NZ591316A - New pyrimidine derivatives and their use in therapy as well as the use of pyrimidine derivatives in the manufacture of a medicament for prevention and/or treatment of Alzheimer's disease - Google Patents

Info

Publication number

NZ591316A

NZ591316A NZ591316A NZ59131606A NZ591316A NZ 591316 A NZ591316 A NZ 591316A NZ 591316 A NZ591316 A NZ 591316A NZ 59131606 A NZ59131606 A NZ 59131606A NZ 591316 A NZ591316 A NZ 591316A

Authority

NZ

New Zealand

Prior art keywords

mmol

imidazol

methyl

pyrimidin

fluoro

Prior art date

2005-10-03

Links

• Espacenet
• Global Dossier
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• 230000002265 prevention Effects 0.000 title abstract description 18
• 208000024827 Alzheimer disease Diseases 0.000 title abstract description 11
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• 239000003814 drug Substances 0.000 title description 9
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• ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 claims 5
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• IDSXLJLXYMLSJM-UHFFFAOYSA-N morpholine;propane-1-sulfonic acid Chemical compound C1COCCN1.CCCS(O)(=O)=O IDSXLJLXYMLSJM-UHFFFAOYSA-N 0.000 claims 4
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• CTCBPRXHVPZNHB-VQFZJOCSSA-N [[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;(2r,3r,4s,5r)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O CTCBPRXHVPZNHB-VQFZJOCSSA-N 0.000 claims 1
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• 125000005843 halogen group Chemical group 0.000 description 65
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 24
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