OA00816A - Process for the preparation of 1,4-benzodiazepine derivatives. - Google Patents

Process for the preparation of 1,4-benzodiazepine derivatives.

Info

Publication number
OA00816A
OA00816A OA50895A OA50895A OA00816A OA 00816 A OA00816 A OA 00816A OA 50895 A OA50895 A OA 50895A OA 50895 A OA50895 A OA 50895A OA 00816 A OA00816 A OA 00816A
Authority
OA
OAPI
Prior art keywords
preparation
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
OA50895A
Other languages
French (fr)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of OA00816A publication Critical patent/OA00816A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/74Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/26Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
OA50895A 1959-12-10 1964-12-16 Process for the preparation of 1,4-benzodiazepine derivatives. OA00816A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
OA00816A true OA00816A (en) 1967-11-15

Family

ID=27485190

Family Applications (7)

Application Number Title Priority Date Filing Date
OA50896A OA00817A (en) 1959-12-10 1964-12-16 Process for the preparation of 1,4-benzodiazepine derivatives.
OA50895A OA00816A (en) 1959-12-10 1964-12-16 Process for the preparation of 1,4-benzodiazepine derivatives.
OA51054A OA00959A (en) 1959-12-10 1964-12-26 Process for the preparation of 1,4-benzodiazepine derivatives.
OA51053A OA00958A (en) 1959-12-10 1964-12-26 Process for the preparation of 1,4-benzodiapine derivatives.
OA51048A OA00953A (en) 1959-12-10 1964-12-26 Process for the preparation of 1,4-benzodiazepine derivatives.
OA52849A OA02384A (en) 1959-12-10 1967-03-30 Process for the preparation of 1,4-benzodiazepine derivatives.
OA52850A OA02385A (en) 1959-12-10 1967-03-30 Process for the preparation of 1,4-benzodiazepine derivatives.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
OA50896A OA00817A (en) 1959-12-10 1964-12-16 Process for the preparation of 1,4-benzodiazepine derivatives.

Family Applications After (5)

Application Number Title Priority Date Filing Date
OA51054A OA00959A (en) 1959-12-10 1964-12-26 Process for the preparation of 1,4-benzodiazepine derivatives.
OA51053A OA00958A (en) 1959-12-10 1964-12-26 Process for the preparation of 1,4-benzodiapine derivatives.
OA51048A OA00953A (en) 1959-12-10 1964-12-26 Process for the preparation of 1,4-benzodiazepine derivatives.
OA52849A OA02384A (en) 1959-12-10 1967-03-30 Process for the preparation of 1,4-benzodiazepine derivatives.
OA52850A OA02385A (en) 1959-12-10 1967-03-30 Process for the preparation of 1,4-benzodiazepine derivatives.

Country Status (11)

Country Link
BE (4) BE598013A (en)
BR (1) BR6024755D0 (en)
CH (9) CH414652A (en)
CY (1) CY324A (en)
DE (5) DE1290143B (en)
ES (2) ES263123A1 (en)
GB (13) GB972964A (en)
MY (1) MY6500178A (en)
NL (2) NL6412251A (en)
OA (7) OA00817A (en)
SE (2) SE310887B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1295563B (en) * 1963-05-29 1969-05-22 American Home Prod Process for the preparation of 5-phenyl-7-chloro-1, 2-dihydro-3H-1, 4-benzodiazepinone (2) -4-oxide
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
AU2002317910B2 (en) * 2001-06-07 2008-06-19 Via Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
US7238717B2 (en) * 2002-05-24 2007-07-03 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
GB972968A (en) 1964-10-21
OA02384A (en) 1970-05-05
CH418341A (en) 1966-08-15
GB972973A (en) 1964-10-21
DE1445908A1 (en) 1969-04-17
SE318283B (en) 1969-12-08
GB972965A (en) 1964-10-21
NL6412251A (en) 1966-01-25
CH408029A (en) 1966-02-28
BR6024755D0 (en) 1973-05-24
CH408940A (en) 1966-03-15
GB972963A (en) 1964-10-21
OA00817A (en) 1967-11-15
CH414653A (en) 1966-06-15
GB972964A (en) 1964-10-21
DE1288609B (en) 1969-02-06
OA02385A (en) 1970-05-05
ES263123A1 (en) 1961-06-01
DE1288610B (en) 1969-02-06
NL6412250A (en) 1966-01-25
SE310887B (en) 1969-05-19
GB972966A (en) 1964-10-21
DE1290143B (en) 1969-03-06
GB972969A (en) 1964-10-21
GB972976A (en) 1964-10-21
OA00953A (en) 1968-03-22
CH414652A (en) 1966-06-15
ES263124A1 (en) 1961-06-01
BE598012A (en) 1961-06-09
MY6500178A (en) 1965-12-31
CH418342A (en) 1966-08-15
GB972970A (en) 1964-10-21
BE598008A (en) 1961-06-09
OA00959A (en) 1968-03-22
CH411910A (en) 1966-04-30
GB972967A (en) 1964-10-21
BE598015A (en) 1961-06-09
GB972961A (en) 1964-10-21
CH396016A (en) 1965-07-31
CH408045A (en) 1966-02-28
CY324A (en) 1965-11-03
OA00958A (en) 1968-03-22
BE598013A (en) 1961-06-09
GB972962A (en) 1964-10-21
GB972972A (en) 1964-10-21
DE1445073A1 (en) 1968-10-31

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