NZ739573A - Improved methods for the acylation of maytansinol - Google Patents

Improved methods for the acylation of maytansinol

Info

Publication number
NZ739573A
NZ739573A NZ73957313A NZ73957313A NZ739573A NZ 739573 A NZ739573 A NZ 739573A NZ 73957313 A NZ73957313 A NZ 73957313A NZ 73957313 A NZ73957313 A NZ 73957313A NZ 739573 A NZ739573 A NZ 739573A
Authority
NZ
New Zealand
Prior art keywords
maytansinol
acylation
improved methods
amino acid
reaction
Prior art date
Application number
NZ73957313A
Other languages
English (en)
Inventor
Wayne Widdison
Robert Yongxin Zhao
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of NZ739573A publication Critical patent/NZ739573A/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
    • H01R12/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, specially adapted for printed circuits, e.g. printed circuit boards [PCB], flat or ribbon cables, or like generally planar structures, e.g. terminal strips, terminal blocks; Coupling devices specially adapted for printed circuits, flat or ribbon cables, or like generally planar structures; Terminals specially adapted for contact with, or insertion into, printed circuits, flat or ribbon cables, or like generally planar structures
    • H01R12/50—Fixed connections
    • H01R12/51—Fixed connections for rigid printed circuits or like structures
    • H01R12/55—Fixed connections for rigid printed circuits or like structures characterised by the terminals
    • H01R12/58—Fixed connections for rigid printed circuits or like structures characterised by the terminals terminals for insertion into holes
    • H01R12/585—Terminals having a press fit or a compliant portion and a shank passing through a hole in the printed circuit board
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/0201—Thermal arrangements, e.g. for cooling, heating or preventing overheating
    • H05K1/0203—Cooling of mounted components
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/11—Printed elements for providing electric connections to or between printed circuits
    • H05K1/115—Via connections; Lands around holes or via connections
    • H05K1/116—Lands, clearance holes or other lay-out details concerning the surrounding of a via
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/18—Printed circuits structurally associated with non-printed electric components
    • H05K1/181—Printed circuits structurally associated with non-printed electric components associated with surface mounted components

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ73957313A 2012-09-26 2013-09-26 Improved methods for the acylation of maytansinol NZ739573A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261705731P 2012-09-26 2012-09-26
NZ706019A NZ706019A (en) 2012-09-26 2013-09-26 Improved methods for the acylation of maytansinol

Publications (1)

Publication Number Publication Date
NZ739573A true NZ739573A (en) 2019-11-29

Family

ID=49328648

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ73957313A NZ739573A (en) 2012-09-26 2013-09-26 Improved methods for the acylation of maytansinol
NZ706019A NZ706019A (en) 2012-09-26 2013-09-26 Improved methods for the acylation of maytansinol

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ706019A NZ706019A (en) 2012-09-26 2013-09-26 Improved methods for the acylation of maytansinol

Country Status (27)

Country Link
US (9) US9012629B2 (OSRAM)
EP (3) EP2900676B1 (OSRAM)
JP (7) JP6517693B2 (OSRAM)
CN (2) CN104768955B (OSRAM)
AU (4) AU2013323572B2 (OSRAM)
BR (2) BR122021022582B1 (OSRAM)
CA (2) CA2884873C (OSRAM)
CY (2) CY1121415T1 (OSRAM)
DK (2) DK3486248T3 (OSRAM)
ES (2) ES2880754T3 (OSRAM)
HR (2) HRP20190473T1 (OSRAM)
HU (2) HUE055443T2 (OSRAM)
IL (2) IL237899A (OSRAM)
LT (2) LT3486248T (OSRAM)
MX (2) MX366701B (OSRAM)
MY (1) MY169250A (OSRAM)
NZ (2) NZ739573A (OSRAM)
PL (2) PL2900676T3 (OSRAM)
PT (2) PT3486248T (OSRAM)
RS (2) RS58493B1 (OSRAM)
RU (2) RU2765072C2 (OSRAM)
SG (1) SG11201501918UA (OSRAM)
SI (2) SI2900676T1 (OSRAM)
SM (2) SMT202100390T1 (OSRAM)
TR (1) TR201903625T4 (OSRAM)
WO (1) WO2014052537A1 (OSRAM)
ZA (1) ZA201501898B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3486248T (pt) * 2012-09-26 2021-07-12 Immunogen Inc Métodos melhorados para a acilação de maitansinol
CN105585579A (zh) * 2014-10-24 2016-05-18 南京联宁生物制药有限公司 一种化合物及其制备方法以及美登素dm1的制备方法
WO2016149464A1 (en) * 2015-03-17 2016-09-22 Regeneron Pharmaceuticals, Inc. Amino acid acylation reagents and methods of using the same
EP3554544A4 (en) 2016-12-16 2020-07-29 Bluefin Biomedicine, Inc. ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
HUE061695T2 (hu) * 2019-04-18 2023-08-28 Indena Spa Diaszteroszelektív eljárás tiol-vagy diszulfid-tartalmú maytansinoid-észterek elõállítására és köztitermékeik
WO2021107133A1 (ja) 2019-11-29 2021-06-03 日本マイクロバイオファーマ株式会社 メイタンシノールの酵素的生産方法
CN121039142A (zh) 2023-04-28 2025-11-28 中外制药株式会社 用于使用n-羧基氨基酸酐产生含酰胺基团化合物的方法

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US4151042A (en) 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
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US4265814A (en) 1978-03-24 1981-05-05 Takeda Chemical Industries Matansinol 3-n-hexadecanoate
JPS5562090A (en) 1978-10-27 1980-05-10 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164687A (en) 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS5566585A (en) 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS55164685A (en) 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164686A (en) 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US4309428A (en) 1979-07-30 1982-01-05 Takeda Chemical Industries, Ltd. Maytansinoids
JPS5622790A (en) * 1979-07-31 1981-03-03 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
JP3054741B2 (ja) * 1989-09-29 2000-06-19 武田薬品工業株式会社 Ｔａｎ―１３１３およびそのアシル誘導体
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
EP2289549A3 (en) * 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
TWI298067B (en) * 2002-01-31 2008-06-21 Daiso Co Ltd New optically active compound, method for kinetic resolution of carbonic acid derivatives and catalyst thereof
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
AU2004240541B2 (en) * 2003-05-20 2009-08-20 Immunogen, Inc. Improved cytotoxic agents comprising new maytansinoids
JP2007503439A (ja) 2003-08-22 2007-02-22 アクティブバイオティクス インコーポレイティッド リファマイシンアナログおよびそれらの使用法
CN104447992A (zh) 2004-09-23 2015-03-25 健泰科生物技术公司 半胱氨酸改造的抗体和偶联物
ES2539126T3 (es) * 2004-12-09 2015-06-26 Janssen Biotech, Inc. Inmunoconjugados anti integrina, métodos para su producción y su uso
US7301019B2 (en) * 2005-01-21 2007-11-27 Immunogen, Inc. Method for the preparation of maytansinoid esters
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ATE535529T1 (de) * 2005-08-09 2011-12-15 Millennium Pharm Inc Verfahren zur acylierung von maytansinol mit chiralen aminosäuren
TW200837067A (en) * 2006-11-06 2008-09-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
JP2008288289A (ja) 2007-05-16 2008-11-27 Oki Electric Ind Co Ltd 電界効果トランジスタとその製造方法
SG176068A1 (en) 2009-06-03 2011-12-29 Immunogen Inc Conjugation methods
EP2480557A2 (en) * 2009-09-25 2012-08-01 Cadila Healthcare Limited Process for the preparation of rapamycin derivatives
CN103313990B (zh) * 2010-11-17 2016-07-20 基因泰克公司 丙氨酰美登醇抗体偶联物
PT3486248T (pt) 2012-09-26 2021-07-12 Immunogen Inc Métodos melhorados para a acilação de maitansinol

Also Published As

Publication number Publication date
CY1121415T1 (el) 2020-05-29
IL237899A (en) 2017-08-31
SI2900676T1 (sl) 2019-04-30
CN104768955A (zh) 2015-07-08
AU2013323572B2 (en) 2017-12-07
LT2900676T (lt) 2019-03-25
RU2648992C2 (ru) 2018-03-29
WO2014052537A1 (en) 2014-04-03
BR122021022582B1 (pt) 2023-01-10
CN108586487A (zh) 2018-09-28
JP2020180150A (ja) 2020-11-05
JP2020117527A (ja) 2020-08-06
US20240313444A1 (en) 2024-09-19
JP6735000B1 (ja) 2020-08-05
SI3486248T1 (sl) 2021-10-29
ZA201501898B (en) 2019-06-26
HUE055443T2 (hu) 2021-11-29
RU2018109295A3 (OSRAM) 2021-06-24
JP2025098242A (ja) 2025-07-01
PT3486248T (pt) 2021-07-12
HUE043285T2 (hu) 2019-08-28
US20240145953A1 (en) 2024-05-02
MX2019008652A (es) 2019-09-13
US10944190B2 (en) 2021-03-09
TR201903625T4 (tr) 2019-04-22
JP2016500657A (ja) 2016-01-14
IL253988A0 (en) 2017-10-31
JP2018109044A (ja) 2018-07-12
US9796731B2 (en) 2017-10-24
US20190013604A1 (en) 2019-01-10
US20250007192A1 (en) 2025-01-02
RS58493B1 (sr) 2019-04-30
US20170137440A1 (en) 2017-05-18
HK1212341A1 (en) 2016-06-10
MX2015003745A (es) 2015-06-24
JP2022068367A (ja) 2022-05-09
CN104768955B (zh) 2018-04-27
BR112015006505A2 (pt) 2017-07-04
DK3486248T3 (da) 2021-07-12
MX366701B (es) 2019-07-22
US20150191488A1 (en) 2015-07-09
CA2884873C (en) 2021-11-23
CA3133906C (en) 2023-05-02
CA3133906A1 (en) 2014-04-03
SG11201501918UA (en) 2015-05-28
US20200153130A1 (en) 2020-05-14
CY1124337T1 (el) 2022-07-22
AU2018201392B2 (en) 2020-03-12
CN108586487B (zh) 2021-11-05
AU2022201557A1 (en) 2022-03-31
PT2900676T (pt) 2019-03-29
AU2020203823B2 (en) 2021-12-09
BR112015006505B1 (pt) 2022-03-15
ES2880754T3 (es) 2021-11-25
HRP20211030T1 (hr) 2021-10-01
US9012629B2 (en) 2015-04-21
US10461449B2 (en) 2019-10-29
ES2716561T3 (es) 2019-06-13
RU2765072C2 (ru) 2022-01-25
RU2015111635A (ru) 2016-11-20
EP3486248A1 (en) 2019-05-22
EP2900676A1 (en) 2015-08-05
US20140142297A1 (en) 2014-05-22
CA2884873A1 (en) 2014-04-03
MY169250A (en) 2019-03-19
RU2018109295A (ru) 2019-02-26
HRP20190473T1 (hr) 2019-05-03
PL2900676T3 (pl) 2019-06-28
AU2020203823A1 (en) 2020-07-02
RS62075B1 (sr) 2021-07-30
JP6517693B2 (ja) 2019-05-22
IL253988B (en) 2019-02-28
LT3486248T (lt) 2021-08-25
AU2013323572A1 (en) 2015-04-02
US20180099980A1 (en) 2018-04-12
SMT201900170T1 (it) 2019-05-10
NZ706019A (en) 2018-03-23
JP2024010055A (ja) 2024-01-23
AU2018201392A1 (en) 2018-03-15
PL3486248T3 (pl) 2021-10-25
US9469655B2 (en) 2016-10-18
EP3904358A1 (en) 2021-11-03
DK2900676T3 (en) 2019-04-08
SMT202100390T1 (it) 2021-09-14
EP3486248B1 (en) 2021-04-07
EP2900676B1 (en) 2018-12-19
MX390615B (es) 2025-03-20
US10100062B2 (en) 2018-10-16

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