NZ593361A - Dipeptidyl peptidase iv inhibitors - Google Patents
Dipeptidyl peptidase iv inhibitorsInfo
- Publication number
- NZ593361A NZ593361A NZ593361A NZ59336110A NZ593361A NZ 593361 A NZ593361 A NZ 593361A NZ 593361 A NZ593361 A NZ 593361A NZ 59336110 A NZ59336110 A NZ 59336110A NZ 593361 A NZ593361 A NZ 593361A
- Authority
- NZ
- New Zealand
- Prior art keywords
- carbonitrile
- acetyl
- pyrrolidine
- methyl
- compounds
- Prior art date
Links
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title 1
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 title 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010012655 Diabetic complications Diseases 0.000 abstract 2
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 2
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
- FGKUTYVILUEBFU-IGNZVWTISA-N (2s)-1-[2-[[(1r,5r)-1,3,8,8-tetramethyl-2,4-dioxo-3-azabicyclo[3.2.1]octan-5-yl]amino]acetyl]pyrrolidine-2-carbonitrile Chemical compound N([C@]12CC[C@@](C1(C)C)(C)C(=O)N(C2=O)C)CC(=O)N1CCC[C@H]1C#N FGKUTYVILUEBFU-IGNZVWTISA-N 0.000 abstract 1
- QXHZRZZNNBKEIO-PRHHBONVSA-N (2s,4r)-4-fluoro-1-[2-[[(1r,3s)-1,2,2-trimethyl-3-[(4-methylsulfonylphenyl)sulfonylmethyl]cyclopentyl]amino]acetyl]pyrrolidine-2-carbonitrile Chemical compound C([C@@H]1C([C@](CC1)(C)NCC(=O)N1[C@@H](C[C@@H](F)C1)C#N)(C)C)S(=O)(=O)C1=CC=C(S(C)(=O)=O)C=C1 QXHZRZZNNBKEIO-PRHHBONVSA-N 0.000 abstract 1
- ZFZVCKOOHHUNHE-LDDOYCOJSA-N (2s,4s)-4-fluoro-1-[2-[[(1r,3s)-1,2,2-trimethyl-3-(1,2,4-triazol-1-ylmethyl)cyclopentyl]amino]acetyl]pyrrolidine-2-carbonitrile Chemical compound C([C@@H]1C([C@](CC1)(C)NCC(=O)N1[C@@H](C[C@H](F)C1)C#N)(C)C)N1C=NC=N1 ZFZVCKOOHHUNHE-LDDOYCOJSA-N 0.000 abstract 1
- ACFHUTXXVCLLDP-PCPGWFQFSA-N (2s,4s)-4-fluoro-1-[2-[[(1r,3s)-1,2,2-trimethyl-3-[[[5-(trifluoromethyl)pyridin-2-yl]amino]methyl]cyclopentyl]amino]acetyl]pyrrolidine-2-carbonitrile Chemical compound C([C@@H]1C([C@](CC1)(C)NCC(=O)N1[C@@H](C[C@H](F)C1)C#N)(C)C)NC1=CC=C(C(F)(F)F)C=N1 ACFHUTXXVCLLDP-PCPGWFQFSA-N 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000002705 Glucose Intolerance Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010056997 Impaired fasting glucose Diseases 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 235000012631 food intake Nutrition 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 201000009104 prediabetes syndrome Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/08—Preparation by ring-closure
- C07D213/09—Preparation by ring-closure involving the use of ammonia, amines, amine salts, or nitriles
- C07D213/12—Preparation by ring-closure involving the use of ammonia, amines, amine salts, or nitriles from unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN65CH2009 | 2009-01-09 | ||
| PCT/IB2010/000008 WO2010079413A2 (en) | 2009-01-09 | 2010-01-07 | Dipeptidyl peptidase iv inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ593361A true NZ593361A (en) | 2012-12-21 |
Family
ID=42316906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ593361A NZ593361A (en) | 2009-01-09 | 2010-01-07 | Dipeptidyl peptidase iv inhibitors |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8466145B2 (https=) |
| EP (1) | EP2376447B1 (https=) |
| JP (2) | JP2012514630A (https=) |
| KR (1) | KR101750420B1 (https=) |
| CN (2) | CN102272099A (https=) |
| AU (1) | AU2010204144B2 (https=) |
| BR (1) | BRPI1006970A2 (https=) |
| CA (1) | CA2749301C (https=) |
| ES (1) | ES2653563T3 (https=) |
| HU (1) | HUE035693T2 (https=) |
| IL (1) | IL213105A (https=) |
| MX (1) | MX2011007340A (https=) |
| NZ (1) | NZ593361A (https=) |
| PL (1) | PL2376447T3 (https=) |
| PT (1) | PT2376447T (https=) |
| SG (1) | SG172924A1 (https=) |
| WO (1) | WO2010079413A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ593361A (en) * | 2009-01-09 | 2012-12-21 | Orchid Res Lab Ltd | Dipeptidyl peptidase iv inhibitors |
| CN103787960A (zh) * | 2014-02-27 | 2014-05-14 | 江苏省激素研究所股份有限公司 | 一种2-氯-5-三氯甲基吡啶的合成方法 |
| CN104496876A (zh) * | 2015-01-13 | 2015-04-08 | 佛山市赛维斯医药科技有限公司 | 一种羟基金刚烷酰胺衍生物、其制备方法和用途 |
| CN105596333A (zh) * | 2016-02-02 | 2016-05-25 | 白强 | 一种防治糖尿病及其并发症的药物组合物及其应用 |
| CN108707143B (zh) * | 2018-06-26 | 2020-06-26 | 中昱医学检验(广州)有限公司 | 一种dpp-4抑制剂及其制备和在糖尿病中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1567902A (en) * | 1975-10-15 | 1980-05-21 | Glaxo Lab Ltd | 1-aminoalkyl-7,7-dimethylnorbornanes |
| DE2659052A1 (de) * | 1976-12-27 | 1978-07-06 | Nattermann A & Cie | N-substituierte 1,2,2-trimethyl-3- carbamoyl-cyclopentan-carbonsaeuren(1) und deren physiologisch vertraegliche salze |
| DE3402623A1 (de) * | 1984-01-26 | 1985-08-01 | Bayer Ag, 5090 Leverkusen | Neue diisocyanate und ihre verwendung zur herstellung von polyurethankunststoffen |
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- 2010-01-07 HU HUE10729125A patent/HUE035693T2/hu unknown
- 2010-01-07 EP EP10729125.4A patent/EP2376447B1/en not_active Not-in-force
- 2010-01-07 SG SG2011050085A patent/SG172924A1/en unknown
- 2010-01-07 JP JP2011544937A patent/JP2012514630A/ja not_active Withdrawn
- 2010-01-07 KR KR1020117016632A patent/KR101750420B1/ko not_active Expired - Fee Related
- 2010-01-07 ES ES10729125.4T patent/ES2653563T3/es active Active
- 2010-01-07 MX MX2011007340A patent/MX2011007340A/es active IP Right Grant
- 2010-01-07 US US13/140,997 patent/US8466145B2/en not_active Expired - Fee Related
- 2010-01-07 BR BRPI1006970A patent/BRPI1006970A2/pt not_active Application Discontinuation
- 2010-01-07 PL PL10729125T patent/PL2376447T3/pl unknown
- 2010-01-07 CN CN2010800038403A patent/CN102272099A/zh active Pending
- 2010-01-07 PT PT107291254T patent/PT2376447T/pt unknown
- 2010-01-07 AU AU2010204144A patent/AU2010204144B2/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2010204144B2 (en) | 2012-02-16 |
| WO2010079413A3 (en) | 2010-12-02 |
| KR20110105820A (ko) | 2011-09-27 |
| EP2376447A2 (en) | 2011-10-19 |
| WO2010079413A2 (en) | 2010-07-15 |
| JP2015091889A (ja) | 2015-05-14 |
| US20110257164A1 (en) | 2011-10-20 |
| CN102272099A (zh) | 2011-12-07 |
| US8466145B2 (en) | 2013-06-18 |
| AU2010204144A1 (en) | 2011-06-23 |
| IL213105A (en) | 2015-09-24 |
| JP5775235B2 (ja) | 2015-09-09 |
| EP2376447A4 (en) | 2012-06-20 |
| CA2749301A1 (en) | 2010-07-15 |
| KR101750420B1 (ko) | 2017-06-26 |
| HUE035693T2 (hu) | 2018-05-28 |
| EP2376447B1 (en) | 2017-08-09 |
| RU2011133213A (ru) | 2013-02-20 |
| ES2653563T3 (es) | 2018-02-07 |
| PL2376447T3 (pl) | 2018-04-30 |
| MX2011007340A (es) | 2011-07-21 |
| CA2749301C (en) | 2019-06-11 |
| CN105384726A (zh) | 2016-03-09 |
| SG172924A1 (en) | 2011-08-29 |
| BRPI1006970A2 (pt) | 2015-09-15 |
| IL213105A0 (en) | 2011-07-31 |
| JP2012514630A (ja) | 2012-06-28 |
| PT2376447T (pt) | 2017-11-15 |
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