
Family
ID=8179264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20028557901A PA8557901A1 (es) | 2001-11-19 | 2002-11-14 | Derivados de benzotiazol piridona sustituido |
Country Status (21)
Country | Link |
---|---|
US (1) | US6599901B1 (es) |
EP (1) | EP1448196B1 (es) |
JP (1) | JP4216192B2 (es) |
KR (1) | KR100577109B1 (es) |
CN (1) | CN100346792C (es) |
AR (1) | AR037528A1 (es) |
AT (1) | ATE306265T1 (es) |
AU (1) | AU2002366194B8 (es) |
BR (1) | BR0214221A (es) |
CA (1) | CA2467551A1 (es) |
DE (1) | DE60206652T2 (es) |
ES (1) | ES2249639T3 (es) |
GT (1) | GT200200233A (es) |
MX (1) | MXPA04004683A (es) |
PA (1) | PA8557901A1 (es) |
PE (1) | PE20030715A1 (es) |
PL (1) | PL369470A1 (es) |
RU (1) | RU2295523C2 (es) |
TW (1) | TW200407137A (es) |
UY (1) | UY27543A1 (es) |
WO (1) | WO2003043634A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
US6727247B2 (en) * | 2001-12-10 | 2004-04-27 | Hoffman-La Roche Inc. | Substituted benzothiazole amide derivatives |
NO346973B1 (en) | 2002-12-20 | 2023-03-20 | Niconovum Ab | A physically and chemically stable nicotine-containing particulate material |
WO2005028484A1 (en) * | 2003-09-19 | 2005-03-31 | F. Hoffmann-La Roche Ag | Thiazolopyridine derivatives as adenosine receptor ligands |
EP1677791A4 (en) | 2003-10-31 | 2007-08-15 | Takeda Pharmaceutical | NITROGENIC CONDENSED HETEROCYCLIC COMPOUNDS |
MX2007000638A (es) * | 2004-07-22 | 2007-03-07 | Hoffmann La Roche | Derivados de benzotiazol. |
JP2008506735A (ja) * | 2004-07-22 | 2008-03-06 | エフ.ホフマン−ラ ロシュ アーゲー | 置換されているベンゾチアゾール類 |
ES2273599B1 (es) * | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
EP1998748B1 (en) | 2006-03-16 | 2015-01-14 | NicoNovum AB | Improved snuff composition |
US20080233156A1 (en) * | 2006-10-11 | 2008-09-25 | Alpharma, Inc. | Pharmaceutical compositions |
PT2144905E (pt) * | 2007-04-04 | 2013-02-26 | Merck Sharp & Dohme | Agentes terapêuticos |
US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
CA3007673A1 (en) | 2015-12-22 | 2017-06-29 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
CN108883399B (zh) | 2015-12-22 | 2021-06-22 | 周格尼克斯国际有限公司 | 芬氟拉明组合物及其制备方法 |
WO2018037306A1 (en) | 2016-08-24 | 2018-03-01 | Zogenix International Limited | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same |
US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
CA3097335A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
US10517841B1 (en) * | 2018-06-14 | 2019-12-31 | Zogenix International Limited | Compositions and methods for treating respiratory depression with fenfluramine |
DE102019110904B4 (de) | 2019-04-26 | 2022-01-20 | Helmholtz-Zentrum Dresden - Rossendorf E. V. | N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung |
US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3374550D1 (en) | 1982-12-21 | 1987-12-23 | Johnsen Jorgensen Plastics Ltd | Dispensing container |
PL207384B1 (pl) * | 2000-06-21 | 2010-12-31 | Hoffmann La Roche | Pochodne benzotiazolu, sposób ich wytwarzania, lek i ich zastosowanie do wytwarzania leku |
-
2002
- 2002-11-05 US US10/288,531 patent/US6599901B1/en not_active Expired - Fee Related
- 2002-11-09 PL PL02369470A patent/PL369470A1/xx not_active Application Discontinuation
- 2002-11-09 RU RU2004118423/04A patent/RU2295523C2/ru not_active IP Right Cessation
- 2002-11-09 MX MXPA04004683A patent/MXPA04004683A/es active IP Right Grant
- 2002-11-09 AU AU2002366194A patent/AU2002366194B8/en not_active Ceased
- 2002-11-09 CN CNB028228901A patent/CN100346792C/zh not_active Expired - Fee Related
- 2002-11-09 WO PCT/EP2002/012543 patent/WO2003043634A1/en active IP Right Grant
- 2002-11-09 ES ES02803360T patent/ES2249639T3/es not_active Expired - Lifetime
- 2002-11-09 AT AT02803360T patent/ATE306265T1/de not_active IP Right Cessation
- 2002-11-09 KR KR1020047007646A patent/KR100577109B1/ko not_active IP Right Cessation
- 2002-11-09 JP JP2003545315A patent/JP4216192B2/ja not_active Expired - Fee Related
- 2002-11-09 DE DE60206652T patent/DE60206652T2/de not_active Expired - Fee Related
- 2002-11-09 CA CA002467551A patent/CA2467551A1/en not_active Abandoned
- 2002-11-09 BR BR0214221-0A patent/BR0214221A/pt not_active IP Right Cessation
- 2002-11-09 EP EP02803360A patent/EP1448196B1/en not_active Expired - Lifetime
- 2002-11-14 PA PA20028557901A patent/PA8557901A1/es unknown
- 2002-11-14 TW TW091133382A patent/TW200407137A/zh unknown
- 2002-11-15 PE PE2002001103A patent/PE20030715A1/es not_active Application Discontinuation
- 2002-11-15 AR ARP020104398A patent/AR037528A1/es not_active Application Discontinuation
- 2002-11-18 GT GT200200233A patent/GT200200233A/es unknown
- 2002-11-18 UY UY27543A patent/UY27543A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE60206652T2 (de) | 2006-06-22 |
KR20050044537A (ko) | 2005-05-12 |
CN1589146A (zh) | 2005-03-02 |
AU2002366194A1 (en) | 2003-06-10 |
UY27543A1 (es) | 2003-05-30 |
GT200200233A (es) | 2003-06-17 |
TW200407137A (en) | 2004-05-16 |
BR0214221A (pt) | 2004-09-21 |
ATE306265T1 (de) | 2005-10-15 |
EP1448196A1 (en) | 2004-08-25 |
MXPA04004683A (es) | 2004-08-12 |
WO2003043634A1 (en) | 2003-05-30 |
DE60206652D1 (de) | 2006-02-23 |
PL369470A1 (en) | 2005-04-18 |
RU2295523C2 (ru) | 2007-03-20 |
AR037528A1 (es) | 2004-11-17 |
CN100346792C (zh) | 2007-11-07 |
KR100577109B1 (ko) | 2006-05-10 |
CA2467551A1 (en) | 2003-05-30 |
RU2004118423A (ru) | 2006-01-10 |
AU2002366194B8 (en) | 2006-11-16 |
US6599901B1 (en) | 2003-07-29 |
JP4216192B2 (ja) | 2009-01-28 |
EP1448196B1 (en) | 2005-10-12 |
ES2249639T3 (es) | 2006-04-01 |
JP2005515980A (ja) | 2005-06-02 |
AU2002366194B2 (en) | 2006-10-26 |
PE20030715A1 (es) | 2003-08-29 |
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