NZ597983A - Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors - Google Patents
Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitorsInfo
- Publication number
- NZ597983A NZ597983A NZ597983A NZ59798310A NZ597983A NZ 597983 A NZ597983 A NZ 597983A NZ 597983 A NZ597983 A NZ 597983A NZ 59798310 A NZ59798310 A NZ 59798310A NZ 597983 A NZ597983 A NZ 597983A
- Authority
- NZ
- New Zealand
- Prior art keywords
- furo
- morpholin
- indol
- ylmethyl
- phosphoinositide
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 title 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- RKURGBLIJFFUCK-UHFFFAOYSA-N 3-[4-[[2-(1h-indol-4-yl)-4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-8-yl]methyl]piperazin-1-yl]propanenitrile Chemical compound C1CN(CCC#N)CCN1CC1=CN=C(OC=2C3=NC(=NC=2N2CCOCC2)C=2C=4C=CNC=4C=CC=2)C3=C1 RKURGBLIJFFUCK-UHFFFAOYSA-N 0.000 abstract 1
- YFVNYGYEGQOOKR-UHFFFAOYSA-N 8-(azetidin-1-ylmethyl)-2-(1h-indol-4-yl)-4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidine Chemical compound C=1N=C2OC3=C(N4CCOCC4)N=C(C=4C=5C=CNC=5C=CC=4)N=C3C2=CC=1CN1CCC1 YFVNYGYEGQOOKR-UHFFFAOYSA-N 0.000 abstract 1
- HMCURYMZQAWYES-UHFFFAOYSA-N 8-[(4-fluoropiperidin-1-yl)methyl]-2-(1h-indol-4-yl)-4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidine Chemical compound C1CC(F)CCN1CC1=CN=C(OC=2C3=NC(=NC=2N2CCOCC2)C=2C=4C=CNC=4C=CC=2)C3=C1 HMCURYMZQAWYES-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- BGQQVLCGNLFQNJ-UHFFFAOYSA-N n-[[2-(1h-indol-4-yl)-4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-8-yl]methyl]-n-methylcyclopropanamine Chemical compound C1CC1N(C)CC(C=C1C2=NC(=N3)C=4C=5C=CNC=5C=CC=4)=CN=C1OC2=C3N1CCOCC1 BGQQVLCGNLFQNJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0914594A GB0914594D0 (en) | 2009-08-20 | 2009-08-20 | Compounds |
| GBGB1005584.6A GB201005584D0 (en) | 2010-04-01 | 2010-04-01 | Compounds |
| PCT/GB2010/051370 WO2011021038A1 (en) | 2009-08-20 | 2010-08-19 | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ597983A true NZ597983A (en) | 2014-05-30 |
Family
ID=42756474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ597983A NZ597983A (en) | 2009-08-20 | 2010-08-19 | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US9200007B2 (enExample) |
| EP (1) | EP2467387B1 (enExample) |
| JP (1) | JP5746172B2 (enExample) |
| CN (1) | CN102498115B (enExample) |
| AU (1) | AU2010286168B2 (enExample) |
| BR (1) | BR112012003955A2 (enExample) |
| CA (1) | CA2771594C (enExample) |
| ES (1) | ES2534326T3 (enExample) |
| IL (1) | IL217903A (enExample) |
| IN (1) | IN2012DN01325A (enExample) |
| MX (1) | MX2012002059A (enExample) |
| NZ (1) | NZ597983A (enExample) |
| PL (1) | PL2467387T3 (enExample) |
| WO (1) | WO2011021038A1 (enExample) |
| ZA (1) | ZA201200910B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2771594C (en) | 2009-08-20 | 2018-05-01 | Karus Therapeutics Limited | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors |
| AU2015268776B2 (en) * | 2010-12-16 | 2017-04-13 | Genentech, Inc. | Tricyclic PI3k inhibitor compounds and methods of use |
| DK2651951T3 (en) | 2010-12-16 | 2014-12-08 | Hoffmann La Roche | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND PROCEDURES FOR USE THEREOF |
| ES2661510T3 (es) | 2011-12-15 | 2018-04-02 | Novartis Ag | Uso de inhibidores de la actividad o función de PI3K |
| GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
| WO2014044722A1 (en) | 2012-09-20 | 2014-03-27 | Basf Se | Azadibenzofurans for electronic applications |
| MX364295B (es) | 2012-11-07 | 2019-04-22 | Karus Therapeutics Ltd | Inhibidores de histona desacetilasa novedosos y su uso en terapia. |
| WO2014072937A1 (en) | 2012-11-08 | 2014-05-15 | Rhizen Pharmaceuticals Sa | Pharmaceutical compositions containing a pde4 inhibitor and a pi3 delta or dual pi3 delta-gamma kinase inhibitor |
| AR095443A1 (es) * | 2013-03-15 | 2015-10-14 | Fundación Centro Nac De Investig Oncológicas Carlos Iii | Heterociclos condensados con acción sobre atr |
| LT2994465T (lt) | 2013-05-10 | 2018-10-10 | Karus Therapeutics Limited | Nauji histono deacetilazės inhibitoriai |
| US9814037B2 (en) * | 2013-06-28 | 2017-11-07 | Intel Corporation | Method for efficient channel estimation and beamforming in FDD system by exploiting uplink-downlink correspondence |
| CN104557955B (zh) * | 2013-10-23 | 2017-05-03 | 上海汇伦生命科技有限公司 | 作为PI3K/mTOR抑制剂的三环类化合物，其制备方法和用途 |
| GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
| GB201514754D0 (en) * | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| GB201514758D0 (en) * | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
| GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| GB201514756D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compound and method of use |
| AU2016369528B2 (en) * | 2015-12-16 | 2021-04-22 | Genentech, Inc. | Process for the preparation of tricyclic PI3K inhibitor compounds and methods for using the same for the treatment of cancer |
| ES2936827T3 (es) | 2016-06-22 | 2023-03-22 | Univ Vanderbilt | Moduladores alostéricos positivos del receptor muscarínico de acetilcolina M4 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| EP3544961B1 (en) | 2016-11-07 | 2021-08-18 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| JP7098167B2 (ja) | 2016-11-07 | 2022-07-11 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子 |
| EP3558309B1 (en) | 2016-11-07 | 2023-07-26 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| GB201702938D0 (en) | 2017-02-23 | 2017-04-12 | Univ Southampton | Methods of generating and screening compartmentalised peptides libraries |
| CN111406058A (zh) | 2017-12-05 | 2020-07-10 | 范德比尔特大学 | 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 |
| TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
| CN111801327B (zh) | 2018-01-10 | 2024-02-09 | 里科瑞尔姆Ip控股有限责任公司 | 苯甲酰胺化合物 |
| WO2022169882A1 (en) | 2021-02-03 | 2022-08-11 | Verge Analytics, Inc. | Methods and treatment of viral infection caused by sars-cov-2 |
| CN117751127A (zh) * | 2021-08-20 | 2024-03-22 | 南京大美生物制药有限公司 | 一种五元含氮杂环并杂芳基类衍生物及其用途 |
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| WO2011079231A1 (en) | 2009-12-23 | 2011-06-30 | Gatekeeper Pharmaceutical, Inc. | Compounds that modulate egfr activity and methods for treating or preventing conditions therewith |
| GB201007347D0 (en) | 2010-04-30 | 2010-06-16 | Karus Therapeutics Ltd | Compounds |
| BR112014001768B1 (pt) | 2011-07-27 | 2019-02-05 | Astrazeneca Ab | composto n-(2-{2-dimetilaminoetil-metilamino}-4-metóxi-5-{[4-(1-metilindol-3-il) pirimidin-2-il]amino}fenil) prop-2-enamida ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e uso do dito composto |
| WO2013017480A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
| GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
| EP3181564B1 (en) | 2012-11-20 | 2019-09-18 | H. Hoffnabb-La Roche Ag | Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants |
| LT2994465T (lt) | 2013-05-10 | 2018-10-10 | Karus Therapeutics Limited | Nauji histono deacetilazės inhibitoriai |
| AU2014273946B2 (en) | 2013-05-30 | 2020-03-12 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using PI3 kinase isoform modulators |
| EP3052494B1 (en) | 2013-06-28 | 2018-12-26 | H. Hoffnabb-La Roche Ag | Azaindazole compounds as inhibitors of t790m containing egfr mutants |
| ES2818933T3 (es) | 2013-10-10 | 2021-04-14 | Acetylon Pharmaceuticals Inc | Inhibidores de la HDAC en combinación con los inhibidores de la pi3k, para el tratamiento del linfoma no Hodgkin |
| GB201321730D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321738D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| GB201321729D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321728D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
| GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
| GB201514756D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compound and method of use |
| GB201514758D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
| GB201514754D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
| GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
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2010
- 2010-08-19 CA CA2771594A patent/CA2771594C/en not_active Expired - Fee Related
- 2010-08-19 JP JP2012525212A patent/JP5746172B2/ja active Active
- 2010-08-19 NZ NZ597983A patent/NZ597983A/en not_active IP Right Cessation
- 2010-08-19 AU AU2010286168A patent/AU2010286168B2/en not_active Ceased
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- 2010-08-19 PL PL10747483T patent/PL2467387T3/pl unknown
- 2010-08-19 EP EP10747483.5A patent/EP2467387B1/en active Active
- 2010-08-19 WO PCT/GB2010/051370 patent/WO2011021038A1/en not_active Ceased
- 2010-08-19 IN IN1325DEN2012 patent/IN2012DN01325A/en unknown
- 2010-08-19 US US13/388,164 patent/US9200007B2/en active Active
- 2010-08-19 CN CN201080036402.7A patent/CN102498115B/zh active Active
- 2010-08-19 ES ES10747483.5T patent/ES2534326T3/es active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2010286168B2 (en) | 2014-05-15 |
| MX2012002059A (es) | 2012-04-19 |
| IL217903A (en) | 2017-08-31 |
| US9580442B2 (en) | 2017-02-28 |
| PL2467387T3 (pl) | 2015-08-31 |
| US9938290B2 (en) | 2018-04-10 |
| ZA201200910B (en) | 2013-05-29 |
| US10501478B2 (en) | 2019-12-10 |
| AU2010286168A1 (en) | 2012-03-08 |
| EP2467387A1 (en) | 2012-06-27 |
| EP2467387B1 (en) | 2015-01-07 |
| ES2534326T3 (es) | 2015-04-21 |
| CN102498115A (zh) | 2012-06-13 |
| JP2013502404A (ja) | 2013-01-24 |
| US20180009826A1 (en) | 2018-01-11 |
| US20120178737A1 (en) | 2012-07-12 |
| CN102498115B (zh) | 2016-12-07 |
| IL217903A0 (en) | 2012-03-29 |
| US20190040079A1 (en) | 2019-02-07 |
| WO2011021038A1 (en) | 2011-02-24 |
| US20160108057A1 (en) | 2016-04-21 |
| BR112012003955A2 (pt) | 2017-09-26 |
| CA2771594A1 (en) | 2011-02-24 |
| JP5746172B2 (ja) | 2015-07-08 |
| CA2771594C (en) | 2018-05-01 |
| US9200007B2 (en) | 2015-12-01 |
| IN2012DN01325A (enExample) | 2015-06-05 |
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