OA11585A - Heterocyclic compounds as inhibitors of rotamase enzymes. - Google Patents

Heterocyclic compounds as inhibitors of rotamase enzymes. Download PDF

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Publication number
OA11585A
OA11585A OA1200100023A OA1200100023A OA11585A OA 11585 A OA11585 A OA 11585A OA 1200100023 A OA1200100023 A OA 1200100023A OA 1200100023 A OA1200100023 A OA 1200100023A OA 11585 A OA11585 A OA 11585A
Authority
OA
OAPI
Prior art keywords
compound
alkyl
formula
benzoxazol
aryl
Prior art date
Application number
OA1200100023A
Other languages
English (en)
Inventor
Mark Ian Kemp
Michael John Palmer
Mark Allen Sanner
Martin James Wythes
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of OA11585A publication Critical patent/OA11585A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
OA1200100023A 1998-07-21 1999-06-28 Heterocyclic compounds as inhibitors of rotamase enzymes. OA11585A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9815880.1A GB9815880D0 (en) 1998-07-21 1998-07-21 Heterocycles

Publications (1)

Publication Number Publication Date
OA11585A true OA11585A (en) 2004-07-26

Family

ID=10835920

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200100023A OA11585A (en) 1998-07-21 1999-06-28 Heterocyclic compounds as inhibitors of rotamase enzymes.

Country Status (45)

Country Link
US (2) US6372736B1 (ja)
EP (1) EP1100797B1 (ja)
JP (2) JP3795329B2 (ja)
KR (2) KR100468185B1 (ja)
CN (3) CN1511837A (ja)
AP (1) AP2001002046A0 (ja)
AR (1) AR019427A1 (ja)
AT (1) ATE233261T1 (ja)
AU (1) AU765925B2 (ja)
BG (1) BG105254A (ja)
BR (1) BR9912330A (ja)
CA (1) CA2338214C (ja)
CO (1) CO5080782A1 (ja)
CR (1) CR6073A (ja)
DE (1) DE69905582T2 (ja)
DK (1) DK1100797T3 (ja)
DZ (1) DZ2851A1 (ja)
EA (1) EA003513B1 (ja)
EE (1) EE200100044A (ja)
ES (1) ES2191484T3 (ja)
GB (1) GB9815880D0 (ja)
GE (1) GEP20033028B (ja)
GT (1) GT199900115A (ja)
HK (1) HK1039779A1 (ja)
HN (1) HN1999000106A (ja)
HR (1) HRP20010052A2 (ja)
HU (1) HUP0103413A3 (ja)
ID (1) ID26991A (ja)
IL (1) IL140244A0 (ja)
IS (1) IS5790A (ja)
MA (1) MA24936A1 (ja)
MY (1) MY118222A (ja)
NO (1) NO20010322L (ja)
NZ (2) NZ522270A (ja)
OA (1) OA11585A (ja)
PA (1) PA8478501A1 (ja)
PE (1) PE20001037A1 (ja)
PL (1) PL345734A1 (ja)
SI (1) SI1100797T1 (ja)
SK (1) SK772001A3 (ja)
SV (1) SV1999000102A (ja)
TN (1) TNSN99147A1 (ja)
TR (1) TR200100135T2 (ja)
TW (1) TWI229672B (ja)
WO (1) WO2000005232A1 (ja)

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DOP2000000107A (es) 1999-12-01 2002-09-16 Agouron Pharmaceutical Inc Compuestos, composiciones y metodos para estimular el crecimiento y alongamiento de las neuronas
FR2805818B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
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JP4812758B2 (ja) * 2004-06-29 2011-11-09 アベンティス・ファーマスーティカルズ・インコーポレイテツド Ｆｋｂｐ結合組成物及びその医薬上の使用
US7728026B2 (en) * 2005-04-11 2010-06-01 Abbott Laboratories, Inc. 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
EP1957477B1 (en) * 2005-09-29 2011-12-07 Abbott Laboratories 1h-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent parp inhibitors
DE602006013191D1 (de) * 2005-11-15 2010-05-06 Abbott Lab Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren
WO2007079078A1 (en) 2005-12-29 2007-07-12 Bayer Schering Pharma Aktiengesellschaft Diamine derivatives as inhibitors of leukotriene a4 hydrolase
RU2462458C2 (ru) * 2006-02-10 2012-09-27 Байомарин Ига Лимитед Лечение миодистрофии дюшена
KR101426093B1 (ko) * 2006-02-10 2014-08-01 서미트 코포레이션 피엘씨 뒤시엔느 근이영양증의 치료
GB0602768D0 (en) * 2006-02-10 2006-03-22 Vastox Plc Treatment of muscular dystrophy
JP5228237B2 (ja) * 2006-05-02 2013-07-03 アボット・ラボラトリーズ 置換１ｈ−ベンゾイミダゾール−４−カルボキサミドは強力なｐａｒｐ阻害薬である
ES2387471T3 (es) * 2006-12-20 2012-09-24 Amgen Inc. Compuestos heterocíclicos y su uso en el tratamiento de la inflamación, la angiogénesis y el cáncer
AR065628A1 (es) * 2007-03-07 2009-06-17 Xenon Pharmaceuticals Inc Compuestos triciclicos de utilidad en el tratamiento de trastornos por carencia de hierro en el organismo
US8067613B2 (en) * 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
LT2170396T (lt) * 2007-08-03 2017-03-10 Summit (Oxford) Limited Vaistų deriniai, skirti diušeno raumenų distrofijos gydymui
GB0715939D0 (en) * 2007-08-15 2007-09-26 Vastox Plc Method of treatment of duchenne muscular dystrophy
GB0715937D0 (en) * 2007-08-15 2007-09-26 Vastox Plc Method of treatment og duchenne muscular dystrophy
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
WO2010083199A1 (en) * 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase
GB0905664D0 (en) * 2009-04-02 2009-05-13 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
RU2686101C2 (ru) 2013-03-12 2019-04-24 Селтакссис, Инк. Способы ингибирования лейкотриен- а4-гидролазы
CA2906086A1 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
BR112015022226A2 (pt) 2013-03-14 2017-07-18 Celtaxsys Inc inibidores de leucotrieno a4 hidrolase
WO2014152518A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
JP6616786B2 (ja) * 2014-05-19 2019-12-04 メリアル インコーポレイテッド 駆虫性化合物
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GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles

Also Published As

Publication number Publication date
DE69905582T2 (de) 2003-09-04
CA2338214C (en) 2006-08-01
SK772001A3 (en) 2001-12-03
NO20010322D0 (no) 2001-01-19
US6562964B1 (en) 2003-05-13
TR200100135T2 (tr) 2001-06-21
AR019427A1 (es) 2002-02-20
EP1100797B1 (en) 2003-02-26
MY118222A (en) 2004-09-30
EA200100052A1 (ru) 2001-06-25
NZ522270A (en) 2004-03-26
GEP20033028B (en) 2003-07-25
GB9815880D0 (en) 1998-09-16
TNSN99147A1 (fr) 2005-11-10
DK1100797T3 (da) 2003-04-22
JP3795329B2 (ja) 2006-07-12
HUP0103413A2 (hu) 2002-05-29
EP1100797A1 (en) 2001-05-23
CA2338214A1 (en) 2000-02-03
ES2191484T3 (es) 2003-09-01
SV1999000102A (es) 2000-07-06
AU4285899A (en) 2000-02-14
TWI229672B (en) 2005-03-21
PA8478501A1 (es) 2000-05-24
CO5080782A1 (es) 2001-09-25
HN1999000106A (es) 1999-11-11
PE20001037A1 (es) 2000-10-11
WO2000005232A1 (en) 2000-02-03
IS5790A (is) 2000-12-22
CN1511837A (zh) 2004-07-14
BG105254A (en) 2001-10-31
JP2002521382A (ja) 2002-07-16
AU765925B2 (en) 2003-10-02
EA003513B1 (ru) 2003-06-26
DZ2851A1 (fr) 2004-02-04
KR20010071013A (ko) 2001-07-28
KR100450008B1 (ko) 2004-09-24
AP2001002046A0 (en) 2001-03-31
IL140244A0 (en) 2002-02-10
HRP20010052A2 (en) 2001-12-31
KR100468185B1 (ko) 2005-01-26
EE200100044A (et) 2002-06-17
JP2004002374A (ja) 2004-01-08
ATE233261T1 (de) 2003-03-15
CR6073A (es) 2004-04-29
HK1039779A1 (zh) 2002-05-10
MA24936A1 (fr) 2000-04-01
HUP0103413A3 (en) 2002-10-28
US6372736B1 (en) 2002-04-16
CN1310718A (zh) 2001-08-29
GT199900115A (es) 2001-01-10
NO20010322L (no) 2001-03-15
CN1611499A (zh) 2005-05-04
DE69905582D1 (de) 2003-04-03
CN1174978C (zh) 2004-11-10
PL345734A1 (en) 2002-01-02
BR9912330A (pt) 2001-04-17
ID26991A (id) 2001-02-22
SI1100797T1 (en) 2003-06-30
NZ508838A (en) 2002-12-20
KR20040062640A (ko) 2004-07-07

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