NZ602025A - Tricyclic indole derivatives as pbr ligands - Google Patents

Tricyclic indole derivatives as pbr ligands

Info

Publication number
NZ602025A
NZ602025A NZ602025A NZ60202511A NZ602025A NZ 602025 A NZ602025 A NZ 602025A NZ 602025 A NZ602025 A NZ 602025A NZ 60202511 A NZ60202511 A NZ 60202511A NZ 602025 A NZ602025 A NZ 602025A
Authority
NZ
New Zealand
Prior art keywords
subject
pet
tracer
pbr
carbazole
Prior art date
Application number
NZ602025A
Other languages
English (en)
Inventor
Umamaheshwar Mokkapati
Joanna Marie Passmore
William John Trigg
Steven Michael Fairway
Bo Shan
Radha Achanath
Harry John Wadsworth
Srinath Balaji
Dennis O’Shea
Dimitrios Mantzilas
Mohamed Afsal Mohammed Kadavilpparampu
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2010/053998 external-priority patent/WO2010109007A2/en
Priority claimed from GBGB1015203.1A external-priority patent/GB201015203D0/en
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of NZ602025A publication Critical patent/NZ602025A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nuclear Medicine (AREA)
NZ602025A 2010-03-26 2011-03-28 Tricyclic indole derivatives as pbr ligands NZ602025A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/EP2010/053998 WO2010109007A2 (en) 2009-03-27 2010-03-26 Indole derivatives
IN1824DE2010 2010-08-02
US12/880,218 US8501153B2 (en) 2009-03-27 2010-09-13 Active enantiomer
GBGB1015203.1A GB201015203D0 (en) 2010-03-26 2010-09-13 Active enantiomer
PCT/EP2011/054744 WO2011117421A1 (en) 2010-03-26 2011-03-28 Tricyclic indole derivatives as pbr ligands

Publications (1)

Publication Number Publication Date
NZ602025A true NZ602025A (en) 2014-08-29

Family

ID=44259848

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ602025A NZ602025A (en) 2010-03-26 2011-03-28 Tricyclic indole derivatives as pbr ligands

Country Status (15)

Country Link
EP (1) EP2552891B1 (enExample)
JP (1) JP5830519B2 (enExample)
KR (1) KR101886879B1 (enExample)
CN (1) CN102834379B (enExample)
AU (1) AU2011231508B2 (enExample)
BR (1) BR112012021579A2 (enExample)
CA (1) CA2792394C (enExample)
ES (1) ES2688574T3 (enExample)
IL (1) IL221510A (enExample)
MX (1) MX2012010954A (enExample)
NZ (1) NZ602025A (enExample)
RU (1) RU2551423C2 (enExample)
SG (1) SG183837A1 (enExample)
WO (1) WO2011117421A1 (enExample)
ZA (1) ZA201208067B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2946159B2 (ja) 1993-04-01 1999-09-06 高浜工業株式会社 瓦焼成用のスペ−サ装着装置
GB201016038D0 (en) 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) * 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
RU2015118217A (ru) * 2012-11-30 2017-01-11 ДжиИ ХЕЛТКЕР ЛИМИТЕД Способ кристаллизации трициклических индольных производных
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
GB201316764D0 (en) * 2013-09-20 2013-11-06 Ge Healthcare Ltd Novel compounds
KR102668112B1 (ko) 2014-12-04 2024-05-23 지이 헬쓰케어 리미티드 방사성 약제로부터의 아세트알데히드의 제거 방법
CN106748802B (zh) * 2016-12-26 2018-11-13 南京理工大学 一种制备含氟仲胺的方法
CN114085221B (zh) * 2021-11-29 2022-12-09 暨南大学 含氮杂环化合物、标记的含氮杂环化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2599740B1 (fr) * 1986-06-05 1988-08-12 Rhone Poulenc Sante Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
JP2005527464A (ja) 2001-08-09 2005-09-15 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体
GB0523506D0 (en) * 2005-11-18 2005-12-28 Hammersmith Imanet Ltd Novel in vivo imaging compounds
BRPI0716583A2 (pt) * 2006-08-24 2013-10-01 Australian Nuclear Science Tec ligandos fluorados para marcar recptores de benzodiazepina perifÉricos
GB0905328D0 (en) * 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives

Also Published As

Publication number Publication date
WO2011117421A1 (en) 2011-09-29
EP2552891A1 (en) 2013-02-06
BR112012021579A2 (pt) 2019-09-24
SG183837A1 (en) 2012-10-30
IL221510A0 (en) 2012-12-02
CN102834379B (zh) 2014-12-24
ZA201208067B (en) 2014-03-26
MX2012010954A (es) 2012-11-23
CA2792394C (en) 2018-04-24
CN102834379A (zh) 2012-12-19
RU2551423C2 (ru) 2015-05-27
HK1179946A1 (en) 2013-10-11
EP2552891B1 (en) 2018-08-08
RU2012141697A (ru) 2014-05-10
AU2011231508A1 (en) 2012-10-04
ES2688574T3 (es) 2018-11-05
KR101886879B1 (ko) 2018-08-08
CA2792394A1 (en) 2011-09-29
JP2013523621A (ja) 2013-06-17
IL221510A (en) 2016-02-29
JP5830519B2 (ja) 2015-12-09
KR20130018711A (ko) 2013-02-25
AU2011231508B2 (en) 2014-07-31

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