CH408940A - Process for the preparation of 1,4-benzodiazepine derivatives - Google Patents

Process for the preparation of 1,4-benzodiazepine derivatives

Info

Publication number
CH408940A
CH408940A CH1348960A CH1348960A CH408940A CH 408940 A CH408940 A CH 408940A CH 1348960 A CH1348960 A CH 1348960A CH 1348960 A CH1348960 A CH 1348960A CH 408940 A CH408940 A CH 408940A
Authority
CH
Switzerland
Prior art keywords
preparation
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
CH1348960A
Other languages
German (de)
Inventor
Reeder Earl
Henryk Sternbach Leo
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to BE605327A priority Critical patent/BE605327A/en
Priority to US149527A priority patent/US3136815A/en
Priority to US154921A priority patent/US3371085A/en
Priority to US326337A priority patent/US3402171A/en
Publication of CH408940A publication Critical patent/CH408940A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CH1348960A 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives CH408940A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BE605327A BE605327A (en) 1960-06-27 1961-06-23 Process for the preparation of benzopnenone derivatives.
US149527A US3136815A (en) 1959-12-10 1961-11-02 Amino substituted benzophenone oximes and derivatives thereof
US154921A US3371085A (en) 1959-12-10 1961-11-20 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
US326337A US3402171A (en) 1960-12-02 1963-11-27 Process for preparing 5-aryl-3h-1, 4-benzodiazepin-2(1h)-ones

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
CH408940A true CH408940A (en) 1966-03-15

Family

ID=27485190

Family Applications (9)

Application Number Title Priority Date Filing Date
CH1230565A CH408045A (en) 1959-12-10 1960-12-02 Process for the preparation of benzophenone derivatives
CH1348960A CH408940A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349160A CH408029A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349460A CH414652A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349360A CH418342A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349260A CH418341A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349060A CH411910A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349560A CH414653A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1389960A CH396016A (en) 1959-12-10 1960-12-13 Process for the preparation of fluorine-containing benzodiazepines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH1230565A CH408045A (en) 1959-12-10 1960-12-02 Process for the preparation of benzophenone derivatives

Family Applications After (7)

Application Number Title Priority Date Filing Date
CH1349160A CH408029A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349460A CH414652A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349360A CH418342A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349260A CH418341A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349060A CH411910A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349560A CH414653A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1389960A CH396016A (en) 1959-12-10 1960-12-13 Process for the preparation of fluorine-containing benzodiazepines

Country Status (11)

Country Link
BE (4) BE598013A (en)
BR (1) BR6024755D0 (en)
CH (9) CH408045A (en)
CY (1) CY324A (en)
DE (5) DE1288609B (en)
ES (2) ES263124A1 (en)
GB (13) GB972961A (en)
MY (1) MY6500178A (en)
NL (2) NL6412251A (en)
OA (7) OA00817A (en)
SE (2) SE310887B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1295563B (en) * 1963-05-29 1969-05-22 American Home Prod Process for the preparation of 5-phenyl-7-chloro-1, 2-dihydro-3H-1, 4-benzodiazepinone (2) -4-oxide
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
CA2446696A1 (en) * 2001-06-07 2002-12-12 Neuro3D Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
EP2399903A1 (en) * 2002-05-24 2011-12-28 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
OA00816A (en) 1967-11-15
SE318283B (en) 1969-12-08
BE598015A (en) 1961-06-09
GB972973A (en) 1964-10-21
GB972972A (en) 1964-10-21
CH396016A (en) 1965-07-31
CH411910A (en) 1966-04-30
GB972976A (en) 1964-10-21
CH418341A (en) 1966-08-15
GB972964A (en) 1964-10-21
BE598013A (en) 1961-06-09
GB972966A (en) 1964-10-21
GB972968A (en) 1964-10-21
DE1288610B (en) 1969-02-06
DE1288609B (en) 1969-02-06
OA02384A (en) 1970-05-05
BE598008A (en) 1961-06-09
ES263123A1 (en) 1961-06-01
CH408029A (en) 1966-02-28
SE310887B (en) 1969-05-19
CH408045A (en) 1966-02-28
CY324A (en) 1965-11-03
OA00953A (en) 1968-03-22
DE1290143B (en) 1969-03-06
MY6500178A (en) 1965-12-31
GB972961A (en) 1964-10-21
BR6024755D0 (en) 1973-05-24
ES263124A1 (en) 1961-06-01
OA00958A (en) 1968-03-22
GB972970A (en) 1964-10-21
DE1445908A1 (en) 1969-04-17
GB972962A (en) 1964-10-21
GB972967A (en) 1964-10-21
OA00817A (en) 1967-11-15
NL6412251A (en) 1966-01-25
GB972963A (en) 1964-10-21
CH414652A (en) 1966-06-15
OA00959A (en) 1968-03-22
GB972969A (en) 1964-10-21
CH418342A (en) 1966-08-15
OA02385A (en) 1970-05-05
CH414653A (en) 1966-06-15
BE598012A (en) 1961-06-09
DE1445073A1 (en) 1968-10-31
NL6412250A (en) 1966-01-25
GB972965A (en) 1964-10-21

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