CH414653A - Process for the preparation of 1,4-benzodiazepine derivatives - Google Patents

Process for the preparation of 1,4-benzodiazepine derivatives

Info

Publication number
CH414653A
CH414653A CH1349560A CH1349560A CH414653A CH 414653 A CH414653 A CH 414653A CH 1349560 A CH1349560 A CH 1349560A CH 1349560 A CH1349560 A CH 1349560A CH 414653 A CH414653 A CH 414653A
Authority
CH
Switzerland
Prior art keywords
preparation
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
CH1349560A
Other languages
German (de)
Inventor
Saucy Gabriel
Reeder Earl
Henryk Sternbach Leo
Keller Oscar
Steiger Norbert
Stempel Arthur
S Sach George
Ian Fryer Rodney
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to US154921A priority Critical patent/US3371085A/en
Priority to US154927A priority patent/US3239564A/en
Publication of CH414653A publication Critical patent/CH414653A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/74Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/26Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CH1349560A 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives CH414653A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US154921A US3371085A (en) 1959-12-10 1961-11-20 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
US154927A US3239564A (en) 1960-12-02 1961-11-20 2 n-substituted amino halobenzo-phenones

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
CH414653A true CH414653A (en) 1966-06-15

Family

ID=27485190

Family Applications (9)

Application Number Title Priority Date Filing Date
CH1230565A CH408045A (en) 1959-12-10 1960-12-02 Process for the preparation of benzophenone derivatives
CH1348960A CH408940A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349060A CH411910A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349460A CH414652A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349560A CH414653A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349260A CH418341A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349360A CH418342A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349160A CH408029A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1389960A CH396016A (en) 1959-12-10 1960-12-13 Process for the preparation of fluorine-containing benzodiazepines

Family Applications Before (4)

Application Number Title Priority Date Filing Date
CH1230565A CH408045A (en) 1959-12-10 1960-12-02 Process for the preparation of benzophenone derivatives
CH1348960A CH408940A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349060A CH411910A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives
CH1349460A CH414652A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives

Family Applications After (4)

Application Number Title Priority Date Filing Date
CH1349260A CH418341A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349360A CH418342A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1349160A CH408029A (en) 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepines
CH1389960A CH396016A (en) 1959-12-10 1960-12-13 Process for the preparation of fluorine-containing benzodiazepines

Country Status (11)

Country Link
BE (4) BE598013A (en)
BR (1) BR6024755D0 (en)
CH (9) CH408045A (en)
CY (1) CY324A (en)
DE (5) DE1290143B (en)
ES (2) ES263124A1 (en)
GB (13) GB972972A (en)
MY (1) MY6500178A (en)
NL (2) NL6412251A (en)
OA (7) OA00816A (en)
SE (2) SE310887B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795231C3 (en) * 1963-05-29 1978-07-13 American Home Products Corp., New York, N.Y. (V.St.A.) Process for the preparation of 5-aryl-1,2-dihydro -3H-1,4-benzodiazepin-2-one-4-oxides
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
IL159105A0 (en) 2001-06-07 2004-05-12 Neuro3D Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
WO2003099773A1 (en) * 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
NL6412250A (en) 1966-01-25
OA00817A (en) 1967-11-15
DE1445073A1 (en) 1968-10-31
OA00958A (en) 1968-03-22
DE1288609B (en) 1969-02-06
GB972966A (en) 1964-10-21
GB972964A (en) 1964-10-21
DE1288610B (en) 1969-02-06
GB972973A (en) 1964-10-21
OA02384A (en) 1970-05-05
GB972965A (en) 1964-10-21
GB972976A (en) 1964-10-21
GB972968A (en) 1964-10-21
GB972963A (en) 1964-10-21
DE1290143B (en) 1969-03-06
GB972970A (en) 1964-10-21
CH418342A (en) 1966-08-15
CH396016A (en) 1965-07-31
OA00816A (en) 1967-11-15
BR6024755D0 (en) 1973-05-24
CH408045A (en) 1966-02-28
CY324A (en) 1965-11-03
CH418341A (en) 1966-08-15
CH408029A (en) 1966-02-28
GB972967A (en) 1964-10-21
ES263124A1 (en) 1961-06-01
GB972962A (en) 1964-10-21
OA00959A (en) 1968-03-22
GB972961A (en) 1964-10-21
OA02385A (en) 1970-05-05
BE598013A (en) 1961-06-09
ES263123A1 (en) 1961-06-01
SE318283B (en) 1969-12-08
DE1445908A1 (en) 1969-04-17
NL6412251A (en) 1966-01-25
GB972969A (en) 1964-10-21
CH414652A (en) 1966-06-15
BE598008A (en) 1961-06-09
OA00953A (en) 1968-03-22
BE598015A (en) 1961-06-09
BE598012A (en) 1961-06-09
CH411910A (en) 1966-04-30
SE310887B (en) 1969-05-19
GB972972A (en) 1964-10-21
MY6500178A (en) 1965-12-31
CH408940A (en) 1966-03-15

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