BE598013A - Process for the preparation of 1,4-benzodiazepine derivatives - Google Patents

Process for the preparation of 1,4-benzodiazepine derivatives

Info

Publication number
BE598013A
BE598013A BE598013A BE598013A BE598013A BE 598013 A BE598013 A BE 598013A BE 598013 A BE598013 A BE 598013A BE 598013 A BE598013 A BE 598013A BE 598013 A BE598013 A BE 598013A
Authority
BE
Belgium
Prior art keywords
preparation
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
BE598013A
Other languages
French (fr)
Inventor
Earl Reeder
Leo Henryk Sternbach
Gabriel Saucy
Oscar Keller
Norbert Steiger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BE598013A publication Critical patent/BE598013A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/74Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/26Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BE598013A 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives BE598013A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
BE598013A true BE598013A (en) 1961-06-09

Family

ID=27485190

Family Applications (4)

Application Number Title Priority Date Filing Date
BE598015A BE598015A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives
BE598012A BE598012A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives
BE598013A BE598013A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives
BE598008A BE598008A (en) 1959-12-10 1960-12-09 1,4-Benzodiazepine derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BE598015A BE598015A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives
BE598012A BE598012A (en) 1959-12-10 1960-12-09 Process for the preparation of 1,4-benzodiazepine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE598008A BE598008A (en) 1959-12-10 1960-12-09 1,4-Benzodiazepine derivatives

Country Status (11)

Country Link
BE (4) BE598015A (en)
BR (1) BR6024755D0 (en)
CH (9) CH414652A (en)
CY (1) CY324A (en)
DE (5) DE1288610B (en)
ES (2) ES263124A1 (en)
GB (13) GB972961A (en)
MY (1) MY6500178A (en)
NL (2) NL6412250A (en)
OA (7) OA00816A (en)
SE (2) SE310887B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795231C3 (en) * 1963-05-29 1978-07-13 American Home Products Corp., New York, N.Y. (V.St.A.) Process for the preparation of 5-aryl-1,2-dihydro -3H-1,4-benzodiazepin-2-one-4-oxides
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
CA2446696A1 (en) * 2001-06-07 2002-12-12 Neuro3D Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
EP2402309A1 (en) * 2002-05-24 2012-01-04 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
GB972973A (en) 1964-10-21
GB972961A (en) 1964-10-21
OA00958A (en) 1968-03-22
ES263124A1 (en) 1961-06-01
OA00953A (en) 1968-03-22
CH411910A (en) 1966-04-30
GB972963A (en) 1964-10-21
CH396016A (en) 1965-07-31
GB972964A (en) 1964-10-21
BE598015A (en) 1961-06-09
MY6500178A (en) 1965-12-31
BR6024755D0 (en) 1973-05-24
DE1445908A1 (en) 1969-04-17
GB972976A (en) 1964-10-21
CH418342A (en) 1966-08-15
NL6412251A (en) 1966-01-25
OA00817A (en) 1967-11-15
BE598008A (en) 1961-06-09
DE1288610B (en) 1969-02-06
OA02384A (en) 1970-05-05
CH408029A (en) 1966-02-28
SE318283B (en) 1969-12-08
GB972972A (en) 1964-10-21
CH414653A (en) 1966-06-15
GB972965A (en) 1964-10-21
CH418341A (en) 1966-08-15
BE598012A (en) 1961-06-09
GB972969A (en) 1964-10-21
GB972967A (en) 1964-10-21
OA02385A (en) 1970-05-05
NL6412250A (en) 1966-01-25
GB972966A (en) 1964-10-21
DE1445073A1 (en) 1968-10-31
GB972970A (en) 1964-10-21
CH414652A (en) 1966-06-15
ES263123A1 (en) 1961-06-01
CH408940A (en) 1966-03-15
OA00959A (en) 1968-03-22
SE310887B (en) 1969-05-19
GB972962A (en) 1964-10-21
DE1290143B (en) 1969-03-06
CH408045A (en) 1966-02-28
CY324A (en) 1965-11-03
GB972968A (en) 1964-10-21
DE1288609B (en) 1969-02-06
OA00816A (en) 1967-11-15

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