IL221510A - Tricyclic indole annulus as ligandes pbr - Google Patents
Tricyclic indole annulus as ligandes pbrInfo
- Publication number
- IL221510A IL221510A IL221510A IL22151012A IL221510A IL 221510 A IL221510 A IL 221510A IL 221510 A IL221510 A IL 221510A IL 22151012 A IL22151012 A IL 22151012A IL 221510 A IL221510 A IL 221510A
- Authority
- IL
- Israel
- Prior art keywords
- indole derivatives
- tricyclic indole
- pbr ligands
- pbr
- ligands
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nuclear Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2010/053998 WO2010109007A2 (en) | 2009-03-27 | 2010-03-26 | Indole derivatives |
| IN1824DE2010 | 2010-08-02 | ||
| US12/880,218 US8501153B2 (en) | 2009-03-27 | 2010-09-13 | Active enantiomer |
| GBGB1015203.1A GB201015203D0 (en) | 2010-03-26 | 2010-09-13 | Active enantiomer |
| PCT/EP2011/054744 WO2011117421A1 (en) | 2010-03-26 | 2011-03-28 | Tricyclic indole derivatives as pbr ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL221510A0 IL221510A0 (en) | 2012-12-02 |
| IL221510A true IL221510A (en) | 2016-02-29 |
Family
ID=44259848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL221510A IL221510A (en) | 2010-03-26 | 2012-08-16 | Tricyclic indole annulus as ligandes pbr |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP2552891B1 (enExample) |
| JP (1) | JP5830519B2 (enExample) |
| KR (1) | KR101886879B1 (enExample) |
| CN (1) | CN102834379B (enExample) |
| AU (1) | AU2011231508B2 (enExample) |
| BR (1) | BR112012021579A2 (enExample) |
| CA (1) | CA2792394C (enExample) |
| ES (1) | ES2688574T3 (enExample) |
| IL (1) | IL221510A (enExample) |
| MX (1) | MX2012010954A (enExample) |
| NZ (1) | NZ602025A (enExample) |
| RU (1) | RU2551423C2 (enExample) |
| SG (1) | SG183837A1 (enExample) |
| WO (1) | WO2011117421A1 (enExample) |
| ZA (1) | ZA201208067B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2946159B2 (ja) | 1993-04-01 | 1999-09-06 | 高浜工業株式会社 | 瓦焼成用のスペ−サ装着装置 |
| GB201016038D0 (en) | 2010-09-24 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method |
| GB201016411D0 (en) | 2010-09-30 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method for cancer |
| US10709798B2 (en) | 2012-11-30 | 2020-07-14 | Ge Healthcare Limited | Crystallization process of tricyclic indole derivatives |
| GB201312768D0 (en) * | 2013-07-17 | 2013-08-28 | Ge Healthcare Ltd | Work-up procedure |
| GB201316764D0 (en) * | 2013-09-20 | 2013-11-06 | Ge Healthcare Ltd | Novel compounds |
| EP3226884B1 (en) | 2014-12-04 | 2021-02-17 | GE Healthcare Limited | Method of removing acetaldehyde from radioactive pharmaceuticals |
| CN106748802B (zh) * | 2016-12-26 | 2018-11-13 | 南京理工大学 | 一种制备含氟仲胺的方法 |
| CN114085221B (zh) * | 2021-11-29 | 2022-12-09 | 暨南大学 | 含氮杂环化合物、标记的含氮杂环化合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2599740B1 (fr) * | 1986-06-05 | 1988-08-12 | Rhone Poulenc Sante | Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant |
| FR2788776B1 (fr) * | 1999-01-26 | 2001-02-23 | Synthelabo | Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique |
| JP2005527464A (ja) | 2001-08-09 | 2005-09-15 | イーライ・リリー・アンド・カンパニー | ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体 |
| GB0523506D0 (en) * | 2005-11-18 | 2005-12-28 | Hammersmith Imanet Ltd | Novel in vivo imaging compounds |
| WO2008022396A1 (en) * | 2006-08-24 | 2008-02-28 | Australian Nuclear Science & Technology Organisation | Fluorinated ligands for targeting peripheral benzodiazepine receptors |
| GB0905328D0 (en) * | 2009-03-27 | 2009-05-13 | Ge Healthcare Ltd | Indole derivatives |
-
2011
- 2011-03-28 BR BR112012021579A patent/BR112012021579A2/pt not_active IP Right Cessation
- 2011-03-28 EP EP11710228.5A patent/EP2552891B1/en active Active
- 2011-03-28 NZ NZ602025A patent/NZ602025A/en unknown
- 2011-03-28 ES ES11710228.5T patent/ES2688574T3/es active Active
- 2011-03-28 CA CA2792394A patent/CA2792394C/en active Active
- 2011-03-28 SG SG2012064382A patent/SG183837A1/en unknown
- 2011-03-28 MX MX2012010954A patent/MX2012010954A/es active IP Right Grant
- 2011-03-28 JP JP2013500538A patent/JP5830519B2/ja active Active
- 2011-03-28 WO PCT/EP2011/054744 patent/WO2011117421A1/en not_active Ceased
- 2011-03-28 RU RU2012141697/04A patent/RU2551423C2/ru active
- 2011-03-28 AU AU2011231508A patent/AU2011231508B2/en active Active
- 2011-03-28 KR KR1020127025137A patent/KR101886879B1/ko active Active
- 2011-03-28 CN CN201180016200.0A patent/CN102834379B/zh active Active
-
2012
- 2012-08-16 IL IL221510A patent/IL221510A/en not_active IP Right Cessation
- 2012-10-25 ZA ZA2012/08067A patent/ZA201208067B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012010954A (es) | 2012-11-23 |
| AU2011231508A1 (en) | 2012-10-04 |
| CN102834379A (zh) | 2012-12-19 |
| KR101886879B1 (ko) | 2018-08-08 |
| RU2551423C2 (ru) | 2015-05-27 |
| CN102834379B (zh) | 2014-12-24 |
| ZA201208067B (en) | 2014-03-26 |
| ES2688574T3 (es) | 2018-11-05 |
| JP5830519B2 (ja) | 2015-12-09 |
| IL221510A0 (en) | 2012-12-02 |
| SG183837A1 (en) | 2012-10-30 |
| NZ602025A (en) | 2014-08-29 |
| CA2792394A1 (en) | 2011-09-29 |
| CA2792394C (en) | 2018-04-24 |
| AU2011231508B2 (en) | 2014-07-31 |
| JP2013523621A (ja) | 2013-06-17 |
| WO2011117421A1 (en) | 2011-09-29 |
| RU2012141697A (ru) | 2014-05-10 |
| EP2552891B1 (en) | 2018-08-08 |
| KR20130018711A (ko) | 2013-02-25 |
| EP2552891A1 (en) | 2013-02-06 |
| BR112012021579A2 (pt) | 2019-09-24 |
| HK1179946A1 (en) | 2013-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |