OA10122A - 17-Alkylketone steroids useful as 5-alpha reductase inhibitors - Google Patents

17-Alkylketone steroids useful as 5-alpha reductase inhibitors Download PDF

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Publication number
OA10122A
OA10122A OA60599A OA60599A OA10122A OA 10122 A OA10122 A OA 10122A OA 60599 A OA60599 A OA 60599A OA 60599 A OA60599 A OA 60599A OA 10122 A OA10122 A OA 10122A
Authority
OA
OAPI
Prior art keywords
compound
formula
daims
estra
triene
Prior art date
Application number
OA60599A
Other languages
English (en)
Inventor
Denis Alan Holt
Mark Alan Levy
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of OA10122A publication Critical patent/OA10122A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
OA60599A 1992-06-30 1994-12-29 17-Alkylketone steroids useful as 5-alpha reductase inhibitors OA10122A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929213835A GB9213835D0 (en) 1992-06-30 1992-06-30 Compounds

Publications (1)

Publication Number Publication Date
OA10122A true OA10122A (en) 1996-12-18

Family

ID=10717920

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60599A OA10122A (en) 1992-06-30 1994-12-29 17-Alkylketone steroids useful as 5-alpha reductase inhibitors

Country Status (23)

Country Link
EP (1) EP0651643A4 (no)
JP (1) JPH08500821A (no)
KR (1) KR950702118A (no)
CN (1) CN1095382A (no)
AP (1) AP412A (no)
AU (1) AU4545993A (no)
BG (1) BG99313A (no)
BR (1) BR9306748A (no)
CA (1) CA2138956A1 (no)
CZ (1) CZ334694A3 (no)
FI (1) FI946189A0 (no)
GB (1) GB9213835D0 (no)
HU (1) HUT69409A (no)
IL (1) IL106158A0 (no)
MA (1) MA22927A1 (no)
MX (1) MX9303970A (no)
NO (1) NO945074L (no)
OA (1) OA10122A (no)
RU (1) RU94046378A (no)
SI (1) SI9300350A (no)
SK (1) SK159994A3 (no)
WO (1) WO1994000125A1 (no)
ZA (1) ZA934645B (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015093264A1 (en) 2013-12-19 2015-06-25 L'oreal Composition

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925774A (en) * 1991-01-07 1999-07-20 Pherin Corporation Estrenes for inducing hypothalamic effects
CA2135056A1 (en) * 1992-05-20 1993-11-25 Donald W. Graham New delta-17 and delta-20 olefinic and saturated 17b-substituted-4-aza-5a-andros-tan-3-ones as 5a-reductase inhibitors
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic
JP7438956B2 (ja) * 2018-02-11 2024-02-27 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 ステロイド系誘導体モジュレーター、その製造方法及び応用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015093264A1 (en) 2013-12-19 2015-06-25 L'oreal Composition

Also Published As

Publication number Publication date
AP412A (en) 1995-09-29
AP9300542A0 (en) 1993-07-31
NO945074L (no) 1995-02-16
EP0651643A1 (en) 1995-05-10
CA2138956A1 (en) 1994-01-06
FI946189A (fi) 1994-12-30
MX9303970A (es) 1994-04-29
SI9300350A (sl) 1993-12-31
EP0651643A4 (en) 1995-10-04
NO945074D0 (no) 1994-12-29
IL106158A0 (en) 1993-10-20
RU94046378A (ru) 1996-10-10
CN1095382A (zh) 1994-11-23
BG99313A (en) 1995-09-29
HUT69409A (en) 1995-09-28
GB9213835D0 (en) 1992-08-12
WO1994000125A1 (en) 1994-01-06
BR9306748A (pt) 1998-12-08
AU4545993A (en) 1994-01-24
CZ334694A3 (en) 1995-10-18
FI946189A0 (fi) 1994-12-30
MA22927A1 (fr) 1994-04-01
JPH08500821A (ja) 1996-01-30
SK159994A3 (en) 1996-01-10
ZA934645B (en) 1994-01-25
KR950702118A (ko) 1995-06-19

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