OA11507A - 2"-Deoxy hygromycin derivatives. - Google Patents
2"-Deoxy hygromycin derivatives. Download PDFInfo
- Publication number
- OA11507A OA11507A OA1200000298A OA1200000298A OA11507A OA 11507 A OA11507 A OA 11507A OA 1200000298 A OA1200000298 A OA 1200000298A OA 1200000298 A OA1200000298 A OA 1200000298A OA 11507 A OA11507 A OA 11507A
- Authority
- OA
- OAPI
- Prior art keywords
- methyl
- deoxy
- oxo
- methylene
- neo
- Prior art date
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- YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 title description 34
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- 238000000034 method Methods 0.000 claims abstract description 34
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- 208000022362 bacterial infectious disease Diseases 0.000 claims abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 272
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 182
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 63
- 125000003118 aryl group Chemical group 0.000 claims description 43
- 125000000217 alkyl group Chemical group 0.000 claims description 40
- 125000000623 heterocyclic group Chemical group 0.000 claims description 36
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- 125000005843 halogen group Chemical group 0.000 claims description 22
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- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical group [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 claims description 21
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- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims 2
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- 239000004633 polyglycolic acid Substances 0.000 description 1
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- 229920000656 polylysine Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
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- 125000003373 pyrazinyl group Chemical group 0.000 description 1
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- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
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- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
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- 238000006884 silylation reaction Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
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- 229960001790 sodium citrate Drugs 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
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- 229940115920 streptococcus dysgalactiae Drugs 0.000 description 1
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- 125000000547 substituted alkyl group Chemical group 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 235000011149 sulphuric acid Nutrition 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000006633 tert-butoxycarbonylamino group Chemical group 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 125000005308 thiazepinyl group Chemical group S1N=C(C=CC=C1)* 0.000 description 1
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- 125000002053 thietanyl group Chemical group 0.000 description 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000003354 tissue distribution assay Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- IIHPVYJPDKJYOU-UHFFFAOYSA-N triphenylcarbethoxymethylenephosphorane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=CC(=O)OCC)C1=CC=CC=C1 IIHPVYJPDKJYOU-UHFFFAOYSA-N 0.000 description 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
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- 150000003952 β-lactams Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8405898P | 1998-05-04 | 1998-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11507A true OA11507A (en) | 2004-05-13 |
Family
ID=22182624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200000298A OA11507A (en) | 1998-05-04 | 2000-10-27 | 2"-Deoxy hygromycin derivatives. |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6342497B1 (es) |
| EP (1) | EP1077984B1 (es) |
| JP (1) | JP2002513798A (es) |
| KR (1) | KR100396099B1 (es) |
| CN (1) | CN1299367A (es) |
| AP (1) | AP1069A (es) |
| AR (1) | AR015776A1 (es) |
| AT (1) | ATE243218T1 (es) |
| AU (1) | AU762302B2 (es) |
| BG (1) | BG104995A (es) |
| BR (1) | BR9910232A (es) |
| CA (1) | CA2331261C (es) |
| DE (1) | DE69908936T2 (es) |
| DK (1) | DK1077984T3 (es) |
| DZ (1) | DZ2779A1 (es) |
| EA (1) | EA004374B1 (es) |
| ES (1) | ES2199559T3 (es) |
| GT (1) | GT199900058A (es) |
| HN (1) | HN1999000064A (es) |
| HR (1) | HRP20000748A2 (es) |
| HU (1) | HUP0102412A3 (es) |
| ID (1) | ID26368A (es) |
| IL (1) | IL139020A0 (es) |
| IS (1) | IS5680A (es) |
| MA (1) | MA26626A1 (es) |
| NO (1) | NO20005551L (es) |
| NZ (1) | NZ507450A (es) |
| OA (1) | OA11507A (es) |
| PA (1) | PA8471901A1 (es) |
| PE (1) | PE20000440A1 (es) |
| PL (1) | PL344085A1 (es) |
| PT (1) | PT1077984E (es) |
| SK (1) | SK16442000A3 (es) |
| TN (1) | TNSN99084A1 (es) |
| TR (1) | TR200003249T2 (es) |
| WO (1) | WO1999057127A1 (es) |
| YU (1) | YU64300A (es) |
| ZA (1) | ZA993063B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6362799A (en) * | 1998-12-02 | 2000-06-19 | Pfizer Products Inc. | Hygromycin a derivatives as antibacterial agents |
| GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| EE200200671A (et) * | 2000-06-02 | 2004-08-16 | Pfizer Products Inc. | Hügromütsiin A derivaadid bakteriaalsete ja algloomadest põhjustatud infektsioonide ravimiseks |
| CN102168034B (zh) * | 2010-11-29 | 2012-12-05 | 中国科学院南海海洋研究所 | 一种海洋链霉菌以及利用该菌制备替达霉素a和b的方法 |
| WO2020041179A1 (en) * | 2018-08-20 | 2020-02-27 | Northeastern University | Hygromycin a compounds and methods of treating spirochete diseases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2832356B2 (ja) * | 1988-03-31 | 1998-12-09 | 武田薬品工業株式会社 | ハイグロマイシン類の合成中間体および製造法 |
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1999
- 1999-04-08 WO PCT/IB1999/000611 patent/WO1999057127A1/en active IP Right Grant
- 1999-04-08 NZ NZ507450A patent/NZ507450A/en unknown
- 1999-04-08 TR TR2000/03249T patent/TR200003249T2/xx unknown
- 1999-04-08 AT AT99909164T patent/ATE243218T1/de not_active IP Right Cessation
- 1999-04-08 ID IDW20002256A patent/ID26368A/id unknown
- 1999-04-08 PT PT99909164T patent/PT1077984E/pt unknown
- 1999-04-08 BR BR9910232-3A patent/BR9910232A/pt not_active IP Right Cessation
- 1999-04-08 CN CN99805810A patent/CN1299367A/zh active Pending
- 1999-04-08 SK SK1644-2000A patent/SK16442000A3/sk unknown
- 1999-04-08 EP EP99909164A patent/EP1077984B1/en not_active Expired - Lifetime
- 1999-04-08 YU YU64300A patent/YU64300A/sh unknown
- 1999-04-08 JP JP2000547096A patent/JP2002513798A/ja active Pending
- 1999-04-08 ES ES99909164T patent/ES2199559T3/es not_active Expired - Lifetime
- 1999-04-08 IL IL13902099A patent/IL139020A0/xx unknown
- 1999-04-08 AU AU28508/99A patent/AU762302B2/en not_active Ceased
- 1999-04-08 DK DK99909164T patent/DK1077984T3/da active
- 1999-04-08 EA EA200001028A patent/EA004374B1/ru not_active IP Right Cessation
- 1999-04-08 CA CA002331261A patent/CA2331261C/en not_active Expired - Fee Related
- 1999-04-08 PL PL99344085A patent/PL344085A1/xx unknown
- 1999-04-08 KR KR10-2000-7012222A patent/KR100396099B1/ko not_active IP Right Cessation
- 1999-04-08 US US09/380,718 patent/US6342497B1/en not_active Expired - Fee Related
- 1999-04-08 HU HU0102412A patent/HUP0102412A3/hu unknown
- 1999-04-08 DE DE69908936T patent/DE69908936T2/de not_active Expired - Fee Related
- 1999-04-16 GT GT199900058A patent/GT199900058A/es unknown
- 1999-04-29 PE PE1999000355A patent/PE20000440A1/es not_active Application Discontinuation
- 1999-04-29 AP APAP/P/1999/001525A patent/AP1069A/en active
- 1999-04-30 AR ARP990102023A patent/AR015776A1/es not_active Application Discontinuation
- 1999-05-03 DZ DZ990079A patent/DZ2779A1/xx active
- 1999-05-03 TN TNTNSN99084A patent/TNSN99084A1/fr unknown
- 1999-05-03 ZA ZA9903063A patent/ZA993063B/xx unknown
- 1999-05-03 MA MA25566A patent/MA26626A1/fr unknown
- 1999-05-03 HN HN1999000064A patent/HN1999000064A/es unknown
- 1999-05-04 PA PA19998471901A patent/PA8471901A1/es unknown
-
2000
- 2000-10-24 IS IS5680A patent/IS5680A/is unknown
- 2000-10-27 OA OA1200000298A patent/OA11507A/en unknown
- 2000-11-03 NO NO20005551A patent/NO20005551L/no not_active Application Discontinuation
- 2000-11-03 HR HR20000748A patent/HRP20000748A2/hr not_active Application Discontinuation
- 2000-11-28 BG BG104995A patent/BG104995A/bg unknown
Also Published As
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