NZ531117A - Compositions and methods relating to novel benzodiazepine compounds and targets thereof - Google Patents
Compositions and methods relating to novel benzodiazepine compounds and targets thereofInfo
- Publication number
- NZ531117A NZ531117A NZ531117A NZ53111702A NZ531117A NZ 531117 A NZ531117 A NZ 531117A NZ 531117 A NZ531117 A NZ 531117A NZ 53111702 A NZ53111702 A NZ 53111702A NZ 531117 A NZ531117 A NZ 531117A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cells
- targets
- compositions
- agent
- methods relating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31256001P | 2001-08-15 | 2001-08-15 | |
| US31368901P | 2001-08-20 | 2001-08-20 | |
| US39667002P | 2002-07-18 | 2002-07-18 | |
| US10/217,878 US20030119029A1 (en) | 1999-04-30 | 2002-08-13 | Compositions and methods relating to novel benzodiazepine compounds and targets thereof |
| PCT/US2002/026171 WO2003015703A2 (fr) | 2001-08-15 | 2002-08-15 | Compositions et procedes relatifs a de nouveaux composes de benzodiazepine et leurs cibles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ531117A true NZ531117A (en) | 2006-03-31 |
Family
ID=27499087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ531117A NZ531117A (en) | 2001-08-15 | 2002-08-15 | Compositions and methods relating to novel benzodiazepine compounds and targets thereof |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1423122A4 (fr) |
| JP (1) | JP2005502652A (fr) |
| AU (1) | AU2002332560B2 (fr) |
| CA (1) | CA2457405A1 (fr) |
| MX (1) | MXPA04001421A (fr) |
| NO (1) | NO20041058L (fr) |
| NZ (1) | NZ531117A (fr) |
| WO (1) | WO2003015703A2 (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8759340B2 (en) | 2007-11-06 | 2014-06-24 | The Regents Of The University Of Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions |
| US8791104B2 (en) | 2005-11-01 | 2014-07-29 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| US8809323B2 (en) | 1999-04-30 | 2014-08-19 | The Regents Of The University Of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060025388A1 (en) * | 1999-04-30 | 2006-02-02 | Glick Gary D | Compositions and methods relating to novel compounds and targets thereof |
| US7144880B2 (en) | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
| US20050113460A1 (en) * | 1999-04-30 | 2005-05-26 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US7276348B2 (en) | 1999-04-30 | 2007-10-02 | Regents Of The University Of Michigan | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof |
| AU2004255153B2 (en) * | 2003-05-01 | 2007-11-22 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US20050272723A1 (en) * | 2004-04-27 | 2005-12-08 | The Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
| JP2008528448A (ja) | 2005-01-03 | 2008-07-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 新規化合物に関連する組成物および方法、ならびにその標的 |
| AU2006309291B2 (en) * | 2005-06-01 | 2010-05-27 | The Regents Of The University Of Michigan | Unsolvated benzodiazepine compositions and methods |
| JP4980358B2 (ja) * | 2005-09-19 | 2012-07-18 | アロー セラピューティクス リミテッド | Ｃ型肝炎感染症を治療するためのベンゾジアゼピン誘導体 |
| US7759338B2 (en) | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
| EP2037741B1 (fr) | 2006-06-09 | 2013-11-27 | The Regents Of The University Of Michigan | Dérives de benzodiazépine utiles dans le traitement de pathologies sur une base immune, inflammatoire ou proliferative. |
| BRPI0808653A2 (pt) | 2007-03-09 | 2014-08-19 | Univ Michigan | Composições e métodos referindo-se a novos compostos e alvos dos mesmos. |
| CA2698248C (fr) | 2007-09-14 | 2017-08-29 | The Regents Of The University Of Michigan | Derives acyles phenyles de guanidine comme inhibiteurs de la f1f0-atpase et leur utilisation |
| EP2352724B1 (fr) | 2008-09-11 | 2015-04-22 | The Regents of the University of Michigan | Aryle guanidines comme inhibiteurs de la f1f0-atpase et leur utilisation medicale |
| WO2010121164A2 (fr) | 2009-04-17 | 2010-10-21 | The Regents Of The University Of Michigan | Composés de 1,4-benzodiazépinone et leur utilisation dans le traitement du cancer |
| US8673897B2 (en) | 2009-09-18 | 2014-03-18 | The Regents Of The University Of Michigan | Benzodiazepinone compounds and methods of treatment using same |
| CA2915237C (fr) | 2009-11-17 | 2017-10-10 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones et composes apparentes presentant des proprietes therapeutiques |
| AU2010322287B2 (en) | 2009-11-17 | 2014-04-03 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898861A (en) * | 1987-03-26 | 1990-02-06 | Hoffmann-La Roche Inc. | Method for inhibiting the proliferation of tumor cells |
| US5776946A (en) * | 1995-08-28 | 1998-07-07 | Mcgeer; Patrick L. | Peripheral benzodiazepine receptor ligands as antiinflammatory agents |
| WO1999058117A1 (fr) * | 1998-05-13 | 1999-11-18 | Sanofi-Synthelabo | Utilisation de composes reduisant l'apoptose |
| FR2779963A1 (fr) * | 1998-06-22 | 1999-12-24 | Centre Nat Rech Scient | Utilisation d'un compose possedant une affinite pour le recepteur mitochondrial des benzodiazepines en therapie du cancer |
| US6277844B1 (en) * | 1998-09-14 | 2001-08-21 | Sydney Spector | Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis |
| DE60007960T2 (de) * | 1999-04-30 | 2004-10-21 | Univ Michigan Ann Arbor | Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen |
| AU5763600A (en) * | 1999-06-22 | 2001-01-09 | Mitokor | Compositions and methods for assaying subcellular conditions and processes usingenergy transfer |
| US7005274B1 (en) * | 1999-09-15 | 2006-02-28 | Migenix Corp. | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass |
| CA2406901A1 (fr) * | 2000-01-14 | 2001-07-19 | Mitokor | Procedes pour identifier les agents liant le recepteur de benzodiazepine peripherique |
-
2002
- 2002-08-15 EP EP02794914A patent/EP1423122A4/fr not_active Withdrawn
- 2002-08-15 AU AU2002332560A patent/AU2002332560B2/en not_active Ceased
- 2002-08-15 CA CA002457405A patent/CA2457405A1/fr not_active Abandoned
- 2002-08-15 NZ NZ531117A patent/NZ531117A/xx not_active IP Right Cessation
- 2002-08-15 JP JP2003520664A patent/JP2005502652A/ja active Pending
- 2002-08-15 WO PCT/US2002/026171 patent/WO2003015703A2/fr active IP Right Grant
- 2002-08-15 MX MXPA04001421A patent/MXPA04001421A/es not_active Application Discontinuation
-
2004
- 2004-03-12 NO NO20041058A patent/NO20041058L/no not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8809323B2 (en) | 1999-04-30 | 2014-08-19 | The Regents Of The University Of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
| US8791104B2 (en) | 2005-11-01 | 2014-07-29 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| US8759340B2 (en) | 2007-11-06 | 2014-06-24 | The Regents Of The University Of Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005502652A (ja) | 2005-01-27 |
| CA2457405A1 (fr) | 2003-02-27 |
| AU2002332560B2 (en) | 2006-01-19 |
| EP1423122A4 (fr) | 2008-12-10 |
| NO20041058L (no) | 2004-05-14 |
| WO2003015703A3 (fr) | 2003-11-13 |
| WO2003015703A2 (fr) | 2003-02-27 |
| MXPA04001421A (es) | 2004-06-03 |
| EP1423122A2 (fr) | 2004-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |