EP1423122A4 - Compositions and methods relating to novel benzodiazepine compounds and targets thereof - Google Patents

Compositions and methods relating to novel benzodiazepine compounds and targets thereof

Info

Publication number
EP1423122A4
EP1423122A4 EP02794914A EP02794914A EP1423122A4 EP 1423122 A4 EP1423122 A4 EP 1423122A4 EP 02794914 A EP02794914 A EP 02794914A EP 02794914 A EP02794914 A EP 02794914A EP 1423122 A4 EP1423122 A4 EP 1423122A4
Authority
EP
European Patent Office
Prior art keywords
targets
compositions
methods relating
benzodiazepine compounds
novel benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02794914A
Other languages
German (de)
French (fr)
Other versions
EP1423122A2 (en
Inventor
Gary D Glick
Anthony W Opipari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/217,878 external-priority patent/US20030119029A1/en
Application filed by University of Michigan filed Critical University of Michigan
Publication of EP1423122A2 publication Critical patent/EP1423122A2/en
Publication of EP1423122A4 publication Critical patent/EP1423122A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP02794914A 2001-08-15 2002-08-15 Compositions and methods relating to novel benzodiazepine compounds and targets thereof Withdrawn EP1423122A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US217878 1998-12-21
US31256001P 2001-08-15 2001-08-15
US312560P 2001-08-15
US31368901P 2001-08-20 2001-08-20
US313689P 2001-08-20
US39667002P 2002-07-18 2002-07-18
US396670P 2002-07-18
US10/217,878 US20030119029A1 (en) 1999-04-30 2002-08-13 Compositions and methods relating to novel benzodiazepine compounds and targets thereof
PCT/US2002/026171 WO2003015703A2 (en) 2001-08-15 2002-08-15 Compositions and methods relating to novel benzodiazepine compounds and targets thereof

Publications (2)

Publication Number Publication Date
EP1423122A2 EP1423122A2 (en) 2004-06-02
EP1423122A4 true EP1423122A4 (en) 2008-12-10

Family

ID=27499087

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02794914A Withdrawn EP1423122A4 (en) 2001-08-15 2002-08-15 Compositions and methods relating to novel benzodiazepine compounds and targets thereof

Country Status (8)

Country Link
EP (1) EP1423122A4 (en)
JP (1) JP2005502652A (en)
AU (1) AU2002332560B2 (en)
CA (1) CA2457405A1 (en)
MX (1) MXPA04001421A (en)
NO (1) NO20041058L (en)
NZ (1) NZ531117A (en)
WO (1) WO2003015703A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025388A1 (en) * 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
ATE258439T1 (en) 1999-04-30 2004-02-15 Univ Michigan USE OF BENZODIAZEPINES TO TREAT APOPTOSIS-INDUCED AUTOIMMUNE DISEASES
AU2004255153B2 (en) * 2003-05-01 2007-11-22 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
JP2008528448A (en) 2005-01-03 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Compositions and methods relating to novel compounds and targets thereof
EP1893218A4 (en) 2005-06-01 2011-01-12 Univ Michigan Unsolvated benzodiazepine compositions and methods
EP1928465A1 (en) * 2005-09-19 2008-06-11 Arrow Therapeutics Limited Benzodiazepine derivatives for treating hepatitis c infection
CA2628193C (en) * 2005-11-01 2012-08-14 The Regents Of The University Of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
WO2007146167A1 (en) 2006-06-09 2007-12-21 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7851465B2 (en) 2007-03-09 2010-12-14 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
CN101855203B (en) 2007-09-14 2014-03-19 密执安州立大学董事会 F1F0-ATPase inhibitors and related methods
CN101918375A (en) 2007-11-06 2010-12-15 密歇根大学董事会 Benzodiazepinone compounds useful in the treatment of skin conditions
AU2009291632B2 (en) 2008-09-11 2013-04-04 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
ES2703752T3 (en) 2009-11-17 2019-03-12 Univ Michigan Regents 1,4-Benzodiazepine-2,5-diones and related compounds that exhibit therapeutic properties

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898861A (en) * 1987-03-26 1990-02-06 Hoffmann-La Roche Inc. Method for inhibiting the proliferation of tumor cells
US5776946A (en) * 1995-08-28 1998-07-07 Mcgeer; Patrick L. Peripheral benzodiazepine receptor ligands as antiinflammatory agents
WO1999058117A1 (en) * 1998-05-13 1999-11-18 Sanofi-Synthelabo Use of compounds for reducing apoptosis
WO1999066958A2 (en) * 1998-06-22 1999-12-29 Centre National De La Recherche Scientifique (Cnrs) Use of a compound having affinity for the benzodiazepine mitochondrial receptor in cancer therapy
WO2000066106A2 (en) * 1999-04-30 2000-11-09 The Regents Of The University Of Michigan Use of benzodiazepines for treating autoimmune diseases induced by apoptosis
WO2001051922A2 (en) * 2000-01-14 2001-07-19 Mitokor Identification of peripheral benzodiazepine receptor binding agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277844B1 (en) * 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
JP2003506014A (en) * 1999-06-22 2003-02-18 マイトコー Compositions and methods for assaying subcellular conditions and processes using energy transfer
US7005274B1 (en) * 1999-09-15 2006-02-28 Migenix Corp. Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898861A (en) * 1987-03-26 1990-02-06 Hoffmann-La Roche Inc. Method for inhibiting the proliferation of tumor cells
US5776946A (en) * 1995-08-28 1998-07-07 Mcgeer; Patrick L. Peripheral benzodiazepine receptor ligands as antiinflammatory agents
WO1999058117A1 (en) * 1998-05-13 1999-11-18 Sanofi-Synthelabo Use of compounds for reducing apoptosis
WO1999066958A2 (en) * 1998-06-22 1999-12-29 Centre National De La Recherche Scientifique (Cnrs) Use of a compound having affinity for the benzodiazepine mitochondrial receptor in cancer therapy
WO2000066106A2 (en) * 1999-04-30 2000-11-09 The Regents Of The University Of Michigan Use of benzodiazepines for treating autoimmune diseases induced by apoptosis
WO2001051922A2 (en) * 2000-01-14 2001-07-19 Mitokor Identification of peripheral benzodiazepine receptor binding agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLUM P ET AL: "STIFF-PERSON SYNDROME: AN AUTOIMMUNE DISEASE", MOVEMENT DISORDERS, RAVEN PRESS, NEW YORK, NY, US, vol. 6, no. 1, 1 January 1991 (1991-01-01), pages 12 - 20, XP000957552, ISSN: 0885-3185 *
SCHLUMPF M ET AL: "DELAYED DEVELOPMENTAL IMMUNOTOXICITY OF PRENATAL BENZODIAZEPINES", TOXICOLOGY IN VITRO, ELSEVIER SCIENCE, GB, vol. 8, no. 5, 1 January 1994 (1994-01-01), pages 1061 - 1065, XP000957564, ISSN: 0887-2333 *
SHAWN Y. STEVENS ET AL.: "Non nucleic acis inhibitors of protein-DNA interactions identified through combinatorial chemistry", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118, 1996, pages 10650 - 10651, XP002499663 *
TANIMOTO Y ET AL: "BENZODIAZEPINE RECEPTOR AGONISTS MODULATE THYMOCYTE APOPTOSIS THROUGH REDUCTION OF THE MITOCHONDRIAL TRANSMEMBRANE POTENTIAL", JAPANESE JOURNAL OF PHARMACOLOGY, JP, vol. 79, no. 2, 1 January 1999 (1999-01-01), pages 177 - 183, XP000957554, ISSN: 0021-5198 *

Also Published As

Publication number Publication date
AU2002332560B2 (en) 2006-01-19
NO20041058L (en) 2004-05-14
MXPA04001421A (en) 2004-06-03
NZ531117A (en) 2006-03-31
WO2003015703A3 (en) 2003-11-13
EP1423122A2 (en) 2004-06-02
WO2003015703A2 (en) 2003-02-27
JP2005502652A (en) 2005-01-27
CA2457405A1 (en) 2003-02-27

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Legal Events

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