NZ598643A - Sustituted ( heteroarylmethyl ) thiohydantoins as anticancer drugs - Google Patents

Sustituted ( heteroarylmethyl ) thiohydantoins as anticancer drugs

Info

Publication number
NZ598643A
NZ598643A NZ598643A NZ59864310A NZ598643A NZ 598643 A NZ598643 A NZ 598643A NZ 598643 A NZ598643 A NZ 598643A NZ 59864310 A NZ59864310 A NZ 59864310A NZ 598643 A NZ598643 A NZ 598643A
Authority
NZ
New Zealand
Prior art keywords
thioxoimidazolidin
benzonitrile
pyridin
oxo
trifluoromethyl
Prior art date
Application number
NZ598643A
Other languages
English (en)
Inventor
Ulrich Lucking
Arwed Cleve
Bernard Haendler
Gimenez Hortensia Faus
Silke Kohr
Horst Irlbacher
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of NZ598643A publication Critical patent/NZ598643A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NZ598643A 2009-09-11 2010-08-28 Sustituted ( heteroarylmethyl ) thiohydantoins as anticancer drugs NZ598643A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09075421 2009-09-11
EP10075069 2010-02-17
PCT/EP2010/005297 WO2011029537A1 (en) 2009-09-11 2010-08-28 Sustituted ( heteroarylmethyl ) thiohydantoins as anticancer drugs

Publications (1)

Publication Number Publication Date
NZ598643A true NZ598643A (en) 2013-10-25

Family

ID=42782041

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ598643A NZ598643A (en) 2009-09-11 2010-08-28 Sustituted ( heteroarylmethyl ) thiohydantoins as anticancer drugs

Country Status (28)

Country Link
US (1) US20120251551A1 (OSRAM)
EP (1) EP2475653A1 (OSRAM)
JP (1) JP2013504523A (OSRAM)
KR (1) KR20120065396A (OSRAM)
CN (1) CN102639523A (OSRAM)
AR (1) AR078166A1 (OSRAM)
AU (1) AU2010294588A1 (OSRAM)
BR (1) BR112012005526A2 (OSRAM)
CA (1) CA2773591A1 (OSRAM)
CL (1) CL2012000623A1 (OSRAM)
CO (1) CO6511228A2 (OSRAM)
CR (1) CR20120113A (OSRAM)
CU (1) CU20120042A7 (OSRAM)
DO (1) DOP2012000063A (OSRAM)
EA (1) EA201200473A1 (OSRAM)
EC (1) ECSP12011716A (OSRAM)
IL (1) IL218390A0 (OSRAM)
IN (1) IN2012DN02081A (OSRAM)
MA (1) MA33566B1 (OSRAM)
MX (1) MX2012002977A (OSRAM)
NZ (1) NZ598643A (OSRAM)
PE (1) PE20121180A1 (OSRAM)
PH (1) PH12012500497A1 (OSRAM)
SG (1) SG178919A1 (OSRAM)
TN (1) TN2012000108A1 (OSRAM)
TW (1) TW201111378A (OSRAM)
UY (1) UY32882A (OSRAM)
WO (1) WO2011029537A1 (OSRAM)

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AU2011261164A1 (en) * 2010-06-01 2012-12-13 The University Of Queensland Haematopoietic-prostaglandin D2 synthase inhibitors
JP6385825B2 (ja) 2011-12-22 2018-09-05 アリオス バイオファーマ インク. 置換されたヌクレオシド、ヌクレオチドおよびそのアナログ
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN104395330B (zh) 2012-05-25 2018-03-13 爱尔兰詹森科学公司 尿嘧啶基螺氧杂环丁烷核苷
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之n-(吡啶-2-基)嘧啶-4-胺衍生物
HUE053946T2 (hu) 2012-12-21 2021-08-30 Janssen Biopharma Inc 4'-Fluor-nukleozidok, 4'-fluor-nukleotidok és analógjaik HCV kezelésére
WO2014153280A1 (en) * 2013-03-22 2014-09-25 Merck Sharp & Dohme Corp. 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
CN104341351B (zh) * 2013-07-30 2018-02-06 北京海美源医药科技有限公司 一种二芳基硫代乙内酰脲衍生物及其应用
JP6430512B2 (ja) * 2013-12-11 2018-11-28 セルジーン クオンティセル リサーチ,インク. リジン特異的デメチラーゼ−1の阻害剤
US20160318897A1 (en) 2013-12-18 2016-11-03 Basf Se Azole compounds carrying an imine-derived substituent
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
CN103896847B (zh) * 2014-04-09 2016-01-20 沈江 一种非甾体类抗雄激素化合物及其制备方法和应用
AU2015257917C1 (en) 2014-05-07 2019-03-14 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
TWI656121B (zh) 2014-08-04 2019-04-11 德商拜耳製藥公司 2-(嗎啉-4-基)-1,7-萘啶
CN106187905B (zh) * 2015-05-05 2020-02-21 北京海步医药科技股份有限公司 丁鲁他胺的结晶形式及其制备方法
ES2819869T3 (es) 2015-10-08 2021-04-19 Bayer Pharma AG Nuevos compuestos macrocíclicos modificados
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CA3057891A1 (en) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
ES2900199T3 (es) 2017-03-28 2022-03-16 Bayer Ag Novedosos compuestos macrocíclicos inhibidores de PTEFB
TW201900604A (zh) 2017-05-18 2019-01-01 印度商Pi工業公司 新穎的脒化合物
WO2019158517A1 (en) 2018-02-13 2019-08-22 Bayer Aktiengesellschaft Use of 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-n-{4-[(s-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large b-cell lymphoma
US12275725B2 (en) 2019-04-11 2025-04-15 University Of Miami Inhibitors of the notch transcriptional activation complex and methods for use of the same
US20230135524A1 (en) * 2020-01-21 2023-05-04 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Aryl hydantoin heterocycles and methods of use
CN117120436A (zh) * 2021-03-30 2023-11-24 苏州开拓药业股份有限公司 一种一步法合成乙内酰硫脲衍生物的方法
WO2025103470A1 (zh) * 2023-11-17 2025-05-22 中国药科大学 作为雄激素受体(ar)拮抗剂的化合物及其应用
CN120309588B (zh) * 2025-06-10 2025-08-12 上海健康医学院 一种具有雄激素受体和组蛋白去乙酰化酶6双重抑制作用的乙内酰硫脲类化合物及其用途

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Also Published As

Publication number Publication date
TN2012000108A1 (en) 2013-09-19
AU2010294588A1 (en) 2012-04-05
PE20121180A1 (es) 2012-08-24
MA33566B1 (fr) 2012-09-01
CO6511228A2 (es) 2012-08-31
SG178919A1 (en) 2012-04-27
MX2012002977A (es) 2012-04-30
CU20120042A7 (es) 2012-06-21
CR20120113A (es) 2012-05-02
BR112012005526A2 (pt) 2016-04-26
ECSP12011716A (es) 2012-04-30
IL218390A0 (en) 2012-04-30
CL2012000623A1 (es) 2012-09-14
EA201200473A1 (ru) 2012-10-30
JP2013504523A (ja) 2013-02-07
CN102639523A (zh) 2012-08-15
TW201111378A (en) 2011-04-01
WO2011029537A1 (en) 2011-03-17
IN2012DN02081A (OSRAM) 2015-08-21
US20120251551A1 (en) 2012-10-04
DOP2012000063A (es) 2012-05-15
PH12012500497A1 (en) 2012-10-22
CA2773591A1 (en) 2011-03-17
AR078166A1 (es) 2011-10-19
EP2475653A1 (en) 2012-07-18
UY32882A (es) 2011-04-29
KR20120065396A (ko) 2012-06-20

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