OA10375A - Interleukin-15 - Google Patents

Interleukin-15 Download PDF

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Publication number
OA10375A
OA10375A OA60897A OA60897A OA10375A OA 10375 A OA10375 A OA 10375A OA 60897 A OA60897 A OA 60897A OA 60897 A OA60897 A OA 60897A OA 10375 A OA10375 A OA 10375A
Authority
OA
OAPI
Prior art keywords
polypeptide
host cell
dna
leu
ser
Prior art date
Application number
OA60897A
Other languages
English (en)
Inventor
Kenneth H Grabstein
Dirk M Anderson
June R Eisenman
Charles Rauch
Victor Fung
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ266264A priority Critical patent/NZ266264A/en
Priority to PT94915781T priority patent/PT772624E/pt
Priority to AT94915781T priority patent/ATE196315T1/de
Priority to ES94915781T priority patent/ES2151927T3/es
Priority to PCT/US1994/003793 priority patent/WO1995027722A1/fr
Priority to EP94915781A priority patent/EP0772624B1/fr
Priority to CA002186747A priority patent/CA2186747C/fr
Priority to DK94915781T priority patent/DK0772624T3/da
Priority to DE69425906T priority patent/DE69425906T2/de
Priority to JP7526299A priority patent/JPH09512165A/ja
Priority to AU67673/94A priority patent/AU680909B2/en
Priority claimed from ZA942636A external-priority patent/ZA942636B/xx
Priority to ZA942636A priority patent/ZA942636B/xx
Priority to FI963828A priority patent/FI117054B/fi
Priority to OA60897A priority patent/OA10375A/en
Application filed by Immunex Corp filed Critical Immunex Corp
Priority to NO19964141A priority patent/NO318435B1/no
Priority to GR20000402710T priority patent/GR3035019T3/el
Publication of OA10375A publication Critical patent/OA10375A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
OA60897A 1994-04-06 1996-09-27 Interleukin-15 OA10375A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
JP7526299A JPH09512165A (ja) 1994-04-06 1994-04-06 インターロイキン１５
DE69425906T DE69425906T2 (de) 1994-04-06 1994-04-06 Interleukin-15
ES94915781T ES2151927T3 (es) 1994-04-06 1994-04-06 Interleuquina-15.
PCT/US1994/003793 WO1995027722A1 (fr) 1994-04-06 1994-04-06 Interleukine-15
EP94915781A EP0772624B1 (fr) 1994-04-06 1994-04-06 Interleukine-15
CA002186747A CA2186747C (fr) 1994-04-06 1994-04-06 Interleukine-15
DK94915781T DK0772624T3 (da) 1994-04-06 1994-04-06 Interleukin-15
NZ266264A NZ266264A (en) 1994-04-06 1994-04-06 Mammalian epithelium-derived t-cell factor called interleukin-15
AT94915781T ATE196315T1 (de) 1994-04-06 1994-04-06 Interleukin-15
PT94915781T PT772624E (pt) 1994-04-06 1994-04-06 Interleucina-15
AU67673/94A AU680909B2 (en) 1994-04-06 1994-04-06 Interleukin-15
ZA942636A ZA942636B (en) 1994-04-06 1994-04-18 Interleukin-15
FI963828A FI117054B (fi) 1994-04-06 1996-09-25 Interleukiini-15:n valmistusmenetelmä ja sitä koodaava DNA-sekvenssi
OA60897A OA10375A (en) 1994-04-06 1996-09-27 Interleukin-15
NO19964141A NO318435B1 (no) 1994-04-06 1996-09-30 Isolert DNA-sekvens fra IL-15, isolert DNA-sekvens som koder for et forloperpolypeptid til det biologisk aktive IL-15 polypeptid, rekombinant ekspresjonsvektor, vertcelle, fremgangsmate for fremstilling av et IL-15 polypeptid, isolert biologisk aktivt IL-15 polypeptidpreparat, farmasoytisk preparat for stimmulering av proliferasjon av T-lymfocytter, samt anvendelse av et polypeptid ifolge oppfinnelsen for fremstilling av et middel for behandling eller forebyggelse av spesifikt angitte sykdommer.
GR20000402710T GR3035019T3 (en) 1994-04-06 2000-12-06 Interleukin-15

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US1994/003793 WO1995027722A1 (fr) 1994-04-06 1994-04-06 Interleukine-15
NZ266264A NZ266264A (en) 1994-04-06 1994-04-06 Mammalian epithelium-derived t-cell factor called interleukin-15
ZA942636A ZA942636B (en) 1994-04-06 1994-04-18 Interleukin-15
OA60897A OA10375A (en) 1994-04-06 1996-09-27 Interleukin-15

Publications (1)

Publication Number Publication Date
OA10375A true OA10375A (en) 2001-11-16

Family

ID=33314371

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60897A OA10375A (en) 1994-04-06 1996-09-27 Interleukin-15

Country Status (11)

Country Link
EP (1) EP0772624B1 (fr)
AT (1) ATE196315T1 (fr)
CA (1) CA2186747C (fr)
DE (1) DE69425906T2 (fr)
DK (1) DK0772624T3 (fr)
ES (1) ES2151927T3 (fr)
GR (1) GR3035019T3 (fr)
NZ (1) NZ266264A (fr)
OA (1) OA10375A (fr)
PT (1) PT772624E (fr)
WO (1) WO1995027722A1 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69622854T2 (de) * 1995-04-02 2003-04-10 Chugai Seiyaku K.K., Tokio/Tokyo Arzneimittel zur Heilung von Thrombozytopenie
CN1200037A (zh) 1995-10-17 1998-11-25 韦恩州立大学 鸡白细胞介素－15及其用途
US6509313B1 (en) 1996-02-28 2003-01-21 Cornell Research Foundation, Inc. Stimulation of immune response with low doses of cytokines
US6451308B1 (en) 1996-04-26 2002-09-17 Beth Israel Deaconess Medical Center Antagonists of interleukin-15
EP1627918A1 (fr) * 1996-04-26 2006-02-22 Beth Israel Deaconess Medical Center, Inc. Antagonistes de l'interleukine-15
US6001973A (en) * 1996-04-26 1999-12-14 Beth Israel Deaconess Medical Center Antagonists of interleukin-15
US6087172A (en) * 1997-10-31 2000-07-11 Hisamitsu Pharmaceutical Co., Inc. Ribozymes targeted to human IL-15 mRNA
US5985663A (en) * 1998-11-25 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of interleukin-15 expression
AU3373300A (en) * 1999-02-24 2000-09-14 Wistar Institute Of Anatomy And Biology, The Method of modifying cytotoxic cells and uses thereof
US6828147B1 (en) 1999-02-24 2004-12-07 The Wistar Institute Of Anatomy And Biology Method of modifying cytotoxic cells and uses thereof
AU6158501A (en) 2000-05-12 2001-11-26 Beth Israel Hospital Compositions and methods for achieving immune suppression
CU23093A1 (es) * 2002-10-09 2005-10-19 Ct Ingenieria Genetica Biotech Composición vacunal que comprende interleucina-15 (il-15)
CN100427597C (zh) * 2003-11-26 2008-10-22 中国医学科学院基础医学研究所 可用于生产人重组白细胞介素-15的原核表达工程菌及纯化方法
CU23472A1 (es) 2004-09-17 2009-12-17 Ct Ingenieria Genetica Biotech Péptido antagonista de la interleucina-15
ES2382775T3 (es) * 2004-10-08 2012-06-13 Government Of The United States Of America,As Represented By The Secretary, Department Of Health And Human Services Inmunoterapia adoptiva con supervivencia de linfocitos T potenciada.
NZ581779A (en) 2005-05-17 2011-09-30 Univ Connecticut Composition and methods for immunomodulation in an organism comprising interleukin-15 polypeptide and interleukin-15 receptor subunit A polypeptide complex
EP1777294A1 (fr) 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Le domaine sushi de IL-15Ralpha comme enhancer sélectif et efficace de l'action de f IL-15 grâce à IL-15Rbeta/gamma, et l' hyperagoniste (IL15Ralpha sushi -IL15) comme protéine fusion
US9303080B2 (en) 2006-01-13 2016-04-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells
ES2470772T3 (es) 2007-05-11 2014-06-24 Altor Bioscience Corporation Moléculas de fusión y variantes de IL-15
AU2008269032B2 (en) 2007-06-27 2013-12-05 Novartis Ag Complexes of IL-15 and IL-15Ralpha and uses thereof
WO2009135031A1 (fr) 2008-04-30 2009-11-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Il-15 substitué
EP2464377B1 (fr) 2009-08-14 2016-07-27 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Utilisation d'il-15 pour améliorer la production thymique et pour traiter la lymphopénie
US11053299B2 (en) 2010-09-21 2021-07-06 Immunity Bio, Inc. Superkine
CN107880136B (zh) 2010-09-21 2021-11-12 阿尔托生物科学有限公司 多聚体il-15可溶性融合分子与其制造与使用方法
EP2537933A1 (fr) 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) Immunocytokines basées sur le domaine IL-15 et IL-15Ralpha sushi
WO2013088114A1 (fr) 2011-12-12 2013-06-20 Cell Medica Limited Procédé de propagation de cellules t
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
PL2812431T3 (pl) 2012-02-09 2020-02-28 Baylor College Of Medicine Mieszanki peptydowe do wytwarzania wielowirusowych CTL o szerokiej swoistości
EP2986312B1 (fr) 2013-04-19 2021-12-15 Cytune Pharma Traitement dérivé de la cytokine avec syndrome de fuite vasculaire réduit
EP2915569A1 (fr) 2014-03-03 2015-09-09 Cytune Pharma Procédé de purification de conjugués à base Il -15/IL-15Ralpha
MA39711A (fr) 2014-04-03 2015-10-08 Nektar Therapeutics Conjugués d'une fraction d'il-15 et d'un polymère
AU2015284248B2 (en) 2014-06-30 2020-04-16 Altor Bioscience Corporation IL-15-based molecules and methods of use thereof
CN113791213A (zh) 2015-09-18 2021-12-14 贝勒医学院 来自病原体的免疫原性抗原鉴定以及与临床效力的相关性
JP7185530B2 (ja) 2016-06-13 2022-12-07 トルク セラピューティクス， インコーポレイテッド 免疫細胞機能を促進するための方法および組成物
CN118562016A (zh) 2016-10-21 2024-08-30 艾尔特生物科技公司 基于多聚体il-15的分子
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
SG10202111394XA (en) 2017-04-13 2021-12-30 Senti Biosciences Inc Combinatorial cancer immunotherapy
CN111093688A (zh) 2017-05-15 2020-05-01 尼克塔治疗公司 长效白细胞介素-15受体激动剂以及相关免疫治疗组合物和方法
KR102008429B1 (ko) * 2017-06-30 2019-08-07 아주대학교산학협력단 인터루킨-15/인터루킨-15 수용체 알파-Fc 복합체를 포함하는 염증질환 치료 또는 예방용 조성물
EP3678701A4 (fr) 2017-09-05 2021-12-01 Torque Therapeutics, Inc. Compositions protéiques thérapeutiques et procédés de préparation et d'utilisation de celles-ci
JP2022512766A (ja) 2018-10-17 2022-02-07 センティ バイオサイエンシズ インコーポレイテッド 組み合わせがん免疫療法
US11419898B2 (en) 2018-10-17 2022-08-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US20220195396A1 (en) * 2020-12-03 2022-06-23 Century Therapeutics, Inc. Genetically Engineered Cells and Uses Thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
WO2023086772A1 (fr) 2021-11-12 2023-05-19 Xencor, Inc. Anticorps bispécifiques se liant à b7h3 et à nkg2d
WO2024102636A1 (fr) 2022-11-07 2024-05-16 Xencor, Inc. Anticorps bispécifiques qui se lient à b7h3 et mica/b

Also Published As

Publication number Publication date
PT772624E (pt) 2001-03-30
DK0772624T3 (da) 2000-11-13
NZ266264A (en) 1997-01-29
WO1995027722A1 (fr) 1995-10-19
ATE196315T1 (de) 2000-09-15
GR3035019T3 (en) 2001-03-30
EP0772624B1 (fr) 2000-09-13
ES2151927T3 (es) 2001-01-16
EP0772624A1 (fr) 1997-05-14
DE69425906D1 (en) 2000-10-19
EP0772624A4 (fr) 1997-07-02
CA2186747C (fr) 2009-01-27
CA2186747A1 (fr) 1995-10-19
DE69425906T2 (de) 2001-03-29

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