BE598008A - 1,4-Benzodiazepine derivatives - Google Patents

1,4-Benzodiazepine derivatives

Info

Publication number
BE598008A
BE598008A BE598008A BE598008A BE598008A BE 598008 A BE598008 A BE 598008A BE 598008 A BE598008 A BE 598008A BE 598008 A BE598008 A BE 598008A BE 598008 A BE598008 A BE 598008A
Authority
BE
Belgium
Prior art keywords
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
BE598008A
Other languages
French (fr)
Inventor
Earl Reeder
Leo Henryk Sternbach
Gabriel Saucy
Oscar Keller
Norbert Steiger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BE598008A publication Critical patent/BE598008A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BE598008A 1959-12-10 1960-12-09 1,4-Benzodiazepine derivatives BE598008A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
BE598008A true BE598008A (en) 1961-06-09

Family

ID=27485190

Family Applications (4)

Application Number Title Priority Date Filing Date
BE598013A BE598013A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives
BE598008A BE598008A (en) 1959-12-10 1960-12-09 1,4-Benzodiazepine derivatives
BE598015A BE598015A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives
BE598012A BE598012A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE598013A BE598013A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
BE598015A BE598015A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives
BE598012A BE598012A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives

Country Status (11)

Country Link
BE (4) BE598013A (en)
BR (1) BR6024755D0 (en)
CH (9) CH408029A (en)
CY (1) CY324A (en)
DE (5) DE1288610B (en)
ES (2) ES263123A1 (en)
GB (13) GB972962A (en)
MY (1) MY6500178A (en)
NL (2) NL6412251A (en)
OA (7) OA00817A (en)
SE (2) SE310887B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1295563B (en) * 1963-05-29 1969-05-22 American Home Prod Process for the preparation of 5-phenyl-7-chloro-1, 2-dihydro-3H-1, 4-benzodiazepinone (2) -4-oxide

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
EP1392663A2 (en) * 2001-06-07 2004-03-03 Neuro3D Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
EP1507756B1 (en) * 2002-05-24 2015-07-22 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1295563B (en) * 1963-05-29 1969-05-22 American Home Prod Process for the preparation of 5-phenyl-7-chloro-1, 2-dihydro-3H-1, 4-benzodiazepinone (2) -4-oxide

Also Published As

Publication number Publication date
DE1290143B (en) 1969-03-06
OA02384A (en) 1970-05-05
GB972964A (en) 1964-10-21
BR6024755D0 (en) 1973-05-24
OA00816A (en) 1967-11-15
GB972970A (en) 1964-10-21
DE1288609B (en) 1969-02-06
CH408045A (en) 1966-02-28
CY324A (en) 1965-11-03
CH414652A (en) 1966-06-15
CH411910A (en) 1966-04-30
BE598012A (en) 1961-06-09
SE318283B (en) 1969-12-08
CH408940A (en) 1966-03-15
OA00959A (en) 1968-03-22
CH418342A (en) 1966-08-15
GB972976A (en) 1964-10-21
MY6500178A (en) 1965-12-31
OA00817A (en) 1967-11-15
DE1445908A1 (en) 1969-04-17
GB972962A (en) 1964-10-21
ES263124A1 (en) 1961-06-01
GB972969A (en) 1964-10-21
GB972967A (en) 1964-10-21
GB972963A (en) 1964-10-21
SE310887B (en) 1969-05-19
CH414653A (en) 1966-06-15
BE598015A (en) 1961-06-09
ES263123A1 (en) 1961-06-01
GB972961A (en) 1964-10-21
GB972973A (en) 1964-10-21
NL6412250A (en) 1966-01-25
OA00953A (en) 1968-03-22
GB972972A (en) 1964-10-21
CH418341A (en) 1966-08-15
NL6412251A (en) 1966-01-25
GB972968A (en) 1964-10-21
BE598013A (en) 1961-06-09
GB972966A (en) 1964-10-21
CH408029A (en) 1966-02-28
DE1288610B (en) 1969-02-06
CH396016A (en) 1965-07-31
OA00958A (en) 1968-03-22
OA02385A (en) 1970-05-05
GB972965A (en) 1964-10-21
DE1445073A1 (en) 1968-10-31

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