NZ586662A - PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JANUS KINASE 2 INHIBITORS - Google Patents
PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JANUS KINASE 2 INHIBITORSInfo
- Publication number
- NZ586662A NZ586662A NZ586662A NZ58666208A NZ586662A NZ 586662 A NZ586662 A NZ 586662A NZ 586662 A NZ586662 A NZ 586662A NZ 58666208 A NZ58666208 A NZ 58666208A NZ 586662 A NZ586662 A NZ 586662A
- Authority
- NZ
- New Zealand
- Prior art keywords
- chronic
- pyrazolo
- compounds
- useful
- leukaemia
- Prior art date
Links
- 229940121730 Janus kinase 2 inhibitor Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 abstract 2
- 108010024121 Janus Kinases Proteins 0.000 abstract 2
- 102000015617 Janus Kinases Human genes 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037398 BCR-ABL1 negative atypical chronic myeloid leukemia Diseases 0.000 abstract 1
- 208000032027 Essential Thrombocythemia Diseases 0.000 abstract 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 abstract 1
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 abstract 1
- 208000035268 Mast Cell Activation disease Diseases 0.000 abstract 1
- 206010028561 Myeloid metaplasia Diseases 0.000 abstract 1
- 208000037538 Myelomonocytic Juvenile Leukemia Diseases 0.000 abstract 1
- 208000014767 Myeloproliferative disease Diseases 0.000 abstract 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 abstract 1
- 208000017733 acquired polycythemia vera Diseases 0.000 abstract 1
- 201000004892 atypical chronic myeloid leukemia Diseases 0.000 abstract 1
- 208000021668 chronic eosinophilic leukemia Diseases 0.000 abstract 1
- 201000010902 chronic myelomonocytic leukemia Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000005992 juvenile myelomonocytic leukemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 206010028537 myelofibrosis Diseases 0.000 abstract 1
- 208000037244 polycythemia vera Diseases 0.000 abstract 1
- 208000003476 primary myelofibrosis Diseases 0.000 abstract 1
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 abstract 1
- 230000009897 systematic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1482407P | 2007-12-19 | 2007-12-19 | |
| PCT/US2008/087362 WO2009085913A1 (en) | 2007-12-19 | 2008-12-18 | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ586662A true NZ586662A (en) | 2012-08-31 |
Family
ID=40431839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ586662A NZ586662A (en) | 2007-12-19 | 2008-12-18 | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JANUS KINASE 2 INHIBITORS |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8937064B2 (enExample) |
| EP (1) | EP2252618A1 (enExample) |
| JP (1) | JP5587206B2 (enExample) |
| KR (1) | KR20100108390A (enExample) |
| CN (1) | CN101932583A (enExample) |
| AU (1) | AU2008343173A1 (enExample) |
| CA (1) | CA2709710A1 (enExample) |
| IL (1) | IL206466A0 (enExample) |
| MX (1) | MX2010006748A (enExample) |
| NZ (1) | NZ586662A (enExample) |
| RU (1) | RU2010129928A (enExample) |
| WO (1) | WO2009085913A1 (enExample) |
| ZA (1) | ZA201004368B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077999A1 (es) * | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
| EP2338888A1 (en) * | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Imidazopyridine derivatives as JAK inhibitors |
| UY33213A (es) * | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| US8785467B2 (en) * | 2010-09-30 | 2014-07-22 | Merck Sharp & Dohme Corp. | Alkoxy pyrimidine PDE10 inhibitors |
| EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
| JP6105578B2 (ja) | 2011-07-21 | 2017-03-29 | トレロ ファーマシューティカルズ， インコーポレイテッド | 複素環式プロテインキナーゼ阻害剤 |
| EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
| CA2856722C (en) | 2011-11-30 | 2022-11-22 | Emory University | Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections |
| CN102887858B (zh) * | 2012-09-07 | 2014-11-19 | 苏州康润医药有限公司 | 3-氯-5-氨基-1h-吡唑-4-甲酸乙酯的合成方法 |
| CN103073549A (zh) * | 2012-09-07 | 2013-05-01 | 苏州康润医药有限公司 | 3-溴吡唑啉[1,5-α]吡嘧啶-2-甲酸的合成工艺 |
| SMT202000713T1 (it) | 2012-12-07 | 2021-03-15 | Vertex Pharma | Pirazolo [1,5-a] pirimidine utili come inibitori dell'atr chinasi per il trattamento di malattie del cancro |
| ES2768678T3 (es) | 2013-12-06 | 2020-06-23 | Vertex Pharma | Compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inhibidor de la ATR quinasa, su preparación, diferentes formas sólidas y derivados radiomarcados de las mismas |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| RU2768621C1 (ru) | 2015-09-30 | 2022-03-24 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr |
| CN112236139A (zh) | 2018-04-13 | 2021-01-15 | 大日本住友制药肿瘤公司 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
| JP7662528B2 (ja) | 2019-02-12 | 2025-04-15 | スミトモ ファーマ アメリカ， インコーポレイテッド | 複素環式タンパク質キナーゼ阻害剤を含む製剤 |
| KR20220088699A (ko) | 2019-09-27 | 2022-06-28 | 디스크 메디슨, 인크. | 골수섬유증 및 관련 상태의 치료 방법 |
| JP2023528223A (ja) | 2020-05-13 | 2023-07-04 | ディスク・メディシン・インコーポレイテッド | 骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体 |
| WO2024076614A2 (en) * | 2022-10-04 | 2024-04-11 | Children's Hospital Medical Center | Multi-cyclic irak and flt3 inhibiting compounds and uses thereof |
| EP4611753A1 (en) | 2022-10-31 | 2025-09-10 | Sumitomo Pharma America, Inc. | Pim1 inhibitor for treating myeloproliferative neoplasms |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| BR9711970A (pt) | 1996-08-28 | 1999-08-24 | Pfizer | Derivados 6,5-substitu¡do-heterobic¡clicos |
| CA2291709A1 (en) | 1997-05-30 | 1998-12-03 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| US6245759B1 (en) | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US7713989B2 (en) | 2000-04-27 | 2010-05-11 | Dow Robert L | Glucocorticoid receptor modulators |
| GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| ATE339419T1 (de) | 2002-08-02 | 2006-10-15 | Vertex Pharma | Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren |
| US7550470B2 (en) | 2002-12-11 | 2009-06-23 | Merck & Co. Inc. | Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors |
| DE60326646D1 (de) | 2002-12-18 | 2009-04-23 | Vertex Pharma | Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen |
| GB2432834A (en) * | 2004-01-12 | 2007-06-06 | Cytopia Res Pty Ltd | Selective Kinase Inhibitors |
| EP2332940B1 (en) * | 2004-03-30 | 2012-10-31 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of JAK and other protein kinases |
| GB0519957D0 (en) | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
| DK1812440T3 (da) * | 2004-11-04 | 2011-01-31 | Vertex Pharma | Pyrazolo[1,5-a]pyrimidiner, der kan anvendes som inhibistorer af proteinkinaser |
| EP1922321A1 (en) | 2005-08-09 | 2008-05-21 | Eirx Therapeutics Ltd | Pyrazoloý1,5-a¨pyrimidine compounds and pharmaceutical compositions containing them |
| CN101801971A (zh) * | 2005-09-30 | 2010-08-11 | 沃泰克斯药物股份有限公司 | 可用作janus激酶抑制剂的脱氮嘌呤 |
| CN101679409B (zh) * | 2006-12-22 | 2014-11-26 | Astex治疗学有限公司 | 双环杂环衍生化合物、其医药组合物和其用途 |
| AU2008226466B2 (en) | 2007-03-09 | 2013-06-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
| NZ582879A (en) | 2007-07-31 | 2012-03-30 | Vertex Pharma | Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
-
2008
- 2008-12-18 KR KR1020107015961A patent/KR20100108390A/ko not_active Withdrawn
- 2008-12-18 WO PCT/US2008/087362 patent/WO2009085913A1/en not_active Ceased
- 2008-12-18 JP JP2010539781A patent/JP5587206B2/ja not_active Expired - Fee Related
- 2008-12-18 AU AU2008343173A patent/AU2008343173A1/en not_active Abandoned
- 2008-12-18 NZ NZ586662A patent/NZ586662A/xx not_active IP Right Cessation
- 2008-12-18 CN CN2008801260776A patent/CN101932583A/zh active Pending
- 2008-12-18 EP EP08867722A patent/EP2252618A1/en not_active Withdrawn
- 2008-12-18 MX MX2010006748A patent/MX2010006748A/es unknown
- 2008-12-18 CA CA2709710A patent/CA2709710A1/en not_active Abandoned
- 2008-12-18 RU RU2010129928/04A patent/RU2010129928A/ru not_active Application Discontinuation
-
2010
- 2010-06-17 IL IL206466A patent/IL206466A0/en unknown
- 2010-06-17 US US12/817,785 patent/US8937064B2/en not_active Expired - Fee Related
- 2010-06-21 ZA ZA2010/04368A patent/ZA201004368B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101932583A (zh) | 2010-12-29 |
| RU2010129928A (ru) | 2012-01-27 |
| IL206466A0 (en) | 2010-12-30 |
| AU2008343173A1 (en) | 2009-07-09 |
| ZA201004368B (en) | 2013-01-30 |
| MX2010006748A (es) | 2010-08-18 |
| US8937064B2 (en) | 2015-01-20 |
| CA2709710A1 (en) | 2009-07-09 |
| EP2252618A1 (en) | 2010-11-24 |
| US20110118255A1 (en) | 2011-05-19 |
| JP5587206B2 (ja) | 2014-09-10 |
| JP2011507881A (ja) | 2011-03-10 |
| KR20100108390A (ko) | 2010-10-06 |
| WO2009085913A1 (en) | 2009-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Patent lapsed | ||
| ERR | Error or correction |
Free format text: THE OWNER HAS BEEN CORRECTED TO 3155030, VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON, MASSACHUSETTS 02210, US Effective date: 20150127 |