OA12252A - Antihypertensive agents and use. - Google Patents
Antihypertensive agents and use. Download PDFInfo
- Publication number
- OA12252A OA12252A OA1200200325A OA1200200325A OA12252A OA 12252 A OA12252 A OA 12252A OA 1200200325 A OA1200200325 A OA 1200200325A OA 1200200325 A OA1200200325 A OA 1200200325A OA 12252 A OA12252 A OA 12252A
- Authority
- OA
- OAPI
- Prior art keywords
- antihypertensive
- sait
- pharmaceutically acceptable
- pharmaceutical composition
- quinapril
- Prior art date
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- 239000002220 antihypertensive agent Substances 0.000 title claims abstract description 63
- 229940030600 antihypertensive agent Drugs 0.000 title claims abstract description 62
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 25
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- 150000003839 salts Chemical class 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 11
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- 239000011591 potassium Substances 0.000 description 1
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- BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229960003401 ramipril Drugs 0.000 description 1
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 1
- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000029865 regulation of blood pressure Effects 0.000 description 1
- 229950001780 sampatrilat Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 229960002909 spirapril Drugs 0.000 description 1
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- HRWCVUIFMSZDJS-SZMVWBNQSA-N spirapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)CC1=CC=CC=C1 HRWCVUIFMSZDJS-SZMVWBNQSA-N 0.000 description 1
- 229950006297 spiraprilat Drugs 0.000 description 1
- 108700006892 spiraprilat Proteins 0.000 description 1
- FMMDBLMCSDRUPA-BPUTZDHNSA-N spiraprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)C(O)=O)CC1=CC=CC=C1 FMMDBLMCSDRUPA-BPUTZDHNSA-N 0.000 description 1
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
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- 239000005720 sucrose Substances 0.000 description 1
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- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 229960004084 temocapril Drugs 0.000 description 1
- FIQOFIRCTOWDOW-BJLQDIEVSA-N temocapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C[C@H](SC1)C=1SC=CC=1)=O)CC1=CC=CC=C1 FIQOFIRCTOWDOW-BJLQDIEVSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- JQSHEDRVRBSFCZ-YWZLYKJASA-N tinofedrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC=CC=1)CC=C(C1=CSC=C1)C=1C=CSC=1 JQSHEDRVRBSFCZ-YWZLYKJASA-N 0.000 description 1
- 229950006638 tinofedrine Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- JIVZKJJQOZQXQB-UHFFFAOYSA-N tolazoline Chemical compound C=1C=CC=CC=1CC1=NCCN1 JIVZKJJQOZQXQB-UHFFFAOYSA-N 0.000 description 1
- 229960002312 tolazoline Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 235000021076 total caloric intake Nutrition 0.000 description 1
- 229960002051 trandolapril Drugs 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 229960002906 trimazosin Drugs 0.000 description 1
- YNZXWQJZEDLQEG-UHFFFAOYSA-N trimazosin Chemical compound N1=C2C(OC)=C(OC)C(OC)=CC2=C(N)N=C1N1CCN(C(=O)OCC(C)(C)O)CC1 YNZXWQJZEDLQEG-UHFFFAOYSA-N 0.000 description 1
- 235000021081 unsaturated fats Nutrition 0.000 description 1
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
- 229960004699 valsartan Drugs 0.000 description 1
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- 229960002769 zofenopril Drugs 0.000 description 1
- IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 description 1
- UQWLOWFDKAFKAP-WXHSDQCUSA-N zofenoprilat Chemical compound C1[C@@H](C(O)=O)N(C(=O)[C@@H](CS)C)C[C@H]1SC1=CC=CC=C1 UQWLOWFDKAFKAP-WXHSDQCUSA-N 0.000 description 1
- 229950001300 zofenoprilat Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19985500P | 2000-04-26 | 2000-04-26 | |
| US24228000P | 2000-10-20 | 2000-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA12252A true OA12252A (en) | 2006-05-11 |
Family
ID=26895229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200200325A OA12252A (en) | 2000-04-26 | 2001-03-22 | Antihypertensive agents and use. |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1280522B1 (cs) |
| JP (1) | JP2003531170A (cs) |
| KR (1) | KR20020091245A (cs) |
| CN (1) | CN1426299A (cs) |
| AP (1) | AP2002002665A0 (cs) |
| AR (1) | AR031104A1 (cs) |
| AT (1) | ATE283691T1 (cs) |
| AU (1) | AU2001247658A1 (cs) |
| BG (1) | BG107264A (cs) |
| BR (1) | BR0110234A (cs) |
| CA (1) | CA2405559A1 (cs) |
| CZ (1) | CZ20023459A3 (cs) |
| DE (1) | DE60107559T2 (cs) |
| DO (1) | DOP2001000150A (cs) |
| EA (1) | EA005245B1 (cs) |
| EE (1) | EE200200611A (cs) |
| ES (1) | ES2231470T3 (cs) |
| HR (1) | HRP20020936A2 (cs) |
| HU (1) | HUP0300403A3 (cs) |
| IL (1) | IL152474A0 (cs) |
| IS (1) | IS6570A (cs) |
| MA (1) | MA26894A1 (cs) |
| MX (1) | MXPA02009662A (cs) |
| NO (1) | NO20025135L (cs) |
| NZ (1) | NZ521713A (cs) |
| OA (1) | OA12252A (cs) |
| PA (1) | PA8516001A1 (cs) |
| PE (1) | PE20011308A1 (cs) |
| PL (1) | PL357906A1 (cs) |
| PT (1) | PT1280522E (cs) |
| SK (1) | SK15132002A3 (cs) |
| SV (1) | SV2002000367A (cs) |
| TN (1) | TNSN01061A1 (cs) |
| WO (1) | WO2001080847A2 (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1481962A1 (en) * | 1997-12-12 | 2004-12-01 | Warner-Lambert Company LLC | New cholesterolemia-lowering carboxyalkylether compound |
| BRPI0812597A2 (pt) * | 2007-06-21 | 2015-02-18 | Actimis Pharmaceuticals Inc | Sal, composição farmacêutica, métodos para o tratamento, prevenção ou melhora de um ou mais sintomas de uma doença mediada por crth2, de uma doença relacionada com eosinófilo, de uma doença relacionada com basófilo, e de uma doença inflamatória, e, processo para a preparação do sal |
| DE102008026033B4 (de) * | 2008-05-30 | 2017-08-24 | Voith Patent Gmbh | Antriebsstrang mit einer hydrodynamischen Maschine |
| SI23149A (sl) * | 2009-09-21 | 2011-03-31 | Silverstone Pharma | Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5298497A (en) * | 1990-05-15 | 1994-03-29 | E. R. Squibb & Sons, Inc. | Method for preventing onset of hypertension employing a cholesterol lowering drug |
| US5648387A (en) * | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
| NZ503982A (en) * | 1997-12-12 | 2002-03-28 | Warner Lambert Co | Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus |
-
2001
- 2001-03-22 WO PCT/US2001/009088 patent/WO2001080847A2/en active IP Right Grant
- 2001-03-22 AU AU2001247658A patent/AU2001247658A1/en not_active Abandoned
- 2001-03-22 BR BR0110234-6A patent/BR0110234A/pt not_active IP Right Cessation
- 2001-03-22 EE EEP200200611A patent/EE200200611A/xx unknown
- 2001-03-22 EA EA200200953A patent/EA005245B1/ru not_active IP Right Cessation
- 2001-03-22 CZ CZ20023459A patent/CZ20023459A3/cs unknown
- 2001-03-22 SK SK1513-2002A patent/SK15132002A3/sk not_active Application Discontinuation
- 2001-03-22 HU HU0300403A patent/HUP0300403A3/hu unknown
- 2001-03-22 AT AT01920625T patent/ATE283691T1/de not_active IP Right Cessation
- 2001-03-22 OA OA1200200325A patent/OA12252A/en unknown
- 2001-03-22 DE DE60107559T patent/DE60107559T2/de not_active Expired - Fee Related
- 2001-03-22 EP EP01920625A patent/EP1280522B1/en not_active Expired - Lifetime
- 2001-03-22 PL PL01357906A patent/PL357906A1/xx not_active Application Discontinuation
- 2001-03-22 CN CN01808632A patent/CN1426299A/zh active Pending
- 2001-03-22 ES ES01920625T patent/ES2231470T3/es not_active Expired - Lifetime
- 2001-03-22 AP APAP/P/2002/002665A patent/AP2002002665A0/en unknown
- 2001-03-22 IL IL15247401A patent/IL152474A0/xx unknown
- 2001-03-22 JP JP2001577946A patent/JP2003531170A/ja active Pending
- 2001-03-22 MX MXPA02009662A patent/MXPA02009662A/es unknown
- 2001-03-22 NZ NZ521713A patent/NZ521713A/en unknown
- 2001-03-22 KR KR1020027014357A patent/KR20020091245A/ko not_active Withdrawn
- 2001-03-22 CA CA002405559A patent/CA2405559A1/en not_active Abandoned
- 2001-03-22 PT PT01920625T patent/PT1280522E/pt unknown
- 2001-03-22 HR HRP20020936 patent/HRP20020936A2/hr not_active Application Discontinuation
- 2001-04-05 SV SV2001000367A patent/SV2002000367A/es not_active Application Discontinuation
- 2001-04-19 TN TNTNSN01061A patent/TNSN01061A1/en unknown
- 2001-04-23 PA PA20018516001A patent/PA8516001A1/es unknown
- 2001-04-24 DO DO2001000150A patent/DOP2001000150A/es unknown
- 2001-04-24 PE PE2001000363A patent/PE20011308A1/es not_active Application Discontinuation
- 2001-04-25 AR ARP010101902A patent/AR031104A1/es unknown
-
2002
- 2002-09-27 IS IS6570A patent/IS6570A/is unknown
- 2002-10-17 MA MA26872A patent/MA26894A1/fr unknown
- 2002-10-25 NO NO20025135A patent/NO20025135L/no not_active Application Discontinuation
- 2002-11-12 BG BG107264A patent/BG107264A/xx unknown
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