NZ602025A - Tricyclic indole derivatives as pbr ligands - Google Patents
Tricyclic indole derivatives as pbr ligandsInfo
- Publication number
- NZ602025A NZ602025A NZ602025A NZ60202511A NZ602025A NZ 602025 A NZ602025 A NZ 602025A NZ 602025 A NZ602025 A NZ 602025A NZ 60202511 A NZ60202511 A NZ 60202511A NZ 602025 A NZ602025 A NZ 602025A
- Authority
- NZ
- New Zealand
- Prior art keywords
- subject
- pet
- tracer
- pbr
- carbazole
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 238000002600 positron emission tomography Methods 0.000 abstract 5
- 239000000700 radioactive tracer Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- ZVDVQPLDTTXLKI-GJQNQZCXSA-N n,n-diethyl-9-(2-fluoranylethyl)-5-methoxy-1,2,3,4-tetrahydrocarbazole-4-carboxamide Chemical compound C12=C(OC)C=CC=C2N(CC[18F])C2=C1C(C(=O)N(CC)CC)CCC2 ZVDVQPLDTTXLKI-GJQNQZCXSA-N 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 238000012879 PET imaging Methods 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
- OOFPLRZRMPMRMB-UHFFFAOYSA-N n,n-diethyl-9-(2-hydroxyethyl)-5-methoxy-1,2,3,4-tetrahydrocarbazole-4-carboxamide Chemical compound C12=C(OC)C=CC=C2N(CCO)C2=C1C(C(=O)N(CC)CC)CCC2 OOFPLRZRMPMRMB-UHFFFAOYSA-N 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 150000008648 triflates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nuclear Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2010/053998 WO2010109007A2 (en) | 2009-03-27 | 2010-03-26 | Indole derivatives |
| IN1824DE2010 | 2010-08-02 | ||
| GBGB1015203.1A GB201015203D0 (en) | 2010-03-26 | 2010-09-13 | Active enantiomer |
| US12/880,218 US8501153B2 (en) | 2009-03-27 | 2010-09-13 | Active enantiomer |
| PCT/EP2011/054744 WO2011117421A1 (en) | 2010-03-26 | 2011-03-28 | Tricyclic indole derivatives as pbr ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ602025A true NZ602025A (en) | 2014-08-29 |
Family
ID=44259848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ602025A NZ602025A (en) | 2010-03-26 | 2011-03-28 | Tricyclic indole derivatives as pbr ligands |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP2552891B1 (enExample) |
| JP (1) | JP5830519B2 (enExample) |
| KR (1) | KR101886879B1 (enExample) |
| CN (1) | CN102834379B (enExample) |
| AU (1) | AU2011231508B2 (enExample) |
| BR (1) | BR112012021579A2 (enExample) |
| CA (1) | CA2792394C (enExample) |
| ES (1) | ES2688574T3 (enExample) |
| IL (1) | IL221510A (enExample) |
| MX (1) | MX2012010954A (enExample) |
| NZ (1) | NZ602025A (enExample) |
| RU (1) | RU2551423C2 (enExample) |
| SG (1) | SG183837A1 (enExample) |
| WO (1) | WO2011117421A1 (enExample) |
| ZA (1) | ZA201208067B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2946159B2 (ja) | 1993-04-01 | 1999-09-06 | 高浜工業株式会社 | 瓦焼成用のスペ−サ装着装置 |
| GB201016038D0 (en) * | 2010-09-24 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method |
| GB201016411D0 (en) | 2010-09-30 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method for cancer |
| BR112015012138A2 (pt) * | 2012-11-30 | 2017-07-11 | Ge Healthcare Ltd | composição, método para obtenção de uma composição, método de formação de imagem in vivo, e, kit |
| GB201312768D0 (en) * | 2013-07-17 | 2013-08-28 | Ge Healthcare Ltd | Work-up procedure |
| GB201316764D0 (en) * | 2013-09-20 | 2013-11-06 | Ge Healthcare Ltd | Novel compounds |
| US10660966B2 (en) | 2014-12-04 | 2020-05-26 | Ge Healthcare Limited | Method for removing acetaldehyde |
| CN106748802B (zh) * | 2016-12-26 | 2018-11-13 | 南京理工大学 | 一种制备含氟仲胺的方法 |
| CN114085221B (zh) * | 2021-11-29 | 2022-12-09 | 暨南大学 | 含氮杂环化合物、标记的含氮杂环化合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2599740B1 (fr) * | 1986-06-05 | 1988-08-12 | Rhone Poulenc Sante | Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant |
| FR2788776B1 (fr) * | 1999-01-26 | 2001-02-23 | Synthelabo | Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique |
| US7160909B2 (en) | 2001-08-09 | 2007-01-09 | Eli Lilly And Company | Cyclopenta[b]indole derivatives as sPLA2 inhibitors |
| GB0523506D0 (en) * | 2005-11-18 | 2005-12-28 | Hammersmith Imanet Ltd | Novel in vivo imaging compounds |
| BRPI0716583A2 (pt) * | 2006-08-24 | 2013-10-01 | Australian Nuclear Science Tec | ligandos fluorados para marcar recptores de benzodiazepina perifÉricos |
| GB0905328D0 (en) * | 2009-03-27 | 2009-05-13 | Ge Healthcare Ltd | Indole derivatives |
-
2011
- 2011-03-28 EP EP11710228.5A patent/EP2552891B1/en active Active
- 2011-03-28 BR BR112012021579A patent/BR112012021579A2/pt not_active IP Right Cessation
- 2011-03-28 KR KR1020127025137A patent/KR101886879B1/ko active Active
- 2011-03-28 CA CA2792394A patent/CA2792394C/en active Active
- 2011-03-28 MX MX2012010954A patent/MX2012010954A/es active IP Right Grant
- 2011-03-28 SG SG2012064382A patent/SG183837A1/en unknown
- 2011-03-28 AU AU2011231508A patent/AU2011231508B2/en active Active
- 2011-03-28 WO PCT/EP2011/054744 patent/WO2011117421A1/en not_active Ceased
- 2011-03-28 CN CN201180016200.0A patent/CN102834379B/zh active Active
- 2011-03-28 RU RU2012141697/04A patent/RU2551423C2/ru active
- 2011-03-28 JP JP2013500538A patent/JP5830519B2/ja active Active
- 2011-03-28 NZ NZ602025A patent/NZ602025A/en unknown
- 2011-03-28 ES ES11710228.5T patent/ES2688574T3/es active Active
-
2012
- 2012-08-16 IL IL221510A patent/IL221510A/en not_active IP Right Cessation
- 2012-10-25 ZA ZA2012/08067A patent/ZA201208067B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2012141697A (ru) | 2014-05-10 |
| CA2792394C (en) | 2018-04-24 |
| AU2011231508A1 (en) | 2012-10-04 |
| KR20130018711A (ko) | 2013-02-25 |
| CN102834379B (zh) | 2014-12-24 |
| KR101886879B1 (ko) | 2018-08-08 |
| EP2552891A1 (en) | 2013-02-06 |
| CA2792394A1 (en) | 2011-09-29 |
| WO2011117421A1 (en) | 2011-09-29 |
| IL221510A0 (en) | 2012-12-02 |
| MX2012010954A (es) | 2012-11-23 |
| BR112012021579A2 (pt) | 2019-09-24 |
| ES2688574T3 (es) | 2018-11-05 |
| HK1179946A1 (en) | 2013-10-11 |
| ZA201208067B (en) | 2014-03-26 |
| AU2011231508B2 (en) | 2014-07-31 |
| SG183837A1 (en) | 2012-10-30 |
| CN102834379A (zh) | 2012-12-19 |
| JP2013523621A (ja) | 2013-06-17 |
| IL221510A (en) | 2016-02-29 |
| EP2552891B1 (en) | 2018-08-08 |
| RU2551423C2 (ru) | 2015-05-27 |
| JP5830519B2 (ja) | 2015-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ602025A (en) | Tricyclic indole derivatives as pbr ligands | |
| WO2008098112A3 (en) | Positron emission tomography imaging method | |
| NZ590923A (en) | Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment | |
| PH12013500270A1 (en) | Peptide radiotracer compositions | |
| MX2012006406A (es) | Anticuerpos multiespecificos, analogos de anticuerpo, composiciones y metodos. | |
| NZ595227A (en) | Tricyclic indole derivates as pbr ligands | |
| RU2013111163A (ru) | Способ in vivo визуализации рака | |
| EP2291075A4 (en) | PEPTIDE COMPOUNDS RELEASING GASTRIN | |
| BR112014010818A2 (pt) | método para preparar complexo de polipeptídeo fisiologicamente ativo | |
| RU2014102944A (ru) | Композиция вакцины для трансдермального или трансмукозального введения | |
| WO2010037851A3 (en) | Indole derivatives suitable for imaging neuroinflammation | |
| Shaghaghi et al. | Current development of sigma-2 receptor radioligands as potential tumor imaging agents | |
| WO2012149552A3 (en) | Dual-isotope positron emitting tomography for disease evaluation | |
| WO2009025914A3 (en) | Radiolabelled fluorobenzamide analogues, their synthesis and use in diagnostic imaging | |
| WO2010127054A3 (en) | Imaging tumor perfusion, and oxidative metabolism using dynamic ace pet in patients with head and neck cancer during radiotherapy | |
| US20160256578A1 (en) | Diagnostic agent for therapeutic effect on cancer | |
| CO6300936A2 (es) | Procedimiento para revertir la remodelacion cardiaca electrofisiologica de un animal con cardiopatia usando beta-adrenoceptores | |
| Monazzam et al. | Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake | |
| MX2013012795A (es) | Procursores novedosos de derivados de glutamato. | |
| NZ708849A (en) | Radiopharmaceutical products for diagnosis and therapy of adrenal carcinoma | |
| WO2014118815A3 (en) | Intraoperative detection of tumor residues using beta- radiation and corresponding probes | |
| MX336321B (es) | 99mtc-tat-bombesina como un nuevo radiofarmaco para la deteccion temprana de cancer de mama. | |
| WO2010013139A3 (en) | Radionuclide-labeled erlotinib | |
| JP2013514319A5 (enExample) | ||
| Liu et al. | Simple automated radiosynthesis of 10-[11C] methoxy-20 (S)-camptothecin and biodistribution in normal mice |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2016 BY COMPUTER PACKAGES INC Effective date: 20150303 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2017 BY COMPUTER PACKAGES INC Effective date: 20160301 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2018 BY COMPUTER PACKAGES INC Effective date: 20170302 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2019 BY COMPUTER PACKAGES INC Effective date: 20180302 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2020 BY ANAQUA SERVICES Effective date: 20190219 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2021 BY ANAQUA SERVICES Effective date: 20200219 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2022 BY ANAQUA SERVICES Effective date: 20210217 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2023 BY ANAQUA SERVICES Effective date: 20220218 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2024 BY ANAQUA SERVICES Effective date: 20230222 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2025 BY ANAQUA SERVICES Effective date: 20240220 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 MAR 2026 BY ANAQUA SERVICES Effective date: 20250219 |