NZ725028A - Membrane-adherent self-assembled systems for treatment of ocular disorders - Google Patents
Membrane-adherent self-assembled systems for treatment of ocular disordersInfo
- Publication number
- NZ725028A NZ725028A NZ725028A NZ72502815A NZ725028A NZ 725028 A NZ725028 A NZ 725028A NZ 725028 A NZ725028 A NZ 725028A NZ 72502815 A NZ72502815 A NZ 72502815A NZ 725028 A NZ725028 A NZ 725028A
- Authority
- NZ
- New Zealand
- Prior art keywords
- delivery system
- present
- liquid crystalline
- alcohol
- nanoparticles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461987012P | 2014-05-01 | 2014-05-01 | |
PCT/US2015/028748 WO2015168523A1 (en) | 2014-05-01 | 2015-05-01 | Membrane-adherent self-assembled systems for treatment of ocular disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ725028A true NZ725028A (en) | 2019-01-25 |
Family
ID=54359368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ725028A NZ725028A (en) | 2014-05-01 | 2015-05-01 | Membrane-adherent self-assembled systems for treatment of ocular disorders |
Country Status (12)
Country | Link |
---|---|
US (2) | US9901544B2 (ko) |
EP (1) | EP3137481B1 (ko) |
JP (1) | JP6452725B2 (ko) |
KR (1) | KR101890503B1 (ko) |
CN (1) | CN106459137B (ko) |
AU (2) | AU2015252908B2 (ko) |
CA (1) | CA2946373C (ko) |
ES (1) | ES2924768T3 (ko) |
MY (1) | MY193694A (ko) |
NZ (1) | NZ725028A (ko) |
SG (1) | SG11201608729RA (ko) |
WO (1) | WO2015168523A1 (ko) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3266446B1 (en) * | 2016-07-07 | 2018-11-21 | Laboratorios SALVAT, S.A. | Ophthalmic composition comprising castor oil and medium chain triglyceride |
WO2018230713A1 (ja) * | 2017-06-16 | 2018-12-20 | 学校法人同志社 | カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用 |
CN110944668A (zh) | 2017-06-16 | 2020-03-31 | 学校法人同志社 | 用于治疗或预防眼部症状、障碍或疾病的包含mTOR抑制剂的药物及其应用 |
EP3643297A4 (en) * | 2017-06-22 | 2021-03-17 | Yonsung Fine Chemical Co., Ltd. | OPHTHALMIC COMPOSITION FOR GLUCOMA TREATMENT |
US11129862B2 (en) | 2017-08-30 | 2021-09-28 | Johnson & Johnson Consumer Inc. | Ophthalmic compositions |
JP7056480B2 (ja) * | 2017-09-08 | 2022-04-19 | ライオン株式会社 | 眼科用組成物及び涙液油層安定化剤 |
CN109316440B (zh) * | 2018-09-29 | 2020-12-29 | 华中科技大学 | 一种温敏性液晶纳米水凝胶及其制备方法与应用 |
WO2020084530A1 (en) * | 2018-10-24 | 2020-04-30 | Ferring B.V. | Mucoadhesive pharmaceutical compositions of corticosteroids |
GB201818043D0 (en) * | 2018-11-05 | 2018-12-19 | Waterford Institute Of Tech | Artifical Tears |
US20210353554A1 (en) * | 2020-05-18 | 2021-11-18 | Max Biology Co. Ltd. | Lipid-polymer compositions and methods of use |
US12016855B2 (en) | 2020-08-26 | 2024-06-25 | Somerset Therapeutics, Llc | Prednisolone and moxifloxacin compositions and methods |
WO2022077060A1 (en) * | 2020-10-13 | 2022-04-21 | University Of South Australia | Antimicrobial compositions and methods of use |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6716830B2 (en) * | 1998-09-30 | 2004-04-06 | Alcon, Inc. | Ophthalmic antibiotic compositions containing moxifloxacin |
PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
JP4049216B2 (ja) * | 2003-05-09 | 2008-02-20 | ポーラ化成工業株式会社 | 液晶構造を有する製剤 |
US20070020299A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
US20050235740A1 (en) * | 2004-04-27 | 2005-10-27 | Guido Desie | Method to improve the quality of dispersion formulations |
WO2006009825A1 (en) * | 2004-06-17 | 2006-01-26 | Virun, Inc. | Compositions comprising a mucoadhesive protein and an active principle for mucosal delivery of said agents |
WO2006062875A1 (en) * | 2004-12-08 | 2006-06-15 | Merck & Co., Inc. | Ophthalmic nanoparticulate formulation of a cyclooxygenase-2 selective inhibitor |
CN101137370B (zh) * | 2005-02-09 | 2014-08-13 | 参天制药株式会社 | 用于治疗疾病或病症的液体制剂 |
US8906392B2 (en) * | 2005-12-16 | 2014-12-09 | University Of Kansas | Nanocluster compositions and methods |
KR20090053892A (ko) * | 2006-07-25 | 2009-05-28 | 오스모티카 코프. | 점안액 |
JP2010064995A (ja) * | 2008-09-12 | 2010-03-25 | Nikko Chemical Co Ltd | 外用消炎鎮痛剤組成物 |
JP5207420B2 (ja) * | 2009-12-25 | 2013-06-12 | 株式会社ケムジェネシス | 低粘度液晶化合物 |
CN101773670A (zh) * | 2009-12-29 | 2010-07-14 | 中山大学 | 一种液晶药物载体 |
JP2012017318A (ja) * | 2010-06-07 | 2012-01-26 | Nikko Chemical Co Ltd | 液晶及びそれを含有する皮膚外用剤 |
US8772273B2 (en) * | 2011-10-04 | 2014-07-08 | Quretino Therapeutics, Inc. | Formulations and uses of retinoic acid receptor selective agonists |
MX2014013315A (es) * | 2012-05-03 | 2015-09-10 | Kala Pharmaceuticals Inc | Nanoparticulas farmaceuticas que muestran la mejora del transporte de la mucosa. |
PT3517541T (pt) * | 2012-05-08 | 2020-08-28 | Nicox Ophthalmics Inc | Forma polimórfica de propionato de fluticasona |
US8765725B2 (en) * | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
-
2015
- 2015-05-01 JP JP2016565482A patent/JP6452725B2/ja active Active
- 2015-05-01 EP EP15785661.8A patent/EP3137481B1/en active Active
- 2015-05-01 AU AU2015252908A patent/AU2015252908B2/en active Active
- 2015-05-01 ES ES15785661T patent/ES2924768T3/es active Active
- 2015-05-01 NZ NZ725028A patent/NZ725028A/en unknown
- 2015-05-01 SG SG11201608729RA patent/SG11201608729RA/en unknown
- 2015-05-01 MY MYPI2016703941A patent/MY193694A/en unknown
- 2015-05-01 WO PCT/US2015/028748 patent/WO2015168523A1/en active Application Filing
- 2015-05-01 CA CA2946373A patent/CA2946373C/en active Active
- 2015-05-01 CN CN201580019868.9A patent/CN106459137B/zh active Active
- 2015-05-01 US US15/308,000 patent/US9901544B2/en active Active
- 2015-05-01 KR KR1020167030513A patent/KR101890503B1/ko active IP Right Grant
-
2018
- 2018-02-27 US US15/906,352 patent/US10603273B2/en active Active
- 2018-03-06 AU AU2018201596A patent/AU2018201596B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2946373A1 (en) | 2015-11-05 |
US9901544B2 (en) | 2018-02-27 |
KR20160147784A (ko) | 2016-12-23 |
SG11201608729RA (en) | 2016-11-29 |
CN106459137A (zh) | 2017-02-22 |
AU2018201596A1 (en) | 2018-03-29 |
US20180185275A1 (en) | 2018-07-05 |
ES2924768T3 (es) | 2022-10-10 |
JP6452725B2 (ja) | 2019-01-16 |
EP3137481A1 (en) | 2017-03-08 |
EP3137481A4 (en) | 2017-12-27 |
EP3137481B1 (en) | 2022-07-06 |
KR101890503B1 (ko) | 2018-08-21 |
US20170049697A1 (en) | 2017-02-23 |
AU2018201596B2 (en) | 2020-02-06 |
JP2017514843A (ja) | 2017-06-08 |
CA2946373C (en) | 2018-07-31 |
US10603273B2 (en) | 2020-03-31 |
MY193694A (en) | 2022-10-25 |
WO2015168523A1 (en) | 2015-11-05 |
CN106459137B (zh) | 2019-04-12 |
AU2015252908A1 (en) | 2016-10-27 |
AU2015252908B2 (en) | 2017-12-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ725028A (en) | Membrane-adherent self-assembled systems for treatment of ocular disorders | |
MX2020012041A (es) | Formulacion farmaceutica. | |
US11376275B2 (en) | Ophthalmic compositions with improved dessication protection and retention | |
JP6832390B2 (ja) | 水性液剤 | |
PH12019550088A1 (en) | Preparation of solid cyclodextrin complexes for ophthalmic active pharmaceutical ingredient delivery | |
JP7055930B2 (ja) | 眼科組成物 | |
CN102784416A (zh) | 一种新型助分娩凝胶及其制备方法和应用 | |
RU2017146716A (ru) | Способ образования наночастиц циклоспорина а/ циклодекстрина | |
KR20170036058A (ko) | 코 적용을 위한 시네올-함유 조성물 | |
JP4751482B2 (ja) | コンタクトレンズ用液剤 | |
JP2006225323A (ja) | 水性外用組成物 | |
JP2006248960A (ja) | 水性外用組成物 | |
JP2022079633A (ja) | 異物感改善用眼科組成物 | |
EP3494970A3 (en) | Hardly soluble therapeutic agents belonging to bcs class ii or iv suspended in the liquid formulation and/or in the final nanofibrous structure | |
CN102772426A (zh) | 壳聚糖作为助分娩润滑剂成分的医药用途 | |
JP6077860B2 (ja) | 液剤 | |
JP2017119693A (ja) | 眼科用組成物及びその製造方法 | |
JP2006206481A (ja) | 水性外用組成物 | |
JP6333023B2 (ja) | 水性医薬組成物 | |
JP6571391B2 (ja) | 水性製剤 | |
CN104606682A (zh) | 一种更昔洛韦眼用制剂及其制备方法 | |
GR1008261B (el) | Συνθεσεις νανοφορεων | |
GR1008332B (el) | Συνθεσεις νανοφορεων | |
CN105232456A (zh) | 丙酸聚六亚甲基胍滴眼液 | |
UA80243U (ru) | Система доставки лекарств |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ERR | Error or correction |
Free format text: THE INVENTOR HAS BEEN CORRECTED TO 3540134, BARMAN, SHIKHA P., 2 BONNIEVALE DRIVEBEDFORD, MASSACHUSETTS 01730, US; 3540135, THEKKEDATH, RITESH V., 335 HUNTINGTON AVENUE, APT #21BOSTON, MASSACHUSETTS 02115, US; 3546668, BARMAN, KOUSHIK, 2 BONNIEVALE DR., BEDFORD, MASSACHUSETTS 01730, US; 3546669, WARD, KEVIN L., 106 CLEREMON AVE., ARLINGTON, MASSACHUSETTS 02476, US; 3546670, CROMWICK, ANNE-MARIE, 11 DONNA RD., SAUGUS, MASSACHUSETTS 01906, US Effective date: 20161125 |
|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAY 2021 BY COMPUTER PACKAGES INC Effective date: 20200418 |
|
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAY 2022 BY COMPUTER PACKAGES INC Effective date: 20210418 |
|
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAY 2023 BY COMPUTER PACKAGES INC Effective date: 20220417 |
|
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 MAY 2024 BY COMPUTER PACKAGES INC Effective date: 20230417 |