OA10975A - Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides - Google Patents
Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides Download PDFInfo
- Publication number
- OA10975A OA10975A OA9900033A OA9900033A OA10975A OA 10975 A OA10975 A OA 10975A OA 9900033 A OA9900033 A OA 9900033A OA 9900033 A OA9900033 A OA 9900033A OA 10975 A OA10975 A OA 10975A
- Authority
- OA
- OAPI
- Prior art keywords
- compound
- acid
- butanoyl
- aspartyl
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/700,950 US5780590A (en) | 1993-10-15 | 1996-08-21 | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
OA10975A true OA10975A (en) | 2001-11-01 |
Family
ID=24815484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA9900033A OA10975A (en) | 1996-08-21 | 1999-02-15 | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
Country Status (21)
Country | Link |
---|---|
US (1) | US5780590A (uk) |
EP (1) | EP0929572A4 (uk) |
JP (1) | JP2001501965A (uk) |
KR (1) | KR20000035797A (uk) |
CN (1) | CN1231671A (uk) |
AP (1) | AP904A (uk) |
AU (1) | AU722112B2 (uk) |
BG (1) | BG103197A (uk) |
BR (1) | BR9711205A (uk) |
CA (1) | CA2263732A1 (uk) |
EA (1) | EA001391B1 (uk) |
HU (1) | HUP9903961A3 (uk) |
IL (1) | IL128556A0 (uk) |
NO (1) | NO990836L (uk) |
NZ (1) | NZ334059A (uk) |
OA (1) | OA10975A (uk) |
PL (1) | PL331713A1 (uk) |
SK (1) | SK14699A3 (uk) |
UA (1) | UA48252C2 (uk) |
WO (1) | WO1998017678A1 (uk) |
ZA (1) | ZA977511B (uk) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274705B1 (en) | 1996-05-02 | 2001-08-14 | Aventis Pharmaceuticals Products Inc. | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
CN1491942A (zh) * | 1996-08-21 | 2004-04-28 | ���µ�˹ҩ����Ʒ��˾ | N-[n-n-(4-(哌啶-4-基)丁酰基)-n-乙基甘氨酰基]化合物的不吸湿的稳定结晶形式 |
WO1999019294A1 (en) * | 1997-05-14 | 1999-04-22 | Aventis Pharmaceuticals Products Inc. Legal/Patents | Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides |
JP2001519411A (ja) * | 1997-10-10 | 2001-10-23 | アヴェンティス ファーマシューティカルズ プロダクツ インコーポレイテッド | アザシクロアルキルアルカノイルプソイドテトラぺプチドの調製方法 |
EP1155033A1 (en) * | 1998-12-30 | 2001-11-21 | Aventis Pharmaceuticals Products Inc. | Process for preparing a stable non-hygroscopic crystalline n-[n-[n-(piperdin-4-yl)butanoyl)-n-ethylglycyl]-(l)-aspartyl]-ss-cyclohexylalanine amide |
US7200838B2 (en) * | 2000-12-20 | 2007-04-03 | National Instruments Corporation | System and method for automatically generating a graphical program in response to a state diagram |
US7544681B2 (en) | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
ES2400772T3 (es) * | 2005-06-07 | 2013-04-12 | Ramot At Tel Aviv University Ltd. | Sales novedosas de fármacos psicotrópicos conjugados y procedimientos para la preparación de las mismas |
EP2051735B1 (en) | 2006-07-17 | 2012-08-29 | Ramot, at Tel Aviv University Ltd. | Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use treating pain and other cns disorders |
WO2009101616A1 (en) | 2008-02-11 | 2009-08-20 | Ramot At Tel Aviv University Ltd. | Novel conjugates for treating neurodegenerative diseases and disorders |
WO2011070579A1 (en) | 2009-12-09 | 2011-06-16 | Biolinerx Ltd. | Methods of improving cognitive functions |
US8377929B2 (en) | 2010-02-24 | 2013-02-19 | Ramot At Tel-Aviv University Ltd. | Crystalline forms of the tri-mesylate salt of perphenazine-GABA and process of producing the same |
WO2012038963A1 (en) | 2010-09-22 | 2012-03-29 | Ramot At Tel-Aviv University Ltd. | An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3821188A (en) * | 1972-06-14 | 1974-06-28 | American Home Prod | Proline and pyroglutamic acid containing tripeptides |
GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
US4683291A (en) * | 1985-10-28 | 1987-07-28 | Scripps Clinic And Research Foundation | Platelet binding inhibitors |
FR2608160B1 (fr) * | 1986-12-15 | 1989-03-31 | Inst Nat Sante Rech Med | Nouveaux derives peptidiques et leur application notamment en therapeutique |
US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
US4992463A (en) * | 1988-07-20 | 1991-02-12 | Monsanto Company | Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation |
US5037808A (en) * | 1988-07-20 | 1991-08-06 | Monsanto Co. | Indolyl platelet-aggregation inhibitors |
US5023233A (en) * | 1989-07-28 | 1991-06-11 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US4952562A (en) * | 1989-09-29 | 1990-08-28 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptides and pseudopeptides |
AU646411B2 (en) * | 1989-09-29 | 1994-02-24 | Rhone-Poulenc Rorer International (Holdings) Inc. | Anti-thrombotic peptides and pseudopeptides |
US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
US5053392A (en) * | 1989-12-01 | 1991-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors |
US5086069A (en) * | 1990-02-05 | 1992-02-04 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptide and pseudopeptide derivatives |
CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
GB9007751D0 (en) * | 1990-04-05 | 1990-06-06 | Ciba Geigy Ag | Novel platelet-aggregation inhibitors |
US5064814A (en) * | 1990-04-05 | 1991-11-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptide and pseudopeptide derivatives |
NZ239876A (en) * | 1990-09-27 | 1993-12-23 | Merck & Co Inc | Glycyl-b-alanine derivatives and pharmaceutical compositions thereof. |
IL99539A0 (en) * | 1990-09-27 | 1992-08-18 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
MX9201416A (es) * | 1991-03-28 | 1992-10-01 | Rhone Poulenc Rorer Int | Peptidos y pseudopeptidos antitromboticos. |
WO1992018117A1 (en) * | 1991-04-11 | 1992-10-29 | Rhone-Poulenc Rorer International (Holdings), Inc. | Anti-thrombotic peptide and pseudopeptide derivatives |
DE69213546T2 (de) * | 1991-05-13 | 1997-02-27 | Fujisawa Pharmaceutical Co | Neue Peptid-Verbindungen und Verfahren zur Herstellung davon |
HU222248B1 (hu) * | 1993-10-15 | 2003-05-28 | Aventis Pharmaceuticals Inc. | Trombózis elleni hatású (aza-cikloalkil)-alkanoil-peptidek, -pszeudopeptidek és ezeket a vegyületeket tartalmazó gyógyászati készítmények |
-
1996
- 1996-08-21 US US08/700,950 patent/US5780590A/en not_active Expired - Lifetime
-
1997
- 1997-08-15 SK SK146-99A patent/SK14699A3/sk unknown
- 1997-08-15 HU HU9903961A patent/HUP9903961A3/hu unknown
- 1997-08-15 KR KR1019997001363A patent/KR20000035797A/ko not_active Application Discontinuation
- 1997-08-15 IL IL12855697A patent/IL128556A0/xx unknown
- 1997-08-15 BR BR9711205A patent/BR9711205A/pt not_active Application Discontinuation
- 1997-08-15 NZ NZ334059A patent/NZ334059A/xx unknown
- 1997-08-15 WO PCT/US1997/014578 patent/WO1998017678A1/en not_active Application Discontinuation
- 1997-08-15 AP APAP/P/1999/001452A patent/AP904A/en active
- 1997-08-15 CN CN97198164A patent/CN1231671A/zh active Pending
- 1997-08-15 PL PL97331713A patent/PL331713A1/xx unknown
- 1997-08-15 EA EA199900216A patent/EA001391B1/ru not_active IP Right Cessation
- 1997-08-15 CA CA002263732A patent/CA2263732A1/en not_active Abandoned
- 1997-08-15 AU AU40749/97A patent/AU722112B2/en not_active Ceased
- 1997-08-15 EP EP97938424A patent/EP0929572A4/en not_active Withdrawn
- 1997-08-15 JP JP10519340A patent/JP2001501965A/ja not_active Ceased
- 1997-08-15 UA UA99031553A patent/UA48252C2/uk unknown
- 1997-08-21 ZA ZA9707511A patent/ZA977511B/xx unknown
-
1999
- 1999-02-15 OA OA9900033A patent/OA10975A/en unknown
- 1999-02-22 BG BG103197A patent/BG103197A/xx active Pending
- 1999-02-22 NO NO990836A patent/NO990836L/no unknown
Also Published As
Publication number | Publication date |
---|---|
WO1998017678A1 (en) | 1998-04-30 |
CA2263732A1 (en) | 1998-04-30 |
JP2001501965A (ja) | 2001-02-13 |
HUP9903961A2 (hu) | 2000-04-28 |
AU722112B2 (en) | 2000-07-20 |
AP9901452A0 (en) | 1999-03-31 |
EA001391B1 (ru) | 2001-02-26 |
EP0929572A4 (en) | 2001-09-12 |
IL128556A0 (en) | 2000-01-31 |
BR9711205A (pt) | 1999-08-17 |
US5780590A (en) | 1998-07-14 |
NO990836L (no) | 1999-04-20 |
NZ334059A (en) | 2000-01-28 |
PL331713A1 (en) | 1999-08-02 |
EP0929572A1 (en) | 1999-07-21 |
AP904A (en) | 2000-11-24 |
BG103197A (en) | 2000-05-31 |
AU4074997A (en) | 1998-05-15 |
UA48252C2 (uk) | 2002-08-15 |
KR20000035797A (ko) | 2000-06-26 |
SK14699A3 (en) | 2000-11-07 |
ZA977511B (en) | 1998-03-03 |
NO990836D0 (no) | 1999-02-22 |
HUP9903961A3 (en) | 2000-12-28 |
EA199900216A1 (ru) | 1999-08-26 |
CN1231671A (zh) | 1999-10-13 |
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