EP1423122A4 - Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles - Google Patents

Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles

Info

Publication number
EP1423122A4
EP1423122A4 EP02794914A EP02794914A EP1423122A4 EP 1423122 A4 EP1423122 A4 EP 1423122A4 EP 02794914 A EP02794914 A EP 02794914A EP 02794914 A EP02794914 A EP 02794914A EP 1423122 A4 EP1423122 A4 EP 1423122A4
Authority
EP
European Patent Office
Prior art keywords
targets
compositions
methods relating
benzodiazepine compounds
novel benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02794914A
Other languages
German (de)
English (en)
Other versions
EP1423122A2 (fr
Inventor
Gary D Glick
Anthony W Opipari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/217,878 external-priority patent/US20030119029A1/en
Application filed by University of Michigan filed Critical University of Michigan
Publication of EP1423122A2 publication Critical patent/EP1423122A2/fr
Publication of EP1423122A4 publication Critical patent/EP1423122A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP02794914A 2001-08-15 2002-08-15 Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles Withdrawn EP1423122A4 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US217878 1998-12-21
US31256001P 2001-08-15 2001-08-15
US312560P 2001-08-15
US31368901P 2001-08-20 2001-08-20
US313689P 2001-08-20
US39667002P 2002-07-18 2002-07-18
US396670P 2002-07-18
US10/217,878 US20030119029A1 (en) 1999-04-30 2002-08-13 Compositions and methods relating to novel benzodiazepine compounds and targets thereof
PCT/US2002/026171 WO2003015703A2 (fr) 2001-08-15 2002-08-15 Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles

Publications (2)

Publication Number Publication Date
EP1423122A2 EP1423122A2 (fr) 2004-06-02
EP1423122A4 true EP1423122A4 (fr) 2008-12-10

Family

ID=27499087

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02794914A Withdrawn EP1423122A4 (fr) 2001-08-15 2002-08-15 Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles

Country Status (8)

Country Link
EP (1) EP1423122A4 (fr)
JP (1) JP2005502652A (fr)
AU (1) AU2002332560B2 (fr)
CA (1) CA2457405A1 (fr)
MX (1) MXPA04001421A (fr)
NO (1) NO20041058L (fr)
NZ (1) NZ531117A (fr)
WO (1) WO2003015703A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025388A1 (en) * 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US7144880B2 (en) 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
DE60007960T2 (de) 1999-04-30 2004-10-21 Univ Michigan Ann Arbor Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
AU2004255153B2 (en) * 2003-05-01 2007-11-22 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
JP2008528448A (ja) 2005-01-03 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 新規化合物に関連する組成物および方法、ならびにその標的
AU2006309291B2 (en) * 2005-06-01 2010-05-27 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
JP4980358B2 (ja) * 2005-09-19 2012-07-18 アロー セラピューティクス リミテッド Ｃ型肝炎感染症を治療するためのベンゾジアゼピン誘導体
US8088759B2 (en) 2005-11-01 2012-01-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
EP2037741B1 (fr) 2006-06-09 2013-11-27 The Regents Of The University Of Michigan Dérives de benzodiazépine utiles dans le traitement de pathologies sur une base immune, inflammatoire ou proliferative.
BRPI0808653A2 (pt) 2007-03-09 2014-08-19 Univ Michigan Composições e métodos referindo-se a novos compostos e alvos dos mesmos.
CA2698248C (fr) 2007-09-14 2017-08-29 The Regents Of The University Of Michigan Derives acyles phenyles de guanidine comme inhibiteurs de la f1f0-atpase et leur utilisation
JP5539212B2 (ja) 2007-11-06 2014-07-02 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 皮膚症状の治療に有用なベンゾジアゼピノン化合物
EP2352724B1 (fr) 2008-09-11 2015-04-22 The Regents of the University of Michigan Aryle guanidines comme inhibiteurs de la f1f0-atpase et leur utilisation medicale
WO2010121164A2 (fr) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan Composés de 1,4-benzodiazépinone et leur utilisation dans le traitement du cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
CA2915237C (fr) 2009-11-17 2017-10-10 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones et composes apparentes presentant des proprietes therapeutiques
AU2010322287B2 (en) 2009-11-17 2014-04-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898861A (en) * 1987-03-26 1990-02-06 Hoffmann-La Roche Inc. Method for inhibiting the proliferation of tumor cells
US5776946A (en) * 1995-08-28 1998-07-07 Mcgeer; Patrick L. Peripheral benzodiazepine receptor ligands as antiinflammatory agents
WO1999058117A1 (fr) * 1998-05-13 1999-11-18 Sanofi-Synthelabo Utilisation de composes reduisant l'apoptose
WO1999066958A2 (fr) * 1998-06-22 1999-12-29 Centre National De La Recherche Scientifique (Cnrs) Utilisation d'un compose possedant une affinite pour le recepteur mitochondrial des benzodiazepines en therapie du cancer
WO2000066106A2 (fr) * 1999-04-30 2000-11-09 The Regents Of The University Of Michigan Applications therapeutiques de benzodiazepines pro-apoptotiques
WO2001051922A2 (fr) * 2000-01-14 2001-07-19 Mitokor Procedes pour identifier les agents liant le recepteur de benzodiazepine peripherique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277844B1 (en) * 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
AU5763600A (en) * 1999-06-22 2001-01-09 Mitokor Compositions and methods for assaying subcellular conditions and processes usingenergy transfer
US7005274B1 (en) * 1999-09-15 2006-02-28 Migenix Corp. Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898861A (en) * 1987-03-26 1990-02-06 Hoffmann-La Roche Inc. Method for inhibiting the proliferation of tumor cells
US5776946A (en) * 1995-08-28 1998-07-07 Mcgeer; Patrick L. Peripheral benzodiazepine receptor ligands as antiinflammatory agents
WO1999058117A1 (fr) * 1998-05-13 1999-11-18 Sanofi-Synthelabo Utilisation de composes reduisant l'apoptose
WO1999066958A2 (fr) * 1998-06-22 1999-12-29 Centre National De La Recherche Scientifique (Cnrs) Utilisation d'un compose possedant une affinite pour le recepteur mitochondrial des benzodiazepines en therapie du cancer
WO2000066106A2 (fr) * 1999-04-30 2000-11-09 The Regents Of The University Of Michigan Applications therapeutiques de benzodiazepines pro-apoptotiques
WO2001051922A2 (fr) * 2000-01-14 2001-07-19 Mitokor Procedes pour identifier les agents liant le recepteur de benzodiazepine peripherique

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLUM P ET AL: "STIFF-PERSON SYNDROME: AN AUTOIMMUNE DISEASE", MOVEMENT DISORDERS, RAVEN PRESS, NEW YORK, NY, US, vol. 6, no. 1, 1 January 1991 (1991-01-01), pages 12 - 20, XP000957552, ISSN: 0885-3185 *
SCHLUMPF M ET AL: "DELAYED DEVELOPMENTAL IMMUNOTOXICITY OF PRENATAL BENZODIAZEPINES", TOXICOLOGY IN VITRO, ELSEVIER SCIENCE, GB, vol. 8, no. 5, 1 January 1994 (1994-01-01), pages 1061 - 1065, XP000957564, ISSN: 0887-2333 *
SHAWN Y. STEVENS ET AL.: "Non nucleic acis inhibitors of protein-DNA interactions identified through combinatorial chemistry", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118, 1996, pages 10650 - 10651, XP002499663 *
TANIMOTO Y ET AL: "BENZODIAZEPINE RECEPTOR AGONISTS MODULATE THYMOCYTE APOPTOSIS THROUGH REDUCTION OF THE MITOCHONDRIAL TRANSMEMBRANE POTENTIAL", JAPANESE JOURNAL OF PHARMACOLOGY, JP, vol. 79, no. 2, 1 January 1999 (1999-01-01), pages 177 - 183, XP000957554, ISSN: 0021-5198 *

Also Published As

Publication number Publication date
JP2005502652A (ja) 2005-01-27
CA2457405A1 (fr) 2003-02-27
AU2002332560B2 (en) 2006-01-19
NO20041058L (no) 2004-05-14
WO2003015703A3 (fr) 2003-11-13
NZ531117A (en) 2006-03-31
WO2003015703A2 (fr) 2003-02-27
MXPA04001421A (es) 2004-06-03
EP1423122A2 (fr) 2004-06-02

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