OA12867A - Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. pepticulcers. - Google Patents

Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. pepticulcers. Download PDF

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Publication number
OA12867A
OA12867A OA1200400327A OA1200400327A OA12867A OA 12867 A OA12867 A OA 12867A OA 1200400327 A OA1200400327 A OA 1200400327A OA 1200400327 A OA1200400327 A OA 1200400327A OA 12867 A OA12867 A OA 12867A
Authority
OA
OAPI
Prior art keywords
group
methyl
substituents
ethyl
added
Prior art date
Application number
OA1200400327A
Other languages
English (en)
Inventor
Hiroshi Banno
Fumihiko Sato
Keiji Kamiyama
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of OA12867A publication Critical patent/OA12867A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA1200400327A 2002-06-14 2003-06-13 Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. pepticulcers. OA12867A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002175086 2002-06-14
JP2003041085 2003-02-19

Publications (1)

Publication Number Publication Date
OA12867A true OA12867A (en) 2006-09-15

Family

ID=29738411

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200400327A OA12867A (en) 2002-06-14 2003-06-13 Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. pepticulcers.

Country Status (19)

Country Link
US (2) US7410981B2 (de)
EP (2) EP1513527B1 (de)
JP (1) JPWO2003106429A1 (de)
KR (1) KR20050009751A (de)
CN (1) CN1678315A (de)
AR (1) AR040221A1 (de)
AT (1) ATE437642T1 (de)
AU (2) AU2003242390A1 (de)
BR (1) BR0311801A (de)
CA (2) CA2489470A1 (de)
DE (1) DE60328603D1 (de)
IL (1) IL165562A0 (de)
MX (1) MXPA04012396A (de)
NO (1) NO20050141L (de)
OA (1) OA12867A (de)
PE (1) PE20040563A1 (de)
PL (1) PL373085A1 (de)
TW (1) TW200307544A (de)
WO (2) WO2003106429A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004022337D1 (de) 2004-04-28 2009-09-10 Hetero Drugs Ltd Verfahren zur herstellung von pyridinylmethyl-1h-benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere
WO2006090845A1 (ja) 2005-02-25 2006-08-31 Takeda Pharmaceutical Company Limited 顆粒の製造方法
KR101148399B1 (ko) * 2005-06-22 2012-05-23 일양약품주식회사 항궤양제 및 점막보호제를 함유하는 경구용 위장질환치료용 약제 조성물
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
MX2009004475A (es) 2006-10-27 2009-08-12 Univ Missouri Composiciones que comprenden agentes acido labiles que inhiben la bomba de protones, por lo menos otro agente farmaceuticamente activo y metodos de uso de las misma.
US8247440B2 (en) 2008-02-20 2012-08-21 Curators Of The University Of Missouri Composition comprising omeprazole, lansoprazole and at least one buffering agent
WO2011056652A1 (en) 2009-10-28 2011-05-12 Newlink Genetics Imidazole derivatives as ido inhibitors
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
WO2016172436A1 (en) * 2015-04-23 2016-10-27 Temple University-Of The Commonwealth System Of Higher Education Polycationic amphiphiles and polymers thereof as antimicrobial agents and methods using same
EP3757107B1 (de) * 2016-06-21 2023-10-25 The Trustees of Columbia University in the City of New York 4-oxo-3,4-dihydrothieno[3,4-d]pyridazin-verbindungen als aldosereduktaseinhibitoren und verfahren zur verwendung davon
WO2018081347A1 (en) 2016-10-26 2018-05-03 Temple University-Of The Commonwealth System Of Higher Education Polycationic amphiphiles as antimicrobial agents and methods using same
ES2983586T3 (es) 2017-07-28 2024-10-23 Applied Therapeutics Inc Composiciones y procedimientos para el tratamiento de la galactosemia
CN113840825A (zh) 2019-04-01 2021-12-24 应用治疗公司 醛糖还原酶抑制剂
JP2022531466A (ja) 2019-05-07 2022-07-06 ユニバーシティ オブ マイアミ 遺伝性ニューロパチーおよび関連障害の処置および検出
PT4148050T (pt) * 2020-06-17 2025-01-29 Ildong Pharmaceutical Co Ltd Novo inibidor da secreção ácida e sua utilização
IT202200001022A1 (it) * 2022-01-21 2023-07-21 Exo Lab Italia Composti farmaceutici ibridi ottenuti mediante coniugazione di un inibitore delle pompe protoniche e un inibitore delle anidrasi carboniche
CN120590773B (zh) * 2025-08-06 2025-12-26 广州仕天材料科技有限公司 一种增强型聚碳酸酯和制备方法及在汽车照明系统中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
KR890000387B1 (ko) * 1984-09-24 1989-03-16 디 엎존 캄파니 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
KR20020004995A (ko) * 1999-04-09 2002-01-16 스타르크, 카르크 트롬빈 억제제의 프로드럭
US6765019B1 (en) * 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
DE60144123D1 (de) * 2000-07-07 2011-04-07 Spectrum Pharmaceuticals Inc Verfahren zur Behandlung von Arzneimittelinduzierter peripherer Neuropathie und verwandten Krankheitsformen
AU2001294228A1 (en) 2000-10-12 2002-04-22 Takeda Chemical Industries Ltd. Benzimidazole compounds, process for producing the same and use thereof
KR20030033007A (ko) * 2001-05-31 2003-04-26 코울터 파머수티컬, 인코포레이티드 세포독소, 약물전구체, 링커 및 이에 유용한 안정화제
EP1437352A4 (de) 2001-09-25 2004-12-08 Takeda Chemical Industries Ltd Benzimidazolverbindung, verfahren zu deren herstellung und deren verwendung

Also Published As

Publication number Publication date
WO2003105845A1 (en) 2003-12-24
EP1513527A1 (de) 2005-03-16
TW200307544A (en) 2003-12-16
IL165562A0 (en) 2006-01-15
AU2003242388A1 (en) 2003-12-31
EP1514870A1 (de) 2005-03-16
US7410981B2 (en) 2008-08-12
AR040221A1 (es) 2005-03-16
AU2003242390A1 (en) 2003-12-31
DE60328603D1 (de) 2009-09-10
CA2489470A1 (en) 2003-12-24
NO20050141L (no) 2005-01-27
NO20050141D0 (no) 2005-01-11
PL373085A1 (en) 2005-08-08
WO2003106429A1 (ja) 2003-12-24
EP1514870A4 (de) 2006-08-23
CN1678315A (zh) 2005-10-05
JPWO2003106429A1 (ja) 2005-10-13
US20050222210A1 (en) 2005-10-06
CA2489361A1 (en) 2003-12-24
BR0311801A (pt) 2005-04-12
EP1513527B1 (de) 2009-07-29
MXPA04012396A (es) 2005-06-17
US20060293371A1 (en) 2006-12-28
ATE437642T1 (de) 2009-08-15
KR20050009751A (ko) 2005-01-25
PE20040563A1 (es) 2004-10-21

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