NZ706723A - Novel process for making compounds for use in the treatment of cancer - Google Patents

Novel process for making compounds for use in the treatment of cancer

Info

Publication number
NZ706723A
NZ706723A NZ706723A NZ70672313A NZ706723A NZ 706723 A NZ706723 A NZ 706723A NZ 706723 A NZ706723 A NZ 706723A NZ 70672313 A NZ70672313 A NZ 70672313A NZ 706723 A NZ706723 A NZ 706723A
Authority
NZ
New Zealand
Prior art keywords
cancer
treatment
novel process
making compounds
making
Prior art date
Application number
NZ706723A
Other languages
English (en)
Inventor
Sriram Naganathan
Nathan Guz
Matthew Pfeiffer
C Gregory Sowell
Tracy Bostick
Jason Yang
Amit Srivastava
Original Assignee
Exelixis Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Genentech Inc filed Critical Exelixis Inc
Publication of NZ706723A publication Critical patent/NZ706723A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
NZ706723A 2012-10-12 2013-10-14 Novel process for making compounds for use in the treatment of cancer NZ706723A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261713104P 2012-10-12 2012-10-12
PCT/US2013/064866 WO2014059422A1 (en) 2012-10-12 2013-10-14 Novel process for making compounds for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
NZ706723A true NZ706723A (en) 2018-07-27

Family

ID=49474740

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ706723A NZ706723A (en) 2012-10-12 2013-10-14 Novel process for making compounds for use in the treatment of cancer

Country Status (31)

Country Link
US (4) US9771347B2 (en:Method)
EP (1) EP2909188B1 (en:Method)
JP (2) JP6300042B2 (en:Method)
KR (1) KR102204520B1 (en:Method)
CN (2) CN104837826B (en:Method)
AU (1) AU2013328929B2 (en:Method)
BR (1) BR112015008113B1 (en:Method)
CA (1) CA2889466C (en:Method)
CL (1) CL2015000926A1 (en:Method)
CR (2) CR20200237A (en:Method)
EA (1) EA030613B1 (en:Method)
ES (1) ES2671502T3 (en:Method)
GE (1) GEP201706690B (en:Method)
HK (1) HK1213567A1 (en:Method)
HR (1) HRP20180670T1 (en:Method)
IL (1) IL238116B (en:Method)
IN (1) IN2015DN03928A (en:Method)
MA (1) MA38085B1 (en:Method)
MX (2) MX372708B (en:Method)
MY (1) MY186549A (en:Method)
NZ (1) NZ706723A (en:Method)
PE (3) PE20151494A1 (en:Method)
PH (1) PH12015500785B1 (en:Method)
PL (1) PL2909188T3 (en:Method)
SA (1) SA515360271B1 (en:Method)
SG (1) SG11201502795VA (en:Method)
SI (1) SI2909188T1 (en:Method)
TR (1) TR201807861T4 (en:Method)
UA (1) UA115455C2 (en:Method)
WO (1) WO2014059422A1 (en:Method)
ZA (1) ZA201502349B (en:Method)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20151494A1 (es) 2012-10-12 2015-11-06 Exelixis Inc Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
EP3316867B1 (en) 2015-06-30 2021-03-10 Genentech, Inc. Immediate-release tablets containing a drug and processes for forming the tablets
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona
CN105330643B (zh) * 2015-12-09 2017-12-05 苏州明锐医药科技有限公司 卡比替尼的制备方法
CN106045969B (zh) * 2016-05-27 2019-04-12 湖南欧亚药业有限公司 一种卡比替尼的合成方法
CN109689102A (zh) 2016-08-12 2019-04-26 基因泰克公司 Mek抑制剂,pd-1轴抑制剂,和vegf抑制剂的组合疗法
TW201815419A (zh) 2016-09-29 2018-05-01 美商建南德克公司 Mek抑制劑、 pd-1軸抑制劑及紫杉烷之組合療法
WO2020187674A1 (en) 2019-03-15 2020-09-24 Sandoz Ag Crystalline (s)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemisuccinate
US20240173329A1 (en) 2021-03-09 2024-05-30 Genentech, Inc. Belvarafenib for use in treatment of brain cancers
EP4319749A1 (en) 2021-04-06 2024-02-14 Genentech, Inc. Combination therapy with belvarafenib and cobimetinib or with belvarafenib, cobimetinib, and atezolizumab

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1563587A (en) * 1924-09-20 1925-12-01 Raney Murray Method of preparing catalytic material
US1628190A (en) * 1926-05-14 1927-05-10 Raney Murray Method of producing finely-divided nickel
US1915473A (en) * 1930-12-31 1933-06-27 Raney Murray Method of preparing catalytic material
US4510139A (en) 1984-01-06 1985-04-09 Sterling Drug Inc. Substituted aminobenzamides and their use as agents which inhibit lipoxygenase activity
US5155110A (en) 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
WO1995026956A1 (fr) 1994-04-01 1995-10-12 Shionogi & Co., Ltd. Derive d'oxime et bactericide le contenant en tant qu'ingredient actif
WO1997012613A1 (en) 1995-10-05 1997-04-10 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
AU5610398A (en) 1997-02-28 1998-09-18 Warner-Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
DE69836378T2 (de) 1997-07-01 2007-10-11 Warner-Lambert Co. Llc Benzoesäure- und Benzamid-Derivate von Anthranilsäure und ihre Anwendung als MEK-Inhibitoren
US6310060B1 (en) * 1998-06-24 2001-10-30 Warner-Lambert Company 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
HUP0003731A3 (en) 1997-07-01 2002-11-28 Warner Lambert Co 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors
US6974878B2 (en) 2001-03-21 2005-12-13 Symyx Technologies, Inc. Catalyst ligands, catalytic metal complexes and processes using same
TR200101704T2 (tr) 1998-12-15 2001-11-21 Warner-Lambert Company Transplant reddinin engellenmesi için bir MEK inhibitörünün kullanımı
IL143236A0 (en) 1998-12-16 2002-04-21 Warner Lambert Co Treatment of arthritis with mek inhibitors
EE200100339A (et) 1998-12-22 2002-10-15 Warner-Lambert Company Kombineeritud kemoteraapia
KR20000047461A (ko) 1998-12-29 2000-07-25 성재갑 트롬빈 억제제
HUP0104933A3 (en) 1999-01-07 2003-12-29 Warner Lambert Co Antiviral method using mek inhibitors
US6696440B1 (en) 1999-01-07 2004-02-24 Warner-Lambert Company Treatment of asthma with MEK inhibitors
NZ513433A (en) 1999-01-13 2003-05-30 Warner Lambert Co Benzoheterocycles, their use as MEK inhibitors and use in treating proliferative diseases such as cancer
BR9916857A (pt) 1999-01-13 2001-12-04 Warner Lambert Co 4 heteroaril diarilaminas
CA2348236A1 (en) 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
EP1144371B1 (en) 1999-01-13 2005-11-09 Warner-Lambert Company Llc Benzenesulphonamide derivatives and their use as mek inhibitors
PL348870A1 (en) 1999-01-13 2002-06-17 Warner Lambert Co 1-heterocycle substituted diarylamines
EP1202726A2 (en) 1999-07-16 2002-05-08 Warner-Lambert Company Llc Method for treating chronic pain using mek inhibitors
DK1202724T3 (da) 1999-07-16 2004-01-26 Warner Lambert Co Fremgangsmåde til behandling af kronisk smerte under anvendelse af mek-inhibitorer
JP2003504398A (ja) 1999-07-16 2003-02-04 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤を用いた慢性疼痛の治療方法
JP2003504399A (ja) 1999-07-16 2003-02-04 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤を用いる慢性疼痛の治療方法
KR100760434B1 (ko) 1999-09-17 2007-10-04 밀레니엄 파머슈티컬스 인코퍼레이티드 벤즈아미드 및 관련된 Ｘａ 인자의 억제제
WO2001068619A1 (en) 2000-03-15 2001-09-20 Warner-Lambert Company 5-amide substituted diarylamines as mex inhibitors
AR033517A1 (es) 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
NZ524120A (en) 2000-07-19 2005-08-26 Warner Lambert Co Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
CZ2003477A3 (cs) * 2000-08-25 2003-10-15 Warner - Lambert Company Llc Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
IL149462A0 (en) 2001-05-09 2002-11-10 Warner Lambert Co Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
US20040039208A1 (en) * 2001-07-20 2004-02-26 Chen Michael Huai Gu Process for making n-aryl-anthranilic acids and their derivatives
DE10141266A1 (de) 2001-08-21 2003-03-06 Syntec Ges Fuer Chemie Und Tec Elektrolumineszierende Derivate der 2,5-Diamino-terephthalsäure und deren Verwendung in organischen Leuchtdioden
US7085492B2 (en) 2001-08-27 2006-08-01 Ibsen Photonics A/S Wavelength division multiplexed device
CN1568184A (zh) 2001-10-31 2005-01-19 辉瑞产品公司 烟碱乙酰胆碱受体激动剂在治疗多动腿综合征中的用途
WO2003062191A1 (en) 2002-01-23 2003-07-31 Warner-Lambert Company Llc N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
DOP2003000556A (es) 2002-01-23 2003-10-31 Warner Lambert Co Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico.
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
PL401637A1 (pl) 2002-03-13 2013-05-27 Array Biopharma Inc. N3 alkilowane pochodne benzimidazolu jako inhibitory MEK
UA76837C2 (uk) 2002-03-13 2006-09-15 Еррей Байофарма Інк. N3 алкіловані похідні бензімідазолу як інгібітори мек
CA2488567A1 (en) 2002-06-11 2003-12-18 Merck & Co., Inc. (halo-benzo carbonyl)heterobicyclic p38 kinase inhibiting agents
GB0214268D0 (en) 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
AU2003248813A1 (en) 2002-07-05 2004-01-23 Beth Israel Deaconess Medical Center Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms
US20050004186A1 (en) 2002-12-20 2005-01-06 Pfizer Inc MEK inhibiting compounds
EP1606283B1 (en) 2003-03-03 2008-10-08 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
TW200505834A (en) 2003-03-18 2005-02-16 Sankyo Co Sulfamide derivative and the pharmaceutical composition thereof
JP2005162727A (ja) 2003-03-18 2005-06-23 Sankyo Co Ltd スルファミド誘導体及びその医薬組成物
GB0308185D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
WO2004113347A1 (en) 2003-06-20 2004-12-29 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
WO2005000818A1 (en) 2003-06-27 2005-01-06 Warner-Lambert Company Llc 5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors
US20050049276A1 (en) 2003-07-23 2005-03-03 Warner-Lambert Company, Llc Imidazopyridines and triazolopyridines
DE602004023207D1 (de) 2003-07-24 2009-10-29 Warner Lambert Co Benzimidazol-derivate als mek-hemmer
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US8084645B2 (en) 2003-09-19 2011-12-27 Chugai Seiyaku Kabushiki Kaisha 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
CA2545659C (en) 2003-11-19 2013-06-04 Array Biopharma Inc. Bicyclic inhibitors of mek
WO2005058887A1 (en) 2003-12-08 2005-06-30 F. Hoffmann-La Roche Ag Novel thiazole derivates
TWI361066B (en) 2004-07-26 2012-04-01 Chugai Pharmaceutical Co Ltd 5-substituted-2-phenylamino benzamides as mek inhibitors
BRPI0518192B8 (pt) * 2004-10-20 2021-05-25 Applied Res Systems Ars Holding N V derivados de 3-arilamino piridina, seu uso e seu processo de fabricação, e composição farmacêutica
WO2006061712A2 (en) 2004-12-10 2006-06-15 Pfizer Inc. Use of mek inhibitors in treating abnormal cell growth
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
CA2927656C (en) 2005-10-07 2019-09-24 Exelixis, Inc. Mek inhibitors and methods of their use
CA2658725A1 (en) 2006-08-16 2008-02-21 Exelixis, Inc. Using pi3k and mek modulators in treatments of cancer
US7999006B2 (en) * 2006-12-14 2011-08-16 Exelixis, Inc. Methods of using MEK inhibitors
PE20151494A1 (es) 2012-10-12 2015-11-06 Exelixis Inc Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer
AU2014381760B2 (en) 2014-02-07 2018-08-02 Sumitomo Chemical Company, Limited Method for producing (R)-1,1,3-trimethyl-4-aminoindane
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona

Also Published As

Publication number Publication date
PH12015500785A1 (en) 2015-06-15
US10793541B2 (en) 2020-10-06
SI2909188T1 (en) 2018-07-31
ES2671502T3 (es) 2018-06-06
PE20151494A1 (es) 2015-11-06
US9771347B2 (en) 2017-09-26
CA2889466A1 (en) 2014-04-17
WO2014059422A1 (en) 2014-04-17
US20170349569A1 (en) 2017-12-07
HK1213878A1 (en) 2016-07-15
AU2013328929A1 (en) 2015-04-30
CL2015000926A1 (es) 2015-08-28
MA38085A1 (fr) 2018-08-31
AU2013328929B2 (en) 2018-01-04
EP2909188A1 (en) 2015-08-26
PH12015500785B1 (en) 2015-06-15
US10239858B2 (en) 2019-03-26
CN104837826B (zh) 2018-07-27
KR102204520B1 (ko) 2021-01-20
CN108948043B (zh) 2021-05-04
EA201590700A1 (ru) 2015-09-30
MX2015004660A (es) 2015-08-07
HK1213567A1 (zh) 2016-07-08
JP2015533175A (ja) 2015-11-19
SA515360271B1 (ar) 2016-05-19
CN108948043A (zh) 2018-12-07
HRP20180670T1 (hr) 2018-07-13
US11414396B2 (en) 2022-08-16
PL2909188T3 (pl) 2018-08-31
MX372708B (es) 2020-05-29
JP6300042B2 (ja) 2018-03-28
PE20200387A1 (es) 2020-02-24
GEP201706690B (en) 2017-06-26
CR20150245A (es) 2015-11-19
CN104837826A (zh) 2015-08-12
BR112015008113B1 (pt) 2022-05-24
US20190185447A1 (en) 2019-06-20
UA115455C2 (uk) 2017-11-10
KR20150067339A (ko) 2015-06-17
US20150210668A1 (en) 2015-07-30
SG11201502795VA (en) 2015-05-28
MX2020005533A (es) 2020-10-12
ZA201502349B (en) 2019-12-18
IL238116B (en) 2018-06-28
MA38085B1 (fr) 2018-11-30
BR112015008113A2 (pt) 2017-07-04
EP2909188B1 (en) 2018-03-07
CR20200237A (es) 2020-07-26
PE20191818A1 (es) 2019-12-27
US20200392104A1 (en) 2020-12-17
EA030613B1 (ru) 2018-08-31
TR201807861T4 (tr) 2018-06-21
MY186549A (en) 2021-07-26
CA2889466C (en) 2021-09-14
JP2018052973A (ja) 2018-04-05
IN2015DN03928A (en:Method) 2015-10-02

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