NZ583689A - F1f0-atpase inhibitors and related methods - Google Patents
F1f0-atpase inhibitors and related methodsInfo
- Publication number
- NZ583689A NZ583689A NZ583689A NZ58368908A NZ583689A NZ 583689 A NZ583689 A NZ 583689A NZ 583689 A NZ583689 A NZ 583689A NZ 58368908 A NZ58368908 A NZ 58368908A NZ 583689 A NZ583689 A NZ 583689A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- alkyl
- mmol
- heteroaryl
- mhz
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
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- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
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| US97255307P | 2007-09-14 | 2007-09-14 | |
| PCT/US2008/076021 WO2009036175A2 (en) | 2007-09-14 | 2008-09-11 | F1f0-atpase inhibitors and related methods |
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| NZ583689A true NZ583689A (en) | 2012-04-27 |
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| NZ583689A NZ583689A (en) | 2007-09-14 | 2008-09-11 | F1f0-atpase inhibitors and related methods |
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|---|---|
| US (1) | US8324258B2 (https=) |
| EP (1) | EP2200977B1 (https=) |
| JP (1) | JP5416122B2 (https=) |
| CN (1) | CN101855203B (https=) |
| AU (1) | AU2008298870C1 (https=) |
| CA (1) | CA2698248C (https=) |
| ES (1) | ES2614498T3 (https=) |
| IL (1) | IL204442A (https=) |
| MX (1) | MX2010002732A (https=) |
| NZ (1) | NZ583689A (https=) |
| WO (1) | WO2009036175A2 (https=) |
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| EP2359831A3 (en) | 1999-04-30 | 2012-02-01 | The Regents of the University of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
| US7144880B2 (en) | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
| EP1948191B1 (en) | 2005-11-01 | 2013-01-16 | The Regents of the University of Michigan | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| CA2680017C (en) | 2007-03-09 | 2013-11-12 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| EP2200977B1 (en) | 2007-09-14 | 2016-11-09 | The Regents of the University of Michigan | F1f0-atpase inhibitors and related methods |
| MX2010004857A (es) | 2007-11-06 | 2010-07-28 | Univ Michigan | Compuestos de benzodiazepinona utiles en el tratamiento de afecciones de la piel. |
| EP2352724B1 (en) * | 2008-09-11 | 2015-04-22 | The Regents of the University of Michigan | Aryl guanidine f1f0-atpase inhibitors and their medical use |
| WO2010121164A2 (en) | 2009-04-17 | 2010-10-21 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
| US8673897B2 (en) | 2009-09-18 | 2014-03-18 | The Regents Of The University Of Michigan | Benzodiazepinone compounds and methods of treatment using same |
| WO2011062765A2 (en) | 2009-11-17 | 2011-05-26 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| CN102753544A (zh) | 2009-11-17 | 2012-10-24 | 密执安大学评议会 | 具有治疗性能的1,4-苯并二氮杂*-2,5-二酮和相关化合物 |
| CA2820044A1 (en) * | 2010-12-08 | 2012-06-14 | Lycera Corporation | Pyridonyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof |
| US9169199B2 (en) | 2010-12-08 | 2015-10-27 | Lycera Corporation | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof |
| AU2011338302A1 (en) * | 2010-12-08 | 2013-07-11 | Lycera Corporation | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof |
| SMT201700445T1 (it) * | 2010-12-08 | 2017-11-15 | Lycera Corporation| | Inibitori della f1f0-atpasi della pirazolilguanidina e loro usi terapeutici |
| EP2861225A4 (en) | 2012-06-08 | 2015-11-18 | Lycera Corp | Saturated acylguanidine for the inhibition of F1F0-ATPASE |
| US9221814B2 (en) | 2012-06-08 | 2015-12-29 | Lycera Corporation | Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof |
| WO2013185045A1 (en) | 2012-06-08 | 2013-12-12 | Lycera Corporation | Indazole guanidine f1f0-atpase inhibitors and therapeutic uses thereof |
| CA2879454A1 (en) | 2012-07-19 | 2014-01-23 | Drexel University | Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same |
| CA2931851A1 (en) * | 2013-12-10 | 2015-06-18 | Lycera Corporation | Trifluoromethyl pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof |
| CA2931850A1 (en) | 2013-12-10 | 2015-06-18 | Lycera Corporation | Alkylpyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof |
| US9914706B2 (en) | 2013-12-10 | 2018-03-13 | Lycera Corporation | N-substituted pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof |
| DK3416964T3 (da) | 2016-02-19 | 2021-02-22 | Phoenix Molecular Designs | 6-Oxo-N-(1-(benzyl)-1H-pyrazol-4-YL)-6,7,8,9-tetrahydropyrido[3',2':4,5]pyrrolo[1,2-A]pyrazin-2-carboxamid-derivater som P90 ribosomal S6 kinase- (RSK-) hæmmere til behandling af cancer |
| WO2019089902A1 (en) | 2017-11-01 | 2019-05-09 | Drexel University | Compounds, compositions, and methods for treating diseases |
| CN108486117B (zh) * | 2018-04-27 | 2020-09-08 | 浙江大学 | 一种rna抑制剂及其在抑制f1f0-atp合成酶活性中的应用 |
| US12378245B2 (en) | 2019-02-11 | 2025-08-05 | Phoenix Molecular Designs | Crystalline forms of an RSK inhibitor |
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| US802394A (en) | 1905-07-27 | 1905-10-24 | Harry W Hill | Base-plate for shaft-bearing stands and the like. |
| US2457405A (en) | 1945-09-25 | 1948-12-28 | Monsanto Chemicals | Halo nitroparaffin modified aminoplasts |
| US3374264A (en) * | 1962-10-04 | 1968-03-19 | Hoffmann La Roche | N-haloacetyl-anthranilic acids and esters |
| US3261828A (en) | 1962-10-04 | 1966-07-19 | Hoffmann La Roche | 3h-1,4-benzodiazepine-2,5(1h,4h)-dione compounds |
| US3384635A (en) | 1966-09-28 | 1968-05-21 | Sterling Drug Inc | 1, 4-benzodiazepine derivatives |
| US3415814A (en) | 1966-09-28 | 1968-12-10 | Sterling Drug Inc | 4-(cyclopropylmethyl)-3h-1,4-benzodiazepine-2,5(1h,4h)-dione |
| AT280290B (de) | 1967-11-24 | 1970-04-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen 1-Phenyl-4-alkyl-3H-1,4-benzodiazepin-2,5-[1H,4H]-dionen |
| USRE30293E (en) * | 1969-03-18 | 1980-06-03 | Knoll A.G. | Process for preparing 1,5-benzodiazepine-2-ones |
| US4108852A (en) | 1969-03-18 | 1978-08-22 | Knoll Ag. | Process for preparing 1,5-benzodiazepine-2-ones |
| GB1363735A (en) | 1970-10-23 | 1974-08-14 | Hoechst Ag | Process for the manufacture of benzimidazolones |
| GB1324469A (en) | 1970-10-28 | 1973-07-25 | Knoll Ag | Derivatives of benzodiazepines |
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- 2008-09-11 MX MX2010002732A patent/MX2010002732A/es not_active Application Discontinuation
- 2008-09-11 JP JP2010524985A patent/JP5416122B2/ja not_active Expired - Fee Related
- 2008-09-11 WO PCT/US2008/076021 patent/WO2009036175A2/en not_active Ceased
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| Publication number | Publication date |
|---|---|
| AU2008298870C1 (en) | 2014-10-09 |
| IL204442A (en) | 2015-05-31 |
| JP2011509238A (ja) | 2011-03-24 |
| EP2200977B1 (en) | 2016-11-09 |
| WO2009036175A2 (en) | 2009-03-19 |
| CA2698248C (en) | 2017-08-29 |
| EP2200977A2 (en) | 2010-06-30 |
| AU2008298870B2 (en) | 2014-04-10 |
| ES2614498T3 (es) | 2017-05-31 |
| CN101855203B (zh) | 2014-03-19 |
| EP2200977A4 (en) | 2011-12-28 |
| CA2698248A1 (en) | 2009-03-19 |
| JP5416122B2 (ja) | 2014-02-12 |
| AU2008298870A1 (en) | 2009-03-19 |
| WO2009036175A3 (en) | 2009-05-07 |
| CN101855203A (zh) | 2010-10-06 |
| MX2010002732A (es) | 2010-06-02 |
| US20100222400A1 (en) | 2010-09-02 |
| US8324258B2 (en) | 2012-12-04 |
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