NZ734532A - Genetically modified major histocompatibility complex mice - Google Patents

Genetically modified major histocompatibility complex mice Download PDF

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Publication number
NZ734532A
NZ734532A NZ734532A NZ73453212A NZ734532A NZ 734532 A NZ734532 A NZ 734532A NZ 734532 A NZ734532 A NZ 734532A NZ 73453212 A NZ73453212 A NZ 73453212A NZ 734532 A NZ734532 A NZ 734532A
Authority
NZ
New Zealand
Prior art keywords
human
microglobulin
mouse
mhc
polypeptide
Prior art date
Application number
NZ734532A
Other languages
English (en)
Inventor
Lynn Macdonald
Andrew Murphy
John Mcwhirter
Vera Voronina
Cagan Gurer
Faith Harris
Sean Stevens
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Priority claimed from NZ719373A external-priority patent/NZ719373B2/en
Publication of NZ734532A publication Critical patent/NZ734532A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NZ734532A 2011-10-28 2012-10-26 Genetically modified major histocompatibility complex mice NZ734532A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161552582P 2011-10-28 2011-10-28
US201161552587P 2011-10-28 2011-10-28
US201261700908P 2012-09-14 2012-09-14
NZ719373A NZ719373B2 (en) 2011-10-28 2012-10-26 Genetically modified major histocompatibility complex mice

Publications (1)

Publication Number Publication Date
NZ734532A true NZ734532A (en) 2022-12-23

Family

ID=47178940

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ734532A NZ734532A (en) 2011-10-28 2012-10-26 Genetically modified major histocompatibility complex mice

Country Status (27)

Country Link
US (3) US9615550B2 (OSRAM)
EP (4) EP2770821B1 (OSRAM)
JP (4) JP6154391B2 (OSRAM)
KR (3) KR101921126B1 (OSRAM)
CN (3) CN104039132B9 (OSRAM)
AU (3) AU2012324016C1 (OSRAM)
BR (1) BR112014009259A2 (OSRAM)
CA (2) CA3074400C (OSRAM)
CY (2) CY1119657T1 (OSRAM)
DK (2) DK3262932T3 (OSRAM)
ES (3) ES2651517T3 (OSRAM)
HK (1) HK1249712B (OSRAM)
HR (2) HRP20171761T1 (OSRAM)
HU (2) HUE045879T2 (OSRAM)
IL (3) IL232097A (OSRAM)
LT (2) LT2770821T (OSRAM)
MX (3) MX391222B (OSRAM)
MY (2) MY178723A (OSRAM)
NZ (1) NZ734532A (OSRAM)
PL (2) PL3262932T3 (OSRAM)
PT (2) PT3262932T (OSRAM)
RS (2) RS59082B1 (OSRAM)
SG (2) SG11201400933VA (OSRAM)
SI (2) SI3262932T1 (OSRAM)
SM (2) SMT201900478T1 (OSRAM)
WO (1) WO2013063346A1 (OSRAM)
ZA (1) ZA201403085B (OSRAM)

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Publication number Publication date
HK1249712B (en) 2020-06-26
AU2017279797C1 (en) 2021-07-15
SMT201700576T1 (it) 2018-01-11
US20130111617A1 (en) 2013-05-02
AU2016202688A1 (en) 2016-05-19
CA3074400A1 (en) 2013-05-02
MY178723A (en) 2020-10-20
PL3262932T3 (pl) 2019-10-31
CA3074400C (en) 2025-03-25
EP4311833A3 (en) 2024-05-01
HRP20171761T1 (hr) 2017-12-29
ES2741649T3 (es) 2020-02-11
DK3262932T3 (da) 2019-08-05
NZ623456A (en) 2016-05-27
CY1121869T1 (el) 2020-10-14
ES2962287T3 (es) 2024-03-18
EP2770821B1 (en) 2017-09-13
EP4311833A2 (en) 2024-01-31
AU2017279797A1 (en) 2018-01-25
KR101921126B1 (ko) 2018-11-23
AU2017279797B2 (en) 2020-10-22
CY1119657T1 (el) 2018-04-04
CN107254480A (zh) 2017-10-17
CN107254480B (zh) 2021-08-10
WO2013063346A1 (en) 2013-05-02
KR20140089560A (ko) 2014-07-15
CN104039132B9 (zh) 2017-09-05
JP2020146041A (ja) 2020-09-17
IL261239B (en) 2019-11-28
RS56656B1 (sr) 2018-03-30
IL232097A (en) 2017-06-29
EP3262932B1 (en) 2019-05-15
US20170164590A1 (en) 2017-06-15
EP3563680A1 (en) 2019-11-06
PT3262932T (pt) 2019-08-26
AU2012324016B2 (en) 2016-01-28
BR112014009259A2 (pt) 2020-10-27
CA2850387A1 (en) 2013-05-02
AU2012324016C1 (en) 2018-02-15
IL232097A0 (en) 2014-05-28
MX391222B (es) 2025-03-21
AU2012324016A1 (en) 2013-05-16
JP2014532412A (ja) 2014-12-08
EP2770821A1 (en) 2014-09-03
DK2770821T3 (da) 2017-11-27
SI3262932T1 (sl) 2019-09-30
US9615550B2 (en) 2017-04-11
AU2012324016A8 (en) 2016-03-03
JP2019068857A (ja) 2019-05-09
JP2017143840A (ja) 2017-08-24
MX355725B (es) 2018-04-27
SG10201603188SA (en) 2016-05-30
MX376167B (es) 2025-03-07
KR102074145B1 (ko) 2020-02-07
JP6866409B2 (ja) 2021-04-28
MY164836A (en) 2018-01-30
AU2016202688B2 (en) 2017-09-28
HUE045879T2 (hu) 2020-01-28
HUE035652T2 (en) 2018-05-28
CN104039132B (zh) 2017-06-16
CN113564188A (zh) 2021-10-29
RS59082B1 (sr) 2019-09-30
PT2770821T (pt) 2017-12-18
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