IL165562A0 - Prodrugs of imidazole derivatives for use as proton pump inhibitors in the treatment of e.g. peptic ulcers - Google Patents
Prodrugs of imidazole derivatives for use as proton pump inhibitors in the treatment of e.g. peptic ulcersInfo
- Publication number
- IL165562A0 IL165562A0 IL16556204A IL16556204A IL165562A0 IL 165562 A0 IL165562 A0 IL 165562A0 IL 16556204 A IL16556204 A IL 16556204A IL 16556204 A IL16556204 A IL 16556204A IL 165562 A0 IL165562 A0 IL 165562A0
- Authority
- IL
- Israel
- Prior art keywords
- prodrugs
- treatment
- proton pump
- imidazole derivatives
- pump inhibitors
- Prior art date
Links
- 208000008469 Peptic Ulcer Diseases 0.000 title 1
- 150000002460 imidazoles Chemical class 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 229940126409 proton pump inhibitor Drugs 0.000 title 1
- 239000000612 proton pump inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002175086 | 2002-06-14 | ||
| JP2003041085 | 2003-02-19 | ||
| PCT/JP2003/007546 WO2003105845A1 (en) | 2002-06-14 | 2003-06-13 | Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. peptic ulcers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL165562A0 true IL165562A0 (en) | 2006-01-15 |
Family
ID=29738411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16556204A IL165562A0 (en) | 2002-06-14 | 2004-12-05 | Prodrugs of imidazole derivatives for use as proton pump inhibitors in the treatment of e.g. peptic ulcers |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20060293371A1 (de) |
| EP (2) | EP1514870A4 (de) |
| JP (1) | JPWO2003106429A1 (de) |
| KR (1) | KR20050009751A (de) |
| CN (1) | CN1678315A (de) |
| AR (1) | AR040221A1 (de) |
| AT (1) | ATE437642T1 (de) |
| AU (2) | AU2003242390A1 (de) |
| BR (1) | BR0311801A (de) |
| CA (2) | CA2489361A1 (de) |
| DE (1) | DE60328603D1 (de) |
| IL (1) | IL165562A0 (de) |
| MX (1) | MXPA04012396A (de) |
| NO (1) | NO20050141L (de) |
| OA (1) | OA12867A (de) |
| PE (1) | PE20040563A1 (de) |
| PL (1) | PL373085A1 (de) |
| TW (1) | TW200307544A (de) |
| WO (2) | WO2003106429A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1740571E (pt) | 2004-04-28 | 2009-09-02 | Hetero Drugs Ltd | Processo para preparar compostos de piridinilmetil-1hbenzimidazol na forma enantiomericamente enriquecida ou como enantiómeros únicos |
| EP1852100B1 (de) | 2005-02-25 | 2018-05-09 | Takeda Pharmaceutical Company Limited | Verfahren zur herstellung eines beschichteten granulats von benzimidazole |
| KR101148399B1 (ko) * | 2005-06-22 | 2012-05-23 | 일양약품주식회사 | 항궤양제 및 점막보호제를 함유하는 경구용 위장질환치료용 약제 조성물 |
| US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
| WO2008057802A2 (en) | 2006-10-27 | 2008-05-15 | The Curators Of The University Of Missouri | Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same |
| CA2716367C (en) | 2008-02-20 | 2015-05-26 | The Curators Of The University Of Missouri | Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same |
| WO2011056652A1 (en) | 2009-10-28 | 2011-05-12 | Newlink Genetics | Imidazole derivatives as ido inhibitors |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| WO2016172436A1 (en) * | 2015-04-23 | 2016-10-27 | Temple University-Of The Commonwealth System Of Higher Education | Polycationic amphiphiles and polymers thereof as antimicrobial agents and methods using same |
| EP3352754B1 (de) * | 2016-06-21 | 2020-09-02 | The Trustees of Columbia University in the City of New York | Aldosereduktaseinhibitoren und verfahren zur verwendung davon |
| WO2018081347A1 (en) | 2016-10-26 | 2018-05-03 | Temple University-Of The Commonwealth System Of Higher Education | Polycationic amphiphiles as antimicrobial agents and methods using same |
| IL272246B2 (en) | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
| KR20220003529A (ko) | 2019-04-01 | 2022-01-10 | 어플라이드 테라퓨틱스 인크. | 알도스 리덕타제의 억제제 |
| MX2021013511A (es) | 2019-05-07 | 2022-02-23 | Univ Miami | Tratamiento y deteccion de neuropatias heredadas y trastornos asociados. |
| AU2021293694B2 (en) * | 2020-06-17 | 2023-12-21 | Ildong Pharmaceutical Co., Ltd. | Novel Acid Secretion Inhibitor and use thereof |
| IT202200001022A1 (it) * | 2022-01-21 | 2023-07-21 | Exo Lab Italia | Composti farmaceutici ibridi ottenuti mediante coniugazione di un inibitore delle pompe protoniche e un inibitore delle anidrasi carboniche |
| CN120590773B (zh) * | 2025-08-06 | 2025-12-26 | 广州仕天材料科技有限公司 | 一种增强型聚碳酸酯和制备方法及在汽车照明系统中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
| KR890000387B1 (ko) * | 1984-09-24 | 1989-03-16 | 디 엎존 캄파니 | 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법 |
| IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| HUP0202431A3 (en) * | 1999-04-09 | 2003-03-28 | Basf Ag | Prodrugs of thrombin inhibitors |
| US6765019B1 (en) * | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| EP1790344B1 (de) * | 2000-07-07 | 2011-02-23 | Spectrum Pharmaceuticals, Inc. | Verfahren zur Behandlung von Arzneimittelinduzierter peripherer Neuropathie und verwandten Krankheitsformen |
| WO2002030920A1 (en) | 2000-10-12 | 2002-04-18 | Takeda Chemical Industries, Ltd. | Benzimidazole compounds, process for producing the same and use thereof |
| US7129261B2 (en) * | 2001-05-31 | 2006-10-31 | Medarex, Inc. | Cytotoxic agents |
| US20040248941A1 (en) | 2001-09-25 | 2004-12-09 | Keiji Kamiyama | Benzimidazone compound, process for producing the same, and use thereof |
-
2003
- 2003-06-13 WO PCT/JP2003/007545 patent/WO2003106429A1/ja not_active Ceased
- 2003-06-13 AT AT03733426T patent/ATE437642T1/de not_active IP Right Cessation
- 2003-06-13 CA CA002489361A patent/CA2489361A1/en not_active Abandoned
- 2003-06-13 EP EP03733425A patent/EP1514870A4/de not_active Withdrawn
- 2003-06-13 PE PE2003000593A patent/PE20040563A1/es not_active Application Discontinuation
- 2003-06-13 PL PL03373085A patent/PL373085A1/xx not_active Application Discontinuation
- 2003-06-13 US US10/517,847 patent/US20060293371A1/en not_active Abandoned
- 2003-06-13 AU AU2003242390A patent/AU2003242390A1/en not_active Abandoned
- 2003-06-13 US US10/517,633 patent/US7410981B2/en not_active Expired - Fee Related
- 2003-06-13 MX MXPA04012396A patent/MXPA04012396A/es not_active Application Discontinuation
- 2003-06-13 WO PCT/JP2003/007546 patent/WO2003105845A1/en not_active Ceased
- 2003-06-13 DE DE60328603T patent/DE60328603D1/de not_active Expired - Lifetime
- 2003-06-13 CA CA002489470A patent/CA2489470A1/en not_active Abandoned
- 2003-06-13 EP EP03733426A patent/EP1513527B1/de not_active Expired - Lifetime
- 2003-06-13 AR ARP030102114A patent/AR040221A1/es not_active Application Discontinuation
- 2003-06-13 BR BR0311801-0A patent/BR0311801A/pt not_active IP Right Cessation
- 2003-06-13 AU AU2003242388A patent/AU2003242388A1/en not_active Abandoned
- 2003-06-13 KR KR10-2004-7020371A patent/KR20050009751A/ko not_active Withdrawn
- 2003-06-13 TW TW092116056A patent/TW200307544A/zh unknown
- 2003-06-13 OA OA1200400327A patent/OA12867A/en unknown
- 2003-06-13 JP JP2004513262A patent/JPWO2003106429A1/ja active Pending
- 2003-06-13 CN CNA038188953A patent/CN1678315A/zh active Pending
-
2004
- 2004-12-05 IL IL16556204A patent/IL165562A0/xx unknown
-
2005
- 2005-01-11 NO NO20050141A patent/NO20050141L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200307544A (en) | 2003-12-16 |
| AU2003242388A1 (en) | 2003-12-31 |
| WO2003106429A1 (ja) | 2003-12-24 |
| OA12867A (en) | 2006-09-15 |
| JPWO2003106429A1 (ja) | 2005-10-13 |
| PE20040563A1 (es) | 2004-10-21 |
| EP1514870A1 (de) | 2005-03-16 |
| CA2489470A1 (en) | 2003-12-24 |
| WO2003105845A1 (en) | 2003-12-24 |
| EP1514870A4 (de) | 2006-08-23 |
| MXPA04012396A (es) | 2005-06-17 |
| US20050222210A1 (en) | 2005-10-06 |
| US20060293371A1 (en) | 2006-12-28 |
| EP1513527B1 (de) | 2009-07-29 |
| ATE437642T1 (de) | 2009-08-15 |
| NO20050141L (no) | 2005-01-27 |
| NO20050141D0 (no) | 2005-01-11 |
| AR040221A1 (es) | 2005-03-16 |
| EP1513527A1 (de) | 2005-03-16 |
| DE60328603D1 (de) | 2009-09-10 |
| PL373085A1 (en) | 2005-08-08 |
| CA2489361A1 (en) | 2003-12-24 |
| AU2003242390A1 (en) | 2003-12-31 |
| BR0311801A (pt) | 2005-04-12 |
| US7410981B2 (en) | 2008-08-12 |
| CN1678315A (zh) | 2005-10-05 |
| KR20050009751A (ko) | 2005-01-25 |
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